Tim
@timisstuck.bsky.social
Executive Editor at Life Science Alliance. I help decide how biology thinks 🤔
Views are my own and do not reflect editorial policy.
www.timfessenden.com
Views are my own and do not reflect editorial policy.
www.timfessenden.com
Pinned
Tim
@timisstuck.bsky.social
· 29d
The value of publishing negative data - News
Scientific journals love news-worthy results. Editors want to publish studies with novel data that scientists will eagerly read and cite in their own work. Because of this desire for novelty, studies ...
www.rockefeller.edu
Giving the gift of negative data 🥰
Since I joined @lsajournal.org I have handled several stellar manuscripts that report null results. These papers do very well and reviewers almost always appreciate them!
Thanks @rockefeller.edu news team for the article!
www.rockefeller.edu/news/38829-t...
Since I joined @lsajournal.org I have handled several stellar manuscripts that report null results. These papers do very well and reviewers almost always appreciate them!
Thanks @rockefeller.edu news team for the article!
www.rockefeller.edu/news/38829-t...
Reposted by Tim
Two new 🔥pre-prints 🔥 TODAY by us & @pwoakes.bsky.social @myosincity.bsky.social
change the way we think about the septin cytoskeleton
Septins buffer mechanical stress on actin and membranes!
Septins are like intermediate filaments
www.biorxiv.org/content/10.6...
www.biorxiv.org/content/10.6...
change the way we think about the septin cytoskeleton
Septins buffer mechanical stress on actin and membranes!
Septins are like intermediate filaments
www.biorxiv.org/content/10.6...
www.biorxiv.org/content/10.6...
a woman in a suit and tie has the words wait what written on her face
ALT: a woman in a suit and tie has the words wait what written on her face
media.tenor.com
January 21, 2026 at 9:18 PM
Two new 🔥pre-prints 🔥 TODAY by us & @pwoakes.bsky.social @myosincity.bsky.social
change the way we think about the septin cytoskeleton
Septins buffer mechanical stress on actin and membranes!
Septins are like intermediate filaments
www.biorxiv.org/content/10.6...
www.biorxiv.org/content/10.6...
change the way we think about the septin cytoskeleton
Septins buffer mechanical stress on actin and membranes!
Septins are like intermediate filaments
www.biorxiv.org/content/10.6...
www.biorxiv.org/content/10.6...
Reposted by Tim
🚨 We are hiring TWO postdocs to join the Cell Migration Lab (cellmig.org) 🇫🇮 as part of the new Centre of Excellence in Immune–Endothelial Interfaces (IMMENs).
Join us to decode immune regulation & develop next-gen imaging tools! 🧪🔬
Details in thread 🧵👇
#ScienceSky #Postdoc #AcademicJobs Please RT🫶
Join us to decode immune regulation & develop next-gen imaging tools! 🧪🔬
Details in thread 🧵👇
#ScienceSky #Postdoc #AcademicJobs Please RT🫶
CELL MIGRATION LAB
We study cell migration in health and disease
cellmig.org
January 21, 2026 at 7:57 AM
🚨 We are hiring TWO postdocs to join the Cell Migration Lab (cellmig.org) 🇫🇮 as part of the new Centre of Excellence in Immune–Endothelial Interfaces (IMMENs).
Join us to decode immune regulation & develop next-gen imaging tools! 🧪🔬
Details in thread 🧵👇
#ScienceSky #Postdoc #AcademicJobs Please RT🫶
Join us to decode immune regulation & develop next-gen imaging tools! 🧪🔬
Details in thread 🧵👇
#ScienceSky #Postdoc #AcademicJobs Please RT🫶
Reposted by Tim
📰 #PressRelease: Researchers in Japan have discovered that amyloid-β deposits disrupt the formation of the placenta & may therefore contribute to the development of #preeclampsia during #pregnancy. www.eurekalert.org/news-release...
In @lsajournal.org: www.life-science-alliance.org/content/9/4/...
In @lsajournal.org: www.life-science-alliance.org/content/9/4/...
January 20, 2026 at 9:00 PM
📰 #PressRelease: Researchers in Japan have discovered that amyloid-β deposits disrupt the formation of the placenta & may therefore contribute to the development of #preeclampsia during #pregnancy. www.eurekalert.org/news-release...
In @lsajournal.org: www.life-science-alliance.org/content/9/4/...
In @lsajournal.org: www.life-science-alliance.org/content/9/4/...
Still no idea wtf the Vault evolved to do, but it can be made useful!! Glad to see this out finally!
“A genetically encoded device for transcriptome storage in mammalian cells”
www.science.org/doi/10.1126/...
“A genetically encoded device for transcriptome storage in mammalian cells”
www.science.org/doi/10.1126/...
A genetically encoded device for transcriptome storage in mammalian cells
Understanding how cells make decisions over time requires the ability to link past molecular states to future phenotypic outcomes. We present TimeVault, a genetically encoded system that records and s...
www.science.org
January 19, 2026 at 3:11 PM
Still no idea wtf the Vault evolved to do, but it can be made useful!! Glad to see this out finally!
“A genetically encoded device for transcriptome storage in mammalian cells”
www.science.org/doi/10.1126/...
“A genetically encoded device for transcriptome storage in mammalian cells”
www.science.org/doi/10.1126/...
Reposted by Tim
I need to admit that @epimechfc.bsky.social is one of best #SCiComm in this era!👍
How can structures at the vertex of 3 cells have effects at the tissue level?
Join me, @laura-rustarazo.bsky.social, to explore how tricellular junctions (TCJs) act as local tension sensors and regulators of global tissue organization. 🧵⤵️ doi.org/10.1126/scie...
Join me, @laura-rustarazo.bsky.social, to explore how tricellular junctions (TCJs) act as local tension sensors and regulators of global tissue organization. 🧵⤵️ doi.org/10.1126/scie...
January 18, 2026 at 3:34 PM
I need to admit that @epimechfc.bsky.social is one of best #SCiComm in this era!👍
Poll of two postdocs I happened to sit with for lunch yesterday (at Rockefeller U):
-Editor at @science.org offered guidance to authors on how to respond to reviewer comments.
-Editors at @nature.com did NOT. Just sent a form email inviting revisions.
-Editor at @science.org offered guidance to authors on how to respond to reviewer comments.
-Editors at @nature.com did NOT. Just sent a form email inviting revisions.
January 17, 2026 at 3:49 PM
Poll of two postdocs I happened to sit with for lunch yesterday (at Rockefeller U):
-Editor at @science.org offered guidance to authors on how to respond to reviewer comments.
-Editors at @nature.com did NOT. Just sent a form email inviting revisions.
-Editor at @science.org offered guidance to authors on how to respond to reviewer comments.
-Editors at @nature.com did NOT. Just sent a form email inviting revisions.
Fantastic work on autophagy in flies from Juhasz and Szabo labs!! Super happy see this work out from world experts in this area.
This study shows that glial Stat92E transcription factor activity is derepressed by selective autophagic elimination of the Stat92E repressor Su(var)2-10/PIAS in Drosophila glia after neural injury.
@BRCGenetics.bsky.social
www.life-science-alliance.org/content/9/3/...
@BRCGenetics.bsky.social
www.life-science-alliance.org/content/9/3/...
January 15, 2026 at 2:49 PM
Fantastic work on autophagy in flies from Juhasz and Szabo labs!! Super happy see this work out from world experts in this area.
Reposted by Tim
To decide whether to select a 3D cell migration assay for your application and how to analyze the resulting data, read:
... about the 3D cell-migration assay and other migration assays here: www.nature.com/articles/s41...
For data analysis, read this review paper: www.nature.com/articles/s41...
... about the 3D cell-migration assay and other migration assays here: www.nature.com/articles/s41...
For data analysis, read this review paper: www.nature.com/articles/s41...
January 13, 2026 at 6:58 PM
To decide whether to select a 3D cell migration assay for your application and how to analyze the resulting data, read:
... about the 3D cell-migration assay and other migration assays here: www.nature.com/articles/s41...
For data analysis, read this review paper: www.nature.com/articles/s41...
... about the 3D cell-migration assay and other migration assays here: www.nature.com/articles/s41...
For data analysis, read this review paper: www.nature.com/articles/s41...
We at @lsajournal.org have discussed doing calls for papers/special issues. Some great journals like @jcellsci.bsky.social have them.
But our leadership was VERY clear: MDPI, Frontiers, and their ilk have so sullied this publication mechanism that no one wanted to go there. The concept is tainted.
But our leadership was VERY clear: MDPI, Frontiers, and their ilk have so sullied this publication mechanism that no one wanted to go there. The concept is tainted.
🧪 Thousands of special issues are stained with PISS (>33% of articles authored by the guest editor). See @hansonmark.bsky.social's thread below for a brief summary, read our preprint (arxiv.org/abs/2601.07563), explore our ShinyApp to see where it occurs (paolocrosetto.shinyapps.io/Editors_as_a...).
January 13, 2026 at 2:47 PM
We at @lsajournal.org have discussed doing calls for papers/special issues. Some great journals like @jcellsci.bsky.social have them.
But our leadership was VERY clear: MDPI, Frontiers, and their ilk have so sullied this publication mechanism that no one wanted to go there. The concept is tainted.
But our leadership was VERY clear: MDPI, Frontiers, and their ilk have so sullied this publication mechanism that no one wanted to go there. The concept is tainted.
interesting
Predicting cell state in previously unseen conditions has typically required retraining for each new biological context. Today, Arc is releasing Stack, a foundation model that learns to simulate cell state under novel conditions directly at inference time, no fine-tuning required.
January 9, 2026 at 7:38 PM
interesting
Reposted by Tim
🚨Introducing DevBioConnect ‼️
Developmental Biology launches a new author webinar series showcasing recently published research, presented by the authors themselves
🗓️ Jan 13 • Feb 10 • Mar 10, 2026 ⏰ 11am–12pm CST 📄 See flyer for details #DevBio #DevelopmentalBiology
🗓️ Jan 13 • Feb 10 • Mar 10, 2026 ⏰ 11am–12pm CST 📄 See flyer for details #DevBio #DevelopmentalBiology
January 7, 2026 at 3:50 PM
🚨Introducing DevBioConnect ‼️
Developmental Biology launches a new author webinar series showcasing recently published research, presented by the authors themselves
🗓️ Jan 13 • Feb 10 • Mar 10, 2026 ⏰ 11am–12pm CST 📄 See flyer for details #DevBio #DevelopmentalBiology
🗓️ Jan 13 • Feb 10 • Mar 10, 2026 ⏰ 11am–12pm CST 📄 See flyer for details #DevBio #DevelopmentalBiology
Too many fabulous seminars here at @rockefeller.edu
On Tuesday @deepakkrish.bsky.social (formerly @prakashlab.bsky.social, now @fletcherlabucb.bsky.social) showed gorgeous loricate choanoflagellates!! Difficult but rewarding to study how these critters deftly manipulate materials at the mesoscale.
On Tuesday @deepakkrish.bsky.social (formerly @prakashlab.bsky.social, now @fletcherlabucb.bsky.social) showed gorgeous loricate choanoflagellates!! Difficult but rewarding to study how these critters deftly manipulate materials at the mesoscale.
January 8, 2026 at 4:08 PM
Too many fabulous seminars here at @rockefeller.edu
On Tuesday @deepakkrish.bsky.social (formerly @prakashlab.bsky.social, now @fletcherlabucb.bsky.social) showed gorgeous loricate choanoflagellates!! Difficult but rewarding to study how these critters deftly manipulate materials at the mesoscale.
On Tuesday @deepakkrish.bsky.social (formerly @prakashlab.bsky.social, now @fletcherlabucb.bsky.social) showed gorgeous loricate choanoflagellates!! Difficult but rewarding to study how these critters deftly manipulate materials at the mesoscale.
Surprised (pleasantly!!) that total science research posts on X were only a wee but more than twice the research posts on Bluesky!
Great news given the huge disparity in total volume between the two platforms.
Great news given the huge disparity in total volume between the two platforms.
X/Twitter's rough full volume is around 500 total million posts every day, or 182 (and a half) billion posts per year.
By contracts, we found 11.2 million research posts in all of 2025 on there.
In other words, 0.000006% of Twitter appears to be sharing research. Basically zero.
By contracts, we found 11.2 million research posts in all of 2025 on there.
In other words, 0.000006% of Twitter appears to be sharing research. Basically zero.
January 8, 2026 at 3:57 PM
Surprised (pleasantly!!) that total science research posts on X were only a wee but more than twice the research posts on Bluesky!
Great news given the huge disparity in total volume between the two platforms.
Great news given the huge disparity in total volume between the two platforms.
Reposted by Tim
Interested in the MBL Physiology Course in Woods Hole and want to learn more before you apply?
Join myself and Cliff at our Virtual Open House TOMORROW 2–3 PM ET. You will hear what the course experience is like and get all your questions answered.
Register/Join: princeton.zoom.us/j/97673682905
Join myself and Cliff at our Virtual Open House TOMORROW 2–3 PM ET. You will hear what the course experience is like and get all your questions answered.
Register/Join: princeton.zoom.us/j/97673682905
Interested in the MBL Physiology Course and want to learn more before you apply?
Join our Virtual Open House on Tues, Jan 6, 2026 | 2–3 PM ET to meet the team, hear what the course experience is like, and get your questions answered.
🔗 Register/Join: https://go.mbl.edu/r5q
Join our Virtual Open House on Tues, Jan 6, 2026 | 2–3 PM ET to meet the team, hear what the course experience is like, and get your questions answered.
🔗 Register/Join: https://go.mbl.edu/r5q
January 5, 2026 at 7:15 PM
Interested in the MBL Physiology Course in Woods Hole and want to learn more before you apply?
Join myself and Cliff at our Virtual Open House TOMORROW 2–3 PM ET. You will hear what the course experience is like and get all your questions answered.
Register/Join: princeton.zoom.us/j/97673682905
Join myself and Cliff at our Virtual Open House TOMORROW 2–3 PM ET. You will hear what the course experience is like and get all your questions answered.
Register/Join: princeton.zoom.us/j/97673682905
Neat!
CRC cells pulling on Collagen I show increased calcium fluctuations, visualized with the calcium reporter K-GECO1
December 27, 2025 at 4:21 PM
Neat!
Giving the gift of negative data 🥰
Since I joined @lsajournal.org I have handled several stellar manuscripts that report null results. These papers do very well and reviewers almost always appreciate them!
Thanks @rockefeller.edu news team for the article!
www.rockefeller.edu/news/38829-t...
Since I joined @lsajournal.org I have handled several stellar manuscripts that report null results. These papers do very well and reviewers almost always appreciate them!
Thanks @rockefeller.edu news team for the article!
www.rockefeller.edu/news/38829-t...
The value of publishing negative data - News
Scientific journals love news-worthy results. Editors want to publish studies with novel data that scientists will eagerly read and cite in their own work. Because of this desire for novelty, studies ...
www.rockefeller.edu
December 23, 2025 at 1:26 PM
Giving the gift of negative data 🥰
Since I joined @lsajournal.org I have handled several stellar manuscripts that report null results. These papers do very well and reviewers almost always appreciate them!
Thanks @rockefeller.edu news team for the article!
www.rockefeller.edu/news/38829-t...
Since I joined @lsajournal.org I have handled several stellar manuscripts that report null results. These papers do very well and reviewers almost always appreciate them!
Thanks @rockefeller.edu news team for the article!
www.rockefeller.edu/news/38829-t...
Reposted by Tim
Vote for JCB’s cover of the year! Explore 12 breathtaking images submitted by our talented authors and pick a favorite. Voting closes on Wednesday, December 31! 👉 www.surveymonkey.com/r/JCB2025Cov...
#ScienceArt
#ScienceArt
December 22, 2025 at 7:30 PM
Vote for JCB’s cover of the year! Explore 12 breathtaking images submitted by our talented authors and pick a favorite. Voting closes on Wednesday, December 31! 👉 www.surveymonkey.com/r/JCB2025Cov...
#ScienceArt
#ScienceArt
Reposted by Tim
I just finished my 28th yr of teaching grad compbio.
Following the inevitable trend, a 3rd of the course is now Deep Learning (DL).
One activity we did was a deep dive into the AlphaGenome pre-print (www.biorxiv.org/content/10.1...).
Question is, how do we evaluate it as a science paper?
1/n
Following the inevitable trend, a 3rd of the course is now Deep Learning (DL).
One activity we did was a deep dive into the AlphaGenome pre-print (www.biorxiv.org/content/10.1...).
Question is, how do we evaluate it as a science paper?
1/n
AlphaGenome: advancing regulatory variant effect prediction with a unified DNA sequence model
Deep learning models that predict functional genomic measurements from DNA sequence are powerful tools for deciphering the genetic regulatory code. Existing methods trade off between input sequence le...
www.biorxiv.org
December 22, 2025 at 7:10 PM
I just finished my 28th yr of teaching grad compbio.
Following the inevitable trend, a 3rd of the course is now Deep Learning (DL).
One activity we did was a deep dive into the AlphaGenome pre-print (www.biorxiv.org/content/10.1...).
Question is, how do we evaluate it as a science paper?
1/n
Following the inevitable trend, a 3rd of the course is now Deep Learning (DL).
One activity we did was a deep dive into the AlphaGenome pre-print (www.biorxiv.org/content/10.1...).
Question is, how do we evaluate it as a science paper?
1/n
With a smaller, somewhat fraught #cellbio2025 behind us I am nevertheless still inspired and amazed at this community.
Curious to hear others’ impressions!!
Curious to hear others’ impressions!!
December 10, 2025 at 7:12 PM
With a smaller, somewhat fraught #cellbio2025 behind us I am nevertheless still inspired and amazed at this community.
Curious to hear others’ impressions!!
Curious to hear others’ impressions!!
Reposted by Tim
Don't miss out on the last "Meet the Editors" session at #CellBio2025! Join us at booth 825 from 14:00–15:00 EST to chat with editors Poonam (Molecular Systems Biology), Sara Monaco (Review Commons) and Tim (Life Science Alliance) to talk about #publishing, life as an editor and more! 🧪 EMBO Press
December 9, 2025 at 4:25 PM
Don't miss out on the last "Meet the Editors" session at #CellBio2025! Join us at booth 825 from 14:00–15:00 EST to chat with editors Poonam (Molecular Systems Biology), Sara Monaco (Review Commons) and Tim (Life Science Alliance) to talk about #publishing, life as an editor and more! 🧪 EMBO Press
Lovely work on the origins of vascular pathologies in progeria. Check out the nice video made by the authors describing their findings 👇
Take a look at this recently published paper in LSA:
The unfolded protein response in progeria arteries originates from non-endothelial cell types @maxperutzlabs.ac.at @gekaragoz.bsky.social
www.life-science-alliance.org/content/9/2/...
The unfolded protein response in progeria arteries originates from non-endothelial cell types @maxperutzlabs.ac.at @gekaragoz.bsky.social
www.life-science-alliance.org/content/9/2/...
December 9, 2025 at 4:25 PM
Lovely work on the origins of vascular pathologies in progeria. Check out the nice video made by the authors describing their findings 👇
Flyers for @lsajournal.org with our cell bio collection:
Collect all 4 to recreate the full artwork by our fantastic collaborator Laurène!
And come get a tshirt with this work today 1-3pm at @embo.org booth 🎊
Collect all 4 to recreate the full artwork by our fantastic collaborator Laurène!
And come get a tshirt with this work today 1-3pm at @embo.org booth 🎊
December 8, 2025 at 3:20 PM
Flyers for @lsajournal.org with our cell bio collection:
Collect all 4 to recreate the full artwork by our fantastic collaborator Laurène!
And come get a tshirt with this work today 1-3pm at @embo.org booth 🎊
Collect all 4 to recreate the full artwork by our fantastic collaborator Laurène!
And come get a tshirt with this work today 1-3pm at @embo.org booth 🎊
Reposted by Tim
G&D Executive Editor, Dr. Eric Sawey is at #cellbio2025!
If you’d like to share your work with us or learn about the journal, drop by the CSHL Press booth or reach out at [email protected]
#genesdev Cold Spring Harbor Laboratory Press
If you’d like to share your work with us or learn about the journal, drop by the CSHL Press booth or reach out at [email protected]
#genesdev Cold Spring Harbor Laboratory Press
December 8, 2025 at 1:55 PM
G&D Executive Editor, Dr. Eric Sawey is at #cellbio2025!
If you’d like to share your work with us or learn about the journal, drop by the CSHL Press booth or reach out at [email protected]
#genesdev Cold Spring Harbor Laboratory Press
If you’d like to share your work with us or learn about the journal, drop by the CSHL Press booth or reach out at [email protected]
#genesdev Cold Spring Harbor Laboratory Press
Reposted by Tim
Join us at booth 825 from 14–15:00 EST on Sun, Mon and Tues to chat with editors Poonam (Molecular Systems Biology), Sara Monaco (Review Commons) and Tim (Life Science Alliance), whether that is to discuss a paper you are writing, talk about publishing or life as an editor. See you! 🧪 #CellBio2025
December 7, 2025 at 3:15 PM
Join us at booth 825 from 14–15:00 EST on Sun, Mon and Tues to chat with editors Poonam (Molecular Systems Biology), Sara Monaco (Review Commons) and Tim (Life Science Alliance), whether that is to discuss a paper you are writing, talk about publishing or life as an editor. See you! 🧪 #CellBio2025
Reposted by Tim
Attending the ASCB/EMBO Cell Bio #cellbio2025 in Philadelphia? Check out the posters from our lab on nuclear mechanobiology, lamins, and mechanotransduction today and on Tuesday. I will be there too and look forward to catching up!
December 7, 2025 at 3:31 PM
Attending the ASCB/EMBO Cell Bio #cellbio2025 in Philadelphia? Check out the posters from our lab on nuclear mechanobiology, lamins, and mechanotransduction today and on Tuesday. I will be there too and look forward to catching up!