Genes & Development
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genesdev.bsky.social
Genes & Development
@genesdev.bsky.social
G&D publishes high-quality research in molecular biology, cancer biology, development, neuroscience and related fields. In addition, G&D also publishes comprehensive Review Articles, Perspectives and Outlooks written by leading scientists.
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🚨 NEW ISSUE ALERT!!! 🚨

New Outlook, Review and Research articles online now at Genes & Development.

Click on the link to learn more:
➡️ https://genesdev.cshlp.org/content/39/21-22.toc
🌟G&D SPOTLIGHT 🌟

REVIEW: Cohesin in 3D: development, differentiation, and disease
By Maria Solé-Ferran and Ana Losada
➡️ https://genesdev.cshlp.org/content/39/11-12/679.abstract

#cohesin #chromatin #chromosome #development #cohesinopathy
November 25, 2025 at 4:00 PM
🌟G&D SPOTLIGHT 🌟

RESEARCH PAPER: Restrictor synergizes with Symplekin and PNUTS to terminate extragenic transcription
By Russo et al., and Gioacchino Natoli
➡️ https://genesdev.cshlp.org/content/37/21-24/1017.abstract

#transcription #transcriptiontermination #restrictor #yeast #noncodingRNA
November 24, 2025 at 4:01 PM
🌟G&D SPOTLIGHT 🌟

REVIEW: CST–Polα/Primase: the second telomere maintenance machine
By Sarah Cai and Titia de Lange
➡️ https://genesdev.cshlp.org/content/37/13-14/555.abstract

#telomere #telomerase #strandsynthesis #polymerase⍺ #primase
November 21, 2025 at 4:01 PM
🌟 G&D SPOTLIGHT 🌟

RESEARCH PAPER: Histone chaperones coupled to DNA replication and transcription control divergent chromatin elements to maintain cell fate
By Franklin et al., and Sihem Cheloufi
➡️ https://genesdev.cshlp.org/content/39/9-10/652.abstract

#histones #transcription #replication
November 20, 2025 at 4:01 PM
🌟G&D SPOTLIGHT 🌟

RESEARCH PAPER: MRN–CtIP, EXO1, and DNA2–WRN/BLM act bidirectionally to process DNA gaps in PARPi-treated cells without strand cleavage
By Seppa et al., and Alessandro Vindigni
➡️ https://genesdev.cshlp.org/content/39/9-10/582.abstract

#DNArepair #BRCA1 #nucleases #PARP #cancer
November 19, 2025 at 4:00 PM
🌟G&D SPOTLIGHT 🌟

RESEARCH PAPER: Hao-Fountain syndrome protein USP7 controls neuronal differentiation via BCOR–ncPRC1.1
By Wolf van der Meer et al., Jeroen Demmers, Yaser Atlasi and Peter Verrijzer
➡️ https://genesdev.cshlp.org/content/39/5-6/401.abstract

#neurodevelopment #epigenetics #polycomb
November 18, 2025 at 4:00 PM
🌟 G&D SPOTLIGHT 🌟

RESEARCH PAPER: ALOX5-mediated ferroptosis acts as a distinct cell death pathway upon oxidative stress in Huntington's disease
By Song et al. and Wei Gu
➡️ https://genesdev.cshlp.org/content/37/5-6/204.abstract

#huntingtonsdisease #ferroptosis #huntingtin #oxidativestress #ROS
November 17, 2025 at 4:01 PM
IN MEMORIAM: A totipotent embryologist: John B. Gurdon
(1933–2025)
By Thoru Pederson
➡️ https://tinyurl.com/gd353471OA

*Photo courtesy of the Cold Spring Harbor Laboratory Archives.
November 14, 2025 at 7:36 PM
OUTLOOK: End of the line: a kinetic ruler model for poly(A) tail termination
By Anita Corbett
➡️ https://genesdev.cshlp.org/content/39/21-22/1267.full

Learn more here:
➡️ https://genesdev.cshlp.org/content/39/21-22/1377.full

#RNAprocessing #mRNA #polyadenylation #ribonucleoprotein #CPAC

November 14, 2025 at 4:00 PM
RESEARCH PAPER: A cell type-specific surveillance complex represses cryptic promoters during differentiation in an adult stem cell lineage
By Matias et al. and Margaret Fuller
➡️ https://genesdev.cshlp.org/content/39/21-22/1318.abstract

#chromatin #transcription #Drosophila #stemcells #germline
November 13, 2025 at 4:01 PM
RESEARCH PAPER: A kinetic ruler controls mRNA poly(A) tail length
By Gabs et al. and Matti Turtola
➡️ https://genesdev.cshlp.org/content/39/21-22/1377.full

#RNAprocessing #mRNA #polyadenylation #ribonucleoprotein #CPAC
November 12, 2025 at 4:01 PM
OUTLOOK: The two faces of MyoD: repressor and activator of gene expression during myogenesis
By Carmen Birchmeier
➡️ https://genesdev.cshlp.org/content/39/21-22/1269.full

Learn more here:
➡️ https://genesdev.cshlp.org/content/39/21-22/1299.abstract

#transcription #muscle #stemcells #openaccess
November 11, 2025 at 7:00 PM
RESEARCH PAPER: Dominant-negative effects of Weaver syndrome-associated EZH2 variants
By Deevy et al., Eric Conway and Adrian Bracken
➡️ https://genesdev.cshlp.org/content/39/21-22/1355.full

Eric Conway
Adrian Bracken

#weaversyndrome #ezh2 #polycomb #mutation #congenitaldisorder #onthecover
November 10, 2025 at 4:05 PM
REVIEW: Multifaceted role of the vitamin B6 pathway in cancer: metabolism, immune interaction, and temporal and spatial regulation
By Mishra et al. and Lingbo Zhang
➡️ https://genesdev.cshlp.org/content/39/21-22/1271.abstract

#cancer #metabolism #vitamin #cancertherapy #cancermetabolism #immune
November 7, 2025 at 7:01 PM
RESEARCH PAPER: Mouse cortical cellular diversification through lineage progression of radial glia
By Yang et al., and Xiaosu Li
➡️ https://genesdev.cshlp.org/content/39/21-22/1338.abstract

#glia #braindevelopment #neuron #neurodevelopment #neuronalprogenitor #neuralstemcell #epigenetics
November 6, 2025 at 4:00 PM
RESEARCH PAPER: MYOD represses gene expression from non-E-box motifs
By Nicoletti, Massenet et al., Luca Caputo and Pier Lorenzo Puri
➡️ https://genesdev.cshlp.org/content/39/21-22/1299.abstract

#transcription #trancriptionfactor #epigenetics #muscle #stemcells
November 5, 2025 at 4:01 PM
🎥 G&D Tapes 🎥

G&D author, Haoming Yu tells us about their new study in #genesdev that uses epigenetic editing to probe the role of H3K4me3 at intergenic regulatory elements.

Learn more here:
➡️ https://genesdev.cshlp.org/content/39/21-22/1290.full

Bluma Lesch
@haomingyu.bsky.social

November 4, 2025 at 7:02 PM
RESEARCH COMMUNICATION: H3K4me3 amplifies transcription at intergenic active regulatory elements
By Yu et. al and Bluma Lesch
➡️ https://genesdev.cshlp.org/content/39/21-22/1290.full

Bluma Lesch
@haomingyu.bsky.social

#transcription #epigenetics #histones #histonePTMs #methylation #enhancers
November 4, 2025 at 4:01 PM
🚨 NEW ISSUE ALERT!!! 🚨

New Outlook, Review and Research articles online now at Genes & Development.

Click on the link to learn more:
➡️ https://genesdev.cshlp.org/content/39/21-22.toc
November 3, 2025 at 5:41 PM
RESOURCE/METHODOLOGY: A genome-wide, CRISPR-based screen reveals new requirements for translation initiation and ubiquitination in driving adipogenic fate change
By Turn et al. and Peter Jackson

Learn more here:
➡️ https://genesdev.cshlp.org/content/39/19-20/1241.abstract
October 13, 2025 at 3:00 PM
RESEARCH PAPER: A noncanonical Pol III-dependent, Microprocessor-independent biogenesis pathway generates a germline-enriched miRNA family
By Sakhawala et al. and Katherine McJunkin

Learn more here:
➡️ https://genesdev.cshlp.org/content/39/19-20/1198.abstract
October 10, 2025 at 3:00 PM
RESEARCH PAPER: SUMO2 promotes histone pre-mRNA processing by stabilizing histone locus body interactions and facilitating U7 snRNP assembly
By He et al. and Michael Matunis

Learn more here:
➡️ https://genesdev.cshlp.org/content/39/19-20/1182.abstract
October 9, 2025 at 3:00 PM
RESEARCH PAPER: Condensation of human OAS proteins initiates diverse antiviral activities in response to West Nile virus
By Briggs et al. and James Burke

Learn more here:
➡️ https://genesdev.cshlp.org/content/39/19-20/1162.abstract
October 8, 2025 at 3:00 PM
RESEARCH COMMUNICATION: Structural basis of nucleosome recognition by the conserved Dsup and HMGN nucleosome-binding motif
By Alegrio-Louro et al. and Andres Leschziner

Learn more here:
➡️ https://genesdev.cshlp.org/content/39/19-20/1155.full
October 7, 2025 at 3:00 PM
REVIEW: Modeling and targeting general and chromosome-specific aneuploidy in cancer.
By Aleah Goldberg, Maria Trifas and Teresa Davoli

Learn more here:
➡️ https://genesdev.cshlp.org/content/39/19-20/1132.abstract
October 6, 2025 at 3:00 PM