Christos Karampelias
@ckarampelias.bsky.social
Postdocking in Helmholtz Zentrum Munich researching pancreas biology.
Interests: developmental biology, endocrinology, diabetes research, teaching and learning in higher education
Alexander von Humboldt and MSCA fellow
Interests: developmental biology, endocrinology, diabetes research, teaching and learning in higher education
Alexander von Humboldt and MSCA fellow
Pinned
I tried to make a feed for news and discussions on all things pancreas biology (exocrine and endocrine!). You can post with the hashtags #PancSky #BetaCellSky #EndocrineSky . Let me know if it is useful and how to modify to make it better!
bsky.app/profile/did:...
bsky.app/profile/did:...
Reposted by Christos Karampelias
On the cusp of closing the genetic association and mechanism gap while laying the foundation for future precision medicine approaches in type 2 #diabetes #genetics @diabetologiajnl.bsky.social link.springer.com/article/10.1...
Bridging the variant-to-function gap in type 2 diabetes: advances and challenges - Diabetologia
Type 2 diabetes is a polygenic, heterogeneous disease affecting over 530 million individuals worldwide, a number projected to rise to 1.3 billion by 2050. Genome-wide association studies have identifi...
link.springer.com
November 22, 2025 at 8:54 PM
On the cusp of closing the genetic association and mechanism gap while laying the foundation for future precision medicine approaches in type 2 #diabetes #genetics @diabetologiajnl.bsky.social link.springer.com/article/10.1...
Medical nutrition therapy for the management of type 2 diabetes mellitus
"Underlying mechanisms, clinical efficacy and potential for sustainable long-term implementation."
www.nature.com/articles/s41...
"Underlying mechanisms, clinical efficacy and potential for sustainable long-term implementation."
www.nature.com/articles/s41...
November 23, 2025 at 7:59 AM
Reposted by Christos Karampelias
🎉Very excited to share our new work on senescence and insulin processing now out in @DiabetologiaJnl link.springer.com/article/10.100…
Fantastic effort by my @dream-diabetes.bsky.social trainees, along with @yichunchen.bsky.social @bruceverchere.bsky.social
@cirtn.bsky.social
Fantastic effort by my @dream-diabetes.bsky.social trainees, along with @yichunchen.bsky.social @bruceverchere.bsky.social
@cirtn.bsky.social
https://link.springer.com/article/10.100…
November 14, 2025 at 3:33 AM
🎉Very excited to share our new work on senescence and insulin processing now out in @DiabetologiaJnl link.springer.com/article/10.100…
Fantastic effort by my @dream-diabetes.bsky.social trainees, along with @yichunchen.bsky.social @bruceverchere.bsky.social
@cirtn.bsky.social
Fantastic effort by my @dream-diabetes.bsky.social trainees, along with @yichunchen.bsky.social @bruceverchere.bsky.social
@cirtn.bsky.social
Cool work using spatial transcriptomics among other methods to discover new mesenchyme signaling on developing pancreas niche #PancSky
🚨 Check out our new paper is now online in its final version!!!
🎉 👏 Congratulations @alejotorrescano.bsky.social who led the study
+ past & current team @labspagnoli.bsky.social
+ collaborators #VigilanteLab @kingslsm.bsky.social
➡️ doi.org/10.1126/scia...
short 🧵 below & more acknowledgments ⤵️
🎉 👏 Congratulations @alejotorrescano.bsky.social who led the study
+ past & current team @labspagnoli.bsky.social
+ collaborators #VigilanteLab @kingslsm.bsky.social
➡️ doi.org/10.1126/scia...
short 🧵 below & more acknowledgments ⤵️
Spatially organized cellular communities shape functional tissue architecture in the pancreas
Spatial maps reveal dynamic epithelial-mesenchymal niches shaping pancreatic development and function.
doi.org
November 13, 2025 at 5:14 PM
Cool work using spatial transcriptomics among other methods to discover new mesenchyme signaling on developing pancreas niche #PancSky
Reposted by Christos Karampelias
Brown et al. demonstrated that stem cell–derived β cells can be engineered to express CD155 to preferentially promote T cell coinhibitory signaling through the CD155/TIGIT axis and restrain both NK cell and T cell activation. 🧪
#PancSky
www.science.org/doi/10.1126/...
#PancSky
www.science.org/doi/10.1126/...
Human stem cell-derived β cells expressing an optimized CD155 reduce cytotoxic immune cell function for application in type 1 diabetes
Engineered β cells with a mutant CD155 help evade immune attack, offering a promising therapeutic approach for type 1 diabetes.
www.science.org
November 10, 2025 at 8:00 PM
Brown et al. demonstrated that stem cell–derived β cells can be engineered to express CD155 to preferentially promote T cell coinhibitory signaling through the CD155/TIGIT axis and restrain both NK cell and T cell activation. 🧪
#PancSky
www.science.org/doi/10.1126/...
#PancSky
www.science.org/doi/10.1126/...
Reposted by Christos Karampelias
TT faculty job opening in #Neuroscience!
We are looking for a colleague to join us in our fantastic Biology Department and Neuroscience Program at Brandeis. We are a group of *very* collaborative, supportive, and productive scientists (& humans!) so please apply
academicjobsonline.org/ajo/jobs/30961
We are looking for a colleague to join us in our fantastic Biology Department and Neuroscience Program at Brandeis. We are a group of *very* collaborative, supportive, and productive scientists (& humans!) so please apply
academicjobsonline.org/ajo/jobs/30961
Brandeis University, Biology Department
Job #AJO30961, Assistant Professor in Biology and Neuroscience Program, Biology Department, Brandeis University, Waltham, Massachusetts, US
academicjobsonline.org
October 22, 2025 at 11:28 PM
TT faculty job opening in #Neuroscience!
We are looking for a colleague to join us in our fantastic Biology Department and Neuroscience Program at Brandeis. We are a group of *very* collaborative, supportive, and productive scientists (& humans!) so please apply
academicjobsonline.org/ajo/jobs/30961
We are looking for a colleague to join us in our fantastic Biology Department and Neuroscience Program at Brandeis. We are a group of *very* collaborative, supportive, and productive scientists (& humans!) so please apply
academicjobsonline.org/ajo/jobs/30961
Reposted by Christos Karampelias
More #gastruloid studies. Benchmarking correlations between RNA/proteins w/ acquiring information @ phosphorylation across #mouse & #human www.biorxiv.org/content/10.1...
Also looking at #Disease modelling. Fantastic #TourDForce Valuable bench marking and insight
@dschweppe.bsky.social #SCBEMs
Also looking at #Disease modelling. Fantastic #TourDForce Valuable bench marking and insight
@dschweppe.bsky.social #SCBEMs
November 6, 2025 at 5:34 PM
More #gastruloid studies. Benchmarking correlations between RNA/proteins w/ acquiring information @ phosphorylation across #mouse & #human www.biorxiv.org/content/10.1...
Also looking at #Disease modelling. Fantastic #TourDForce Valuable bench marking and insight
@dschweppe.bsky.social #SCBEMs
Also looking at #Disease modelling. Fantastic #TourDForce Valuable bench marking and insight
@dschweppe.bsky.social #SCBEMs
Happy to share that our preprint is now published at @embomolmed.org! We expanded on the benchmark of porcine ductal organoids by a pretty extensive proteomics dataset to compare organoids derived from different developmental stages of the pig #devbio #PancSky www.embopress.org/doi/full/10....
Benchmarking porcine pancreatic ductal organoids for drug screening applications | EMBO Molecular Medicine
imageimageState-of-the-art single-cell RNA sequencing and proteomics approaches were employed
to benchmark porcine and human pancreatic ductal organoid systems for use as a drug
screening and testing ...
www.embopress.org
November 5, 2025 at 7:50 PM
Happy to share that our preprint is now published at @embomolmed.org! We expanded on the benchmark of porcine ductal organoids by a pretty extensive proteomics dataset to compare organoids derived from different developmental stages of the pig #devbio #PancSky www.embopress.org/doi/full/10....
So cool embryonic pancreas epithelium modeling using stem cells by the Wells lab! #PancSky
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Human pancreatic organoids derived from pluripotent stem cells recapitulate pancreatic organogenesis
Pancreas organogenesis relies on sequential interactions between the pancreatic epithelium and surrounding mesodermal cell types that initiate epithelial budding and branching to form a complex ductal...
www.biorxiv.org
November 1, 2025 at 4:24 PM
So cool embryonic pancreas epithelium modeling using stem cells by the Wells lab! #PancSky
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
New from the @heikolickert.bsky.social clan and great work from Carina together with all collaborators and the Theis lab to study pancreas development across species, bringing new insights into conserved pathways using multimodal computational analysis www.nature.com/articles/s41... #PancSky
A multimodal cross-species comparison of pancreas development - Nature Communications
This study establishes the pig as a complementary model for studying human pancreas development. It shows pigs mimic human developmental tempo, gene regulation, and endocrine cell emergence, offering ...
www.nature.com
October 23, 2025 at 7:03 PM
New from the @heikolickert.bsky.social clan and great work from Carina together with all collaborators and the Theis lab to study pancreas development across species, bringing new insights into conserved pathways using multimodal computational analysis www.nature.com/articles/s41... #PancSky
Reposted by Christos Karampelias
Instead of listing every possible thing the latest AI/LLM CAN do, the question is, what are the sort of things in academia and publishing that we WANT humans to do?
And are we funding/rewarding/prioritizing that?
And are we funding/rewarding/prioritizing that?
October 20, 2025 at 6:08 PM
Instead of listing every possible thing the latest AI/LLM CAN do, the question is, what are the sort of things in academia and publishing that we WANT humans to do?
And are we funding/rewarding/prioritizing that?
And are we funding/rewarding/prioritizing that?
Direct comparison of GLP1 therapies with metabolic surgery in obese www.nature.com/articles/s41...
Macrovascular and microvascular outcomes of metabolic surgery versus GLP-1 receptor agonists in patients with diabetes and obesity - Nature Medicine
In an observational study comparing individuals with type 2 diabetes and obesity who underwent metabolic surgery with similar individuals who received GLP-1 receptor agonist treatment, metabolic surge...
www.nature.com
October 18, 2025 at 7:09 AM
Direct comparison of GLP1 therapies with metabolic surgery in obese www.nature.com/articles/s41...
Great work from my friend @lithoviusv.bsky.social with very nice combination of disease modeling and a drug gable solution to pair it with! @PancSky www.biorxiv.org/content/10.1...
Ghrelin and relamorelin alleviate hypoglycaemia in humanised mice with congenital hyperinsulinism
KATP-channel related hyperinsulinism (KATPHI) is a genetic disorder of the pancreatic beta cells, manifesting as life-threatening hypoglycaemia in neonates due to dysregulated insulin secretion. Manag...
www.biorxiv.org
October 15, 2025 at 6:43 PM
Great work from my friend @lithoviusv.bsky.social with very nice combination of disease modeling and a drug gable solution to pair it with! @PancSky www.biorxiv.org/content/10.1...
Interesting knockout phenotype on intestinal stem cell regeneration.
@embomolmed.org
www.embopress.org/doi/full/10....
@embomolmed.org
www.embopress.org/doi/full/10....
Injury-induced intestinal stem cell renewal requires capillary morphogenesis gene 2 | EMBO Molecular Medicine
imageimageHyaline Fibromatosis Syndrome (HFS) is caused by mutations in the CMG2 gene. Full
loss of function mutations lead to death around 18 months due to recurrent diarrhea
of unknown origin. We us...
www.embopress.org
October 12, 2025 at 6:44 AM
Interesting knockout phenotype on intestinal stem cell regeneration.
@embomolmed.org
www.embopress.org/doi/full/10....
@embomolmed.org
www.embopress.org/doi/full/10....
Further evidence for JAK inhibitors in improving beta cell function from a study cohort of human islets. www.science.org/doi/10.1126/... #PancSky
Functional recovery of islet β cells in human type 2 diabetes: Transcriptome signatures unveil therapeutic approaches
Human T2D beta cell function was restored, the rescuing mechanisms disentangled, and hits identified to promote T2D remission.
www.science.org
October 11, 2025 at 6:45 AM
Further evidence for JAK inhibitors in improving beta cell function from a study cohort of human islets. www.science.org/doi/10.1126/... #PancSky
Reposted by Christos Karampelias
In preprints: gastruloids get (a)head
Wilhelmus A. Brouwer @wesselbrouwer.bsky.social and
Luca Braccioli @bracciolilab.bsky.social discuss the #preprint by Balaskas et al. "An advanced head-to-tail mouse embryo model with hypoxia-mediated neural patterning”
journals.biologists.com/dev/article/...
Wilhelmus A. Brouwer @wesselbrouwer.bsky.social and
Luca Braccioli @bracciolilab.bsky.social discuss the #preprint by Balaskas et al. "An advanced head-to-tail mouse embryo model with hypoxia-mediated neural patterning”
journals.biologists.com/dev/article/...
October 6, 2025 at 5:44 PM
In preprints: gastruloids get (a)head
Wilhelmus A. Brouwer @wesselbrouwer.bsky.social and
Luca Braccioli @bracciolilab.bsky.social discuss the #preprint by Balaskas et al. "An advanced head-to-tail mouse embryo model with hypoxia-mediated neural patterning”
journals.biologists.com/dev/article/...
Wilhelmus A. Brouwer @wesselbrouwer.bsky.social and
Luca Braccioli @bracciolilab.bsky.social discuss the #preprint by Balaskas et al. "An advanced head-to-tail mouse embryo model with hypoxia-mediated neural patterning”
journals.biologists.com/dev/article/...
Reposted by Christos Karampelias
dos Santos et al. provide novel insights into the molecular underpinnings of islet cell dysfunction in #type1diabetes, highlighting pathways that may be leveraged to preserve residual β-cell function and modulate α-cell activity. 🧪
#PancSky
www.jci.org/articles/vie...
#PancSky
www.jci.org/articles/vie...
October 3, 2025 at 12:49 PM
dos Santos et al. provide novel insights into the molecular underpinnings of islet cell dysfunction in #type1diabetes, highlighting pathways that may be leveraged to preserve residual β-cell function and modulate α-cell activity. 🧪
#PancSky
www.jci.org/articles/vie...
#PancSky
www.jci.org/articles/vie...
Reposted by Christos Karampelias
Do zebrafish regenerate their hearts equally? In our new paper at the @tillymommersteeg.bsky.social lab we uncovered variations in the regenerative response of 7 wt zebrafish strains leading us to identify a critical role of oxidative phosphorylation in long-term heart regeneration.
rdcu.be/eI1v5
rdcu.be/eI1v5
Oxidative phosphorylation is required for cardiomyocyte re-differentiation and long-term fish heart regeneration
Nature Cardiovascular Research - Lekkos et al. show that a metabolic switch toward oxidative phosphorylation is required for cardiomyocyte re-differentiation and heart regeneration after injury in...
rdcu.be
October 1, 2025 at 11:26 AM
Do zebrafish regenerate their hearts equally? In our new paper at the @tillymommersteeg.bsky.social lab we uncovered variations in the regenerative response of 7 wt zebrafish strains leading us to identify a critical role of oxidative phosphorylation in long-term heart regeneration.
rdcu.be/eI1v5
rdcu.be/eI1v5
Reposted by Christos Karampelias
It's online! In this series of perspectives @dev-journal.bsky.social, yours truly talks about the exciting open questions and many things to do in the field of dev bio and neuroscience #DevBio🧪 #PIsOfTomorrow journals.biologists.com/dev/article/...
Pathway to Independence: a forecast for the future of developmental biology
ABSTRACT. In 2022, Development launched its Pathway to Independence (PI) programme, aimed at supporting postdocs as they transition to their first independent position. In 2025, we welcome our third c...
journals.biologists.com
September 30, 2025 at 11:00 AM
It's online! In this series of perspectives @dev-journal.bsky.social, yours truly talks about the exciting open questions and many things to do in the field of dev bio and neuroscience #DevBio🧪 #PIsOfTomorrow journals.biologists.com/dev/article/...
Reposted by Christos Karampelias
Out @natcomms.nature.com:
our work on how the ❤️-supporting pericardium forms & acts in pediatric heart conditions.🎈🫀
Expanding our preprint & with our first HCR (thx to @thelovelylab.bsky.social!).
Congrats all! #devbio #zebrafish #CHD @cupediatrics.bsky.social @cudevbio.bsky.social
rdcu.be/eIJm5
our work on how the ❤️-supporting pericardium forms & acts in pediatric heart conditions.🎈🫀
Expanding our preprint & with our first HCR (thx to @thelovelylab.bsky.social!).
Congrats all! #devbio #zebrafish #CHD @cupediatrics.bsky.social @cudevbio.bsky.social
rdcu.be/eIJm5
September 30, 2025 at 5:55 PM
Out @natcomms.nature.com:
our work on how the ❤️-supporting pericardium forms & acts in pediatric heart conditions.🎈🫀
Expanding our preprint & with our first HCR (thx to @thelovelylab.bsky.social!).
Congrats all! #devbio #zebrafish #CHD @cupediatrics.bsky.social @cudevbio.bsky.social
rdcu.be/eIJm5
our work on how the ❤️-supporting pericardium forms & acts in pediatric heart conditions.🎈🫀
Expanding our preprint & with our first HCR (thx to @thelovelylab.bsky.social!).
Congrats all! #devbio #zebrafish #CHD @cupediatrics.bsky.social @cudevbio.bsky.social
rdcu.be/eIJm5
Reposted by Christos Karampelias
Hey friends and colleagues ! Vancouver Coastal Health Research Institute - VCHRI is now on Bluesky, give them a follow @vchresearch.bsky.social
Vancouver Coastal Health Research Institute (@vchresearch.bsky.social)
Vancouver Coastal Health Research Institute — Leading innovative research with health impact in Canada.
vchri.ca
vchresearch.bsky.social
September 14, 2025 at 9:49 AM
Hey friends and colleagues ! Vancouver Coastal Health Research Institute - VCHRI is now on Bluesky, give them a follow @vchresearch.bsky.social
New tool to study beta-cell biology on tissue slices www.biorxiv.org/content/10.1... #PancSky
Efficient transduction of pancreas tissue slices with genetically encoded calcium integrators
This study combines live pancreas tissue slices with adenoviral transduction of the Calcium Modulated Photoactivatable Ratiometric Integrator 2 (CaMPARI2) biosensor for high-throughput analysis of isl...
www.biorxiv.org
September 13, 2025 at 10:47 AM
New tool to study beta-cell biology on tissue slices www.biorxiv.org/content/10.1... #PancSky
Because science camaraderie is forever: New work on citrullination from the @genanderlab.bsky.social and my good friend Kim! This hits close to home as we had a lot of discussions with Kim about protein translation in development and OPP assays during our PhD time! www.science.org/doi/abs/10.1...
The citrullinating enzyme PADI4 governs progenitor cell proliferation and translation in developing hair follicles
Citrullination, a posttranslational modification, affects progenitor cell states and tissue formation.
www.science.org
September 13, 2025 at 6:28 AM
Because science camaraderie is forever: New work on citrullination from the @genanderlab.bsky.social and my good friend Kim! This hits close to home as we had a lot of discussions with Kim about protein translation in development and OPP assays during our PhD time! www.science.org/doi/abs/10.1...
Clinical trial results on gluten-free diet effects in type 1 diabetes prevention have a look academic.oup.com/jes/article/... #PancSky
β-Cell Function and Glucose Tolerance in Persons With Multiple Islet Autoantibodies Randomized to a Gluten-free Diet
AbstractPurpose. A randomized clinical trial was conducted to evaluate the impact of a gluten-free diet (GFD) on β-cell function and glucose tolerance in p
academic.oup.com
September 6, 2025 at 5:39 AM
Clinical trial results on gluten-free diet effects in type 1 diabetes prevention have a look academic.oup.com/jes/article/... #PancSky