Simon Cleary
@simoncleary.bsky.social
Research group leader and lecturer in pharmacology at King's College London: kcl.ac.uk/people/simon-cleary
Research interests: pulmonary vascular biology, immunology + developing new therapeutics and microscopy methods.
Research interests: pulmonary vascular biology, immunology + developing new therapeutics and microscopy methods.
Reposted by Simon Cleary
Good news!! Oral Nalbuphine reduces cough count baseline by ~50 % in Idiopathic Pulmonary Fibrosis–Associated Cough jamanetwork.com/journals/jam...
Oral Nalbuphine in Idiopathic Pulmonary Fibrosis–Associated Cough
This randomized clinical trial examines the safety and efficacy of oral nalbuphine in patients with chronic cough caused by idiopathic pulmonary fibrosis.
jamanetwork.com
January 23, 2026 at 2:55 AM
Good news!! Oral Nalbuphine reduces cough count baseline by ~50 % in Idiopathic Pulmonary Fibrosis–Associated Cough jamanetwork.com/journals/jam...
Nice evidence for a role for the ectonucleotidase CD39 in limiting pulmonary thromboembolism in sickle cell disease with striking footage of this process!
January 15, 2026 at 4:42 PM
Nice evidence for a role for the ectonucleotidase CD39 in limiting pulmonary thromboembolism in sickle cell disease with striking footage of this process!
Reposted by Simon Cleary
"Does this handle survival plots too?" asked @load-dependent.bsky.social
Yes it does! See below for RECOVERY.
Only catch is it doesn't like the dotted lines that appear in some survival plots (because the PDF geometry treats this as lots of little separate lines rather than one single entry).
Yes it does! See below for RECOVERY.
Only catch is it doesn't like the dotted lines that appear in some survival plots (because the PDF geometry treats this as lots of little separate lines rather than one single entry).
January 14, 2026 at 10:48 AM
"Does this handle survival plots too?" asked @load-dependent.bsky.social
Yes it does! See below for RECOVERY.
Only catch is it doesn't like the dotted lines that appear in some survival plots (because the PDF geometry treats this as lots of little separate lines rather than one single entry).
Yes it does! See below for RECOVERY.
Only catch is it doesn't like the dotted lines that appear in some survival plots (because the PDF geometry treats this as lots of little separate lines rather than one single entry).
Reposted by Simon Cleary
Tumor-draining Lymph nodes - Online event next week!
follow the link to register
On January 13 from 11:30 – 1:00 pm ET, @thelundlab.bsky.social , Dr. Ivan Maillard, @actonlab.bsky.social , & Dr. Burkhard Ludewig will discuss lymph node remodeling in cancer:
events.cancer.gov/dcb/tdln #TLDNForums
follow the link to register
On January 13 from 11:30 – 1:00 pm ET, @thelundlab.bsky.social , Dr. Ivan Maillard, @actonlab.bsky.social , & Dr. Burkhard Ludewig will discuss lymph node remodeling in cancer:
events.cancer.gov/dcb/tdln #TLDNForums
Tumor-Draining Lymph Nodes: Gaps and Opportunities Forum Series (Overview) | Events Registration
OverviewLymph node (LN) metastasis is a hallmark of disease progression in most solid tumors and remains one of the most consistent predictors of poor prognosis and reduced overall survival. In partic...
events.cancer.gov
January 9, 2026 at 11:39 AM
Tumor-draining Lymph nodes - Online event next week!
follow the link to register
On January 13 from 11:30 – 1:00 pm ET, @thelundlab.bsky.social , Dr. Ivan Maillard, @actonlab.bsky.social , & Dr. Burkhard Ludewig will discuss lymph node remodeling in cancer:
events.cancer.gov/dcb/tdln #TLDNForums
follow the link to register
On January 13 from 11:30 – 1:00 pm ET, @thelundlab.bsky.social , Dr. Ivan Maillard, @actonlab.bsky.social , & Dr. Burkhard Ludewig will discuss lymph node remodeling in cancer:
events.cancer.gov/dcb/tdln #TLDNForums
Reposted by Simon Cleary
Absolutely delighted that our latest paper is out today @natimmunol.nature.com. It has taken five years to uncover a role for cross-presentation in shaping the immune visibility of tumour antigens. A labour of love led by @drjonlim.bsky.social and Oliver Schulz. Great start of 2026!
Researchers at the Crick have uncovered how certain proteins that become exposed on dying tumour cells can be detected by the immune system, alerting it to the cancer’s presence and prompting an immune response.
www.crick.ac.uk/news/2025-12...
www.crick.ac.uk/news/2025-12...
Lifting cancer’s invisibility cloak
Dying tumour cells alert the immune system to fight cancer.
www.crick.ac.uk
January 2, 2026 at 5:26 PM
Absolutely delighted that our latest paper is out today @natimmunol.nature.com. It has taken five years to uncover a role for cross-presentation in shaping the immune visibility of tumour antigens. A labour of love led by @drjonlim.bsky.social and Oliver Schulz. Great start of 2026!
This is cool stuff - imaging covalent drug biodistribution using tissue clearing methods
December 22, 2025 at 4:48 PM
This is cool stuff - imaging covalent drug biodistribution using tissue clearing methods
Reposted by Simon Cleary
Please check out our job post @biologists.bsky.social!
We are recruiting a Postdoc Scientist to develop cutting-edge tools and techniques for bioengineering human lymphatic networks, as part of an interdisciplinary collaboration with the group of Prof Dame Molly Stevens!
bit.ly/3La9idq
We are recruiting a Postdoc Scientist to develop cutting-edge tools and techniques for bioengineering human lymphatic networks, as part of an interdisciplinary collaboration with the group of Prof Dame Molly Stevens!
bit.ly/3La9idq
Postdoctoral position in vascular bioengineering in Oxford, UK - the Node
The Stone Group at the Institute of Developmental and Regenerative Medicine, University of Oxford, is looking for a motivated Postdoctoral Research Scientist to develop tools and techniques that enabl...
bit.ly
December 20, 2025 at 9:39 AM
Please check out our job post @biologists.bsky.social!
We are recruiting a Postdoc Scientist to develop cutting-edge tools and techniques for bioengineering human lymphatic networks, as part of an interdisciplinary collaboration with the group of Prof Dame Molly Stevens!
bit.ly/3La9idq
We are recruiting a Postdoc Scientist to develop cutting-edge tools and techniques for bioengineering human lymphatic networks, as part of an interdisciplinary collaboration with the group of Prof Dame Molly Stevens!
bit.ly/3La9idq
Enjoyed learning about the importance of Batf3 for IL-17-producing γδ T cell responses that protect neonates during influenza infection! Congrats Pedro and colleagues!
Isn't this the coolest Christmas present (or miracle) for a #gdTcell aficionado?! Our latest preprint showing the role of BATF3 on gd T cells is ou on bioRxiv:
www.biorxiv.org/content/10.6...
www.biorxiv.org/content/10.6...
BATF3 controls the homeostatic maintenance and function of innate-like γδ T cells
γδ T cells compose an evolutionarily conserved lineage of lymphocytes, with both adaptive- and innate-like characteristics, contributing to tissue homeostasis, immune surveillance, and rapid responses...
www.biorxiv.org
December 19, 2025 at 4:19 PM
Enjoyed learning about the importance of Batf3 for IL-17-producing γδ T cell responses that protect neonates during influenza infection! Congrats Pedro and colleagues!
Reposted by Simon Cleary
Are you an emerging clinical academic leader in respiratory medicine?
Come and join @vpd-hlri.bsky.social and @royalpapworth.bsky.social and build your career!
Get in touch if you’d like to discuss.
www.cam.ac.uk/jobs/assista...
Come and join @vpd-hlri.bsky.social and @royalpapworth.bsky.social and build your career!
Get in touch if you’d like to discuss.
www.cam.ac.uk/jobs/assista...
Assistant/Associate Professor in Respiratory Medicine (Honorary Consultant) (Fixed Term)
An exciting opportunity has arisen for a new University of Cambridge-Royal Papworth Hospital NHS Foundation Trust Assistant/Associate Professor in Respiratory Medicine. We are seeking applications
www.cam.ac.uk
December 16, 2025 at 10:53 PM
Are you an emerging clinical academic leader in respiratory medicine?
Come and join @vpd-hlri.bsky.social and @royalpapworth.bsky.social and build your career!
Get in touch if you’d like to discuss.
www.cam.ac.uk/jobs/assista...
Come and join @vpd-hlri.bsky.social and @royalpapworth.bsky.social and build your career!
Get in touch if you’d like to discuss.
www.cam.ac.uk/jobs/assista...
Fun revisiting this study and looking at the eLife peer review system for this postLight:
Insightful ‘postLight’ just uploaded by @simoncleary.bsky.social 👀
Simon revisits work discovering structures that control megakaryocyte protrusion events: extracellular matrix cages – work reviewed and published at @elife.bsky.social
#postLight: prelights.biologists.com/highlights/m...
Simon revisits work discovering structures that control megakaryocyte protrusion events: extracellular matrix cages – work reviewed and published at @elife.bsky.social
#postLight: prelights.biologists.com/highlights/m...
Megakaryocytes assemble a three-dimensional cage of extracellular matrix that controls their maturation and anchoring to the vascular niche - preLights
The megakaryocyte: trapped in a cage of its own making
prelights.biologists.com
December 8, 2025 at 11:30 AM
Fun revisiting this study and looking at the eLife peer review system for this postLight:
Heading to BSI congress? Plan on attending this all-star session, Thursday at 11AM, chaired by @doreenlau.bsky.social and me!
🔬 Is seeing believing?
Discover how cutting-edge imaging and multi-omics are transforming our understanding of immune cell interactions and spatial immunobiology.
Don’t miss this parallel session at #BSI25! Secure your place: bit.ly/3IkxWq8
Discover how cutting-edge imaging and multi-omics are transforming our understanding of immune cell interactions and spatial immunobiology.
Don’t miss this parallel session at #BSI25! Secure your place: bit.ly/3IkxWq8
December 1, 2025 at 1:35 PM
Heading to BSI congress? Plan on attending this all-star session, Thursday at 11AM, chaired by @doreenlau.bsky.social and me!
Reposted by Simon Cleary
Outstanding PhD fellowship call OPEN for excellent students.
lacaixafoundation.org/en/doctoral-...
This is for students incoming from outside Spain. And it is VERY well supported (ie at European levels).
If you’re interested in doing a PhD in our lab @irbbarcelona.org, reach out!!!!
lacaixafoundation.org/en/doctoral-...
This is for students incoming from outside Spain. And it is VERY well supported (ie at European levels).
If you’re interested in doing a PhD in our lab @irbbarcelona.org, reach out!!!!
Doctoral INPhINIT fellowships - Incoming Call 2026
We grant 30 fellowships for researchers of any nationality who wish to pursue a doctorate in a STEM discipline at research centres of excellence in Spain or Portugal.
www.google.com
November 26, 2025 at 7:43 AM
Outstanding PhD fellowship call OPEN for excellent students.
lacaixafoundation.org/en/doctoral-...
This is for students incoming from outside Spain. And it is VERY well supported (ie at European levels).
If you’re interested in doing a PhD in our lab @irbbarcelona.org, reach out!!!!
lacaixafoundation.org/en/doctoral-...
This is for students incoming from outside Spain. And it is VERY well supported (ie at European levels).
If you’re interested in doing a PhD in our lab @irbbarcelona.org, reach out!!!!
Looking forward to chairing a session with @doreenlau.bsky.social at the British Society for Immunology Congress next week!
Great line-up of speakers. Send an email if you would like to meet at or around the conference.
Great line-up of speakers. Send an email if you would like to meet at or around the conference.
November 25, 2025 at 3:48 PM
Looking forward to chairing a session with @doreenlau.bsky.social at the British Society for Immunology Congress next week!
Great line-up of speakers. Send an email if you would like to meet at or around the conference.
Great line-up of speakers. Send an email if you would like to meet at or around the conference.
Reposted by Simon Cleary
We are recruiting a Reader/Professor of Immunobiology at @kingslsm.bsky.social . This is a unique opportunity to shape basic immunology at @kingscollegelondon.bsky.social . Please RP.
www.kcl.ac.uk/jobs/131447-...
www.kcl.ac.uk/jobs/131447-...
Reader in/Professor of Immunobiology | King's College London
www.kcl.ac.uk
November 24, 2025 at 12:30 PM
We are recruiting a Reader/Professor of Immunobiology at @kingslsm.bsky.social . This is a unique opportunity to shape basic immunology at @kingscollegelondon.bsky.social . Please RP.
www.kcl.ac.uk/jobs/131447-...
www.kcl.ac.uk/jobs/131447-...
'B' frequently happens and would grind my gears if it weren't so funny.
What's more irritating in talks?
A) Speakers saying "I'm going to switch gears" when they mean "I'm going to change direction and talk about something else"?
B) A metaphorical collaboration slide that shows 3 or more gear cogs in a configuration that could not possible work.
A) Speakers saying "I'm going to switch gears" when they mean "I'm going to change direction and talk about something else"?
B) A metaphorical collaboration slide that shows 3 or more gear cogs in a configuration that could not possible work.
November 14, 2025 at 2:49 PM
'B' frequently happens and would grind my gears if it weren't so funny.
Great to hear good news on reproducibility!
CD44 is involved in cell adhesion, migration & signaling.
It is key in inflammation and immune diseases & cancer.
Good news: most commercial CD44 antibodies are highly specific and work well for:
• Western blot
• Immunofluorescence
• Flow cytometry
Full report: zenodo.org/records/1562...
It is key in inflammation and immune diseases & cancer.
Good news: most commercial CD44 antibodies are highly specific and work well for:
• Western blot
• Immunofluorescence
• Flow cytometry
Full report: zenodo.org/records/1562...
November 14, 2025 at 8:40 AM
Great to hear good news on reproducibility!
Reposted by Simon Cleary
Delighted that this study is finally out @embojournal.org. A detailed analysis of how DNGR-1/CLEC9A signals to promote cross-presentation of dead cell-associated antigens yet does not activate dendritic cells.
www.embopress.org/doi/full/10....
www.embopress.org/doi/full/10....
DNGR-1 signalling limits dendritic cell activation for optimal antigen cross-presentation | The EMBO Journal
imageimageDNGR-1 (CLEC9A) is a C-type lectin receptor of type-1 conventional dendritic cells (cDC1s) with an important role in cross-presentation of dead cell antigens. This study explores how it equips cDC1s with the ability to cross-present such ...
www.embopress.org
November 3, 2025 at 5:23 PM
Delighted that this study is finally out @embojournal.org. A detailed analysis of how DNGR-1/CLEC9A signals to promote cross-presentation of dead cell-associated antigens yet does not activate dendritic cells.
www.embopress.org/doi/full/10....
www.embopress.org/doi/full/10....
Assaying lung samples using spectral flow cytometry? Check out AutoSpectral:
Pre-print alert! And this one really is a must read for anyone that does spectral #flowcytometry. It is a complete, fully-automated spectral unmixing pipeline that reduces error up to 9000-fold.
Want to get a tough sample, like lung, looking like this? Read more!
www.biorxiv.org/content/10.1...
Want to get a tough sample, like lung, looking like this? Read more!
www.biorxiv.org/content/10.1...
October 28, 2025 at 8:25 AM
Assaying lung samples using spectral flow cytometry? Check out AutoSpectral:
Reposted by Simon Cleary
Some good weekend reading. If you thought we’d put the final nails in the coffin of ivermectin as a Covid treatment, you’d be right. But this Perspective goes the extra mile to put the coffin in a lead-lined box and sink it to the bottom of the ocean. 🧵
Membrane Perturbations and Assay Interferences by Ivermectin Explain Its In Vitro SARS-CoV-2 Antiviral Activities and Lack of Translatability
The antiparasitic drug ivermectin was proposed as a repurposed drug for the treatment of SARS-CoV-2 infection based on in vitro studies, but proved ineffective in high-quality clinical trials. When ex...
pubs.acs.org
October 12, 2025 at 7:39 PM
Some good weekend reading. If you thought we’d put the final nails in the coffin of ivermectin as a Covid treatment, you’d be right. But this Perspective goes the extra mile to put the coffin in a lead-lined box and sink it to the bottom of the ocean. 🧵
Reposted by Simon Cleary
It’s official! 🎉
Our latest paper on the role of the extracellular matrix (ECM) in megakaryopoiesis is out in @elife.bsky.social !
🔗 elifesciences.org/articles/104...
I’m thrilled to share this story with you in a short thread 👇
Our latest paper on the role of the extracellular matrix (ECM) in megakaryopoiesis is out in @elife.bsky.social !
🔗 elifesciences.org/articles/104...
I’m thrilled to share this story with you in a short thread 👇
October 9, 2025 at 7:48 PM
It’s official! 🎉
Our latest paper on the role of the extracellular matrix (ECM) in megakaryopoiesis is out in @elife.bsky.social !
🔗 elifesciences.org/articles/104...
I’m thrilled to share this story with you in a short thread 👇
Our latest paper on the role of the extracellular matrix (ECM) in megakaryopoiesis is out in @elife.bsky.social !
🔗 elifesciences.org/articles/104...
I’m thrilled to share this story with you in a short thread 👇
Reposted by Simon Cleary
BioImage analysis friends - King's are recruiting for a full-time, permanent facility position! Come and work with fun microscopes and fun people (and me!) - please share! www.kcl.ac.uk/jobs/126345-...
Bioimage Analysis Specialist | King's College London
www.kcl.ac.uk
September 29, 2025 at 9:48 AM
BioImage analysis friends - King's are recruiting for a full-time, permanent facility position! Come and work with fun microscopes and fun people (and me!) - please share! www.kcl.ac.uk/jobs/126345-...
Reposted by Simon Cleary
For this #FluorescenceFriday, a gorgeous image of an adult mouse kidney labeled with AQP2 and alpha SMA antibodies. AQP2 (green) marks the collecting duct and distal connecting segment while SMA marks the arterial tree. Courtesy of talented postdoc Sarah McLarnon.
September 26, 2025 at 5:51 PM
For this #FluorescenceFriday, a gorgeous image of an adult mouse kidney labeled with AQP2 and alpha SMA antibodies. AQP2 (green) marks the collecting duct and distal connecting segment while SMA marks the arterial tree. Courtesy of talented postdoc Sarah McLarnon.
PhD scholarships available incl. a project with me & Alex Ivetic at King's College London - great programme, facilities, city, colleagues!
Please forward to any suitable undergraduates/MSc students/research assistants.
Info: kcl-mrcdtp.com/project/enha...
Please forward to any suitable undergraduates/MSc students/research assistants.
Info: kcl-mrcdtp.com/project/enha...
Enhancing pulmonary vascular function to heal injured lungs - MRC DTP
To develop improved treatments for inflammatory diseases, we need a better understanding of how pro-inflammatory leukocyte responses resolve. During inflammatory resolution, some recruited leukocytes ...
kcl-mrcdtp.com
September 25, 2025 at 9:44 AM
PhD scholarships available incl. a project with me & Alex Ivetic at King's College London - great programme, facilities, city, colleagues!
Please forward to any suitable undergraduates/MSc students/research assistants.
Info: kcl-mrcdtp.com/project/enha...
Please forward to any suitable undergraduates/MSc students/research assistants.
Info: kcl-mrcdtp.com/project/enha...
Reposted by Simon Cleary
Pleased to see this out now in @jem.org 🔬
We characterise the early immune response during M. tuberculosis infection in mouse models and demonstrate a detrimental role for type I interferon activated neutrophils in TB lesions. Thanks to all involved @crick.ac.uk and i3S, Porto.
We characterise the early immune response during M. tuberculosis infection in mouse models and demonstrate a detrimental role for type I interferon activated neutrophils in TB lesions. Thanks to all involved @crick.ac.uk and i3S, Porto.
William J. Branchett, Anne O’Garra @crick.ac.uk et al. reveal that type I signaling early during M. #tuberculosis infection favors #neutrophil swarming and limits CD4+ T cell–#macrophage interactions in #TB lesions, impeding TB disease control. rupress.org/jem/article/...
September 24, 2025 at 6:10 AM
Pleased to see this out now in @jem.org 🔬
We characterise the early immune response during M. tuberculosis infection in mouse models and demonstrate a detrimental role for type I interferon activated neutrophils in TB lesions. Thanks to all involved @crick.ac.uk and i3S, Porto.
We characterise the early immune response during M. tuberculosis infection in mouse models and demonstrate a detrimental role for type I interferon activated neutrophils in TB lesions. Thanks to all involved @crick.ac.uk and i3S, Porto.
Reposted by Simon Cleary
🚨 New paper in @jclinical-invest.bsky.social!
Kidney lymphatics are a promising target in transplant rejection
🗺️ In rejection, lymphatics expand and adversely remodel
⚡️ Although they have an anti-inflammatory profile, they are attacked by the immune system
www.jci.org/articles/vie...
1/4
Kidney lymphatics are a promising target in transplant rejection
🗺️ In rejection, lymphatics expand and adversely remodel
⚡️ Although they have an anti-inflammatory profile, they are attacked by the immune system
www.jci.org/articles/vie...
1/4
September 17, 2025 at 12:32 PM
🚨 New paper in @jclinical-invest.bsky.social!
Kidney lymphatics are a promising target in transplant rejection
🗺️ In rejection, lymphatics expand and adversely remodel
⚡️ Although they have an anti-inflammatory profile, they are attacked by the immune system
www.jci.org/articles/vie...
1/4
Kidney lymphatics are a promising target in transplant rejection
🗺️ In rejection, lymphatics expand and adversely remodel
⚡️ Although they have an anti-inflammatory profile, they are attacked by the immune system
www.jci.org/articles/vie...
1/4