Caetano Reis e Sousa
@reisesousalab.bsky.social
We are the Immunobiology Lab at the Francis Crick Institute (@crick.ac.uk). We study how the body detects and responds to infection, cancer and tissue damage.
Reposted by Caetano Reis e Sousa
We had another full house at our Annual Science Meeting this week, which featured over 100 posters and 30 talks by our Crick colleagues.
These yearly events are a great way for us all to get together and discover what teams from every corner of the building have been working on.
These yearly events are a great way for us all to get together and discover what teams from every corner of the building have been working on.
November 7, 2025 at 10:28 AM
We had another full house at our Annual Science Meeting this week, which featured over 100 posters and 30 talks by our Crick colleagues.
These yearly events are a great way for us all to get together and discover what teams from every corner of the building have been working on.
These yearly events are a great way for us all to get together and discover what teams from every corner of the building have been working on.
Cool new paper from @drmichaelway.bsky.social. Check it out!
Researchers at the Crick have discovered that mice lacking a specific gene responsible for cell structure lose intestinal balance and experience systemic inflammation, mirroring a lethal condition seen in humans.
www.crick.ac.uk/news/2025-11...
www.crick.ac.uk/news/2025-11...
How weakness in cell structure affects the host-microbiome relationship
Mice lacking a gene responsible for cell structure lose intestinal balance and experience systemic inflammation, mirroring a lethal condition seen in humans.
www.crick.ac.uk
November 13, 2025 at 9:22 PM
Cool new paper from @drmichaelway.bsky.social. Check it out!
Delighted to have written this Insight article together with @victor-bosteels.bsky.social and Will Stainier about a cool new story by Tam et al. And with a title to honour Jason Cyster’s heritage.
Insights @jem.org: Bosteels, Stainier, and @reisesousalab.bsky.social highlight work by Tam et al. (rupress.org/jem/article/...) revealing that GPR34, a lysophosphatidylserine receptor, promotes apoptotic cell uptake and cross-presentation by type 1 #DendriticCells. rupress.org/jem/article/...
November 13, 2025 at 9:18 PM
Delighted to have written this Insight article together with @victor-bosteels.bsky.social and Will Stainier about a cool new story by Tam et al. And with a title to honour Jason Cyster’s heritage.
Reposted by Caetano Reis e Sousa
DNGR-1 signalling limits dendritic cell activation for optimal antigen cross-presentation
@reisesousalab.bsky.social et al implicate recruitment of phosphatase SHIP1 by receptor DNGR-1/CLEC9A in uncoupling of cross-presentation from inflammatory induction
www.embopress.org/doi/full/10....
@reisesousalab.bsky.social et al implicate recruitment of phosphatase SHIP1 by receptor DNGR-1/CLEC9A in uncoupling of cross-presentation from inflammatory induction
www.embopress.org/doi/full/10....
November 6, 2025 at 9:02 AM
DNGR-1 signalling limits dendritic cell activation for optimal antigen cross-presentation
@reisesousalab.bsky.social et al implicate recruitment of phosphatase SHIP1 by receptor DNGR-1/CLEC9A in uncoupling of cross-presentation from inflammatory induction
www.embopress.org/doi/full/10....
@reisesousalab.bsky.social et al implicate recruitment of phosphatase SHIP1 by receptor DNGR-1/CLEC9A in uncoupling of cross-presentation from inflammatory induction
www.embopress.org/doi/full/10....
End of our Annual Science Meeting @crick.ac.uk with a quiz. - happy winners and quiz organisers below. Thanks to everyone who made these two days of science so inspiring and enjoyable!
November 6, 2025 at 8:50 PM
End of our Annual Science Meeting @crick.ac.uk with a quiz. - happy winners and quiz organisers below. Thanks to everyone who made these two days of science so inspiring and enjoyable!
Great day today @crick.ac.uk Annual Science Meeting. Lots of exciting science and a convivial atmosphere. Looking forward to Day 2 tomorrow!
November 5, 2025 at 11:28 PM
Great day today @crick.ac.uk Annual Science Meeting. Lots of exciting science and a convivial atmosphere. Looking forward to Day 2 tomorrow!
Thanks, Ivan!
November 4, 2025 at 9:28 AM
Thanks, Ivan!
Thank you to all the present and former members of @reisesousalab.bsky.social and colleagues @crick.ac.uk who helped. But the real hero is Mike Buck, who persevered over several years to bring this study to fruition!
November 3, 2025 at 5:23 PM
Thank you to all the present and former members of @reisesousalab.bsky.social and colleagues @crick.ac.uk who helped. But the real hero is Mike Buck, who persevered over several years to bring this study to fruition!
Fascinating Yin and Yang, the significance of which we can only speculate at.
November 3, 2025 at 5:23 PM
Fascinating Yin and Yang, the significance of which we can only speculate at.
But the mutant DNGR-1 loses the ability to signal for endocytic vesicle rupture, a pre-requisite for cross-presentation. Conversely, mutating Dectin-1 to make it "DNGR-1-like" causes it to lose activatory activity and gain the ability to promote cross-presentation.
November 3, 2025 at 5:23 PM
But the mutant DNGR-1 loses the ability to signal for endocytic vesicle rupture, a pre-requisite for cross-presentation. Conversely, mutating Dectin-1 to make it "DNGR-1-like" causes it to lose activatory activity and gain the ability to promote cross-presentation.
It is down to a single conserved amino acid in the signalling domain. Mutate it and the receptor becomes activatory, much like its cousin Dectin-1.
November 3, 2025 at 5:23 PM
It is down to a single conserved amino acid in the signalling domain. Mutate it and the receptor becomes activatory, much like its cousin Dectin-1.
Delighted that this study is finally out @embojournal.org. A detailed analysis of how DNGR-1/CLEC9A signals to promote cross-presentation of dead cell-associated antigens yet does not activate dendritic cells.
www.embopress.org/doi/full/10....
www.embopress.org/doi/full/10....
DNGR-1 signalling limits dendritic cell activation for optimal antigen cross-presentation | The EMBO Journal
imageimageDNGR-1 (CLEC9A) is a C-type lectin receptor of type-1 conventional dendritic cells (cDC1s) with an important role in cross-presentation of dead cell antigens. This study explores how it equips cDC1s with the ability to cross-present such ...
www.embopress.org
November 3, 2025 at 5:23 PM
Delighted that this study is finally out @embojournal.org. A detailed analysis of how DNGR-1/CLEC9A signals to promote cross-presentation of dead cell-associated antigens yet does not activate dendritic cells.
www.embopress.org/doi/full/10....
www.embopress.org/doi/full/10....
Wonderful day celebrating Paul Nurse after he steps down from being the Director @crick.ac.uk. We are all very grateful to him for having created an amazing institute.
October 23, 2025 at 8:35 PM
Wonderful day celebrating Paul Nurse after he steps down from being the Director @crick.ac.uk. We are all very grateful to him for having created an amazing institute.
Reposted by Caetano Reis e Sousa
Researchers at the Crick found that virgin female mice can become aggressive towards pups when hungry, but only in certain hormonal states.
It highlights the importance of understanding hormones when observing how different physical states interact in the brain.
www.crick.ac.uk/news/2025-10...
It highlights the importance of understanding hormones when observing how different physical states interact in the brain.
www.crick.ac.uk/news/2025-10...
Hunger influences the behaviour of female mice towards pups
Researchers find that virgin female mice can become aggressive towards pups when hungry, but only in certain hormonal states.
www.crick.ac.uk
October 22, 2025 at 3:14 PM
Researchers at the Crick found that virgin female mice can become aggressive towards pups when hungry, but only in certain hormonal states.
It highlights the importance of understanding hormones when observing how different physical states interact in the brain.
www.crick.ac.uk/news/2025-10...
It highlights the importance of understanding hormones when observing how different physical states interact in the brain.
www.crick.ac.uk/news/2025-10...
Amazing opportunity.
We're now recruiting early career group leaders at the Crick to lead ambitious research programmes and explore bold scientific questions.
Hear our Director, Edith Heard, explain why the Crick is a unique place for curiosity-driven research.
Apply now ➡️ www.crick.ac.uk/careers-stud...
Hear our Director, Edith Heard, explain why the Crick is a unique place for curiosity-driven research.
Apply now ➡️ www.crick.ac.uk/careers-stud...
October 9, 2025 at 2:57 PM
Amazing opportunity.
Applications for the Crick PhD programme now open. One studentship available in our lab, starting Autumn 2026. Apply!
Motivated graduates with backgrounds in biological or biomedical sciences, physics, chemistry, mathematics, engineering and/or computer science are invited to apply to our 4-year fully funded PhD programme.
Apply by 05 November 2025
www.crick.ac.uk/careers-and-...
Apply by 05 November 2025
www.crick.ac.uk/careers-and-...
PhD students
Our PhD programme attracts the brightest scientific minds and is an opportunity for talented people to embark on their career in biomedical research.
www.crick.ac.uk
October 2, 2025 at 7:48 PM
Applications for the Crick PhD programme now open. One studentship available in our lab, starting Autumn 2026. Apply!
Many congratulations!
September 25, 2025 at 11:20 AM
Many congratulations!
Reposted by Caetano Reis e Sousa
NEW PODCAST: ‘A Question of Science’ with Professor Brian Cox.
In every episode, panels of scientists and experts answer audience questions about some of the biggest issues facing us today.
Listen to the first episode, ‘Can we live forever?’: lnk.to/AQOSAgeingBB
In every episode, panels of scientists and experts answer audience questions about some of the biggest issues facing us today.
Listen to the first episode, ‘Can we live forever?’: lnk.to/AQOSAgeingBB
September 17, 2025 at 5:25 AM
NEW PODCAST: ‘A Question of Science’ with Professor Brian Cox.
In every episode, panels of scientists and experts answer audience questions about some of the biggest issues facing us today.
Listen to the first episode, ‘Can we live forever?’: lnk.to/AQOSAgeingBB
In every episode, panels of scientists and experts answer audience questions about some of the biggest issues facing us today.
Listen to the first episode, ‘Can we live forever?’: lnk.to/AQOSAgeingBB
Reposted by Caetano Reis e Sousa
Cardoso et al. @reisesousalab.bsky.social show that DNGR-1–deficient pre-cDCs display cell-intrinsic alterations in their ability to colonize peripheral organs. rupress.org/jem/article/...
📘 #Macrophages and #DendriticCells in Health and Disease 👉 rupress.org/jem/collecti...
📘 #Macrophages and #DendriticCells in Health and Disease 👉 rupress.org/jem/collecti...
September 17, 2025 at 10:02 AM
Cardoso et al. @reisesousalab.bsky.social show that DNGR-1–deficient pre-cDCs display cell-intrinsic alterations in their ability to colonize peripheral organs. rupress.org/jem/article/...
📘 #Macrophages and #DendriticCells in Health and Disease 👉 rupress.org/jem/collecti...
📘 #Macrophages and #DendriticCells in Health and Disease 👉 rupress.org/jem/collecti...
Reposted by Caetano Reis e Sousa
Edith Heard our new CEO shares ten lessons from her life in science, from curiosity, courage and coffee to the secrets of our genetic code.
www.crick.ac.uk/news/2025-09...
www.crick.ac.uk/news/2025-09...
Edith Heard life lessons
Edith Heard, the Crick’s new Director and CEO, shares ten lessons from a life in science, spanning curiosity, courage, coffee, and the secrets of our genetic code.
www.crick.ac.uk
September 10, 2025 at 1:32 PM
Edith Heard our new CEO shares ten lessons from her life in science, from curiosity, courage and coffee to the secrets of our genetic code.
www.crick.ac.uk/news/2025-09...
www.crick.ac.uk/news/2025-09...
Nice to spend 3 days hearing about the great science and translational activity going on at VIB IRC Ghent. With a useful reminder to avoid yoga on the toilet!
September 10, 2025 at 7:32 PM
Nice to spend 3 days hearing about the great science and translational activity going on at VIB IRC Ghent. With a useful reminder to avoid yoga on the toilet!
Congratulations Juliana!
September 3, 2025 at 8:04 AM
Congratulations Juliana!
Great keynote lecture by Ruslan Medzhitov on how the “educated” immune system of pet shop mice allows them to resist experimental allergic sensitisation. Thought provoking, as usual. #IUIS2025.
August 20, 2025 at 5:27 PM
Great keynote lecture by Ruslan Medzhitov on how the “educated” immune system of pet shop mice allows them to resist experimental allergic sensitisation. Thought provoking, as usual. #IUIS2025.
Wonderful to see Klaus Rajewsky honored with the first ever EFIS Lifetime Achievement Award! #iIUIS2025 in Vienna.
August 19, 2025 at 10:49 AM
Wonderful to see Klaus Rajewsky honored with the first ever EFIS Lifetime Achievement Award! #iIUIS2025 in Vienna.
Reposted by Caetano Reis e Sousa
The "data" package Secretary Kennedy used to bolster his argument for discontinuing #BARDA funding for #mRNA research doesn't support his argument. @jakescottmd.bsky.social lays it out in a must read for @statnews.com. www.statnews.com/2025/08/13/r...
Kennedy's case against mRNA vaccines collapses under his own evidence
“This isn't scientific disagreement. It's either staggering incompetence or willful misrepresentation,” writes infectious disease physician Jake Scott.
www.statnews.com
August 13, 2025 at 4:25 PM
The "data" package Secretary Kennedy used to bolster his argument for discontinuing #BARDA funding for #mRNA research doesn't support his argument. @jakescottmd.bsky.social lays it out in a must read for @statnews.com. www.statnews.com/2025/08/13/r...