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Hao Yin @haoyin.bsky.social · 2h

Hao's Preprint Reading List
October 11 2025

Endothelial TGFBR1/2 inhibits neuroinflammation

Endothelial ZBTB16 inhibits heart aging

Smooth muscle TGFβ2 inhibits thoracic aortic aneurysm

Treg inhibits abdominal aortic aneurysm

Spatially-resolved👤multi-organ aging

docs.google.com/document/d/e...

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The Interactive Fly @interactivefly.bsky.social · 22h

Bischoff, M. C., Norton, J. E., Clark, S. E., Peifer, M. (2025). Plexin/Semaphorin antagonism orchestrates collective cell migration and organ sculpting by regulating epithelial-mesenchymal balance. Sci Adv, 11(25):eadu3741 www.science.org/doi/10.1126/...

Plexin/Semaphorin antagonism orchestrates collective cell migration and organ sculpting by regulating epithelial-mesenchymal balance

An axon guidance factor restricts gap growth in a non-neuronal migrating cell sheet, allowing organ sculpting.

www.science.org

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Hao Yin @haoyin.bsky.social · 19h

#AbdominalAorticAneurysm

Global p27 KO🐭 + topical elastase + oral BAPN➡️
⏫Abdominal aortic diameter
⏫SMC apoptosis
⏬SMC content
⏫Mφ infiltr (M1 polarized)

Any senescence?🧐

#JVascRes 2025
karger.com/jvr/article/...

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Reposted by Hao Yin

Rachael Ott @rachaelott.bsky.social · 20h

For #FluorescenceFriday, α-spectrin (red) and lipid droplets (green) are shown in adipocytes 🔬 #Microscopy #CellBiology

α-spectrin (red), lipid droplets (green), and nuclei (blue) are shown in adipocytes. Scale bar is 20 μm.

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Journal of Cell Biology @jcb.org · Aug 11

Geng, @kjverhey1.bsky.social et al find that KIF1C forms condensates where the exposed #kinesin motor domains entangle nearby #microtubules, causing them to bend & break in a process dependent on motor processivity, cluster properties, cytoplasmic viscosity, & MT anchors rupress.org/jcb/article/...

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Nat Clarke @natclarke.bsky.social · 2d

🚨 My lab is hiring at all levels!

Interested in animal origins & evolutionary cell biology?

I'm recruiting a postdoc, PhD students & a research assistant to study the molecular evolution of cell adhesion using marine invertebrates + comparative genomics.

🔗: clarkelab.com/join/

Please repost!

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Stacey Ogden 🦔 @labogden.bsky.social · 23h

Happy #FluorescenceFriday! This is a maximum intensity projection of depth shaded actin (🌈) in a section from an E9.5 🐭 neural tube (NT). 🔬 by postdoc @christinaadaly.bsky.social 👩‍🔬 🧪 Image shows the floor plate and lumen of the developing NT.

#SciArt #DevBio #DevNeuro

Rainbow shading of a confocal micrograph of a developing mouse neural tube. The protein actin is stained and colored in rainbow to indicate depth in the section.

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Andrea Caldarola @andreacaldarola.bsky.social · 1d

For #FluorescenceFriday : 3 cells start at the same Ca2+ concentration but undergo 3 different Histamine responses. Imaged using the lifetime-based sensor Tq-Ca-FLITS.

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Hao Yin @haoyin.bsky.social · 22h

The critique from the REAL expert👇
@ralfhadams.bsky.social

Ralf H. Adams @ralfhadams.bsky.social · 23h

A recent preprint (Yang et al., doi.org/10.1101/2025...) challenges an article from my lab published in 2024 (Koh et al. 2024, PMID: 39537918). We strongly dispute their claims (please see our comment on bioRXiv).

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Degeneration and Impaired Resilience of Skull Bone and Hematopoietic Bone Marrow

Bone marrow health is central to transplantations, blood formation, and cancer progression. However, the bone marrow niche deteriorates with age, impairing haematopoietic stem cell function. Contrary ...

doi.org

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Ralf H. Adams @ralfhadams.bsky.social · 23h

The thread on X covers useful findings and publications, which have independently confirmed key results of our paper from 2024.

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Ralf H. Adams @ralfhadams.bsky.social · 23h

Among the issues covered in the thread on X, we also point out that critical images presented by Yang et al. show the dural vasculature and not the sinusoidal vessels of bone marrow.

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Ralf H. Adams @ralfhadams.bsky.social · 23h

While many of us have left X for good reasons, I have posted a long thread with useful illustrations and background there because of more generous character limits:
x.com/ralfhadams/s...

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Ralf H. Adams @ralfhadams.bsky.social · 23h

A recent preprint (Yang et al., doi.org/10.1101/2025...) challenges an article from my lab published in 2024 (Koh et al. 2024, PMID: 39537918). We strongly dispute their claims (please see our comment on bioRXiv).

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Degeneration and Impaired Resilience of Skull Bone and Hematopoietic Bone Marrow

Bone marrow health is central to transplantations, blood formation, and cancer progression. However, the bone marrow niche deteriorates with age, impairing haematopoietic stem cell function. Contrary ...

doi.org

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Reposted by Hao Yin

Developmental Biology @devbiol.bsky.social · 1d

#DBfeature

Research facilities in the UK, France, and Japan maintaining transgenic lines for Avian developmental biology

By Lindsay Henderson, Yuya Okuzaki, Christophe Marcelle, Mike McGrew, and Ken-ichi Nishijima

tinyurl.com/4drw4d6a
#SpecialIssue on Avian model systems

Fluorescent microscopy images of transgenic chicken resources maintained at the NARF, The Roslin Institute. (A) GFP chicken embryo with a ‘red’ graft placed into the limb bud with micro-surgery. The graft is about 50–100 μM. (B) Stage 32 HH limb bud from the CSF1R-eGFP embryo. Macrophages (green) are concentrated in areas of cell death, blood vessels (red) are labelled with SNA lectin. (C) ACTN line embryo spinal cord stage 16 HH. (D) Dorsal Root Ganglion of the nervous system of a Chameleon transgenic chicken embryo. Nerves going into the dorsal root ganglion are red, and nerves coming out are green. (E) Fluorescent image of the dorsal skin (periderm) from a membrane GFP chick embryo. (F) FUCHI cell cycle reporter embryo stage 23 HH. All images were provided by members of The Roslin Institute Chicken Embryology (RICE) group.

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Developmental Biology @devbiol.bsky.social · 1d

#DBfeature 🐣🫀

Proteomic analysis of chick embryonic heart in experimental hypoxia shows upregulation in anaerobic glycolysis, apoptosis-related proteins, cell adhesion proteins, and secretory activity

By David Sedmera, Eliska Drobna Krejci, Ondrej Nanka, and Adam Eckhardt

tinyurl.com/y3vdmx2s

STRING analysis of protein-protein interaction (106 proteins with significantly higher concentration in hypoxia) – divided to 7 clusters containing more than one protein. Compared to the genes downregulated in hypoxia, there are more numerous protein interactions, attesting to the activation of key pathways allowing the adaptation of the heart to hypoxic stress. The clusters are colour-coded; protein abbreviations correspond to their names

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Hao Yin @haoyin.bsky.social · 22h

This is cool 🤠
Congratulations 🥳🥳🥳
Will read and learn 📚

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@NicoliLab @nicolilab.bsky.social · 22h

Identifying the cellular and molecular factors that contribute to tissue mechanical strength is a critical step for developing regenerative medicine approaches. Thank you to all who contributed to this work!

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@NicoliLab @nicolilab.bsky.social · 22h

We found that the ECM composition underlying the stem cells affects wound healing speed!

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@NicoliLab @nicolilab.bsky.social · 22h

We define the extracellular matrix composition in the developing zebrafish fin fold, and how stem cells regulate adhesion molecule expression in the superficial cell layer above.

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@NicoliLab @nicolilab.bsky.social · 23h

So excited to announce lab alumni Dr. Helen Mengze He and Liana Boraas work at @yalecvrc.bsky.social in collaboration with the Kaelyn Sumigray lab @yaleschoolofmed.bsky.social is published today in @natcomms.nature.com and highlighted in Yale News! medicine.yale.edu/news-article...

Unlocking the Skin’s Natural Healing Power

Researchers show that embryonic skin stem cells rely on a specialized mechanism to resist injury. The findings could lead to new strategies for repairing wounds

medicine.yale.edu

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Hao Yin @haoyin.bsky.social · 1d

Sometimes, poor perfusion is attributed to a Venule🤓

Age-related rarefaction of capillary meshwork converging into principal cortical venules, most pronounced in layer 6/CC➡️
Gliosis+demyelination in 🐭 #WhiteMatterAging

#SciArt
@andyshihlab.bsky.social #NatNeuro 2025
www.nature.com/articles/s41...

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Hao Yin @haoyin.bsky.social · 1d

😮‍💨

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Thibaut Brunet @thibautbrunet.bsky.social · 6d

Thanks for sticking until the end, and for more insights (notably on different knock-out techniques and on the risk posed by unexpected alternative start codons...), check out the paper: www.cell.com/cell-reports... 🙏

A selection-based knockout approach for a choanoflagellate reveals regulation of multicellular development by Hippo signaling

Combredet et al. report a robust and fast gene-knockout method for the choanoflagellate Salpingoeca rosetta, one of the closest relatives of animals. Inactivation of genes encoding homologs of compone...

www.cell.com

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Thibaut Brunet @thibautbrunet.bsky.social · 6d

And just a few weeks ago, beautiful work by @akankshi.bsky.social has shown that a self-terminating YAP/ECM loop sets organ size in zebrafish semicircular canals: www.biorxiv.org/content/10.1...

A self-limiting mechanotransduction feedback loop ensures robust organ formation

Organ development requires integration of mechanical forces, biochemical signals, and transcriptional programs to achieve proper size and architecture. Mechanotransduction feedback loops convert mecha...

www.biorxiv.org

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Thibaut Brunet @thibautbrunet.bsky.social · 6d

Surprisingly, disrupting warts kinases in S. rosetta caused a very animal-like phenotype: giant rosettes colonies!

This suggests the molecular pathways that control multicellular development in animals and choanos might be more conserved than we expected...

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