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Life Science Alliance @lsajournal.org · 5h

ADAMTS10 and ADAMTS17 regulate bone growth and extracellular matrix formation by promoting secretion and deposition of fibronectin, fibrillin-1, and collagen type VI www.life-science-alliance.org/content/8/12...

Life Science Alliance @lsajournal.org · 11h

AHR activation can positively or negatively affect immune responses. Here we investigate whether TCDD toxicity is due to prolonged duration of AHR activation and show that duration of stimulation is not responsible on its own. www.life-science-alliance.org/content/8/12...

Life Science Alliance @lsajournal.org · 11h

This study focuses on schizophrenia-related genes in a genetically tractable system and identifies the requirement of both glial and neuronal MMPs during developmental remodeling. @reviewcommons.org www.life-science-alliance.org/content/8/12...

Life Science Alliance @lsajournal.org · 23h

A variant of Lnk/SH2B3 adaptor has been reported as a risk for several autoimmune diseases, including type 1 diabetes.
www.life-science-alliance.org/content/8/12...

Life Science Alliance @lsajournal.org · 1d

Flavonoids, plant compounds with antioxidant properties, regulate the internal biological clock in Arabidopsis plants by modulating cellular levels of reactive oxygen species. @winkellab.bsky.social
www.life-science-alliance.org/content/8/12...

Life Science Alliance @lsajournal.org · 3d

KANSL3 controls hepatocyte differentiation and metabolism via histone acetylation. Loss of this epigenetic regulator leads to hyperplasia and liver fibrosis. #Epigenetics #Metabolism #Hepatology #NSLComplex @mwiese.bsky.social www.life-science-alliance.org/content/8/12...

Life Science Alliance @lsajournal.org · 5d

This study examines how the combined deletion of ADAMTS10 and ADAMTS17 proteases affects bone growth and skin development, suggesting roles in ECM regulation and postnatal survival. www.life-science-alliance.org/content/8/12...

Life Science Alliance @lsajournal.org · 6d

The authors found that Lnk prevents the abnormal activation of DCs by GM-CSF, followed by autocrine IL-27/IL-27R loops, and protects individuals from developing autoimmune diabetes. www.life-science-alliance.org/content/8/12...

Life Science Alliance @lsajournal.org · 6d

Explore how RNA-sequencing data can reveal splicing events' role in predicting nonsense-mediated mRNA decay during sepsis. This could offer new diagnostic and therapeutic insights. www.life-science-alliance.org/content/8/12...

Life Science Alliance @lsajournal.org · 7d

Take a look at this recently published paper in LSA:
Daytime SHP2 inhibitor dosing, when immune cell numbers are elevated, shrinks neurofibromas
@cincychildrenscbdi.bsky.social @cincyresearch.bsky.social
www.life-science-alliance.org/content/8/12...

Life Science Alliance @lsajournal.org · 7d

Here comes our October issue, including:
-Manchette architecture revealed by cryo-EM
-Cell-free epigenome profiling in asymptomatic COVID-19 patients
-How to fine-tune RING E3 ubiquitin ligase activity
-HINT1 serves as a sensor of cell density, and more!
www.life-science-alliance.org/content/8/10

Life Science Alliance @lsajournal.org · 8d

New research shows that flavonoids aid in timekeeping in plants by controlling oxidative stress. This adds to our understanding of the plant clock, with potential for improving agriculture.
@winkellab.bsky.social
www.life-science-alliance.org/content/8/12...

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Life Science Alliance @lsajournal.org · 8d

Have you already seen this research article at LSA:
Longer internal exons tend to have more tandem repeats and more frequently experience insertions and deletions
www.life-science-alliance.org/content/8/12...

Life Science Alliance @lsajournal.org · 13d

A computational analysis of alternative splicing and nonsense-mediated decay using critically ill patients' RNA-sequencing data can elucidate sepsis transcriptomics and potentially associated protein targets.
www.life-science-alliance.org/content/8/12...

Life Science Alliance @lsajournal.org · 14d

SHP2 inhibition may be a general strategy to target benign tumors in which T cells and myeloid cells are pro-tumorigenic. @cincychildrenscbdi.bsky.social @cincyresearch.bsky.social www.life-science-alliance.org/content/8/12...

Life Science Alliance @lsajournal.org · 14d

The authors found that insertions and deletions occur more frequently in longer internal exons and mostly encode structure-less regions, and that half of them are attributable to alterations in tandem repeats.
www.life-science-alliance.org/content/8/12...

Life Science Alliance @lsajournal.org · 15d

Have you already read this Research Article recently published in LSA?
CTPS2 regulates CTP synthetase activity by interacting with CTPS1 @institutimagine.bsky.social www.life-science-alliance.org/content/8/11...

Life Science Alliance @lsajournal.org · 20d

Artificial intelligence can unlock new gene functions, but prediction models are limited by current knowledge. Integrating mass fingerprinting with machine learning improves these predictions. www.life-science-alliance.org/content/8/11...

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Life Science Alliance @lsajournal.org · 21d

This study shows that overexpression of the acetyltransferases ATase1 and ATase2 in the mouse alters the quality of the secretory pathway, causing a progeria-like phenotype. @waismancenter.bsky.social
www.life-science-alliance.org/content/8/12...

Life Science Alliance @lsajournal.org · 22d

Human CTP synthetase 1 and 2 form complexes, co-localizing in filament-cytoophidia structures. Their interaction modifies enzymatic activity independently of cytoophidia, revealing a new regulation mechanism. @institutimagine.bsky.social
www.life-science-alliance.org/content/8/11...

Life Science Alliance @lsajournal.org · 23d

Human skeletal muscles play a more direct role in the pathogenesis of enterovirus D68 through productive infection, which leads to structural destruction, functional loss, and hampered regeneration.
@bmlaksono.bsky.social @debbyvanriel.bsky.social
www.life-science-alliance.org/content/8/11...

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Life Science Alliance @lsajournal.org · 24d

ES cells implement specialized survival strategies in response to different AA limitations, highlighting their ability to reprogram cellular biochemistry under nutrient stress. www.life-science-alliance.org/content/8/11...

Life Science Alliance @lsajournal.org · 27d

Artificial intelligence offers a solution to unlock the potential of new gene functions. However, prediction models are limited by available knowledge. By combining mass fingerprinting with machine learning, prediction can be improved. www.life-science-alliance.org/content/8/11...

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Life Science Alliance @lsajournal.org · 28d

@Waismancenter.bsky.social
In a new study, the Puglielli laboratory at UW-Madison shows that overexpression of the acetyltransferases ATase1 and ATase2 in the mouse alters the quality of the secretory pathway, causing a progeria-like phenotype.
www.life-science-alliance.org/content/8/12...

Life Science Alliance @lsajournal.org · 28d

This study reveals that TIL products expanded from pediatric neuroblastoma tumors exhibit anti-cancer capabilities, with γδ T cells as the primary active agents. #CancerResearch #Immunotherapy www.life-science-alliance.org/content/8/11...

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