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Reposted by Christos Karampelias

Development @dev-journal.bsky.social · 2d

In preprints: gastruloids get (a)head

Wilhelmus A. Brouwer @wesselbrouwer.bsky.social and
Luca Braccioli @bracciolilab.bsky.social discuss the #preprint by Balaskas et al. "An advanced head-to-tail mouse embryo model with hypoxia-mediated neural patterning”

journals.biologists.com/dev/article/...

In Preprints: A new preprint curation initiative from Development

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Reposted by Christos Karampelias

Islet Biology Lab - UMH @isletbiologylab.bsky.social · 6d

dos Santos et al. provide novel insights into the molecular underpinnings of islet cell dysfunction in #type1diabetes, highlighting pathways that may be leveraged to preserve residual β-cell function and modulate α-cell activity. 🧪
#PancSky

www.jci.org/articles/vie...

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Reposted by Christos Karampelias

kostaslekkos.bsky.social @klekkos.bsky.social · 8d

Do zebrafish regenerate their hearts equally? In our new paper at the @tillymommersteeg.bsky.social lab we uncovered variations in the regenerative response of 7 wt zebrafish strains leading us to identify a critical role of oxidative phosphorylation in long-term heart regeneration.
rdcu.be/eI1v5

Oxidative phosphorylation is required for cardiomyocyte re-differentiation and long-term fish heart regeneration

Nature Cardiovascular Research - Lekkos et al. show that a metabolic switch toward oxidative phosphorylation is required for cardiomyocyte re-differentiation and heart regeneration after injury in...

rdcu.be

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Reposted by Christos Karampelias

MwahahahahahadScientist @mads100tist.bsky.social · 9d

It's online! In this series of perspectives @dev-journal.bsky.social, yours truly talks about the exciting open questions and many things to do in the field of dev bio and neuroscience #DevBio🧪 #PIsOfTomorrow journals.biologists.com/dev/article/...

Pathway to Independence: a forecast for the future of developmental biology

ABSTRACT. In 2022, Development launched its Pathway to Independence (PI) programme, aimed at supporting postdocs as they transition to their first independent position. In 2025, we welcome our third c...

journals.biologists.com

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Reposted by Christos Karampelias

Christian Mosimann @chrmosimann.bsky.social · 8d

Out @natcomms.nature.com:
our work on how the ❤️-supporting pericardium forms & acts in pediatric heart conditions.🎈🫀

Expanding our preprint & with our first HCR (thx to @thelovelylab.bsky.social!).

Congrats all! #devbio #zebrafish #CHD @cupediatrics.bsky.social @cudevbio.bsky.social
rdcu.be/eIJm5

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Christos Karampelias @ckarampelias.bsky.social · 11d

New work on NKX2.2 on islet specification www.biorxiv.org/content/10.1...

#PancSky

Human NKX2.2 influences islet endocrine cell fate choices through regulation of WNT pathway genes

Transcriptional regulation is a key central mechanism of cell fate determination in developing tissues. The homeobox transcription factor NKX2.2 is an essential regulator of mouse and human pancreatic...

www.biorxiv.org

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Reposted by Christos Karampelias

Jim Johnson 🇨🇦 @jimjohnsonsci.bsky.social · 25d

Hey friends and colleagues ! Vancouver Coastal Health Research Institute - VCHRI is now on Bluesky, give them a follow @vchresearch.bsky.social

Vancouver Coastal Health Research Institute (@vchresearch.bsky.social)

Vancouver Coastal Health Research Institute — Leading innovative research with health impact in Canada. vchri.ca

vchresearch.bsky.social

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Christos Karampelias @ckarampelias.bsky.social · 26d

New tool to study beta-cell biology on tissue slices www.biorxiv.org/content/10.1... #PancSky

Efficient transduction of pancreas tissue slices with genetically encoded calcium integrators

This study combines live pancreas tissue slices with adenoviral transduction of the Calcium Modulated Photoactivatable Ratiometric Integrator 2 (CaMPARI2) biosensor for high-throughput analysis of isl...

www.biorxiv.org

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Christos Karampelias @ckarampelias.bsky.social · 26d

Because science camaraderie is forever: New work on citrullination from the @genanderlab.bsky.social and my good friend Kim! This hits close to home as we had a lot of discussions with Kim about protein translation in development and OPP assays during our PhD time! www.science.org/doi/abs/10.1...

The citrullinating enzyme PADI4 governs progenitor cell proliferation and translation in developing hair follicles

Citrullination, a posttranslational modification, affects progenitor cell states and tissue formation.

www.science.org

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Christos Karampelias @ckarampelias.bsky.social · Sep 6

Clinical trial results on gluten-free diet effects in type 1 diabetes prevention have a look academic.oup.com/jes/article/... #PancSky

β-Cell Function and Glucose Tolerance in Persons With Multiple Islet Autoantibodies Randomized to a Gluten-free Diet

AbstractPurpose. A randomized clinical trial was conducted to evaluate the impact of a gluten-free diet (GFD) on β-cell function and glucose tolerance in p

academic.oup.com

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Reposted by Christos Karampelias

Islet Biology Lab - UMH @isletbiologylab.bsky.social · Sep 5

Blom et al. provide critical clues as to how β-cell secretory functions are specifically impacted by cytokines and nitric oxide that may contribute to the development of β-cell autoantigens relevant to #type1diabetes. 🧪
#PancSky

doi.org/10.2337/db25...

Proinflammatory Cytokines Mediate Pancreatic β-Cell–Specific Alterations to Golgi Integrity via iNOS-Dependent Mitochondrial Inhibition

Type 1 diabetes (T1D) is caused by the selective autoimmune ablation of pancreatic β-cells. Emerging evidence reveals β-cell secretory dysfunction arises e

doi.org

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Christos Karampelias @ckarampelias.bsky.social · Aug 24

Check out the latest manuscript from the @heikolickert.bsky.social lab on generating a defined stem-cell derived islet product for transplantation.
A thorough characterization of the system particularly by our star PhD students Nike and Nicole! #PancSky
www.biorxiv.org/content/10.1...

Endocrine-enriched stem cell-derived islets improve long-term safety in vivo

Fully differentiated stem cell-derived islets (SC-islets) are proven to normalise blood glucose in type 1 diabetic patients. However, the presence of off-target cell types and the immature SC-islet fu...

www.biorxiv.org

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Reposted by Christos Karampelias

Benjamin Furtwängler @bfurtwa.bsky.social · Aug 22

We’re excited to present this integrative analysis of single-cell proteomics and transcriptomics of the human HSPC hierarchy. Now published in @science.org together with @fabiantheis.bsky.social, @erwinschoof.bsky.social, @porsebo.bsky.social.
www.science.org/doi/10.1126/...
🧵

Mapping early human blood cell differentiation using single-cell proteomics and transcriptomics

Single-cell transcriptomics (scRNA-seq) has facilitated the characterization of cell state heterogeneity and recapitulation of differentiation trajectories. However, the exclusive use of mRNA measurem...

www.science.org

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Christos Karampelias @ckarampelias.bsky.social · Aug 22

Great tool need to test

Luciano Martelotto @lgmartelotto.bsky.social · Aug 22

www.biorxiv.org/content/10.1...

anndataR improves interoperability between R and Python in single-cell transcriptomics

Many single-cell transcriptomics datasets are stored in the HDF5-backed AnnData (H5AD) file format, as popularised by the Python scverse ecosystem. However, accessing these datasets from R, allowing u...

www.biorxiv.org

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Reposted by Christos Karampelias

Christian Mosimann @chrmosimann.bsky.social · Aug 15

Looking for a #postdoc opportunity? Funded positions available @cuanschutz.bsky.social to advance our #zebrafish transgenesis tools - and to look into developmental origins of congenital disease!
#devbio

Christian Mosimann @chrmosimann.bsky.social · Jul 16

Grateful to receive an R24 NOA from NIH/ORIP to advance phiC31-based transgenesis tools in #zebrafish. 🐟

Collab with @aburger2009.bsky.social & Breuss labs @cuanschutz.bsky.social. 🧬

...and: big THX to everyone who already helped w/ sharing #pIGLET reagents! 🐽
#ShareYourTools #MakeMoreTransgenics

piglet from winnie the pooh says thank you

ALT: piglet from winnie the pooh says thank you

media.tenor.com

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Christos Karampelias @ckarampelias.bsky.social · Aug 14

Interesting work on sirtuins in regulation of proliferation in the pancreas

Islet Biology Lab - UMH @isletbiologylab.bsky.social · Aug 12

Wortham et al. identified the protein deacetylase Sirtuin 2 (SIRT2) as a regulator of β-cell proliferation whose inactivation results in controlled β-cell expansion. 🧪
#PancSky

www.jci.org/articles/vie...

JCI - The protein deacetylase SIRT2 exerts metabolic control over adaptive β cell proliferation

www.jci.org

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Reposted by Christos Karampelias

Stylianos Lefkopoulos (he/him) @slefkopoulos.bsky.social · Aug 13

Anyone here interested in #metabolism in #devbio ?
We recently published a Review article by Jin Zhang & co discussing the relationship between metabolism and #embryogenesis. Enjoy the read! :D
👉https://rdcu.be/eADIT
www.nature.com/articles/s41...

Metabolic regulation of key developmental events during mammalian embryogenesis - Nature Cell Biology

This Review discusses the intricate relationship between metabolism and embryogenesis, highlighting the orchestration of key developmental processes by metabolites and signalling molecules that provid...

www.nature.com

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Christos Karampelias @ckarampelias.bsky.social · Aug 8

This thread is hilarious. Given the environmental impact of some of these privately-owned LLMs that reason like PhDs that can formulate our email responses one might have to rethink their general use. Maybe something good would be to charge 15 Euro per month for use

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Reposted by Christos Karampelias

Development @dev-journal.bsky.social · Jul 28

Transitions in development – an interview with Jeffrey Farrell

@jeffreyafarrell.bsky.social talks about becoming a group leader, his insights on advocacy for developmental biology and his belief in unifying single-cell biology with classical approaches.

journals.biologists.com/dev/article/...

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Reposted by Christos Karampelias

John Wallingford @jbwallingford.bsky.social · Jul 29

Great opportunity here to build your skills and your professional network! Apply for the SciComm Interns program!
#devbiolwriteclub
@socdevbio.bsky.social

Society for Developmental Biology @socdevbio.bsky.social · Jul 23

Applications are now open for the 2026 SDB Science Communication Internship. Graduate student and postdoc members of the Society for Developmental Biology are eligible to apply. Deadline: August 15. Learn more: www.sdbonline.org/science_comm...

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Reposted by Christos Karampelias

Ali Maximilian Erturk @erturklab.bsky.social · Jul 30

We developed MouseMapper AI, a deep learning ensemble for the analysis of whole-body systems, including the nervous and immune systems, to map disease/drug perturbations tissue by tissue, organ by organ, at the cellular level in 3D.
biorxiv.org/content/10.1...

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Reposted by Christos Karampelias

Christian Frezza @frezzalab.bsky.social · Jul 27

Good Sunday all. A beautiful selection of papers in #cancermetabolism and #mitochondrialbiology is ready for you here: biomed.news/bims-camemi/... @biomednews.bsky.social #keepreading

"If your eyes are blinded with your worries, you cannot see the beauty of the sunset." - Jiddu Krishnamurti

an illustration of a bird holding a stack of books with reading time written above it

ALT: an illustration of a bird holding a stack of books with reading time written above it

media.tenor.com

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Reposted by Christos Karampelias

Kevin Mitchell @wiringthebrain.bsky.social · Jul 27

Identifying reproducible biomarkers for microbiome association studies requires sample sizes of thousands www.sciencedirect.com/science/arti...

Identifying reproducible biomarkers for microbiome association studies requires thousands of sample sizes

www.sciencedirect.com

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Reposted by Christos Karampelias

Islet Biology Lab - UMH @isletbiologylab.bsky.social · Jul 24

Auddino et al. discuss the potential link between cellular stresses and isomiR biogenesis, and how this association could improve our knowledge of islet inflammation and dysfunction. 🧪
#PancSky

www.cell.com/trends/endoc...

A three-layer perspective on miRNA regulation in β cell inflammation

MicroRNAs (miRNAs) are noncoding RNA molecules that regulate gene expression post-transcriptionally and influence numerous biological processes. Aberrant miRNA expression is linked to diseases such as...

www.cell.com

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Reposted by Christos Karampelias

@LaBonneLaB @labonnelab.bsky.social · Jul 26

Some journals are claiming that you need to pay big $$ for gold open access to comply with NIH's new public access policy. FYI that is total bs. You can comply by depositing the Accepted Manuscript into PubMed Central on the Date of Publication without embargo. Pass it on.

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