Lightnews — Scholar-powered news

Keith Hornberger @krhornberger.bsky.social · 22h

You’ve also just learned something valuable about the culture of whichever company told you this, so maybe it’s for the best

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Keith Hornberger @krhornberger.bsky.social · 22h

Sorry this happened to you KC. I would have hoped they could offer something more constructive. This kind of elitism was rampant when I first got into industry 23 years ago. It’s improved today - but far from gone

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Keith Hornberger @krhornberger.bsky.social · 22h

Discovery of BRD9 Molecular Glue Degraders That Spare Cardiomyocytes

Molecular glue degraders (MGDs) represent a class of drug-like small molecules that induce targeted protein degradation (TPD) by promoting selective protein–protein interactions. MGDs offer a promisin...

pubs.acs.org

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Reposted by Keith Hornberger

C&EN (Chemical & Engineering News) @cenmag.bsky.social · 3d

The 2025 #NobelPrize in Chemistry has been awarded to Susumu Kitagawa, Richard Robson and Omar M. Yaghi “for the development of metal–organic frameworks.” Stay tuned for the full story to come! cen.acs.org/people/nobel...

#ChemNobel #Chem #Chemistry #chemsky 🧪

The 2025 chemistry Nobel goes to MOFs

Susumu Kitagawa, Richard Robson and Omar M. Yaghi win the prize for developing metal–organic frameworks

cen.acs.org

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Keith Hornberger @krhornberger.bsky.social · 3d

🤦‍♂️

Keith Hornberger @krhornberger.bsky.social · 3d

I sincerely hope that LNPs get their due someday and aren’t forgotten in the wake of the mRNA vaccine medicine Nobel. They make the whole thing actually work!

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Keith Hornberger @krhornberger.bsky.social · 3d

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Keith Hornberger @krhornberger.bsky.social · 3d

Fleischmann died over a decade ago so is ineligible. And anyway, maybe we can let the physicists have that one even though they’re electrochemists 😂

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Keith Hornberger @krhornberger.bsky.social · 3d

😂

Keith Hornberger @krhornberger.bsky.social · 3d

It’s Nobel Prize in Chemistry Eve, and you know what that means - it’s time for the annual survey!

Who will win this year’s chemistry Nobel? Wrong answers only.

a cartoon hand is pressing a red button that says wrong answer

ALT: a cartoon hand is pressing a red button that says wrong answer

media.tenor.com

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Keith Hornberger @krhornberger.bsky.social · 3d

Rational design of the linkers in targeting chimeras

Targeting chimeras (TACs), such as PROTACs, LYTACs, AUTACs, and ATTECs, have emerged as promising strategies for selectively degrading proteins, including undruggable targets. These approaches leverag...

pubs.rsc.org

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Keith Hornberger @krhornberger.bsky.social · 7d

If true, this really worries me a lot. It fuels my worst fears that AI tools will drive brain rot by encouraging us to take our hands off the wheel and not worry so much about what’s right or wrong anymore.

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Keith Hornberger @krhornberger.bsky.social · 7d

I recently visited a PUI where some faculty told me that AI tool use to complete homework is rampant and the students are getting (wrong) info from “studying” with chemistry YouTubers. And then totally failing exams because no homework practice and no studying. Thoughts? Corroboration?

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Keith Hornberger @krhornberger.bsky.social · 7d

Translational Research on the Oral Delivery of the Cytotoxic PROTAC Molecule via Tumor-Targeting Prodrug Strategy for Triple-Negative Breast Cancer Treatment

In the present work, we have identified a proteolysis targeting chimera (PROTAC) molecule that potently and selectively degrades CDK4, CDK6, and CDK9, inhibiting triple-negative breast cancer (TNBC) c...

pubs.acs.org

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Keith Hornberger @krhornberger.bsky.social · 9d

ChEMBL is a great — and free — resource for the community. Here’s the latest.

Drug and Clinical Candidate Drug Data in ChEMBL

Drug and Clinical Candidate Drug Data in ChEMBL

ChEMBL is a large-scale, open-access, FAIR database of bioactive molecules with drug-like properties. ChEMBL 35 contains 17,500 approved drugs, and drugs that are progressing through the clinical deve...

pubs.acs.org

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Keith Hornberger @krhornberger.bsky.social · 10d

GSPT1 degraders: research progress, development strategies and challenges

Dysregulation of GSPT1 which is a critical translation termination factor plays an important role in oncogenesis and cancer progression. However, GSPT…

www.sciencedirect.com

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Keith Hornberger @krhornberger.bsky.social · 11d

Enzyme-Activated Sugar-Coated Bifunctional Degraders

Targeted protein degradation with compounds like proteolysis targeting chimeras (PROTACs) directs disease-associated proteins to the E3 ligase ubiquitin-proteasome system for removal. However, commonl...

pubs.acs.org

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Keith Hornberger @krhornberger.bsky.social · 14d

Optimizing linker rigidity to improve intracellular behavior of PROTACs targeting hematopoietic prostaglandin D synthase

Proteolysis-targeting chimeras (PROTACs) are emerging as powerful tools for targeted protein degradation. Among the key factors influencing their efficacy, linker design plays a critical role by affec...

pubs.rsc.org

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Keith Hornberger @krhornberger.bsky.social · 15d

I have to admit, I don’t keep a supply of ginger syrup just lying around most of the time. I’ve already consumed an entire door shelf in the fridge with various syrups, and my wife might kill me if I make any more!

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Keith Hornberger @krhornberger.bsky.social · 15d

Data-Driven Generation of Conformational Ensembles and Ternary Complexes for PROTAC and Other Chimera Systems

We present the protolysis-targeting chimera (PROTAC) Conformer Generator, a fast and knowledge-based tool for generating robust conformational ensembles of PROTACs and other chimeric degraders. The mo...

pubs.acs.org

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Keith Hornberger @krhornberger.bsky.social · 15d

I think a piece of @chemjobber.bsky.social just died on this one 😂

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Keith Hornberger @krhornberger.bsky.social · 15d

Great lineup and agree re: Barr Hill gin! Sasha Petraske has a nice riff on the Bee’s Knees called The Business (emphasis on the Bizzzz 🐝) that just swaps out the lemon juice for lime juice and is a bit snappier. And of course one should consider the Penicillin when talking about honey cocktails.

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Keith Hornberger @krhornberger.bsky.social · 17d

In-cell proximity target validation methods for heterobifunctional molecules with CRBN- or VHL-binder using AirID

In-cell proximity target validation methods for heterobifunctional molecules with CRBN- or VHL-binder using AirID - Communications Biology

The development of AirID-based tools (ThBD–AirID, VHL–AirID) to validate protein interactomes of heterobifunctional molecules in cells reveals E3 binder–dependent proximity proteins of a protein of interest.

www.nature.com

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Keith Hornberger @krhornberger.bsky.social · 18d

Characterization of PROTAC specificity and endogenous protein interactomes using ProtacID

Characterization of PROTAC specificity and endogenous protein interactomes using ProtacID - Nature Communications

PROTAC development has surged in popularity, however our ability to characterize PROTAC specificity in living cells has lagged behind. Here, the authors develop ProtacID, a flexible proximity-dependen...

www.nature.com

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Keith Hornberger @krhornberger.bsky.social · 21d

Exactly this - I’ve never loved the term but the trait is so unmistakable when you see it in someone. Today is just me just rambling about how I wish I could bottle that up and give it to everyone as a tonic 😂

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