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lsajournal.org
Life Science Alliance
@lsajournal.org
300 followers 13 following 340 posts
#OpenAccess community-driven journal for peer-reviewed research in all areas of the life sciences. By EMBO Press (@embopress.org), Rockefeller University Press (@rupress.org), and Cold Spring Harbor Laboratory Press (@cshlpress.bsky.social).
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lsajournal.org
Have you already had a chance to look at this methods paper recently published in LSA:
Intravital imaging the formation and resolution of MHC class II–positive T cell activation niches?
@urochester.bsky.social
www.life-science-alliance.org/content/9/3/...
January 12, 2026 at 4:04 PM
lsajournal.org
Discovery of a novel endothelial basolateral cilia based mechanism for embryonic vascular stability that is based on platelet-derived growth factor-BB and heparan sulfate proteoglycans interaction to promote pericyte migration and recruitment.
www.life-science-alliance.org/content/9/3/...
January 9, 2026 at 4:05 PM
lsajournal.org
This study shows that glial Stat92E transcription factor activity is derepressed by selective autophagic elimination of the Stat92E repressor Su(var)2-10/PIAS in Drosophila glia after neural injury.
@BRCGenetics.bsky.social
www.life-science-alliance.org/content/9/3/...
January 8, 2026 at 9:34 PM
Reposted by Life Science Alliance
edinuni-irr.bsky.social
New study ( @gram-lab.bsky.social and @fengfishlab.bsky.social ) finds that tissue regeneration is controlled by a well-orchestrated network of signals. This network is influenced by injury severity, timing, and the immune system.

🔎 edin.ac/4styRa0
📰 edin.ac/4jnQsfq

@lsajournal.org
January 6, 2026 at 12:43 PM
lsajournal.org
This Perspective discusses how the Integrated Stress Response restores homeostasis during acute stress but may become maladaptive when chronically engaged, disrupting cell trajectories. www.life-science-alliance.org/content/9/3/...
January 6, 2026 at 9:34 PM
lsajournal.org
In vivo screen reveals specific roles of Hippo pathway components in development and regeneration
@gram-lab.bsky.social @edinuni-irr.bsky.social @fengfishlab.bsky.social @michaelanosfairley.bsky.social
www.life-science-alliance.org/content/9/3/...
January 6, 2026 at 4:04 PM
lsajournal.org
This study describes the generation of two new fluorescent reporter strains that label MHC class II-positive cells, CD8-positive T cells & the utilization of the class II reporter to image the kinetics of an inflammatory response. @urochester.bsky.social www.life-science-alliance.org/content/9/3/...
January 5, 2026 at 9:34 PM
lsajournal.org
Kicking off 2026 with amazing findings in our latest issue:

-Modulating T cell glycolysis boosts cytotoxicity
-A subtle temperature shift rewires epigenetics in Drosophila
-Structural flexibility determines fluorescence spectra of luciferases

www.life-science-alliance.org/content/9/1
January 5, 2026 at 4:04 PM
lsajournal.org
This new Perspective explores how the Integrated Stress Response maintains homeostasis during acute stress but may become maladaptive when chronically engaged, driving pathological cell trajectories with key implications for chronic diseases.
www.life-science-alliance.org/content/9/3/...
December 30, 2025 at 9:34 PM
lsajournal.org
Distinct roles of Yap/Taz highlight their essential function in coordinating tissue growth and immune responses during repair.
@gram-lab.bsky.social @edinuni-irr.bsky.social @fengfishlab.bsky.social @michaelanosfairley.bsky.social
www.life-science-alliance.org/content/9/3/...
December 30, 2025 at 4:04 PM
lsajournal.org
Loss of the RB tumor suppressor drives centromere transcription, resulting in DNA damage and whole chromosome segregation errors. www.life-science-alliance.org/content/9/3/...
December 26, 2025 at 4:04 PM
Reposted by Life Science Alliance
rockefeller.edu
Scientific publishing has a bias against negative results and that hurts science, says Tim Fessenden, editor of @lsajournal.org, a publication of @rupress.org. Here’s how journal editors can help.
The value of publishing negative data - News
Scientific journals love news-worthy results. Editors want to publish studies with novel data that scientists will eagerly read and cite in their own work. Because of this desire for novelty, studies ...
www.rockefeller.edu
December 23, 2025 at 2:30 PM
lsajournal.org
The study shows how blood and lymphatic endothelial cells change their metabolism when they are growing and resting. It reveals different pathways that support their specific functions.
@reviewcommons.org
www.life-science-alliance.org/content/9/3/...
December 25, 2025 at 4:04 PM
Reposted by Life Science Alliance
timisstuck.bsky.social
Giving the gift of negative data 🥰

Since I joined @lsajournal.org I have handled several stellar manuscripts that report null results. These papers do very well and reviewers almost always appreciate them!

Thanks @rockefeller.edu news team for the article!

www.rockefeller.edu/news/38829-t...
The value of publishing negative data - News
Scientific journals love news-worthy results. Editors want to publish studies with novel data that scientists will eagerly read and cite in their own work. Because of this desire for novelty, studies ...
www.rockefeller.edu
December 23, 2025 at 1:26 PM
lsajournal.org
Enhancing lung tissue preservation during cold storage and ex vivo lung perfusion is possible by adding Cystatin C to the preservation solution. This approach boosts tissue protection and minimizes injury.
#LungHealth #MedicalInnovation
www.life-science-alliance.org/content/9/2/...
December 24, 2025 at 4:04 PM
Reposted by Life Science Alliance
rupress.org
Why do negative data, or null results, matter? @lsajournal.org's Tim Fessenden (@timisstuck.bsky.social) shares his insider perspective on why and how the scientific community should actively encourage the publication of negative results. From @rockefeller.edu 👉 www.rockefeller.edu/news/38829-t...
The value of publishing negative data - News
Scientific journals love news-worthy results. Editors want to publish studies with novel data that scientists will eagerly read and cite in their own work. Because of this desire for novelty, studies…
www.rockefeller.edu
December 23, 2025 at 4:00 PM
lsajournal.org
CryoEM and biochemical analyses reveal that CENP-A/H4 octasomes form stable, flexible chromatin intermediates that may facilitate CCAN engagement and centromere organization.
@uio.no
www.life-science-alliance.org/content/9/3/...
December 23, 2025 at 9:34 PM
lsajournal.org
Take a look at this recently published research article in LSA:
A role for the cholinergic neuron circadian clock in RNA metabolism and mediating neurodegeneration
www.life-science-alliance.org/content/9/3/...
December 23, 2025 at 4:04 PM
lsajournal.org
A new paper from the Manning lab describes that loss of the RB tumor suppressor drives centromere transcription, resulting in DNA damage and whole chromosome segregation errors. www.life-science-alliance.org/content/9/3/...
December 19, 2025 at 9:34 PM
lsajournal.org
The study shows how blood and lymphatic endothelial cells reorganize metabolism in proliferating and quiescent states, revealing distinct pathway dependencies that sustain their specialized functions.
@reviewcommons.org
www.life-science-alliance.org/content/9/3/...
December 19, 2025 at 4:05 PM
lsajournal.org
Unknown driver mutations are enriched in Alzheimer's patients with Y chromosome loss, suggesting LOY-driven clonal myeloid expansion may contribute to distinct disease-associated mutational profiles.
Loss of Y chromosome in Alzheimer’s patients co-occurs with somatic mutations beyond CHIP drivers
Loss of Y chromosome (LOY) and clonal hematopoiesis of indeterminate potential (CHIP) are common age-related events with implications for aging and Alzheimer disease (AD). LOY is linked to increased…
www.life-science-alliance.org
December 18, 2025 at 9:34 PM
lsajournal.org
The authors present a detailed step-by-step protocol for preparing custom-made cell culture media and provide guidance on its use in cancer metabolism experiments.
@dkfz.bsky.social @mtprentzell.bsky.social
www.life-science-alliance.org/content/9/2/...
December 18, 2025 at 4:04 PM
lsajournal.org
Cystatin C added to the preservation solution during cold storage and ex vivo lung perfusion of donor lungs, results in improved tissue preservation and protection against lung tissue injury.
www.life-science-alliance.org/content/9/2/...
December 17, 2025 at 4:05 PM
lsajournal.org
New study in @LSAjournal reveals that CENP-A/H4 octasomes form flexible chromatin intermediates that may guide centromere assembly via CCAN. @uio.no @NCMMnews
#chromatin #centromere #CENP-A #cryo-EM #nucleosome #octasome
www.life-science-alliance.org/content/9/3/...
December 16, 2025 at 9:34 PM
lsajournal.org
ALS is a neurodegenerative disease commonly marked by disrupted RNA-binding protein function; this study investigates circadian regulation of RNA metabolism in spinal cord cholinergic neurons--the cell-type of ALS disease origin and fatality.
www.life-science-alliance.org/content/9/3/...
December 16, 2025 at 4:04 PM