preLights
@prelights.bsky.social
A preprint highlights service run by the biological community and supported by The Company of Biologists (@biologists.bsky.social).
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preLights
@prelights.bsky.social
· Sep 1
🚨 New call for preLighters!🚨
Help us highlight the most exciting biological #preprints. Share your insights, build your profile, and be part of a supportive community! 🌍
Interested? Apply today & help shape the future of science publishing! 📢
More info: prelights.biologists.com/news/join-th...
Help us highlight the most exciting biological #preprints. Share your insights, build your profile, and be part of a supportive community! 🌍
Interested? Apply today & help shape the future of science publishing! 📢
More info: prelights.biologists.com/news/join-th...
At the Centre for Regenerative Medicine #UoE, ECRs discuss preprints + now publish their discussions on #preLights!
First #preprint they highlight brings membrane lipids & their spatial organization to the spotlight. @epfl-brainmind.bsky.social
#preLight ⬇️
prelights.biologists.com/highlights/t...
First #preprint they highlight brings membrane lipids & their spatial organization to the spotlight. @epfl-brainmind.bsky.social
#preLight ⬇️
prelights.biologists.com/highlights/t...
The lipidomic architecture of the mouse brain - preLights
Lipids get the space they deserve: Fusar Bassini et al. pioneer a MALDI-MS imaging and computational analysis, bring membrane lipids and their spatial organization to the spotlight and provide evidenc...
prelights.biologists.com
February 10, 2026 at 3:23 PM
At the Centre for Regenerative Medicine #UoE, ECRs discuss preprints + now publish their discussions on #preLights!
First #preprint they highlight brings membrane lipids & their spatial organization to the spotlight. @epfl-brainmind.bsky.social
#preLight ⬇️
prelights.biologists.com/highlights/t...
First #preprint they highlight brings membrane lipids & their spatial organization to the spotlight. @epfl-brainmind.bsky.social
#preLight ⬇️
prelights.biologists.com/highlights/t...
Reposted by preLights
Excited to share our work on epithelial multilayering - identifying why stem cell stay in the basal layer and how and why differentiating cells move up. Great collab with @manningresearch.bsky.social and Niessen labs! Check out preprint and great summary below www.biorxiv.org/content/10.6...
February 10, 2026 at 6:14 AM
Excited to share our work on epithelial multilayering - identifying why stem cell stay in the basal layer and how and why differentiating cells move up. Great collab with @manningresearch.bsky.social and Niessen labs! Check out preprint and great summary below www.biorxiv.org/content/10.6...
Reposted by preLights
A new preprint introduces aDISCO, a DISCO-based clearing approach that makes whole archival FFPE human tissues transparent and antibody-compatible, enabling true 3D light-sheet histology across brain & multiple organs at cellular resolution. Aguzzi & Helmchen teams.
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
February 8, 2026 at 7:41 PM
A new preprint introduces aDISCO, a DISCO-based clearing approach that makes whole archival FFPE human tissues transparent and antibody-compatible, enabling true 3D light-sheet histology across brain & multiple organs at cellular resolution. Aguzzi & Helmchen teams.
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Reposted by preLights
Just published: "Planetary microbiome structure and generalist-driven gene flow across disparate habitats" by @podlesny.bsky.social @chanyeong-kim.bsky.social and @jonas-bio.bsky.social www.cell.com/cell/fulltex...
See the quoted post below for a thread on the preprint!
See the quoted post below for a thread on the preprint!
February 9, 2026 at 5:08 PM
Just published: "Planetary microbiome structure and generalist-driven gene flow across disparate habitats" by @podlesny.bsky.social @chanyeong-kim.bsky.social and @jonas-bio.bsky.social www.cell.com/cell/fulltex...
See the quoted post below for a thread on the preprint!
See the quoted post below for a thread on the preprint!
Reposted by preLights
🚨Preprint alert🚨 How does chromatin “architecture” form at CTCF sites? Our new preprint with @voslab.org and @andersshansen.bsky.social shows CTCF dimerization promotes nucleosome oligomerization on chromatin. tinyurl.com/CTCF-nucleos...
February 9, 2026 at 3:04 PM
🚨Preprint alert🚨 How does chromatin “architecture” form at CTCF sites? Our new preprint with @voslab.org and @andersshansen.bsky.social shows CTCF dimerization promotes nucleosome oligomerization on chromatin. tinyurl.com/CTCF-nucleos...
Neurons contain “hotspots” for mitochondrial biogenesis at distal branch points. #preprint
First #preLight posted by Lorena Olifiers - take a look! ⬇️👀
First #preLight posted by Lorena Olifiers - take a look! ⬇️👀
Check out my first @prelights.bsky.social article, based on some great work done by Dr. Tejashree Waingankar & @samlewis.bsky.social at UC Berkeley 🔬🧬🧠
prelights.biologists.com/highlights/s...
prelights.biologists.com/highlights/s...
Self-renewal of neuronal mitochondria through asymmetric division - preLights
Neurons contain “hotspots” for mitochondrial biogenesis at distal branch points
prelights.biologists.com
February 9, 2026 at 12:23 PM
Reposted by preLights
New preprint from the lab! We identify the ZnF protein Mulberry as a condensation-dependent structural regulator of genome topology that organizes “multi-way regulatory hubs” in early Drosophila embryos.
www.biorxiv.org/content/10.6...
www.biorxiv.org/content/10.6...
February 5, 2026 at 10:56 AM
New preprint from the lab! We identify the ZnF protein Mulberry as a condensation-dependent structural regulator of genome topology that organizes “multi-way regulatory hubs” in early Drosophila embryos.
www.biorxiv.org/content/10.6...
www.biorxiv.org/content/10.6...
Discussing #arXiv preprint 'Kosmos: An AI Scientist for Autonomous Discovery' 🤖
Manuel Lessi & @ramadio.bsky.social share their excitement and worries + discuss possible uses of Kosmos. Includes a lovely graphic created by Theodora M Stougiannou
#preLight⬇️
prelights.biologists.com/highlights/k...
Manuel Lessi & @ramadio.bsky.social share their excitement and worries + discuss possible uses of Kosmos. Includes a lovely graphic created by Theodora M Stougiannou
#preLight⬇️
prelights.biologists.com/highlights/k...
Kosmos: An AI Scientist for Autonomous Discovery - preLights
Helping researchers from start to finish. Kosmos aids the research workflow by reading the literature, proposing hypotheses, generating and running analyses, and producing traceable, reproducible repo...
prelights.biologists.com
February 5, 2026 at 3:17 PM
Discussing #arXiv preprint 'Kosmos: An AI Scientist for Autonomous Discovery' 🤖
Manuel Lessi & @ramadio.bsky.social share their excitement and worries + discuss possible uses of Kosmos. Includes a lovely graphic created by Theodora M Stougiannou
#preLight⬇️
prelights.biologists.com/highlights/k...
Manuel Lessi & @ramadio.bsky.social share their excitement and worries + discuss possible uses of Kosmos. Includes a lovely graphic created by Theodora M Stougiannou
#preLight⬇️
prelights.biologists.com/highlights/k...
Reposted by preLights
Our new preprint is live!🎉
Cytosolic factors govern vimentin network architecture and mechanics. Cytosolic components shape vimentin IF networks & mechanics - beyond minimal reconstitutions.
On bioRxiv now!
Congrats @dyuthisreekumar.bsky.social
www.biorxiv.org/content/10.6...
Cytosolic factors govern vimentin network architecture and mechanics. Cytosolic components shape vimentin IF networks & mechanics - beyond minimal reconstitutions.
On bioRxiv now!
Congrats @dyuthisreekumar.bsky.social
www.biorxiv.org/content/10.6...
February 2, 2026 at 6:18 PM
Our new preprint is live!🎉
Cytosolic factors govern vimentin network architecture and mechanics. Cytosolic components shape vimentin IF networks & mechanics - beyond minimal reconstitutions.
On bioRxiv now!
Congrats @dyuthisreekumar.bsky.social
www.biorxiv.org/content/10.6...
Cytosolic factors govern vimentin network architecture and mechanics. Cytosolic components shape vimentin IF networks & mechanics - beyond minimal reconstitutions.
On bioRxiv now!
Congrats @dyuthisreekumar.bsky.social
www.biorxiv.org/content/10.6...
Reposted by preLights
A new algorithm called BOUQUET maps which genes interact with transcriptional condensates by integrating 3D genome topology and protein binding data. The approach identifies "3D-super-enhancers"—exceptionally protein-rich regulatory...
https://www.biorxiv.org/content/10.1101/2024.02.01.578210
https://www.biorxiv.org/content/10.1101/2024.02.01.578210
February 4, 2026 at 4:23 PM
A new algorithm called BOUQUET maps which genes interact with transcriptional condensates by integrating 3D genome topology and protein binding data. The approach identifies "3D-super-enhancers"—exceptionally protein-rich regulatory...
https://www.biorxiv.org/content/10.1101/2024.02.01.578210
https://www.biorxiv.org/content/10.1101/2024.02.01.578210
Reposted by preLights
Delighted to speak with @reinierprosee.bsky.social @prelights.bsky.social about the work that we do at the Journal of Emerging Investigators. Check it out here!
Helping the next generation of scientists find their voice. 📣
Discover how @seahsamantha.bsky.social empowers students through her path from preLights to Executive Editor of the Journal of Emerging Investigators.
Interview: prelights.biologists.com/news/from-pr...
Discover how @seahsamantha.bsky.social empowers students through her path from preLights to Executive Editor of the Journal of Emerging Investigators.
Interview: prelights.biologists.com/news/from-pr...
February 4, 2026 at 10:15 AM
Delighted to speak with @reinierprosee.bsky.social @prelights.bsky.social about the work that we do at the Journal of Emerging Investigators. Check it out here!
Reposted by preLights
Time for a thread on our Christmas preprint “Origin and evolution of acrocentric chromosomes in human and great apes”. I had so much fun with this project and paper. It will be hard to summarize in a thread, but I’ll try www.biorxiv.org/content/10.6... [1/21]
February 2, 2026 at 2:58 PM
Time for a thread on our Christmas preprint “Origin and evolution of acrocentric chromosomes in human and great apes”. I had so much fun with this project and paper. It will be hard to summarize in a thread, but I’ll try www.biorxiv.org/content/10.6... [1/21]
Reposted by preLights
New preprint from the lab! We dig into the regulatory roles of TEs in the mouse placenta, with some surprising findings. Led by the awesome @smamante.bsky.social. Particular kudos to him for navigating the many twists and turns of the project.
www.biorxiv.org
February 2, 2026 at 10:25 AM
New preprint from the lab! We dig into the regulatory roles of TEs in the mouse placenta, with some surprising findings. Led by the awesome @smamante.bsky.social. Particular kudos to him for navigating the many twists and turns of the project.
Reposted by preLights
🧬📄 Preprint update (v2): We added new biochemical experiments that clarify how IWS1 associates with the transcription elongation complex and further define competition between IWS1 and RECQL5. 🧪⚙️
www.biorxiv.org/content/10.1...
Structural model is already available in the PDB (9MLC).
www.biorxiv.org/content/10.1...
Structural model is already available in the PDB (9MLC).
February 2, 2026 at 4:33 PM
🧬📄 Preprint update (v2): We added new biochemical experiments that clarify how IWS1 associates with the transcription elongation complex and further define competition between IWS1 and RECQL5. 🧪⚙️
www.biorxiv.org/content/10.1...
Structural model is already available in the PDB (9MLC).
www.biorxiv.org/content/10.1...
Structural model is already available in the PDB (9MLC).
Reposted by preLights
Mitosis has a timing system. If chromosomes attach properly, cells divide on schedule and keep proliferating. If attachment is slow or incomplete, the delay is recorded — and daughter cells stop dividing.
We explore this link in our new preprint.
🔗 www.biorxiv.org/content/10.6...
We explore this link in our new preprint.
🔗 www.biorxiv.org/content/10.6...
January 29, 2026 at 11:32 AM
Mitosis has a timing system. If chromosomes attach properly, cells divide on schedule and keep proliferating. If attachment is slow or incomplete, the delay is recorded — and daughter cells stop dividing.
We explore this link in our new preprint.
🔗 www.biorxiv.org/content/10.6...
We explore this link in our new preprint.
🔗 www.biorxiv.org/content/10.6...
Reposted by preLights
New preprint! We show how mesoscopic nonequilibrium fluctuations in active gels emerge from the breaking of detailed balance at the molecular scale. Warning: Long technical paper ahead! Enjoy! @mpipks.bsky.social @ub.edu @ubics.bsky.social @icreacommunity.bsky.social
arxiv.org/abs/2601.20483
arxiv.org/abs/2601.20483
January 30, 2026 at 6:08 PM
New preprint! We show how mesoscopic nonequilibrium fluctuations in active gels emerge from the breaking of detailed balance at the molecular scale. Warning: Long technical paper ahead! Enjoy! @mpipks.bsky.social @ub.edu @ubics.bsky.social @icreacommunity.bsky.social
arxiv.org/abs/2601.20483
arxiv.org/abs/2601.20483
Reposted by preLights
Friends! I am so happy to share our new preprint!
Hydrogen peroxide has been the most common reactive chemical threat to life forms since the Great Oxygenation Event 2.5 billion years ago.
How do animals like C. elegans sense it fast and escape?
www.biorxiv.org/content/10.6...
Thread 1/
Hydrogen peroxide has been the most common reactive chemical threat to life forms since the Great Oxygenation Event 2.5 billion years ago.
How do animals like C. elegans sense it fast and escape?
www.biorxiv.org/content/10.6...
Thread 1/
January 28, 2026 at 3:13 PM
Friends! I am so happy to share our new preprint!
Hydrogen peroxide has been the most common reactive chemical threat to life forms since the Great Oxygenation Event 2.5 billion years ago.
How do animals like C. elegans sense it fast and escape?
www.biorxiv.org/content/10.6...
Thread 1/
Hydrogen peroxide has been the most common reactive chemical threat to life forms since the Great Oxygenation Event 2.5 billion years ago.
How do animals like C. elegans sense it fast and escape?
www.biorxiv.org/content/10.6...
Thread 1/
Reposted by preLights
Check out our new preprint! We uncover the full molecular mechanism of rotavirus membrane penetration and cytosolic escape using cryo-ET, live-cell imaging, and single-molecule assays. (1/3)
🔗 biorxiv.org/content/10.6...
🔗 biorxiv.org/content/10.6...
January 27, 2026 at 5:03 PM
Check out our new preprint! We uncover the full molecular mechanism of rotavirus membrane penetration and cytosolic escape using cryo-ET, live-cell imaging, and single-molecule assays. (1/3)
🔗 biorxiv.org/content/10.6...
🔗 biorxiv.org/content/10.6...
The threefold way an epithelium copes with cell misplacement: pulling them up, killing them less, and removing the unwanted.
Ruoheng Li discusses a #preprint from @florisbosveld.bsky.social & colleagues @ybellaichelab.bsky.social
Check out the #preLight ⬇️👀
prelights.biologists.com/highlights/t...
Ruoheng Li discusses a #preprint from @florisbosveld.bsky.social & colleagues @ybellaichelab.bsky.social
Check out the #preLight ⬇️👀
prelights.biologists.com/highlights/t...
Tissue mechanics and systemic signaling safeguard epithelial tissue against spindle misorientation - preLights
The threefold way an epithelium copes with cell misplacement: pulling them up, killing them less, and removing the unwanted.
prelights.biologists.com
January 28, 2026 at 3:36 PM
The threefold way an epithelium copes with cell misplacement: pulling them up, killing them less, and removing the unwanted.
Ruoheng Li discusses a #preprint from @florisbosveld.bsky.social & colleagues @ybellaichelab.bsky.social
Check out the #preLight ⬇️👀
prelights.biologists.com/highlights/t...
Ruoheng Li discusses a #preprint from @florisbosveld.bsky.social & colleagues @ybellaichelab.bsky.social
Check out the #preLight ⬇️👀
prelights.biologists.com/highlights/t...
Reposted by preLights
In preprints: shedding light – chemogenetic induction of menstruation in mice
Aishwarya V. Bhurke and Ripla Arora from @aroralab.bsky.social discuss the recent preprint by @cagricevrim.bsky.social, @karalmckinley.bsky.social and colleagues on the X-mens menstruation model.
doi.org/10.1242/dev....
Aishwarya V. Bhurke and Ripla Arora from @aroralab.bsky.social discuss the recent preprint by @cagricevrim.bsky.social, @karalmckinley.bsky.social and colleagues on the X-mens menstruation model.
doi.org/10.1242/dev....
January 27, 2026 at 2:48 PM
In preprints: shedding light – chemogenetic induction of menstruation in mice
Aishwarya V. Bhurke and Ripla Arora from @aroralab.bsky.social discuss the recent preprint by @cagricevrim.bsky.social, @karalmckinley.bsky.social and colleagues on the X-mens menstruation model.
doi.org/10.1242/dev....
Aishwarya V. Bhurke and Ripla Arora from @aroralab.bsky.social discuss the recent preprint by @cagricevrim.bsky.social, @karalmckinley.bsky.social and colleagues on the X-mens menstruation model.
doi.org/10.1242/dev....
Reposted by preLights
Latest work from the lab by Aude Nommick et al., in which we propose a "size-scaling" model for microtubule force exertion that regulates centrosome centration vs decentration during embryo development!
@ijmonod.bsky.social
www.biorxiv.org/content/10.6...
@ijmonod.bsky.social
www.biorxiv.org/content/10.6...
January 26, 2026 at 3:45 PM
Latest work from the lab by Aude Nommick et al., in which we propose a "size-scaling" model for microtubule force exertion that regulates centrosome centration vs decentration during embryo development!
@ijmonod.bsky.social
www.biorxiv.org/content/10.6...
@ijmonod.bsky.social
www.biorxiv.org/content/10.6...
Reposted by preLights
A new extreme of meiotic evolution:
✔️ 𝗻𝗼 crossovers
✔️ 𝗻𝗼 gene conversion
✔️ 𝗻𝗼𝗿𝗺𝗮𝗹 meiosis & fertility
Sex mimics clonality without becoming asexual, in the holocentric multicellular eukaryote 𝘙𝘩𝘺𝘯𝘤𝘩𝘰𝘴𝘱𝘰𝘳𝘢 𝘵𝘦𝘯𝘶𝘪𝘴.
more about it:
www.biorxiv.org/content/10.6...
✔️ 𝗻𝗼 crossovers
✔️ 𝗻𝗼 gene conversion
✔️ 𝗻𝗼𝗿𝗺𝗮𝗹 meiosis & fertility
Sex mimics clonality without becoming asexual, in the holocentric multicellular eukaryote 𝘙𝘩𝘺𝘯𝘤𝘩𝘰𝘴𝘱𝘰𝘳𝘢 𝘵𝘦𝘯𝘶𝘪𝘴.
more about it:
www.biorxiv.org/content/10.6...
January 27, 2026 at 10:57 AM
A new extreme of meiotic evolution:
✔️ 𝗻𝗼 crossovers
✔️ 𝗻𝗼 gene conversion
✔️ 𝗻𝗼𝗿𝗺𝗮𝗹 meiosis & fertility
Sex mimics clonality without becoming asexual, in the holocentric multicellular eukaryote 𝘙𝘩𝘺𝘯𝘤𝘩𝘰𝘴𝘱𝘰𝘳𝘢 𝘵𝘦𝘯𝘶𝘪𝘴.
more about it:
www.biorxiv.org/content/10.6...
✔️ 𝗻𝗼 crossovers
✔️ 𝗻𝗼 gene conversion
✔️ 𝗻𝗼𝗿𝗺𝗮𝗹 meiosis & fertility
Sex mimics clonality without becoming asexual, in the holocentric multicellular eukaryote 𝘙𝘩𝘺𝘯𝘤𝘩𝘰𝘴𝘱𝘰𝘳𝘢 𝘵𝘦𝘯𝘶𝘪𝘴.
more about it:
www.biorxiv.org/content/10.6...
The cell cortex behaves like a sorting hat: it groups membrane proteins by how tightly they bind to dynamic actin. 🪄🎩
Insightful post from Teodora Piskova covering recent work of the #MayorLab & team @ncbsbangalore.bsky.social #CellBio #preprint
#preLight ⬇️
prelights.biologists.com/highlights/a...
Insightful post from Teodora Piskova covering recent work of the #MayorLab & team @ncbsbangalore.bsky.social #CellBio #preprint
#preLight ⬇️
prelights.biologists.com/highlights/a...
Active flows drive clustering and sorting of membrane components with differential affinity to dynamic actin cytoskeleton - preLights
The cell cortex behaves like a sorting hat: it groups membrane proteins by how tightly they bind to dynamic actin.
prelights.biologists.com
January 27, 2026 at 11:31 AM
The cell cortex behaves like a sorting hat: it groups membrane proteins by how tightly they bind to dynamic actin. 🪄🎩
Insightful post from Teodora Piskova covering recent work of the #MayorLab & team @ncbsbangalore.bsky.social #CellBio #preprint
#preLight ⬇️
prelights.biologists.com/highlights/a...
Insightful post from Teodora Piskova covering recent work of the #MayorLab & team @ncbsbangalore.bsky.social #CellBio #preprint
#preLight ⬇️
prelights.biologists.com/highlights/a...
Reposted by preLights
The extended version of my thesis procrastination project/subcortex visualization package is out now in both Python and R, now that I’ve graduated 🤠 This figure shows the 9 atlases included (and counting)!
Preprint: www.biorxiv.org/content/10.6...
Website: anniegbryant.github.io/subcortex_vi...
Preprint: www.biorxiv.org/content/10.6...
Website: anniegbryant.github.io/subcortex_vi...
January 27, 2026 at 3:04 AM
The extended version of my thesis procrastination project/subcortex visualization package is out now in both Python and R, now that I’ve graduated 🤠 This figure shows the 9 atlases included (and counting)!
Preprint: www.biorxiv.org/content/10.6...
Website: anniegbryant.github.io/subcortex_vi...
Preprint: www.biorxiv.org/content/10.6...
Website: anniegbryant.github.io/subcortex_vi...
Reposted by preLights
Our latest preprint on how regional cellular, molecular, and other forms of heterogeneity shape macroscopic wave dynamics is now out:
www.biorxiv.org/content/10.6...
For a full thread, see:
x.com/_victorbarne...
www.biorxiv.org/content/10.6...
For a full thread, see:
x.com/_victorbarne...
January 26, 2026 at 8:22 AM
Our latest preprint on how regional cellular, molecular, and other forms of heterogeneity shape macroscopic wave dynamics is now out:
www.biorxiv.org/content/10.6...
For a full thread, see:
x.com/_victorbarne...
www.biorxiv.org/content/10.6...
For a full thread, see:
x.com/_victorbarne...