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Stylianos Lefkopoulos (he/him)

@slefkopoulos.bsky.social

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Stylianos Lefkopoulos (he/him) @slefkopoulos.bsky.social · Jun 7

Traveling to the @isscr.org meeting in HK soon? Feeling like browsing through important #StemCell work published during the past year on your way there? Take a look at our collection of papers published across @natureportfolio.nature.com during the past 12 months!

www.nature.com/collections/...

A year of stem cell and developmental biology

In recent years, the field of stem cell and developmental biology has seen remarkable breakthroughs that have deepened our understanding of how organisms ...

www.nature.com

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Reposted by Stylianos Lefkopoulos (he/him)

Matthew Neville @mattneville.bsky.social · 1d

Now published! Our paper on:
(1) Accurate sequencing of sperm at scale
(2) Positive selection of spermatogenesis driver mutations across the exome
(3) Offspring disease risks from male reproductive aging
[1/n]
www.nature.com/articles/s41...

Sperm sequencing reveals extensive positive selection in the male germline - Nature

A combination of whole-genome NanoSeq with deep whole-exome and targeted NanoSeq is used to accurately characterize mutation rates and genes under positive selection in sperm cells.

www.nature.com

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Reposted by Stylianos Lefkopoulos (he/him)

James Briscoe @jamesbriscoe.bsky.social · 2d

Very sad news, John Gurdon has died.

A developmental biologist's developmental biologist, Nobel prize winner

His work is the foundation of much of today's dev & stem cell bio.

An inspiration to many, including me. Always asking questions & wanting the answers

www.magd.cam.ac.uk/news/profess...

Professor Sir John Gurdon FRS (1933-2025) | Magdalene College

Magdalene College is deeply saddened to announce the death of Professor Sir John Gurdon FRS, who served as Master of the College from 1995 to 2002.

www.magd.cam.ac.uk

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Reposted by Stylianos Lefkopoulos (he/him)

Alejandro Montenegro @aemonten.bsky.social · 2d

We, editors, don't "count votes", and yes, we may make decisions that differ from your recommendation. And that doesn't mean we "are wrong".

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Stylianos Lefkopoulos (he/him) @slefkopoulos.bsky.social · 2d

Ha - I actually said the exact same thing today during site visits, interesting timing!

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Stylianos Lefkopoulos (he/him) @slefkopoulos.bsky.social · 3d

“The Nobel Prize in Physiology or Medicine 2025 was awarded to Mary E. Brunkow, Fred Ramsdell and Shimon Sakaguchi "for their discoveries concerning peripheral immune tolerance".” #nobelprize #immunology

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Stylianos Lefkopoulos (he/him) @slefkopoulos.bsky.social · 5d

Elegant new study in our journal by @sarawickstrom.bsky.social @katemiro.bsky.social & co!

Nature Cell Biology @natcellbio.nature.com · 5d

💫NEW: @sarawickstrom.bsky.social @katemiro.bsky.social & co show that mechano-osmotic changes in the #nucleus induce general #transcriptional repression and prime #chromatin for cell fate transitions by relieving repression of specific differentiation genes. #pluripotency
bit.ly/3VMcyNZ

Mechano-osmotic signals control chromatin state and fate transitions in pluripotent stem cells - Nature Cell Biology

McCreery, Stubb et al. show that mechano-osmotic changes in the nucleus induce general transcriptional repression and prime chromatin for cell fate transitions by relieving repression of specific differentiation genes.

bit.ly

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Stylianos Lefkopoulos (he/him) @slefkopoulos.bsky.social · 7d

I’m always incredibly excited to go through the monthly physical copy (yes, even though I do know its content).
@natcellbio.nature.com

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Reposted by Stylianos Lefkopoulos (he/him)

Daryl Jason Verzosa David @djdavid.bsky.social · 9d

Sept 2025 marks 4 years after I joined @natcellbio.nature.com & 7.5+ years since starting editorial at @natcomms.nature.com !
To mark this occasion, I’ll highlight 5 pieces that I’ve had the privilege to help shepherd to publication. (a thread for today/tomorrow)
Bonus Pic of me as a baby editor .

Me standing beside a Springer Nature Berlin Bear. At our Springer Nature Office.

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Stylianos Lefkopoulos (he/him) @slefkopoulos.bsky.social · 13d

And to avoid confusion, as I have already received a few comments, our journal is ofc a cell biology journal. Our aim is not to include within our scope every clinical trial, but rather some of those presenting approaches directly linked to cell biology (for example, stem cell-based therapy).

Reposted by Stylianos Lefkopoulos (he/him)

Francesca Cesari @francesari.bsky.social · 14d

An article in Nature tracks trends in freshwater fish biodiversity in streams and rivers across the US over the last three decades and finds that fish biodiversity diverged across cold and warm streams, with a disproportionately large impact on cold streams.🧪
www.nature.com/articles/s41...

Diverging fish biodiversity trends in cold and warm rivers and streams - Nature

In the past three decades, fish abundance, richness and uniqueness have diverged across cold and warm streams, and the effects on native fish communities of stream warming and increases in introduced fishes have magnified each other.

www.nature.com

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Stylianos Lefkopoulos (he/him) @slefkopoulos.bsky.social · 14d

No surprise - I still haven’t met in person most of the NCB team.

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Stylianos Lefkopoulos (he/him) @slefkopoulos.bsky.social · 14d

Hahahahaha not quite 😂

Stylianos Lefkopoulos (he/him) @slefkopoulos.bsky.social · 14d

Although we ‘re colleagues, I still haven’t met @ritastrack.bsky.social, and yet I feel like I know her, through her strong presence on social media, the great work she’s published, and numerous researchers I ‘ve met and who always had sth great to say about her. All the best for your new role!

Rita Strack @ritastrack.bsky.social · 24d

"It is a big loss for Nature Methods and its audience. I think your role there in the past decade has transformed and re-defined the imaging related landscape for the entire community." 😭 These notes make me sentimental, but they also show me that doing this job well matters. #editorgoals

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Stylianos Lefkopoulos (he/him) @slefkopoulos.bsky.social · 15d

In the 26-year history of our journal @natcellbio.nature.com this has never happened before, but the time has come: Nature Cell Biology is now open to considering #ClinicalTrials . I’m curious to hear what people in the field are up to - please reach out to me!
#CellTherapy #stemcells #genetherapy

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Stylianos Lefkopoulos (he/him) @slefkopoulos.bsky.social · 15d

For a second I panicked 😂

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Stylianos Lefkopoulos (he/him) @slefkopoulos.bsky.social · 17d

It all eventually questions the propriety of allowing and tolerating the driving force behind everything: 💰
The world is built on that force and I do wonder how feasible it ‘d be to change that - *at least* for matters where even using the word ‘market’ is inhumane; it’s everywhere around us.

Stylianos Lefkopoulos (he/him) @slefkopoulos.bsky.social · 17d

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Stylianos Lefkopoulos (he/him) @slefkopoulos.bsky.social · 18d

It’s a slight adaptation of this recipe: drveganblog.com/roasted-caul...

Roasted Cauliflower Steaks - Easy Vegan Dinner | Dr. Vegan

Try this delicious roasted cauliflower steaks served with creamy chickpea hummus. A perfect plant-based, gluten-free, and healthy vegan dinner, ready in 45 minutes!

drveganblog.com

Stylianos Lefkopoulos (he/him) @slefkopoulos.bsky.social · 18d

It’s a slight adaptation of this recipe: drveganblog.com/roasted-caul...

Roasted Cauliflower Steaks - Easy Vegan Dinner | Dr. Vegan

Try this delicious roasted cauliflower steaks served with creamy chickpea hummus. A perfect plant-based, gluten-free, and healthy vegan dinner, ready in 45 minutes!

drveganblog.com

Stylianos Lefkopoulos (he/him) @slefkopoulos.bsky.social · 18d

It’s a slight adaptation of this recipe: drveganblog.com/roasted-caul...

Roasted Cauliflower Steaks - Easy Vegan Dinner | Dr. Vegan

Try this delicious roasted cauliflower steaks served with creamy chickpea hummus. A perfect plant-based, gluten-free, and healthy vegan dinner, ready in 45 minutes!

drveganblog.com

Stylianos Lefkopoulos (he/him) @slefkopoulos.bsky.social · 18d

I think the hummus covers that

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Stylianos Lefkopoulos (he/him) @slefkopoulos.bsky.social · 19d

Ever since I switched to a vegetarian diet, I ‘ve been trying to find new recipes and familiarize myself with a different cooking philosophy. Believe me: #vegetarian & #vegan recipes can be INCREDIBLE! And this is absolutely one of them: cauliflower steak served with roasted potatoes and hummus.

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Stylianos Lefkopoulos (he/him) @slefkopoulos.bsky.social · 19d

Every single time I see this “he or she”, a glimpse of hope dies inside me.

Reposted by Stylianos Lefkopoulos (he/him)

Carmelo Ferrai @carmeloferrai.bsky.social · 21d

EpiSci - 🧬 - 🧪 -

A subset of transposable elements as mechano-response enhancer elements in controlling human embryonic stem cell fate

www.nature.com/articles/s41...

A subset of transposable elements as mechano-response enhancer elements in controlling human embryonic stem cell fate - Nature Cell Biology

Sun et al. identify a subset of transposable elements that serve as mechano-response enhancer elements that control gene expression and human stem cell fate.

www.nature.com

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Stylianos Lefkopoulos (he/him) @slefkopoulos.bsky.social · 22d

I LOVE THEM!