Battling the TB blues: a pharmacokinetic-pharmacodynamic approach by Aguilar-Ayala and colleagues to characterise the activity of TBAJ-587 and its metabolites

Exposing hydrophilic residues pushes misfolded ER proteins towards degradation.

The necessary wait – How an immature glymphatic system fails to suppress Zika virus infection in the brain

Planar cell polarity protein, Vangl2, goes out of its way to shape the heart through a planar polarity-independent mechanism.

HAK-actin is a new probe that may help researchers see the actin cytoskeleton in sharper detail using expansion microscopy.

A deep dive into how transcription factors shape radial glia fate and clonal dynamics

Those who migrate together, develop together: Marsupial cranial neural crest cells migrate as epithelial-like sheets to form craniofacial structures, providing a potential mechanism that promotes acce...

How do endothelial cells differ across tissues? A new single-cell atlas of over 3 million cells shows how microenvironmental signals shape endothelial diversity.

By blurring the line between venom and digestion, Uloboridae spiders remind us that evolution doesn’t discard complexity — it reshapes it.

This research uncovers how tinkering with a basic energy pathway in cells can unexpectedly switch off key immune signals—pointing to new ways of controlling inflammation and even cancer.

Welcome to our monthly trawl for developmental and stem cell biology (and related) preprints. The preprints this month are hosted on bioRxiv.

The authors present an “identifiability-guided assessment” framework—a new approach to pinpoint which parameters in a personalized digital twin model can be confidently trusted.

Do you love fashion shows? Well, chicken’s MHC class II is an immune fashion icon that presents the same viral peptide to T cells in both a 9- and 10-amino acid outfit.

Back to 100 years anniversary page

Mass extinction can be detected in phylogenetic trees that have been estimated using flawed methodologies.

Naah, MHV plays stress granules like a pro: show up late, strip out the translation machinery, keep your RNA away, and let these 'empty shells' persist while you replicate freely.

Designing protein binders computationally requires more than just filling in histidines—you need smarter placement of histidine and other charged amino acids to get truly pH-sensitive protein interact...

Engineered deletions are a powerful probe for studying genome architecture, function, and regulation. Yet, the lack of effective methods to create them in large numbers and at multi-kilobase scale has...

The physics behind the immune response: focus on viscoelasticity

Symbioses have been fundamental to colonization of terrestrial ecosystems by plants and their evolution. Emergence of the ancient arbuscular mycorrhizal symbiosis was followed by the diversification of alternative intracellular symbioses, such as the ericoid mycorrhizae (ErM). We aimed at understanding how these diversifications occurred. We sequenced the genomes of ErM-forming liverworts, and reconstituted symbiosis under laboratory conditions. We demonstrated the existence of a nutrient-regulated symbiotic state that enables ErM and underlies intracellular colonization of plant tissues. Comparative transcriptomic analyses identified an ancestral gene module associated with intracellular symbiosis beyond ErM. Genetic manipulations in the liverwort Marchantia paleacea, phylogenetics and transactivation assays demonstrated its essential function for intracellular symbiosis. We conclude that plant have maintained, and convergently recruited, an ancestral gene module for intracellular symbioses.

A mathematical model translates aggregated single-cell RNA sequencing data into stages of disease