Tim
@timisstuck.bsky.social
Executive Editor at Life Science Alliance. I help decide how biology thinks 🤔
Views are my own and do not reflect editorial policy.
www.timfessenden.com
Views are my own and do not reflect editorial policy.
www.timfessenden.com
Last a huge finding on PD-1 signaling from T cell whisperer Ron Germain. Targeting PD-1 boosts anti tumor immunity short term but they argue it also impedes formation of high-avidity effector clones.
I wonder if this tanked some immuno-oncology pharma programs...
doi.org/10.1038/s415...
I wonder if this tanked some immuno-oncology pharma programs...
doi.org/10.1038/s415...
January 29, 2026 at 6:02 PM
Last a huge finding on PD-1 signaling from T cell whisperer Ron Germain. Targeting PD-1 boosts anti tumor immunity short term but they argue it also impedes formation of high-avidity effector clones.
I wonder if this tanked some immuno-oncology pharma programs...
doi.org/10.1038/s415...
I wonder if this tanked some immuno-oncology pharma programs...
doi.org/10.1038/s415...
Poll of two postdocs I happened to sit with for lunch yesterday (at Rockefeller U):
-Editor at @science.org offered guidance to authors on how to respond to reviewer comments.
-Editors at @nature.com did NOT. Just sent a form email inviting revisions.
-Editor at @science.org offered guidance to authors on how to respond to reviewer comments.
-Editors at @nature.com did NOT. Just sent a form email inviting revisions.
January 17, 2026 at 3:49 PM
Poll of two postdocs I happened to sit with for lunch yesterday (at Rockefeller U):
-Editor at @science.org offered guidance to authors on how to respond to reviewer comments.
-Editors at @nature.com did NOT. Just sent a form email inviting revisions.
-Editor at @science.org offered guidance to authors on how to respond to reviewer comments.
-Editors at @nature.com did NOT. Just sent a form email inviting revisions.
With a smaller, somewhat fraught #cellbio2025 behind us I am nevertheless still inspired and amazed at this community.
Curious to hear others’ impressions!!
Curious to hear others’ impressions!!
December 10, 2025 at 7:12 PM
With a smaller, somewhat fraught #cellbio2025 behind us I am nevertheless still inspired and amazed at this community.
Curious to hear others’ impressions!!
Curious to hear others’ impressions!!
Flyers for @lsajournal.org with our cell bio collection:
Collect all 4 to recreate the full artwork by our fantastic collaborator Laurène!
And come get a tshirt with this work today 1-3pm at @embo.org booth 🎊
Collect all 4 to recreate the full artwork by our fantastic collaborator Laurène!
And come get a tshirt with this work today 1-3pm at @embo.org booth 🎊
December 8, 2025 at 3:20 PM
Flyers for @lsajournal.org with our cell bio collection:
Collect all 4 to recreate the full artwork by our fantastic collaborator Laurène!
And come get a tshirt with this work today 1-3pm at @embo.org booth 🎊
Collect all 4 to recreate the full artwork by our fantastic collaborator Laurène!
And come get a tshirt with this work today 1-3pm at @embo.org booth 🎊
Today and every day at #cellbio2025
💥 find me and chat about @lsajournal.org
💥 take a gorgeous flyer
💥 get a free t-shirt 🥳
💥 find me and chat about @lsajournal.org
💥 take a gorgeous flyer
💥 get a free t-shirt 🥳
December 7, 2025 at 2:09 PM
Today and every day at #cellbio2025
💥 find me and chat about @lsajournal.org
💥 take a gorgeous flyer
💥 get a free t-shirt 🥳
💥 find me and chat about @lsajournal.org
💥 take a gorgeous flyer
💥 get a free t-shirt 🥳
Has anyone seen this executive order establishing "Genesis Mission" at the DOE?
In particular the provision that this initiative will be provided with "scientific datasets" and "experimental and production tools" to further its mission.
www.whitehouse.gov/presidential...
In particular the provision that this initiative will be provided with "scientific datasets" and "experimental and production tools" to further its mission.
www.whitehouse.gov/presidential...
December 3, 2025 at 7:36 PM
Has anyone seen this executive order establishing "Genesis Mission" at the DOE?
In particular the provision that this initiative will be provided with "scientific datasets" and "experimental and production tools" to further its mission.
www.whitehouse.gov/presidential...
In particular the provision that this initiative will be provided with "scientific datasets" and "experimental and production tools" to further its mission.
www.whitehouse.gov/presidential...
The assumed link between conceptual advance and journal impact factor is alive and well 😔
December 1, 2025 at 2:01 PM
The assumed link between conceptual advance and journal impact factor is alive and well 😔
The latest AI slop published by @springernature.com (great work!) has me wondering if, unlike the rat testicle one, this could be explained by English illiteracy? The graphics are not obviously wrong. Does anyone know?
November 30, 2025 at 1:02 PM
The latest AI slop published by @springernature.com (great work!) has me wondering if, unlike the rat testicle one, this could be explained by English illiteracy? The graphics are not obviously wrong. Does anyone know?
Today!! Freshly jetlagged from #sfn25 in San Diego, I will discuss publishing negative data at the fantastic R^3 series (Scientific Rigor, Reproducibility, and Reporting) @rockefeller.edu
Check out their website for other topics they cover: www.rockefeller.edu/research/r3/
Check out their website for other topics they cover: www.rockefeller.edu/research/r3/
November 20, 2025 at 3:22 PM
Today!! Freshly jetlagged from #sfn25 in San Diego, I will discuss publishing negative data at the fantastic R^3 series (Scientific Rigor, Reproducibility, and Reporting) @rockefeller.edu
Check out their website for other topics they cover: www.rockefeller.edu/research/r3/
Check out their website for other topics they cover: www.rockefeller.edu/research/r3/
Obsessed w this work we just published @lsajournal.org :
This acetyltransferase mediates metabolic adaptation to starvation… but can be replaced by a 2 degree temperature shift!!
This is why fruit flies you guys!
This acetyltransferase mediates metabolic adaptation to starvation… but can be replaced by a 2 degree temperature shift!!
This is why fruit flies you guys!
November 18, 2025 at 4:05 PM
Obsessed w this work we just published @lsajournal.org :
This acetyltransferase mediates metabolic adaptation to starvation… but can be replaced by a 2 degree temperature shift!!
This is why fruit flies you guys!
This acetyltransferase mediates metabolic adaptation to starvation… but can be replaced by a 2 degree temperature shift!!
This is why fruit flies you guys!
Weather update here in San Diego 🥰
November 16, 2025 at 5:28 PM
Weather update here in San Diego 🥰
Today at #sfn2025 I’ll be at @rupress.org booth 3719! Come say hi and chat about the many routes to publishing your neuroscience work!
November 16, 2025 at 5:27 PM
Today at #sfn2025 I’ll be at @rupress.org booth 3719! Come say hi and chat about the many routes to publishing your neuroscience work!
Excellent reporting and interviews in this episode, from Season 2 of The Harvard Project @wnyc.org @bostonglobe.com
Highly recommend this podcast for everyone in life sciences in the US (and beyond)
www.wnycstudios.org/podcasts/otm...
Highly recommend this podcast for everyone in life sciences in the US (and beyond)
www.wnycstudios.org/podcasts/otm...
November 11, 2025 at 4:59 PM
Excellent reporting and interviews in this episode, from Season 2 of The Harvard Project @wnyc.org @bostonglobe.com
Highly recommend this podcast for everyone in life sciences in the US (and beyond)
www.wnycstudios.org/podcasts/otm...
Highly recommend this podcast for everyone in life sciences in the US (and beyond)
www.wnycstudios.org/podcasts/otm...
Publishers being very naughty with retractions...
I found this purely by chance. Elsevier states in a retraction notice from Oct 2025 that the authors requested retraction in 2019!!! And they posted a preprint ~disproving~ their prior paper in 2021 (in the link)
What on earth took so long??
I found this purely by chance. Elsevier states in a retraction notice from Oct 2025 that the authors requested retraction in 2019!!! And they posted a preprint ~disproving~ their prior paper in 2021 (in the link)
What on earth took so long??
November 6, 2025 at 3:59 PM
Publishers being very naughty with retractions...
I found this purely by chance. Elsevier states in a retraction notice from Oct 2025 that the authors requested retraction in 2019!!! And they posted a preprint ~disproving~ their prior paper in 2021 (in the link)
What on earth took so long??
I found this purely by chance. Elsevier states in a retraction notice from Oct 2025 that the authors requested retraction in 2019!!! And they posted a preprint ~disproving~ their prior paper in 2021 (in the link)
What on earth took so long??
Catch me speaking as part of @rockefeller.edu R3 program: Scientific Rigor, Reproducibility, and Reporting www.rockefeller.edu/research/r3/
I'll provide the perspective of a journal editor @lsajournal.org on the value of publishing negative data. If you're in the Tri-I come check it out!
I'll provide the perspective of a journal editor @lsajournal.org on the value of publishing negative data. If you're in the Tri-I come check it out!
November 5, 2025 at 4:30 PM
Catch me speaking as part of @rockefeller.edu R3 program: Scientific Rigor, Reproducibility, and Reporting www.rockefeller.edu/research/r3/
I'll provide the perspective of a journal editor @lsajournal.org on the value of publishing negative data. If you're in the Tri-I come check it out!
I'll provide the perspective of a journal editor @lsajournal.org on the value of publishing negative data. If you're in the Tri-I come check it out!
Putting numbers to what we have all experienced: out of 1,800 academics polled, most have reduced use of X. Bsky has not replaced it.
October 31, 2025 at 2:52 PM
Putting numbers to what we have all experienced: out of 1,800 academics polled, most have reduced use of X. Bsky has not replaced it.
This week @rupress.org introduces our team to the broader research community at @rockefeller.edu 🥳
Researchers at Rockefeller benefit enormously from a world-class academic press right on their campus! Come say hi 👋
Researchers at Rockefeller benefit enormously from a world-class academic press right on their campus! Come say hi 👋
October 20, 2025 at 7:11 PM
This week @rupress.org introduces our team to the broader research community at @rockefeller.edu 🥳
Researchers at Rockefeller benefit enormously from a world-class academic press right on their campus! Come say hi 👋
Researchers at Rockefeller benefit enormously from a world-class academic press right on their campus! Come say hi 👋
Reminder of the importance of negative results for research quality and integrity, published in @plosbiology.org
@lsajournal.org will gladly consider your manuscript with negative or confirmatory results!
Read the full piece here: doi.org/10.1371/jour...
@lsajournal.org will gladly consider your manuscript with negative or confirmatory results!
Read the full piece here: doi.org/10.1371/jour...
October 20, 2025 at 12:56 PM
Reminder of the importance of negative results for research quality and integrity, published in @plosbiology.org
@lsajournal.org will gladly consider your manuscript with negative or confirmatory results!
Read the full piece here: doi.org/10.1371/jour...
@lsajournal.org will gladly consider your manuscript with negative or confirmatory results!
Read the full piece here: doi.org/10.1371/jour...
I've been claimed!
Life Science Alliance @lsajournal.org is now on @researchgate.bsky.social 🥳
If you peruse ResearchGate, give us a follow!
Life Science Alliance @lsajournal.org is now on @researchgate.bsky.social 🥳
If you peruse ResearchGate, give us a follow!
October 15, 2025 at 6:41 PM
I've been claimed!
Life Science Alliance @lsajournal.org is now on @researchgate.bsky.social 🥳
If you peruse ResearchGate, give us a follow!
Life Science Alliance @lsajournal.org is now on @researchgate.bsky.social 🥳
If you peruse ResearchGate, give us a follow!
Lady day here #cshlcancer @cshlmeetings.bsky.social
Congrats to @lsajournal.org travel award winner Debolina Ganguly from Judith Agudo’s group!!
Debolina is exploring how tissue-specific differences in antigen presentation can modulate the systemic immune response. Excellent talk!!
Congrats to @lsajournal.org travel award winner Debolina Ganguly from Judith Agudo’s group!!
Debolina is exploring how tissue-specific differences in antigen presentation can modulate the systemic immune response. Excellent talk!!
September 20, 2025 at 2:19 PM
Lady day here #cshlcancer @cshlmeetings.bsky.social
Congrats to @lsajournal.org travel award winner Debolina Ganguly from Judith Agudo’s group!!
Debolina is exploring how tissue-specific differences in antigen presentation can modulate the systemic immune response. Excellent talk!!
Congrats to @lsajournal.org travel award winner Debolina Ganguly from Judith Agudo’s group!!
Debolina is exploring how tissue-specific differences in antigen presentation can modulate the systemic immune response. Excellent talk!!
Congrats to @lsajournal.org travel award winner Jess Hebert from Monte Winslow’s group!!
Jess presented innovative new mouse models (already available at @jacksonlab.bsky.social) to engineer complex genotypes that modulate cancer metastasis.
Presented here #cshlcancer @cshlmeetings.bsky.social
Jess presented innovative new mouse models (already available at @jacksonlab.bsky.social) to engineer complex genotypes that modulate cancer metastasis.
Presented here #cshlcancer @cshlmeetings.bsky.social
September 19, 2025 at 3:17 PM
Congrats to @lsajournal.org travel award winner Jess Hebert from Monte Winslow’s group!!
Jess presented innovative new mouse models (already available at @jacksonlab.bsky.social) to engineer complex genotypes that modulate cancer metastasis.
Presented here #cshlcancer @cshlmeetings.bsky.social
Jess presented innovative new mouse models (already available at @jacksonlab.bsky.social) to engineer complex genotypes that modulate cancer metastasis.
Presented here #cshlcancer @cshlmeetings.bsky.social
Spending a few lovely days at @cshlmeetings.bsky.social for the tumor biology meeting. My second time here for this meeting, highly recommend!
September 18, 2025 at 10:16 PM
Spending a few lovely days at @cshlmeetings.bsky.social for the tumor biology meeting. My second time here for this meeting, highly recommend!
Exploring the best practices on AI in peer review (for preprints in this case) is sorely needed.
Author views seem polarized on use of AI in peer review more broadly. See discordant survey results for physicists:
Author views seem polarized on use of AI in peer review more broadly. See discordant survey results for physicists:
September 18, 2025 at 4:12 PM
Exploring the best practices on AI in peer review (for preprints in this case) is sorely needed.
Author views seem polarized on use of AI in peer review more broadly. See discordant survey results for physicists:
Author views seem polarized on use of AI in peer review more broadly. See discordant survey results for physicists:
Aggrieved editor post incoming...
At @lsajournal.org we offer to consider manuscripts that have been declined after review at one of our partner journals.
We have to be fast, fair, and accurate. It's hard! Instead of saying "no thanks" this author wanted to make a point.
At @lsajournal.org we offer to consider manuscripts that have been declined after review at one of our partner journals.
We have to be fast, fair, and accurate. It's hard! Instead of saying "no thanks" this author wanted to make a point.
September 16, 2025 at 4:11 PM
Aggrieved editor post incoming...
At @lsajournal.org we offer to consider manuscripts that have been declined after review at one of our partner journals.
We have to be fast, fair, and accurate. It's hard! Instead of saying "no thanks" this author wanted to make a point.
At @lsajournal.org we offer to consider manuscripts that have been declined after review at one of our partner journals.
We have to be fast, fair, and accurate. It's hard! Instead of saying "no thanks" this author wanted to make a point.