Alejo Rodriguez-Fraticelli
@alejofraticelli.bsky.social
Aging and cancer stem cell heterogeneity - ICREA research professor - Quantitative Stem Cell Dynamics lab
at IRB Barcelona 🇦🇷🇪🇺🇺🇸 fraticellilab.com
at IRB Barcelona 🇦🇷🇪🇺🇺🇸 fraticellilab.com
Pinned
Lineage tracing: Dynamics, cellular memory, and somatic evolution
Recent advances in high-resolution lineage tracing technologies and single-cell genomics are allowing researchers to quantify cell state dynamics at unprecedented scales. Across cancer and immunity, …
meetings.embo.org
EMBO workshop on Single cell Lineage Tracing!
Sept 18-21 in Sant Feliu, Girona, Spain.
Registration OPEN!!!!!
Tons of opportunities for talks (including some full length ones).
You don’t want to miss it!
meetings.embo.org/event/25-lin...
Sept 18-21 in Sant Feliu, Girona, Spain.
Registration OPEN!!!!!
Tons of opportunities for talks (including some full length ones).
You don’t want to miss it!
meetings.embo.org/event/25-lin...
Reposted by Alejo Rodriguez-Fraticelli
Emergence and Self-organisation across biological scales! I hope you are ready for next year conference! It will be an incredible event April 20-22 2026. The first of many #LakeConference organised by
@ehannezo.bsky.social @alleninstitute.org and James Sharpe @embl.org
@ehannezo.bsky.social @alleninstitute.org and James Sharpe @embl.org
#CellBio community, this one is for you! Applications are open for the #LakeConference on Modeling Life from Cells to Tissues – co-hosted with Circuit Neuroscience Basel!
📆 April 20-22, 2026
📍 Seattle, USA
🔬 All career stages welcomed.
Apply to attend by 12/12: alleninstitute.org/events/aics-...
📆 April 20-22, 2026
📍 Seattle, USA
🔬 All career stages welcomed.
Apply to attend by 12/12: alleninstitute.org/events/aics-...
2026 Lake Conference
Join the Allen Institute for Cell Science and Circuit Neuroscience Basel in Seattle, Washington, April 20–22, 2026, for a 3 day conference, Modeling...
alleninstitute.org
November 26, 2025 at 10:58 AM
Emergence and Self-organisation across biological scales! I hope you are ready for next year conference! It will be an incredible event April 20-22 2026. The first of many #LakeConference organised by
@ehannezo.bsky.social @alleninstitute.org and James Sharpe @embl.org
@ehannezo.bsky.social @alleninstitute.org and James Sharpe @embl.org
Outstanding PhD fellowship call OPEN for excellent students.
lacaixafoundation.org/en/doctoral-...
This is for students incoming from outside Spain. And it is VERY well supported (ie at European levels).
If you’re interested in doing a PhD in our lab @irbbarcelona.org, reach out!!!!
lacaixafoundation.org/en/doctoral-...
This is for students incoming from outside Spain. And it is VERY well supported (ie at European levels).
If you’re interested in doing a PhD in our lab @irbbarcelona.org, reach out!!!!
Doctoral INPhINIT fellowships - Incoming Call 2026
We grant 30 fellowships for researchers of any nationality who wish to pursue a doctorate in a STEM discipline at research centres of excellence in Spain or Portugal.
www.google.com
November 26, 2025 at 7:43 AM
Outstanding PhD fellowship call OPEN for excellent students.
lacaixafoundation.org/en/doctoral-...
This is for students incoming from outside Spain. And it is VERY well supported (ie at European levels).
If you’re interested in doing a PhD in our lab @irbbarcelona.org, reach out!!!!
lacaixafoundation.org/en/doctoral-...
This is for students incoming from outside Spain. And it is VERY well supported (ie at European levels).
If you’re interested in doing a PhD in our lab @irbbarcelona.org, reach out!!!!
I didn’t get to meet the legend of Garcia Bellido as a PhD student at the “Severo Ochoa” as he was already half retiring… but even then, his presence in the department was all encompassing… My condolences to the family of scientists that he mentored. What a giant - we’ll always be in his debt.
November 17, 2025 at 8:15 AM
I didn’t get to meet the legend of Garcia Bellido as a PhD student at the “Severo Ochoa” as he was already half retiring… but even then, his presence in the department was all encompassing… My condolences to the family of scientists that he mentored. What a giant - we’ll always be in his debt.
Reposted by Alejo Rodriguez-Fraticelli
Can't help but sharing this thought on #Genetics from A. Garcia Bellido (1936-2025). His legacy runs deep through the work of his disciples and readers but it is there.
November 17, 2025 at 6:33 AM
Can't help but sharing this thought on #Genetics from A. Garcia Bellido (1936-2025). His legacy runs deep through the work of his disciples and readers but it is there.
Reposted by Alejo Rodriguez-Fraticelli
Calling cancer data scientists! 📊 💽 🧮
We have a number of open positions in our core facility @icr.ac.uk These are bioinformatician staff scientist like roles to work on exciting single cell, spatial & other genomics data from across our Institute. A PhD is required. jobs.icr.ac.uk/vacancies/13...
We have a number of open positions in our core facility @icr.ac.uk These are bioinformatician staff scientist like roles to work on exciting single cell, spatial & other genomics data from across our Institute. A PhD is required. jobs.icr.ac.uk/vacancies/13...
Data Scientist in Sutton | The Institute of Cancer Research
View details and apply for this Data Scientist vacancy in Sutton.
Salary : Salary range £39,805 to £53,500 (Dependent on experience )
Reporting to: Professor Trevor Gra...
jobs.icr.ac.uk
November 13, 2025 at 2:59 PM
Calling cancer data scientists! 📊 💽 🧮
We have a number of open positions in our core facility @icr.ac.uk These are bioinformatician staff scientist like roles to work on exciting single cell, spatial & other genomics data from across our Institute. A PhD is required. jobs.icr.ac.uk/vacancies/13...
We have a number of open positions in our core facility @icr.ac.uk These are bioinformatician staff scientist like roles to work on exciting single cell, spatial & other genomics data from across our Institute. A PhD is required. jobs.icr.ac.uk/vacancies/13...
Reposted by Alejo Rodriguez-Fraticelli
A parts list of promoters and gRNA scaffolds for mammalian genome engineering and molecular recording - @jshendure.bsky.social @troymcdiarmid.bsky.social @uwgenome.bsky.social go.nature.com/49eTPCu
A parts list of promoters and gRNA scaffolds for mammalian genome engineering and molecular recording - Nature Biotechnology
Prime editing in mammalian cells benefits from a comprehensive list of genetic parts.
go.nature.com
November 11, 2025 at 4:36 PM
A parts list of promoters and gRNA scaffolds for mammalian genome engineering and molecular recording - @jshendure.bsky.social @troymcdiarmid.bsky.social @uwgenome.bsky.social go.nature.com/49eTPCu
Reposted by Alejo Rodriguez-Fraticelli
Demain mercredi 12 nov. 17h30, leçon #2 de #EmmanuellePassegue @columbiauniversity.bsky.social , Prof. Invitée @college-de-france.fr sur les cellules souches hématopoïétiques🩸 ‘Environmental crosstalk and niche regulation’ 🧫. Free access, no registration.
November 11, 2025 at 7:53 AM
Demain mercredi 12 nov. 17h30, leçon #2 de #EmmanuellePassegue @columbiauniversity.bsky.social , Prof. Invitée @college-de-france.fr sur les cellules souches hématopoïétiques🩸 ‘Environmental crosstalk and niche regulation’ 🧫. Free access, no registration.
Reposted by Alejo Rodriguez-Fraticelli
Our latest collaboration with the talented Susi @sbantele.bsky.social and Jiri Lukas is out now @science.org 🤩. We reveal the hidden price for DNA repair, with potential implications for genome function, gene therapy and ageing👇
𝗖𝗮𝗻 𝗰𝗲𝗹𝗹𝘀 𝗲𝘃𝗲𝗿 𝘁𝗿𝘂𝗹𝘆 𝗿𝗲𝗰𝗼𝘃𝗲𝗿 𝗳𝗿𝗼𝗺 𝗗𝗡𝗔 𝗱𝗮𝗺𝗮𝗴𝗲?Excited to share our new study “Repair of DNA double-strand breaks leaves heritable impairment to genome function”, revealing DNA repair’s hidden cost, out now @science.org tinyurl.com/5n6zw3ye. Led by @sbantele.bsky.social and Jiri Lukas.🧵👇1/n
Repair of DNA double-strand breaks leaves heritable impairment to genome function
Upon DNA breakage, a genomic locus undergoes alterations in three-dimensional chromatin architecture to facilitate signaling and repair. Although cells possess mechanisms to repair damaged DNA, it is ...
tinyurl.com
November 7, 2025 at 8:34 AM
Our latest collaboration with the talented Susi @sbantele.bsky.social and Jiri Lukas is out now @science.org 🤩. We reveal the hidden price for DNA repair, with potential implications for genome function, gene therapy and ageing👇
Reposted by Alejo Rodriguez-Fraticelli
Development that lasts a life time. Check out the 2025 special issue of @dev-journal.bsky.social on Lifelong Development: the Maintenance, Regeneration and Plasticity of Tissues
journals.biologists.com/dev/issue/15...
journals.biologists.com/dev/issue/15...
Volume 152 Issue 20 | Development | The Company of Biologists
journals.biologists.com
November 5, 2025 at 8:54 AM
Development that lasts a life time. Check out the 2025 special issue of @dev-journal.bsky.social on Lifelong Development: the Maintenance, Regeneration and Plasticity of Tissues
journals.biologists.com/dev/issue/15...
journals.biologists.com/dev/issue/15...
Brilliant development!!!
(1/10) How do diverse leukemia mutations converge on the same molecular program? In #RibackLab first manuscript @cp-cell.bsky.social, collaboration with @goodell-lab.bsky.social shows that disparate mutations rewire shared protein networks to form nuclear condensates called C-bodies.
November 4, 2025 at 10:23 PM
Brilliant development!!!
Reposted by Alejo Rodriguez-Fraticelli
So cool embryonic pancreas epithelium modeling using stem cells by the Wells lab! #PancSky
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Human pancreatic organoids derived from pluripotent stem cells recapitulate pancreatic organogenesis
Pancreas organogenesis relies on sequential interactions between the pancreatic epithelium and surrounding mesodermal cell types that initiate epithelial budding and branching to form a complex ductal...
www.biorxiv.org
November 1, 2025 at 4:24 PM
So cool embryonic pancreas epithelium modeling using stem cells by the Wells lab! #PancSky
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
I am starting to believe that for every major advancement in cancer therapeutics (especially new modalities) we should always run a small ph2b arm with the new therapy being applied ahead of the SoC, and not always after. Obv not easy for rare cancers… but otherwise what’s the bottleneck?
November 1, 2025 at 9:06 PM
I am starting to believe that for every major advancement in cancer therapeutics (especially new modalities) we should always run a small ph2b arm with the new therapy being applied ahead of the SoC, and not always after. Obv not easy for rare cancers… but otherwise what’s the bottleneck?
Reposted by Alejo Rodriguez-Fraticelli
🧬 Excited to share Nicheformer out now in Nature Methods!
A transformer foundation model linking single-cell & spatial omics, learning spatial context from gene expression to map tissue organization.
Led by Ale Tejada & Anna Schaar 👏
👉 www.nature.com/articles/s41...
A transformer foundation model linking single-cell & spatial omics, learning spatial context from gene expression to map tissue organization.
Led by Ale Tejada & Anna Schaar 👏
👉 www.nature.com/articles/s41...
October 30, 2025 at 7:19 PM
🧬 Excited to share Nicheformer out now in Nature Methods!
A transformer foundation model linking single-cell & spatial omics, learning spatial context from gene expression to map tissue organization.
Led by Ale Tejada & Anna Schaar 👏
👉 www.nature.com/articles/s41...
A transformer foundation model linking single-cell & spatial omics, learning spatial context from gene expression to map tissue organization.
Led by Ale Tejada & Anna Schaar 👏
👉 www.nature.com/articles/s41...
Reposted by Alejo Rodriguez-Fraticelli
🧵1/17
📣Thrilled to share our latest study just out in Cancer Discovery!
➡️
aacrjournals.org/cancerdiscov...
📣Thrilled to share our latest study just out in Cancer Discovery!
➡️
aacrjournals.org/cancerdiscov...
A plastic EMP1⁺ to LGR5⁺ cell state conversion as a bypass to KRAS-G12D pharmacological inhibition in metastatic colorectal cancer
Abstract. Inhibitors of the oncogene KRAS hold promise for treating metastatic CRC (mCRC). Here we show that a selective, covalent small molecule inhibitor of the active (ON) conformation of RAS-G12D,...
aacrjournals.org
October 23, 2025 at 6:07 PM
🧵1/17
📣Thrilled to share our latest study just out in Cancer Discovery!
➡️
aacrjournals.org/cancerdiscov...
📣Thrilled to share our latest study just out in Cancer Discovery!
➡️
aacrjournals.org/cancerdiscov...
Reposted by Alejo Rodriguez-Fraticelli
Our recent Cancer Discovery study (Centonze et al.) shows that within hours, metastatic CRC cells switch from an EMP1⁺ invasive state to an LGR5⁺ stem-like program, highlighting that Plasticity is a dynamic, regulated cell-state decision
#Bluetorial below👇🏼
#KRAS #Plasticity #ColorectalCancer
#Bluetorial below👇🏼
#KRAS #Plasticity #ColorectalCancer
🧵1/17
📣Thrilled to share our latest study just out in Cancer Discovery!
➡️
aacrjournals.org/cancerdiscov...
📣Thrilled to share our latest study just out in Cancer Discovery!
➡️
aacrjournals.org/cancerdiscov...
A plastic EMP1⁺ to LGR5⁺ cell state conversion as a bypass to KRAS-G12D pharmacological inhibition in metastatic colorectal cancer
Abstract. Inhibitors of the oncogene KRAS hold promise for treating metastatic CRC (mCRC). Here we show that a selective, covalent small molecule inhibitor of the active (ON) conformation of RAS-G12D,...
aacrjournals.org
October 27, 2025 at 2:39 PM
Our recent Cancer Discovery study (Centonze et al.) shows that within hours, metastatic CRC cells switch from an EMP1⁺ invasive state to an LGR5⁺ stem-like program, highlighting that Plasticity is a dynamic, regulated cell-state decision
#Bluetorial below👇🏼
#KRAS #Plasticity #ColorectalCancer
#Bluetorial below👇🏼
#KRAS #Plasticity #ColorectalCancer
Beautiful, insightful study from Boezio et al. One of the best clonal analyses I’ve seen so far. We’ll dig in this week! Check it out!
October 26, 2025 at 8:22 PM
Beautiful, insightful study from Boezio et al. One of the best clonal analyses I’ve seen so far. We’ll dig in this week! Check it out!
Reposted by Alejo Rodriguez-Fraticelli
That merely being “under review” by a Nature family journal is offered as a quality proxy for a paper is a tragic illustration of the extent to which academia is addicted to brands and outsources evaluation
October 25, 2025 at 6:37 PM
That merely being “under review” by a Nature family journal is offered as a quality proxy for a paper is a tragic illustration of the extent to which academia is addicted to brands and outsources evaluation
Reposted by Alejo Rodriguez-Fraticelli
The CRG PhD call is now open. Exciting opportunities across diverse topics and within a world-class scientific environment.
Our group is offering one PhD position to study chromatin evolution.
Consider applying or share with anyone who might be interested!
www.crg.eu/en/content/t...
Our group is offering one PhD position to study chromatin evolution.
Consider applying or share with anyone who might be interested!
www.crg.eu/en/content/t...
Are you looking for a PhD? Join us in Barcelona! You'll dive into a community of >100 PhD students from 30 countries exploring the frontiers of biology. You can also join an online workshop on 6 November (15:00 CET) to learn how to find the right lab for you.
More info: www.crg.eu/en/content/t...
More info: www.crg.eu/en/content/t...
October 23, 2025 at 11:54 AM
The CRG PhD call is now open. Exciting opportunities across diverse topics and within a world-class scientific environment.
Our group is offering one PhD position to study chromatin evolution.
Consider applying or share with anyone who might be interested!
www.crg.eu/en/content/t...
Our group is offering one PhD position to study chromatin evolution.
Consider applying or share with anyone who might be interested!
www.crg.eu/en/content/t...
Reposted by Alejo Rodriguez-Fraticelli
Reposted by Alejo Rodriguez-Fraticelli
We are recuiting two new Associate Professors here in Oxford Biochemistry. Come join us! Reach out to me if you have any questions. Please repost! tinyurl.com/mr3m7bd3
October 17, 2025 at 2:56 PM
We are recuiting two new Associate Professors here in Oxford Biochemistry. Come join us! Reach out to me if you have any questions. Please repost! tinyurl.com/mr3m7bd3
Reposted by Alejo Rodriguez-Fraticelli
We are happy to share our latest work in @nature.com . We study the genomic and cellular basis of facultative symbiosis in Oculina patagonica - a Mediterranean coral remarkable for its ability to survive long periods without algal symbionts. Led by Shani Levy and @xgrau.bsky.social
rdcu.be/eLbaZ
rdcu.be/eLbaZ
October 15, 2025 at 7:58 PM
We are happy to share our latest work in @nature.com . We study the genomic and cellular basis of facultative symbiosis in Oculina patagonica - a Mediterranean coral remarkable for its ability to survive long periods without algal symbionts. Led by Shani Levy and @xgrau.bsky.social
rdcu.be/eLbaZ
rdcu.be/eLbaZ
Reposted by Alejo Rodriguez-Fraticelli
This meeting will be a significant event for those advancing research in stem cell-based embryo models. Submit your abstract and scholarship application by Oct 21!
www.keystonesymposia.org/conferences/...
www.keystonesymposia.org/conferences/...
October 15, 2025 at 7:15 AM
This meeting will be a significant event for those advancing research in stem cell-based embryo models. Submit your abstract and scholarship application by Oct 21!
www.keystonesymposia.org/conferences/...
www.keystonesymposia.org/conferences/...
Reposted by Alejo Rodriguez-Fraticelli
We have two fantastically well-funded #PhD studentships available through the @evomg-dn.bsky.social #EU doctoral network (led by brilliant @mirimiam.bsky.social, @crg.eu). These enable students to move to the UK and come and work with us @icr.ac.uk to exploit #cancer #evolution for patient benefit.
October 14, 2025 at 8:21 PM
We have two fantastically well-funded #PhD studentships available through the @evomg-dn.bsky.social #EU doctoral network (led by brilliant @mirimiam.bsky.social, @crg.eu). These enable students to move to the UK and come and work with us @icr.ac.uk to exploit #cancer #evolution for patient benefit.
Reposted by Alejo Rodriguez-Fraticelli
Looking forward to a day at EMBL Barcelona for Science by the Beach
Seminar at noon
Science by the beach | EMBL.org share.google/Eb8dktOiuUbJ...
Seminar at noon
Science by the beach | EMBL.org share.google/Eb8dktOiuUbJ...
European Molecular Biology Laboratory
With support from more than 30 countries, laboratories at six locations across Europe and thousands of scientists and engineers working together, the European Molecular Biology Laboratory is a powerho...
EMBL.org
October 14, 2025 at 6:38 AM
Looking forward to a day at EMBL Barcelona for Science by the Beach
Seminar at noon
Science by the beach | EMBL.org share.google/Eb8dktOiuUbJ...
Seminar at noon
Science by the beach | EMBL.org share.google/Eb8dktOiuUbJ...
Reposted by Alejo Rodriguez-Fraticelli
The @crick.ac.uk is recruiting Early Career Group Leaders
- Lab set-up, research costs, salaries for up to 5 researchers
- Support for up to 12 years
- Access to our core facilities
- Competitive salary
- Fantastic colleagues
- All areas of biology
Deadline 27 Nov
www.crick.ac.uk/careers-stud...
- Lab set-up, research costs, salaries for up to 5 researchers
- Support for up to 12 years
- Access to our core facilities
- Competitive salary
- Fantastic colleagues
- All areas of biology
Deadline 27 Nov
www.crick.ac.uk/careers-stud...
Early career group leaders
We appoint researchers from across biology and biomedicine to set up their first groups at the Crick.
www.crick.ac.uk
October 10, 2025 at 8:20 AM
The @crick.ac.uk is recruiting Early Career Group Leaders
- Lab set-up, research costs, salaries for up to 5 researchers
- Support for up to 12 years
- Access to our core facilities
- Competitive salary
- Fantastic colleagues
- All areas of biology
Deadline 27 Nov
www.crick.ac.uk/careers-stud...
- Lab set-up, research costs, salaries for up to 5 researchers
- Support for up to 12 years
- Access to our core facilities
- Competitive salary
- Fantastic colleagues
- All areas of biology
Deadline 27 Nov
www.crick.ac.uk/careers-stud...