Nature Biotechnology
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RNA structures are hard to solve, but experimental and computational approaches are evolving. This new Perspective in @natbiotech.nature.com shows how their interplay will be the driving force to help the field forward. www.nature.com/articles/s41...
Integrated experimental and AI innovations for RNA structure determination - Nature Biotechnology
RNA’s dynamic nature and complex physiochemical properties make it difficult to structurally resolve. This Perspectives examines how integrating experimental and computational approaches to structure ...
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January 7, 2026 at 8:25 AM
RNA structures are hard to solve, but experimental and computational approaches are evolving. This new Perspective in @natbiotech.nature.com shows how their interplay will be the driving force to help the field forward. www.nature.com/articles/s41...
The contrastive learning framework DrugCLIP enables screening of ~10,000 human proteins against 500 million compounds in under 24 hours, achieving experimentally validated hit rate up to 17.5%. #NBThighlight www.science.org/doi/10.1126/...
Deep contrastive learning enables genome-wide virtual screening
Recent breakthroughs in protein structure prediction have opened new avenues for genome-wide drug discovery, yet existing virtual screening methods remain computationally prohibitive. We present DrugC...
www.science.org
January 9, 2026 at 4:44 PM
The contrastive learning framework DrugCLIP enables screening of ~10,000 human proteins against 500 million compounds in under 24 hours, achieving experimentally validated hit rate up to 17.5%. #NBThighlight www.science.org/doi/10.1126/...
Research Briefing: Machine learning framework reveals a concordant cell-state landscape across single-cell datasets www.nature.com/articles/s41...
Client Challenge
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January 8, 2026 at 3:53 PM
Research Briefing: Machine learning framework reveals a concordant cell-state landscape across single-cell datasets www.nature.com/articles/s41...
Now with oligos: antibody–oligonucleotide conjugates are the new drug modality to watch doi.org/10.1038/s415...
January 8, 2026 at 3:05 PM
Now with oligos: antibody–oligonucleotide conjugates are the new drug modality to watch doi.org/10.1038/s415...
Balancing immunity with Tregs go.nature.com/4qNezXD
January 7, 2026 at 2:29 PM
Balancing immunity with Tregs go.nature.com/4qNezXD
Moving beyond monogenic disorders in clinical healthcare - @ki.se @scilifelab.se go.nature.com/4spqsof
Moving beyond monogenic disorders in clinical healthcare - Nature Biotechnology
Our understanding of the genetic mechanisms underlying rare diseases has rapidly advanced over the past decade, largely because of technological innovations. Yet clinical practice still has a strong m...
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January 6, 2026 at 5:41 PM
Moving beyond monogenic disorders in clinical healthcare - @ki.se @scilifelab.se go.nature.com/4spqsof
Integrated experimental and AI innovations for RNA structure determination go.nature.com/3NcBzk8
Integrated experimental and AI innovations for RNA structure determination - Nature Biotechnology
RNA’s dynamic nature and complex physiochemical properties make it difficult to structurally resolve. This Perspectives examines how integrating experimental and computational approaches to structure ...
go.nature.com
January 6, 2026 at 2:57 PM
Integrated experimental and AI innovations for RNA structure determination go.nature.com/3NcBzk8
CHANGE-seq-BE finds off-target changes in the genome from base editors #NBTintheNews via @stjuderesearch.bsky.social www.stjude.org/media-resour...
CHANGE-seq-BE finds off-target changes in the genome from base editors
Find how Circularization for High-throughput Analysis of Nuclease Genome-wide Effects by Sequencing Base Editors (CHANGE-seq-BE) improves finding off-targets.
www.stjude.org
January 5, 2026 at 7:56 PM
CHANGE-seq-BE finds off-target changes in the genome from base editors #NBTintheNews via @stjuderesearch.bsky.social www.stjude.org/media-resour...
Research Briefing: Improving adenine base editor precision with directed evolution and extended guide RNAs www.nature.com/articles/s41...
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Improving adenine base editor precision with directed evolution and extended guide RNAs - Nature Biotechnology
Although base editing has potential as a gene therapy tool, bystander edits limit its clinical use for many pathogenic mutations. This work uses directed evolution to optimize adenine base editors and...
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January 5, 2026 at 7:26 PM
Research Briefing: Improving adenine base editor precision with directed evolution and extended guide RNAs www.nature.com/articles/s41...
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rdcu.be/eXG52
Revealing a coherent cell-state landscape across single-cell datasets with CONCORD - @zevgartner.bsky.social @ucsanfrancisco.bsky.social go.nature.com/4jsNxSL
Revealing a coherent cell-state landscape across single-cell datasets with CONCORD - Nature Biotechnology
CONCORD generates denoised cell encodings that preserve key biological structures in single-cell datasets.
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January 5, 2026 at 4:44 PM
Revealing a coherent cell-state landscape across single-cell datasets with CONCORD - @zevgartner.bsky.social @ucsanfrancisco.bsky.social go.nature.com/4jsNxSL
Mapping isoforms and regulatory mechanisms from spatial transcriptomics data with SPLISOSM - @columbiasysbio.bsky.social @davidaknowles.bsky.social go.nature.com/3NaXw31
Mapping isoforms and regulatory mechanisms from spatial transcriptomics data with SPLISOSM - Nature Biotechnology
Differential isoform usage is identified with high statistical power from spatial transcriptomics data.
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January 5, 2026 at 4:33 PM
Mapping isoforms and regulatory mechanisms from spatial transcriptomics data with SPLISOSM - @columbiasysbio.bsky.social @davidaknowles.bsky.social go.nature.com/3NaXw31
CRISPR–Cas3-based editing for targeted deletions in a mouse model of transthyretin amyloidosis - @utokyoofficial.bsky.social go.nature.com/4bkfOcb
CRISPR–Cas3-based editing for targeted deletions in a mouse model of transthyretin amyloidosis - Nature Biotechnology
Cas3 nuclease is used for therapeutic deletion of a gene in mice.
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January 5, 2026 at 4:21 PM
CRISPR–Cas3-based editing for targeted deletions in a mouse model of transthyretin amyloidosis - @utokyoofficial.bsky.social go.nature.com/4bkfOcb
Engineering bispecific exosome activators of T cells to target immune checkpoint inhibitor-resistant metastatic melanoma - @columbiacancer.bsky.social go.nature.com/496Ins7
Engineering bispecific exosome activators of T cells to target immune checkpoint inhibitor-resistant metastatic melanoma - Nature Biotechnology
Engineered inhalable exosomes deliver a bispecific T cell activator to pembrolizumab-resistant metastatic melanoma.
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January 5, 2026 at 4:09 PM
Engineering bispecific exosome activators of T cells to target immune checkpoint inhibitor-resistant metastatic melanoma - @columbiacancer.bsky.social go.nature.com/496Ins7
Reposted by Nature Biotechnology
One of our top-rated posts on @altmetric.com in 2025 was published in @natbiotech.nature.com. You can read 'Nanocarrier imaging at single-cell resolution across entire mouse bodies with deep learning' open access here: spklr.io/63322BQufI
Nanocarrier imaging at single-cell resolution across entire mouse bodies with deep learning - Nature Biotechnology
An integrated experimental and deep learning pipeline reveals cell-level targeting of nanocarriers in whole bodies.
spklr.io
December 31, 2025 at 5:30 PM
One of our top-rated posts on @altmetric.com in 2025 was published in @natbiotech.nature.com. You can read 'Nanocarrier imaging at single-cell resolution across entire mouse bodies with deep learning' open access here: spklr.io/63322BQufI
Sensitive and unbiased genome-wide profiling of base-editor-induced off-target activity using CHANGE-seq-BE - @stjuderesearch.bsky.social go.nature.com/4qB6qp8
Sensitive and unbiased genome-wide profiling of base-editor-induced off-target activity using CHANGE-seq-BE - Nature Biotechnology
Base editor off-target effects are profiled with high precision in a tailored approach.
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January 2, 2026 at 7:12 PM
Sensitive and unbiased genome-wide profiling of base-editor-induced off-target activity using CHANGE-seq-BE - @stjuderesearch.bsky.social go.nature.com/4qB6qp8
Single-strand deaminase-assisted editing for functional RNA manipulation go.nature.com/3MZrB5K
Single-strand deaminase-assisted editing for functional RNA manipulation - Nature Biotechnology
A single-strand deaminase-assisted platform simultaneously rewrites multiple bases within a single RNA transcript.
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January 2, 2026 at 7:05 PM
Single-strand deaminase-assisted editing for functional RNA manipulation go.nature.com/3MZrB5K
Effective combinatorial antifungal therapy using a host defense peptide mimic that self-assembles into delivery micelles go.nature.com/45r0M0t
Effective combinatorial antifungal therapy using a host defense peptide mimic that self-assembles into delivery micelles - Nature Biotechnology
Codelivery of an antifungal drug within antifungal micelles achieves effective combinatorial therapy.
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January 2, 2026 at 6:48 PM
Effective combinatorial antifungal therapy using a host defense peptide mimic that self-assembles into delivery micelles go.nature.com/45r0M0t
Predicting small molecule–RNA interactions without RNA tertiary structures - @tsinghuauniversity.bsky.social go.nature.com/494J2ug
Predicting small molecule–RNA interactions without RNA tertiary structures - Nature Biotechnology
SMRTnet predicts compounds that bind to disease-associated RNA targets.
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January 2, 2026 at 6:39 PM
Predicting small molecule–RNA interactions without RNA tertiary structures - @tsinghuauniversity.bsky.social go.nature.com/494J2ug
Troubleshooting common errors in assemblies of long-read metagenomes - @merenbey.bsky.social @banfieldlab.bsky.social go.nature.com/44P7nSm
Troubleshooting common errors in assemblies of long-read metagenomes - Nature Biotechnology
Long-read sequence assemblies from metagenomes contain frequent errors.
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January 2, 2026 at 4:39 PM
Troubleshooting common errors in assemblies of long-read metagenomes - @merenbey.bsky.social @banfieldlab.bsky.social go.nature.com/44P7nSm
Recent patents relating to methods, devices and use of liquid biopsy go.nature.com/3MWRuTG
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Liquid biopsy - Nature Biotechnology
Recent patents relating to methods, devices and use of liquid biopsy.
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January 2, 2026 at 4:27 PM
Recent patents relating to methods, devices and use of liquid biopsy go.nature.com/3MWRuTG
rdcu.be/eWZtJ
rdcu.be/eWZtJ
A strategy for combinatorial cancer immunotherapy uses Cas13d to knock down immunosuppressive genes in vivo go.nature.com/4gYcS4Z
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Multiplexed inhibition of immunosuppressive genes with Cas13d for combinatorial cancer immunotherapy - Nature Biotechnology
A strategy for combinatorial cancer immunotherapy uses Cas13d to knock down immunosuppressive genes in vivo.
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January 1, 2026 at 9:54 PM
A strategy for combinatorial cancer immunotherapy uses Cas13d to knock down immunosuppressive genes in vivo go.nature.com/4gYcS4Z
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Recent moves of note in and around the biotech and pharma industries go.nature.com/3N9ypO5
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People - Nature Biotechnology
Recent moves of note in and around the biotech and pharma industries.
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December 31, 2025 at 5:31 PM
Recent moves of note in and around the biotech and pharma industries go.nature.com/3N9ypO5
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rdcu.be/eWZtr
This pioneer in programmable biology creates new methods for the computer science and bioengineering communities and translates those advances to try to solve some of the most fundamental problems facing our world go.nature.com/4pzXi3P
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Five questions with Pranam Chatterjee - Nature Biotechnology
This pioneer in programmable biology creates new methods for the computer science and bioengineering communities and translates those advances to try to solve some of the most fundamental problems fac...
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December 31, 2025 at 5:10 PM
This pioneer in programmable biology creates new methods for the computer science and bioengineering communities and translates those advances to try to solve some of the most fundamental problems facing our world go.nature.com/4pzXi3P
rdcu.be/eWZpA
rdcu.be/eWZpA
Research Highlight: Metagenomic editing integrates large DNA sequences into gut bacteria in vivo www.nature.com/articles/s41...
Metagenomic editing integrates large DNA sequences into gut bacteria in vivo - Nature Biotechnology
Nature Biotechnology - Metagenomic editing integrates large DNA sequences into gut bacteria in vivo
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December 31, 2025 at 3:02 PM
Research Highlight: Metagenomic editing integrates large DNA sequences into gut bacteria in vivo www.nature.com/articles/s41...
Primary T cells with multiple genetic modifications are rapidly isolated by negative selection go.nature.com/4gBnaqY
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SEED-Selection enables high-efficiency enrichment of primary T cells edited at multiple loci - Nature Biotechnology
Primary T cells with multiple genetic modifications are rapidly isolated by negative selection.
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December 31, 2025 at 3:37 AM
Primary T cells with multiple genetic modifications are rapidly isolated by negative selection go.nature.com/4gBnaqY
rdcu.be/eULac
rdcu.be/eULac