Islet Biology Lab - UMH
@isletbiologylab.bsky.social
We're interested in islet cell function and survival in #type1diabetes. Headed by Laura Marroquí (IDiBE/UMH) and Reinaldo dos Santos (FISABIO and IDiBE/UMH). 🧪
For more info about our lab: linktr.ee/isletbiologylab
For more info about our lab: linktr.ee/isletbiologylab
Abedi et al. conducted a comprehensive analysis of gene expression and chromatin accessibility in immune cells from the pancreatic lymph nodes and spleens of individuals with and without #type1diabetes. 🧪
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
Joint profiling of gene expression and chromatin accessibility in pancreatic lymph nodes and spleens in human type 1 diabetes
Joint chromatin accessibility and transcriptomic profiling of human and mouse pancreatic lymph nodes uncovers distinct features of CD4 T cells in T1D.
www.science.org
November 25, 2025 at 10:31 AM
Abedi et al. conducted a comprehensive analysis of gene expression and chromatin accessibility in immune cells from the pancreatic lymph nodes and spleens of individuals with and without #type1diabetes. 🧪
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
Nguyen et al. identified a novel ROS-Ca2+ overload-mTORC1 cytopathic mechanism that underlies impaired autophagy and proposed various protective strategies to correct or relieve pathogenic alteration in β-cell lipotoxicity. 🧪
#PancSky
insight.jci.org/articles/vie...
#PancSky
insight.jci.org/articles/vie...
November 24, 2025 at 10:39 AM
Nguyen et al. identified a novel ROS-Ca2+ overload-mTORC1 cytopathic mechanism that underlies impaired autophagy and proposed various protective strategies to correct or relieve pathogenic alteration in β-cell lipotoxicity. 🧪
#PancSky
insight.jci.org/articles/vie...
#PancSky
insight.jci.org/articles/vie...
Reposted by Islet Biology Lab - UMH
⏰Last call - applications closing soon!
Apply now for EASD’s 1st Immunology School for Endocrinology to explore
✅ Latest #immunology concepts in #T1D,
✅ Early detection and disease staging,
✅ Disease-modifying therapies and #betacell replacement
👉 www.easd.org/education/me...
Apply now for EASD’s 1st Immunology School for Endocrinology to explore
✅ Latest #immunology concepts in #T1D,
✅ Early detection and disease staging,
✅ Disease-modifying therapies and #betacell replacement
👉 www.easd.org/education/me...
📢 EASD will host its 1st Immunology School for Endocrinology: #Immunology in #Type1Diabetes - bridging the science and clinical impact.
📅 26 - 27 March 2026 |📍Vienna, Austria
Open to EASD Members; doctors, researchers/pharmacists in endocrinology/diabetology.
Apply 👉 www.easd.org/education/me...
📅 26 - 27 March 2026 |📍Vienna, Austria
Open to EASD Members; doctors, researchers/pharmacists in endocrinology/diabetology.
Apply 👉 www.easd.org/education/me...
November 24, 2025 at 10:30 AM
⏰Last call - applications closing soon!
Apply now for EASD’s 1st Immunology School for Endocrinology to explore
✅ Latest #immunology concepts in #T1D,
✅ Early detection and disease staging,
✅ Disease-modifying therapies and #betacell replacement
👉 www.easd.org/education/me...
Apply now for EASD’s 1st Immunology School for Endocrinology to explore
✅ Latest #immunology concepts in #T1D,
✅ Early detection and disease staging,
✅ Disease-modifying therapies and #betacell replacement
👉 www.easd.org/education/me...
Frørup et al. aimed to evaluate cathepsin S as a treatment target in type 1 diabetes by examining the effects of oral administration of the potent and selective Ctss inhibitor LY3000328 on autoimmune diabetes and glucose tolerance in the NOD mouse. 🧪
#PancSky
www.sciencedirect.com/science/arti...
#PancSky
www.sciencedirect.com/science/arti...
Evaluation of the pharmacological cathepsin S inhibitor LY3000328 on autoimmune diabetes in mice
There is an emerging role for the lysosomal protease cathepsin S (CTSS) in the pathogenesis of type 1 diabetes (T1D). This is supported by key finding…
www.sciencedirect.com
November 21, 2025 at 6:33 AM
Frørup et al. aimed to evaluate cathepsin S as a treatment target in type 1 diabetes by examining the effects of oral administration of the potent and selective Ctss inhibitor LY3000328 on autoimmune diabetes and glucose tolerance in the NOD mouse. 🧪
#PancSky
www.sciencedirect.com/science/arti...
#PancSky
www.sciencedirect.com/science/arti...
Wong et al. provide a historical perspective, particularly highlighting areas of progress in understanding aspects of aetiology and immune pathogenesis, and utility in helping to shape the immunotherapeutic landscape. 🧪
link.springer.com/article/10.1...
link.springer.com/article/10.1...
Is the NOD mouse a good model for type 1 diabetes? - Diabetologia
The NOD mouse is the best-known, although by no means the only, murine model of type 1 diabetes. In this review, we provide a historical perspective, particularly highlighting areas of progress in und...
link.springer.com
November 20, 2025 at 2:11 PM
Wong et al. provide a historical perspective, particularly highlighting areas of progress in understanding aspects of aetiology and immune pathogenesis, and utility in helping to shape the immunotherapeutic landscape. 🧪
link.springer.com/article/10.1...
link.springer.com/article/10.1...
Reposted by Islet Biology Lab - UMH
📣 Final weeks to apply for the 2nd Early Career Academy Meeting! A 3-day programme for early-career researchers to learn, collaborate and connect with #diabetes experts.
📅 30 March - 1 April 2026 |📍Düsseldorf
⏰ Deadline: 2 December 2025
Explore the programme and apply now 👉 easd.org/academy/academ
📅 30 March - 1 April 2026 |📍Düsseldorf
⏰ Deadline: 2 December 2025
Explore the programme and apply now 👉 easd.org/academy/academ
November 19, 2025 at 1:05 PM
📣 Final weeks to apply for the 2nd Early Career Academy Meeting! A 3-day programme for early-career researchers to learn, collaborate and connect with #diabetes experts.
📅 30 March - 1 April 2026 |📍Düsseldorf
⏰ Deadline: 2 December 2025
Explore the programme and apply now 👉 easd.org/academy/academ
📅 30 March - 1 April 2026 |📍Düsseldorf
⏰ Deadline: 2 December 2025
Explore the programme and apply now 👉 easd.org/academy/academ
Ziegler et al. show that, in this randomised controlled trial involving infants genetically at risk for #type1diabetes, the high-dose oral insulin treatment schedule did not prevent islet autoantibodies but might have modified the natural course of #T1D. 🧪
www.thelancet.com/journals/lan...
www.thelancet.com/journals/lan...
Efficacy of once-daily, high-dose, oral insulin immunotherapy in children genetically at risk for type 1 diabetes (POInT): a European, randomised, placebo-controlled, primary prevention trial
There was no evidence that high-dose, daily oral insulin prevents the development
of islet autoantibodies. Further studies are needed to assess the benefit of primary
oral insulin therapy for preventi...
www.thelancet.com
November 19, 2025 at 9:04 AM
Ziegler et al. show that, in this randomised controlled trial involving infants genetically at risk for #type1diabetes, the high-dose oral insulin treatment schedule did not prevent islet autoantibodies but might have modified the natural course of #T1D. 🧪
www.thelancet.com/journals/lan...
www.thelancet.com/journals/lan...
Findings by Préfontaine et al. suggest that the expression of proinsulin-processing enzymes and the production of insulin are sustained in both chemically induced DNA damage-related senescence and in endogenous senescent adult human beta cells. 🧪
#PancSky
link.springer.com/article/10.1...
#PancSky
link.springer.com/article/10.1...
Insulin production is sustained during DNA damage-mediated senescence in adult human beta cells - Diabetologia
Aims/hypothesis Residual pancreatic beta cells in type 1 diabetes show reduced insulin production but the mechanisms remain unclear. Beta cells undergo stress responses during type 1 diabetes, includi...
link.springer.com
November 18, 2025 at 12:23 PM
Findings by Préfontaine et al. suggest that the expression of proinsulin-processing enzymes and the production of insulin are sustained in both chemically induced DNA damage-related senescence and in endogenous senescent adult human beta cells. 🧪
#PancSky
link.springer.com/article/10.1...
#PancSky
link.springer.com/article/10.1...
Murrall et al. used archival, immunolabeled 2D pancreas sections to assess morphological endocrine object parameters in donors with or without #type1diabetes, varying in age and disease duration. 🧪
#PancSky
www.science.org/doi/full/10....
#PancSky
www.science.org/doi/full/10....
Small things matter: Lack of extraislet β cells in type 1 diabetes
Early loss of small extraislet β cells in children with type 1 diabetes could explain age-related differences in disease.
www.science.org
November 17, 2025 at 10:16 AM
Murrall et al. used archival, immunolabeled 2D pancreas sections to assess morphological endocrine object parameters in donors with or without #type1diabetes, varying in age and disease duration. 🧪
#PancSky
www.science.org/doi/full/10....
#PancSky
www.science.org/doi/full/10....
Our PhD student Daniel Llorens is attending the EASD Scientists Training Course 2025 this week in Barcelona!
Great opportunity for learning, collaboration, and inspiration!
Wishing all participants a productive and inspiring week! 👏
#EASD #DiabetesResearch
Great opportunity for learning, collaboration, and inspiration!
Wishing all participants a productive and inspiring week! 👏
#EASD #DiabetesResearch
🎉 Happening Now! The EASD Scientists Training Course 2025 is in full swing this week @idibaps.bsky.social in beautiful Barcelona, Spain! 🇪🇸
📸 👇 Take a look at the image below and join us in wishing all participants continued success throughout the week!
Supported by Lilly Diabetes International
📸 👇 Take a look at the image below and join us in wishing all participants continued success throughout the week!
Supported by Lilly Diabetes International
November 12, 2025 at 3:43 PM
Our PhD student Daniel Llorens is attending the EASD Scientists Training Course 2025 this week in Barcelona!
Great opportunity for learning, collaboration, and inspiration!
Wishing all participants a productive and inspiring week! 👏
#EASD #DiabetesResearch
Great opportunity for learning, collaboration, and inspiration!
Wishing all participants a productive and inspiring week! 👏
#EASD #DiabetesResearch
In the Finnish #Type1Diabetes Prediction and Prevention study, Kuusela et al. compared how islet autoimmunity starts and progresses to diabetes in children with vs. without a first-degree relative with T1D. 🧪
link.springer.com/article/10.1...
link.springer.com/article/10.1...
Islet autoimmunity and progression to type 1 diabetes in the Finnish DIPP study: comparison between genetically susceptible children with and without an affected first-degree relative - Diabetologia
Aims/hypothesis Islet autoimmunity during presymptomatic type 1 diabetes is heterogeneous. We hypothesised that a positive family history of type 1 diabetes is associated with specific characteristics...
link.springer.com
November 12, 2025 at 3:41 PM
In the Finnish #Type1Diabetes Prediction and Prevention study, Kuusela et al. compared how islet autoimmunity starts and progresses to diabetes in children with vs. without a first-degree relative with T1D. 🧪
link.springer.com/article/10.1...
link.springer.com/article/10.1...
Reposted by Islet Biology Lab - UMH
We are delighted to host the 2nd Annual Susie Clee Memorial Lecture this Thursday 4pm PST which will be given by Dr Melkem Kebede of the University of Sydney.
November 11, 2025 at 11:21 PM
We are delighted to host the 2nd Annual Susie Clee Memorial Lecture this Thursday 4pm PST which will be given by Dr Melkem Kebede of the University of Sydney.
Brown et al. demonstrated that stem cell–derived β cells can be engineered to express CD155 to preferentially promote T cell coinhibitory signaling through the CD155/TIGIT axis and restrain both NK cell and T cell activation. 🧪
#PancSky
www.science.org/doi/10.1126/...
#PancSky
www.science.org/doi/10.1126/...
Human stem cell-derived β cells expressing an optimized CD155 reduce cytotoxic immune cell function for application in type 1 diabetes
Engineered β cells with a mutant CD155 help evade immune attack, offering a promising therapeutic approach for type 1 diabetes.
www.science.org
November 10, 2025 at 8:00 PM
Brown et al. demonstrated that stem cell–derived β cells can be engineered to express CD155 to preferentially promote T cell coinhibitory signaling through the CD155/TIGIT axis and restrain both NK cell and T cell activation. 🧪
#PancSky
www.science.org/doi/10.1126/...
#PancSky
www.science.org/doi/10.1126/...
Gitelman et al. show that teplizumab was well tolerated and demonstrated a safety and tolerability profile consistent with that observed in participants aged ≥8 years in clinical trials and post-marketing experience to date. 🧪
link.springer.com/article/10.1...
link.springer.com/article/10.1...
Safety and pharmacokinetics of teplizumab in children less than 8 years of age with stage 2 type 1 diabetes - Diabetologia
Aims/hypothesis Teplizumab is approved in the USA and seven other countries to delay stage 3 type 1 diabetes onset in individuals ≥8 years of age with stage 2 type 1 diabetes. As part of a US Food and...
link.springer.com
November 7, 2025 at 11:39 AM
Gitelman et al. show that teplizumab was well tolerated and demonstrated a safety and tolerability profile consistent with that observed in participants aged ≥8 years in clinical trials and post-marketing experience to date. 🧪
link.springer.com/article/10.1...
link.springer.com/article/10.1...
Reposted by Islet Biology Lab - UMH
⏰Reminder: Apply for EASD’s 1st Immunology School for Endocrinology focusing on #immunology in #T1D!
🗓 26 - 27 March 2026 |📍Vienna, Austria
Explore cutting-edge topics like early detection, disease-modifying therapies, and beta-cell replacement.
🔗 www.easd.org/education/me...
🗓 26 - 27 March 2026 |📍Vienna, Austria
Explore cutting-edge topics like early detection, disease-modifying therapies, and beta-cell replacement.
🔗 www.easd.org/education/me...
📢 EASD will host its 1st Immunology School for Endocrinology: #Immunology in #Type1Diabetes - bridging the science and clinical impact.
📅 26 - 27 March 2026 |📍Vienna, Austria
Open to EASD Members; doctors, researchers/pharmacists in endocrinology/diabetology.
Apply 👉 www.easd.org/education/me...
📅 26 - 27 March 2026 |📍Vienna, Austria
Open to EASD Members; doctors, researchers/pharmacists in endocrinology/diabetology.
Apply 👉 www.easd.org/education/me...
November 6, 2025 at 9:36 AM
⏰Reminder: Apply for EASD’s 1st Immunology School for Endocrinology focusing on #immunology in #T1D!
🗓 26 - 27 March 2026 |📍Vienna, Austria
Explore cutting-edge topics like early detection, disease-modifying therapies, and beta-cell replacement.
🔗 www.easd.org/education/me...
🗓 26 - 27 March 2026 |📍Vienna, Austria
Explore cutting-edge topics like early detection, disease-modifying therapies, and beta-cell replacement.
🔗 www.easd.org/education/me...
Reposted by Islet Biology Lab - UMH
Personal investigador #CIBEROBN descifra un mecanismo que evita la pérdida de actividad de tejido adiposo pardo durante el envejecimiento 👇
#RecercaUB | 🧓 Desxifrat un mecanisme que evita la pèrdua d’activitat del teixit adipós marró durant l’envelliment
➡️ Un bon funcionament d’aquest teixit, principal productor de calor corporal, és clau per evitar malalties metabòliques i cardiovasculars.
@biologiaub.bsky.social @ibub-ub.bsky.social
➡️ Un bon funcionament d’aquest teixit, principal productor de calor corporal, és clau per evitar malalties metabòliques i cardiovasculars.
@biologiaub.bsky.social @ibub-ub.bsky.social
Desxifrat un mecanisme que evita la pèrdua d’activitat del teixit adipós marró durant l’envelliment
web.ub.edu
November 5, 2025 at 2:01 PM
Personal investigador #CIBEROBN descifra un mecanismo que evita la pérdida de actividad de tejido adiposo pardo durante el envejecimiento 👇
Guthalu Kondegowda et al. investigated the role and mechanisms of circulating extracellular vesicles on #type1diabetes pathogenesis and β-cell cytotoxicity. 🧪
#PancSky
www.biorxiv.org/content/10.1...
#PancSky
www.biorxiv.org/content/10.1...
Proinflammatory circulating extracellular vesicles from type 1 diabetes patients contribute to beta cell cytotoxicity and disease pathogenicity
In Type 1 diabetes (T1D), β-cell loss and autoimmunity initiate years before disease diagnosis. However, the mechanisms remain unknown. Here, we investigated the role and mechanisms of circulating ext...
www.biorxiv.org
November 5, 2025 at 6:23 AM
Guthalu Kondegowda et al. investigated the role and mechanisms of circulating extracellular vesicles on #type1diabetes pathogenesis and β-cell cytotoxicity. 🧪
#PancSky
www.biorxiv.org/content/10.1...
#PancSky
www.biorxiv.org/content/10.1...
Reposted by Islet Biology Lab - UMH
🚀 Ready to launch your postdoc journey?
Check out WashU’s new Postdoc Passport for everything you need to get started. Register for the virtual event December 4th.
postdoc.wustl.edu/prospective-...
Check out WashU’s new Postdoc Passport for everything you need to get started. Register for the virtual event December 4th.
postdoc.wustl.edu/prospective-...
PASSPoRT to WashU | Office of Postdoctoral Affairs | Washington University in St. Louis
Pathways to Advanced Scientific Skills through Postdoctoral Research Training (PASSPoRT) Register Here Thank you for considering WashU for your...
postdoc.wustl.edu
October 30, 2025 at 4:00 PM
🚀 Ready to launch your postdoc journey?
Check out WashU’s new Postdoc Passport for everything you need to get started. Register for the virtual event December 4th.
postdoc.wustl.edu/prospective-...
Check out WashU’s new Postdoc Passport for everything you need to get started. Register for the virtual event December 4th.
postdoc.wustl.edu/prospective-...
Miranda et al. used optogenetics in conjunction with hormone secretion measurements, electrophysiology, and cytoplasmic free Ca2+ concentration imaging to interrogate the relative roles of paracrine and electrical control of β-cells by δ-cells. 🧪
#PancSky
doi.org/10.2337/db25...
#PancSky
doi.org/10.2337/db25...
October 31, 2025 at 6:12 AM
Miranda et al. used optogenetics in conjunction with hormone secretion measurements, electrophysiology, and cytoplasmic free Ca2+ concentration imaging to interrogate the relative roles of paracrine and electrical control of β-cells by δ-cells. 🧪
#PancSky
doi.org/10.2337/db25...
#PancSky
doi.org/10.2337/db25...
Yu et al. integrated newly generated human single-cell RNA sequencing (RNA-seq) datasets (Carnegie stages 10–15) with existing data and mapped the gene co-expression networks (GCNs) underlying pancreatic lineage progression in humans and mice. 🧪
www.sciencedirect.com/science/arti...
www.sciencedirect.com/science/arti...
Reconstructing human pancreatic gene networks enhances stem cell-derived β cell induction
Generating functional β cells from stem cells remains a major challenge in regenerative medicine due to the incomplete recapitulation of human pancrea…
www.sciencedirect.com
October 29, 2025 at 3:23 PM
Yu et al. integrated newly generated human single-cell RNA sequencing (RNA-seq) datasets (Carnegie stages 10–15) with existing data and mapped the gene co-expression networks (GCNs) underlying pancreatic lineage progression in humans and mice. 🧪
www.sciencedirect.com/science/arti...
www.sciencedirect.com/science/arti...
Reposted by Islet Biology Lab - UMH
🚨Excited to kick off our online seminar series on Metabolism in Development and Physiology!
Please help us grow a collaborative and supportive community by joining (<1min): forms.gle/Y8QzucogKKrZ...
#Metabolism #Development #StemCells
Please RT! 🙏
Please help us grow a collaborative and supportive community by joining (<1min): forms.gle/Y8QzucogKKrZ...
#Metabolism #Development #StemCells
Please RT! 🙏
October 28, 2025 at 4:39 PM
🚨Excited to kick off our online seminar series on Metabolism in Development and Physiology!
Please help us grow a collaborative and supportive community by joining (<1min): forms.gle/Y8QzucogKKrZ...
#Metabolism #Development #StemCells
Please RT! 🙏
Please help us grow a collaborative and supportive community by joining (<1min): forms.gle/Y8QzucogKKrZ...
#Metabolism #Development #StemCells
Please RT! 🙏
Levi-D'Ancona et al. review the impact of mitophagy on β cell responses to (patho)physiologic stressors that underlie the development of type 1 and type 2 diabetes.
www.cell.com/trends/endoc...
www.cell.com/trends/endoc...
Mitophagy in the adaptation to pancreatic β cell stress in diabetes
Mitophagy is a crucial quality control process that preserves metabolic efficiency
by selectively targeting damaged mitochondria for removal. Given the high metabolic
demand of pancreatic β cells’ ins...
www.cell.com
October 27, 2025 at 11:11 AM
Levi-D'Ancona et al. review the impact of mitophagy on β cell responses to (patho)physiologic stressors that underlie the development of type 1 and type 2 diabetes.
www.cell.com/trends/endoc...
www.cell.com/trends/endoc...
Just a reminder — our 2nd CIBER-DZD joint webinar is happening next week! 🧪🔬
It’s free and packed with insights from leading researchers in Spain and Germany on metabolism and exercise.
🗓️ July 15 | 🕞 15:30–16:30 (CEST)
🔗 tinyurl.com/bdcu9wfz
It’s free and packed with insights from leading researchers in Spain and Germany on metabolism and exercise.
🗓️ July 15 | 🕞 15:30–16:30 (CEST)
🔗 tinyurl.com/bdcu9wfz
October 24, 2025 at 4:01 PM
Just a reminder — our 2nd CIBER-DZD joint webinar is happening next week! 🧪🔬
It’s free and packed with insights from leading researchers in Spain and Germany on metabolism and exercise.
🗓️ July 15 | 🕞 15:30–16:30 (CEST)
🔗 tinyurl.com/bdcu9wfz
It’s free and packed with insights from leading researchers in Spain and Germany on metabolism and exercise.
🗓️ July 15 | 🕞 15:30–16:30 (CEST)
🔗 tinyurl.com/bdcu9wfz
Reposted by Islet Biology Lab - UMH
#dkNET is hiring a motivated Postdoctoral Researcher in AI/ML to advance diabetes research at University of California Los Angeles (UCLA) under the supervision of Dr. Wei Wang. Excited to make an impact? Apply today: dknet.org/about/positi...
#AI #MachineLearning #Diabetes #hiring
#AI #MachineLearning #Diabetes #hiring
October 23, 2025 at 11:50 PM
#dkNET is hiring a motivated Postdoctoral Researcher in AI/ML to advance diabetes research at University of California Los Angeles (UCLA) under the supervision of Dr. Wei Wang. Excited to make an impact? Apply today: dknet.org/about/positi...
#AI #MachineLearning #Diabetes #hiring
#AI #MachineLearning #Diabetes #hiring
Reposted by Islet Biology Lab - UMH
New from the @heikolickert.bsky.social clan and great work from Carina together with all collaborators and the Theis lab to study pancreas development across species, bringing new insights into conserved pathways using multimodal computational analysis www.nature.com/articles/s41... #PancSky
A multimodal cross-species comparison of pancreas development - Nature Communications
This study establishes the pig as a complementary model for studying human pancreas development. It shows pigs mimic human developmental tempo, gene regulation, and endocrine cell emergence, offering ...
www.nature.com
October 23, 2025 at 7:03 PM
New from the @heikolickert.bsky.social clan and great work from Carina together with all collaborators and the Theis lab to study pancreas development across species, bringing new insights into conserved pathways using multimodal computational analysis www.nature.com/articles/s41... #PancSky