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Arne Elofsson @bioinfo.se · 1h

mRNA initiation and termination are spatially coordinated | Science www.science.org/doi/10.1126/...

mRNA initiation and termination are spatially coordinated

Transcriptional initiation and termination decisions drive messenger RNA (mRNA) isoform diversity but the relationship between them remains poorly understood. By systematically profiling joint usage o...

www.science.org

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Arne Elofsson @bioinfo.se · 1h

Targeted protein evolution in the gut microbiome by diversity-generating retroelements | Science www.science.org/doi/10.1126/...

Targeted protein evolution in the gut microbiome by diversity-generating retroelements

Diversity-generating retroelements (DGRs) accelerate evolution by rapidly diversifying variable proteins. The human gastrointestinal microbiota harbors the greatest density of DGRs known in nature, su...

www.science.org

Arne Elofsson @bioinfo.se · 2h

Andrzej Bargiel Describes How He Skied Down Everest explorersweb.com/andrzej-barg...

Andrzej Bargiel Describes How He Skied Down Everest » Explorersweb

Until now, we knew very little about the strategy the Polish skier used to ski down Everest without bottled oxygen. Here's his detailed account.

explorersweb.com

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Reposted by Arne Elofsson

GAMA Miguel Angel @miangoar.bsky.social · 2h

I just want to create hype and say that I made a 10-class course to introduce people to AI-driven protein design. It’s around 750 slides and will be freely available for anyone who wants to use them and, most importantly, improve them. Stay tuned :)

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Arne Elofsson @bioinfo.se · 2h

More than 30% of this century’s science Nobel prizewinners immigrated: see their journeys www.nature.com/articles/d41...

More than 30% of this century’s science Nobel prizewinners immigrated: see their journeys

The most common destination for eventual Nobel laureates in physics, chemistry and medicine since 2000 is the United States, Nature has found.

www.nature.com

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Reposted by Arne Elofsson

Ewan Birney @ewanbirney.bsky.social · 15h

A reminder that the PhD program for EMBL is open for winter recruitment round. If you want to understand life at a molecular level and have a quantitative science (you don't have to have done biology - we love our mathematicians/physcists/chemists!) apply www.embl.org/about/info/e...

Application – EMBL International PhD Programme

www.embl.org

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Reposted by Arne Elofsson

Stockholm University @stockholm-uni.bsky.social · 1d

–Det är ett otroligt välförtjänt pris som uppmärksammar ett nytt, mångsidigt och förutsägbart sätt att bygga porösa material, säger Tom Willhammar, som forskar om sk MOF:ar vid Stockholms universitet om årets Nobelpris i kemi som belönar metallorganiska ramverk
#NobelPrize
www.su.se/nyheter/m%C3...

Mångsidig teknik som bidrar till lösningar på våra största utmaningar - Stockholms universitet

Årets Nobelpris i kemi handlar om metallorganiska ramverk, en molekylär arkitektur som kan användas inom många olika områden. Vid Stockholms universitet pågår sedan många år forskning om metallorganis...

www.su.se

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Arne Elofsson @bioinfo.se · 1d

www.nature.com/articles/d41...

Ultra-sensitive DNA sequencing maps mutations that precede cancer

Scientists have used low-error genome-sequencing methods in normal tissues from large cohorts of individuals to scan for mutations that set the stage for cancer.

www.nature.com

Arne Elofsson @bioinfo.se · 1d

www.nature.com/articles/s41...

Age and gender distortion in online media and large language models - Nature

Stereotypes of age-related gender bias are socially distorted, as evidenced by the age gap in the representations of women and men across various media and algorithms, despite no systematic age differences in the workforce.

www.nature.com

Arne Elofsson @bioinfo.se · 1d

www.nature.com/articles/s41...

Enzyme specificity prediction using cross attention graph neural networks - Nature

Nature - Enzyme specificity prediction using cross attention graph neural networks

www.nature.com

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Reposted by Arne Elofsson

Marcel Dickmanns | 🌿❄️🔬 @madic.bsky.social · 2d

You can get MSAs directly from AlphaFold DB now (alphafold.ebi.ac.uk). I also missed the FoldSeek implementation, which lets you search for structurally similar proteins direktly.

This saves some clicking around. Neat!

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Reposted by Arne Elofsson

Ezgi Karaca @ezgikaraca.bsky.social · 3d

And the legacy continues! 😊

@amjjbonvin.bsky.social @bioinfo.se @lindorfflarsen.bsky.social #EMBOIntegMod25 ! 🍀🧿

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Reposted by Arne Elofsson

Nature @nature.com · 2d

Quantum tunnelling — when a particle skips through a barrier that classical physics would forbid — happens faster when objects have less energy

go.nature.com/3WwR6MZ

‘Tour de force’ experiment probes quantum tunnelling in action

Probing photons inside a barrier also challenges a long-standing interpretation of quantum physics.

go.nature.com

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Reposted by Arne Elofsson

Randall Munroe @xkcd.com · 2d

Ping

xkcd.com/3150/

4-panel comic. (1) [person finds bottle on shore] (2) [person reads message from inside bottle: ICMP ECHO REQUEST...] (3) [person writes on message ICMP ECHO REPLY...] (4) [person puts bottle back in water and leaves]

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Arne Elofsson @bioinfo.se · 4d

www.pnas.org/doi/10.1073/...

Energy expenditure and obesity across the economic spectrum | PNAS

Global economic development has been associated with an increased prevalence of obesity and related health problems. Increased caloric intake and r...

www.pnas.org

Reposted by Arne Elofsson

Kevin J. CREATURE @kevinjkircher.com · 5d

Sometimes I think about how from 1935-1975ish, Bell Labs produced an insane amount of revolutionary science and technology, including 11 Nobel Prizes, the transistor, UNIX, C, the laser, the solar cell, information theory, etc. The secret? Provide scientists with ample, steady, no-strings funding.

sites.stat.columbia.edu

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Reposted by Arne Elofsson

Shiv Ramdas Mens Rice Activist @nameshiv.bsky.social · 5d

The Ig Nobel is incredible , one year an Indian guy won it for calculating the average surface area of an elephant and during his acceptance they had an elephant hold up a sign with the surface area of the scientist on it, they do showbiz better than the Oscars

Jeffrey J. Hall @mrjeffu.bsky.social · 20d

Video: a Japanese scientist was attacked by flies while giving the acceptance speech for his Ig Nobel Prize-winning research paper that proved painting Zebra-like stripes on cows led to a decrease in biting fly attacks.

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Reposted by Arne Elofsson

clyde bruckman's ghost's final repost says free link @ultralaser.bsky.social · 5d

terrible things are happening outside. poor helpless people are being dragged out of their homes. families are torn apart. men, women, and children are separated. children come home from school to find that their parents have disappeared.

diary of anne frank, january 13, 1943.

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Reposted by Arne Elofsson

Kresten Lindorff-Larsen @lindorfflarsen.bsky.social · 7d

Looking for a PhD? Go work with Giulio 👇

Giulio Tesei @giuliotesei.bsky.social · 7d

I'm hiring for a PhD position at Malmö University, Sweden!

The project will focus on molecular modelling of proteins, lipids, and biomolecular condensates at cell membranes.

More details and application form: tinyurl.com/4zm92365

Please feel free to share!

@vetenskapsradet.bsky.social | @mau.se

Snapshot of a condensate near a lipid membrane with Swedish Research Council and Malmö University logos.

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Arne Elofsson @bioinfo.se · 7d

Machine learning matches enzymes with molecular substrates www.nature.com/articles/d41...

Machine learning matches enzymes with molecular substrates

An open-access webtool enables users to predict enzymes that can perform oxidative chemistry on a given molecule.

www.nature.com

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Arne Elofsson @bioinfo.se · 7d

Elaborate machinery for inserting proteins into the outer membrane of bacteria www.nature.com/articles/d41...

Elaborate machinery for inserting proteins into the outer membrane of bacteria

Bacteria in the gut use an unusual molecular apparatus to insert complex proteins into their outer membrane.

www.nature.com

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Reposted by Arne Elofsson

Gonzalo Parra @gonzaparra.bsky.social · 7d

After months of buildup, it’s finally real! 🎉 The Evolutionary Systems Biophysics Group (ESBG) is officially alive at @bsc-cns.bsky.social . Proud to start this new adventure as a Ramon y Cajal Junior Group Leader🧬
Thanks to all who have been part of this process!
tinyurl.com/4r9vf4zx

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Reposted by Arne Elofsson

Aaron Reichlin-Melnick @reichlinmelnick.bsky.social · 8d

What a line from the Pope! I am so pleased he is carrying on Pope Francis’ advocacy for immigrants.

More pointedly, the pope said, "Someone who says, I'm against abortion, but is in favor of the death penalty is not really pro-life. Someone who says, I'm against abortion but I'm in agreement with the inhuman treatment of immigrants in the United States, I don't know if that's pro-life."

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Simon Dürr @simonduerr.eu · 8d

Cool work to design phospho-tyrosine binder by the Baker lab. They show it works but success rate is low (<0.1%) and binders are not super strong (>500nM, likely related to cost of desolvating the phosphate) .
www.biorxiv.org/content/10.1...

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Arne Elofsson @bioinfo.se · 9d

www.nature.com/articles/s41...

Learning the natural history of human disease with generative transformers - Nature

Delphi-2M forecasts a person’s future health, covering more than 1,000 diseases, provides insights into co-morbidity dynamics and generates synthetic data for the training of AI models that have never seen actual data.

www.nature.com

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