Trevor Graham
@trevorgraham.bsky.social
Director, Centre for Evolution and Cancer @cec-icr.bsky.social at @icr.ac.uk
Genomics, epigenetics, evolution, mathematical modelling, data science, bowel cancer
Genomics, epigenetics, evolution, mathematical modelling, data science, bowel cancer
Pinned
Trevor Graham
@trevorgraham.bsky.social
· Nov 12
I've started a list of people working on #cancer #evolution. Many more to be added, so do let me know if that is you. Also if you would like to be removed. go.bsky.app/QuAF4Mo
First paper from the exceptional Marco Bezzi, group leader in our @cec-icr.bsky.social: a disease-matched syngeneic mouse modelling platform for prostate cancer evolution. Many results here, highlighted is MYC/MAPK driving castration resistance & remodelling tumour microenvrn Congrats! @icr.ac.uk
ProMPt: A modular preclinical platform for functional modelling of prostate cancer heterogeneity and therapeutic vulnerabilities
Prostate cancer progression is driven by heterogenous genetic, phenotypic, and microenvironmental programs that remain challenging to model experimentally. Existing systems such as genetically enginee...
www.biorxiv.org
November 24, 2025 at 10:14 AM
First paper from the exceptional Marco Bezzi, group leader in our @cec-icr.bsky.social: a disease-matched syngeneic mouse modelling platform for prostate cancer evolution. Many results here, highlighted is MYC/MAPK driving castration resistance & remodelling tumour microenvrn Congrats! @icr.ac.uk
Reposted by Trevor Graham
Fantastic opportunity from @turajliclab.bsky.social! 🚀
The CanDy Lab is recruiting an Associate Scientist to drive cutting-edge cancer research across @cruk-mi.bsky.social and @crick.ac.uk.
A rare chance to lead, grow, and shape high-impact science 👇
www.cruk.manchester.ac.uk/career/mi-25...
The CanDy Lab is recruiting an Associate Scientist to drive cutting-edge cancer research across @cruk-mi.bsky.social and @crick.ac.uk.
A rare chance to lead, grow, and shape high-impact science 👇
www.cruk.manchester.ac.uk/career/mi-25...
MI/25/63 Associate Scientist | Cancer Research UK Manchester Institute
We are seeking a highly motivated and accomplished Associate Scientist to help lead and shape the programme. You will act as an operational deputy to Professor Samra Turajlic, helping to bridge activi...
www.cruk.manchester.ac.uk
November 16, 2025 at 5:36 PM
Fantastic opportunity from @turajliclab.bsky.social! 🚀
The CanDy Lab is recruiting an Associate Scientist to drive cutting-edge cancer research across @cruk-mi.bsky.social and @crick.ac.uk.
A rare chance to lead, grow, and shape high-impact science 👇
www.cruk.manchester.ac.uk/career/mi-25...
The CanDy Lab is recruiting an Associate Scientist to drive cutting-edge cancer research across @cruk-mi.bsky.social and @crick.ac.uk.
A rare chance to lead, grow, and shape high-impact science 👇
www.cruk.manchester.ac.uk/career/mi-25...
@kevinmonahan.bsky.social & I have an open clinical #PhD position between @stmarkshospital.bsky.social and @icr.ac.uk If you're interested in the biology of pre-cancer in the bowel & want to translate biology for cancer prevention this one could be for you... funded by the brilliant #40tude
We are looking for our new Tom Smith Clinical Research Fellow in #LynchSyndrome and Early Onset ColorectalCancer with @trevorgraham.bsky.social in translational science … thanks to 40tude curing colon cancer for supporting this fellowship - get in touch! @stmarksgenomics.bsky.social @icr.ac.uk
November 17, 2025 at 2:53 PM
@kevinmonahan.bsky.social & I have an open clinical #PhD position between @stmarkshospital.bsky.social and @icr.ac.uk If you're interested in the biology of pre-cancer in the bowel & want to translate biology for cancer prevention this one could be for you... funded by the brilliant #40tude
Calling cancer data scientists! 📊 💽 🧮
We have a number of open positions in our core facility @icr.ac.uk These are bioinformatician staff scientist like roles to work on exciting single cell, spatial & other genomics data from across our Institute. A PhD is required. jobs.icr.ac.uk/vacancies/13...
We have a number of open positions in our core facility @icr.ac.uk These are bioinformatician staff scientist like roles to work on exciting single cell, spatial & other genomics data from across our Institute. A PhD is required. jobs.icr.ac.uk/vacancies/13...
Data Scientist in Sutton | The Institute of Cancer Research
View details and apply for this Data Scientist vacancy in Sutton.
Salary : Salary range £39,805 to £53,500 (Dependent on experience )
Reporting to: Professor Trevor Gra...
jobs.icr.ac.uk
November 13, 2025 at 2:59 PM
Calling cancer data scientists! 📊 💽 🧮
We have a number of open positions in our core facility @icr.ac.uk These are bioinformatician staff scientist like roles to work on exciting single cell, spatial & other genomics data from across our Institute. A PhD is required. jobs.icr.ac.uk/vacancies/13...
We have a number of open positions in our core facility @icr.ac.uk These are bioinformatician staff scientist like roles to work on exciting single cell, spatial & other genomics data from across our Institute. A PhD is required. jobs.icr.ac.uk/vacancies/13...
New @natgenet.nature.com paper from the brilliant @eszterlakatos.bsky.social presents evidence that chromatin alterations disrupt antigen presentation & neoantigens in colorectal cancer. Also that immune escape is part of the "Big Bang", at the outset of CRC growth. www.nature.com/articles/s41...
Epigenetically driven and early immune evasion in colorectal cancer evolution - Nature Genetics
This study nominates immune escape as an early event in colorectal cancer and shows how this can be driven through both genetic and epigenetic changes.
www.nature.com
November 5, 2025 at 4:36 PM
New @natgenet.nature.com paper from the brilliant @eszterlakatos.bsky.social presents evidence that chromatin alterations disrupt antigen presentation & neoantigens in colorectal cancer. Also that immune escape is part of the "Big Bang", at the outset of CRC growth. www.nature.com/articles/s41...
Congratulations Alvaro! And your exciting papers are following...
PhD convocation ceremony at @icr.ac.uk with DrDr Alvaro Graces. His thesis entitled Clonal Dynamics and evolutionary pathways in high grade serous ovarian cancer under therapeutic pressure siggests our current use of chemotherapy can be better optimised. @trevorgraham.bsky.social
November 1, 2025 at 3:01 PM
Congratulations Alvaro! And your exciting papers are following...
Ouse Valley Viaduct, Sussex, UK
October 24, 2025 at 12:26 PM
Ouse Valley Viaduct, Sussex, UK
Reposted by Trevor Graham
🚨🚨🚨
Two super well-funded PhD grants from our MSCA Doctoral Network @evomg-dn.bsky.social at our lab at @melisupf.bsky.social, @crg.eu and the @evomg-bcn.bsky.social Program.
If you're excited about evolution, genomics and biomedical research, this is your DN! 😃
Further info: www.evomg-dn.eu and 👇
Two super well-funded PhD grants from our MSCA Doctoral Network @evomg-dn.bsky.social at our lab at @melisupf.bsky.social, @crg.eu and the @evomg-bcn.bsky.social Program.
If you're excited about evolution, genomics and biomedical research, this is your DN! 😃
Further info: www.evomg-dn.eu and 👇
EVOMG-DN
EvoMG-DN is a European Doctoral Network funded by the Horizon Europe Marie Skłodowska-Curie Actions (MSCA), composed of 14 beneficiaries and associated partners from both academic and non-academic sectors.
www.evomg-dn.eu
October 15, 2025 at 7:02 AM
🚨🚨🚨
Two super well-funded PhD grants from our MSCA Doctoral Network @evomg-dn.bsky.social at our lab at @melisupf.bsky.social, @crg.eu and the @evomg-bcn.bsky.social Program.
If you're excited about evolution, genomics and biomedical research, this is your DN! 😃
Further info: www.evomg-dn.eu and 👇
Two super well-funded PhD grants from our MSCA Doctoral Network @evomg-dn.bsky.social at our lab at @melisupf.bsky.social, @crg.eu and the @evomg-bcn.bsky.social Program.
If you're excited about evolution, genomics and biomedical research, this is your DN! 😃
Further info: www.evomg-dn.eu and 👇
We have two fantastically well-funded #PhD studentships available through the @evomg-dn.bsky.social #EU doctoral network (led by brilliant @mirimiam.bsky.social, @crg.eu). These enable students to move to the UK and come and work with us @icr.ac.uk to exploit #cancer #evolution for patient benefit.
October 14, 2025 at 8:21 PM
We have two fantastically well-funded #PhD studentships available through the @evomg-dn.bsky.social #EU doctoral network (led by brilliant @mirimiam.bsky.social, @crg.eu). These enable students to move to the UK and come and work with us @icr.ac.uk to exploit #cancer #evolution for patient benefit.
Reposted by Trevor Graham
Big, beautiful trees!!
SMART-PTA for whole-genome+transcriptome on thousand of single cells from the normal human esophagus 🤯 Massively scaling up the power of scWGS to build deep phylogenies and chart somatic evolution from birth throughout life.
www.biorxiv.org/content/10.1...
SMART-PTA for whole-genome+transcriptome on thousand of single cells from the normal human esophagus 🤯 Massively scaling up the power of scWGS to build deep phylogenies and chart somatic evolution from birth throughout life.
www.biorxiv.org/content/10.1...
October 14, 2025 at 2:37 PM
Big, beautiful trees!!
SMART-PTA for whole-genome+transcriptome on thousand of single cells from the normal human esophagus 🤯 Massively scaling up the power of scWGS to build deep phylogenies and chart somatic evolution from birth throughout life.
www.biorxiv.org/content/10.1...
SMART-PTA for whole-genome+transcriptome on thousand of single cells from the normal human esophagus 🤯 Massively scaling up the power of scWGS to build deep phylogenies and chart somatic evolution from birth throughout life.
www.biorxiv.org/content/10.1...
Great flash talks from Anton Patrikeev (HPV evolution in head and neck cancer) and Florian Gabel (resistance evolution in prostate cancer) both from our @cec-icr.bsky.social @icr.ac.uk #CrickCancerConf
October 7, 2025 at 10:45 AM
Great flash talks from Anton Patrikeev (HPV evolution in head and neck cancer) and Florian Gabel (resistance evolution in prostate cancer) both from our @cec-icr.bsky.social @icr.ac.uk #CrickCancerConf
Reposted by Trevor Graham
Happy to share the Biodiversity Cell Atlas white paper, out today in @nature.com. We look at the possibilities, challenges, and potential impacts of molecularly mapping cells across the tree of life.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
September 24, 2025 at 3:12 PM
Happy to share the Biodiversity Cell Atlas white paper, out today in @nature.com. We look at the possibilities, challenges, and potential impacts of molecularly mapping cells across the tree of life.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Here's @calumgabbutt.bsky.social's nice thread on our #EVOFLUx paper in @nature.com that uses fluctuating methylation to track cancer evolution
Cancer is an evolutionary disease, but does knowing a cancer’s evolutionary past help predict its future? Out today in @nature, we learnt the evolution of 2000 lymphoid cancers and found it was highly correlated with clinical outcomes! (1/7)
rdcu.be/eFrrc
rdcu.be/eFrrc
Fluctuating DNA methylation tracks cancer evolution at clinical scale
Nature - Cancer evolutionary dynamics are quantitatively inferred using a method, EVOFLUx, applied to fluctuating DNA methylation.
rdcu.be
September 12, 2025 at 1:50 PM
Here's @calumgabbutt.bsky.social's nice thread on our #EVOFLUx paper in @nature.com that uses fluctuating methylation to track cancer evolution
Studying cancer evolution needs multi-region or single cell seq for phylogenetics, right? Amazingly (I think!) we found single-sample bulk methylation suffices, via analysis of "fluctuating methylation". In @nature.com today led by brilliant @calumgabbutt.bsky.social www.nature.com/articles/s41...
Fluctuating DNA methylation tracks cancer evolution at clinical scale - Nature
Cancer evolutionary dynamics are quantitatively inferred using a method, EVOFLUx, applied to fluctuating DNA methylation.
www.nature.com
September 10, 2025 at 3:21 PM
Studying cancer evolution needs multi-region or single cell seq for phylogenetics, right? Amazingly (I think!) we found single-sample bulk methylation suffices, via analysis of "fluctuating methylation". In @nature.com today led by brilliant @calumgabbutt.bsky.social www.nature.com/articles/s41...
This looks very cool... implementing mathematical models of cell and tissue biology from plain-text human readable statements. I want to have a play with it! Congratulations Paul @mathcancer.bsky.social and team
Really excited to share our new @cellpress.bsky.social Cell paper with @fertiglab.bsky.social and colleagues. 1/n
www.cell.com/cell/fulltex...
@jktgfoundation.bsky.social @itcrtraining.bsky.social @smbmathbiology.bsky.social #mathbio #mathonco @mathonco.bsky.social @deniswirtz.bsky.social
www.cell.com/cell/fulltex...
@jktgfoundation.bsky.social @itcrtraining.bsky.social @smbmathbiology.bsky.social #mathbio #mathonco @mathonco.bsky.social @deniswirtz.bsky.social
Human interpretable grammar encodes multicellular systems biology models to democratize virtual cell laboratories
We developed a plain text modeling language—a cell behavior hypothesis grammar—to
easily build virtual cell models and connect them to data, helping scientists to unlock
the hidden dynamics of tissues...
www.cell.com
July 29, 2025 at 6:15 AM
This looks very cool... implementing mathematical models of cell and tissue biology from plain-text human readable statements. I want to have a play with it! Congratulations Paul @mathcancer.bsky.social and team
Congrats Kit! @yosoykit.bsky.social Extremely worthy recipient of the Leah Edelstein-Kehset prize #SMB2025: she is leading the way modelling disease progression to improve early detection and prevention of #cancer
smb.org/SMB-Awards
smb.org/SMB-Awards
July 17, 2025 at 7:05 PM
Congrats Kit! @yosoykit.bsky.social Extremely worthy recipient of the Leah Edelstein-Kehset prize #SMB2025: she is leading the way modelling disease progression to improve early detection and prevention of #cancer
smb.org/SMB-Awards
smb.org/SMB-Awards
Goldschmidt's hopeful monsters in cancer: single cell DNAseq shows whole genome doubling (WGD) is an ongoing and frequent mutational process in ovarian cancer. www.nature.com/articles/s41... beautiful work from @sohrabshah.bsky.social and team
Ongoing genome doubling shapes evolvability and immunity in ovarian cancer - Nature
A single-cell sequencing study using more than 30,000 tumour genomes from human ovarian cancers shows that whole-genome doubling is an ongoing mutational process that drives tumour evolution and disru...
www.nature.com
July 17, 2025 at 8:24 AM
Goldschmidt's hopeful monsters in cancer: single cell DNAseq shows whole genome doubling (WGD) is an ongoing and frequent mutational process in ovarian cancer. www.nature.com/articles/s41... beautiful work from @sohrabshah.bsky.social and team
Reposted by Trevor Graham
Schmidt Fellowships for #AI in #cancer research 2025 round is now open. These are pathway to independence fellowships between @icr.ac.uk & @imperialcollegeldn.bsky.social that support fellows to be competitive for faculty jobs at the end of the 2 year funding. www.imperial.ac.uk/jobs/search-...
Search jobs for external candidates | Jobs | Imperial College London
www.imperial.ac.uk
July 15, 2025 at 8:01 AM
Schmidt Fellowships for #AI in #cancer research 2025 round is now open. These are pathway to independence fellowships between @icr.ac.uk & @imperialcollegeldn.bsky.social that support fellows to be competitive for faculty jobs at the end of the 2 year funding. www.imperial.ac.uk/jobs/search-...
Schmidt Fellowships for #AI in #cancer research 2025 round is now open. These are pathway to independence fellowships between @icr.ac.uk & @imperialcollegeldn.bsky.social that support fellows to be competitive for faculty jobs at the end of the 2 year funding. www.imperial.ac.uk/jobs/search-...
Search jobs for external candidates | Jobs | Imperial College London
www.imperial.ac.uk
July 15, 2025 at 8:01 AM
Schmidt Fellowships for #AI in #cancer research 2025 round is now open. These are pathway to independence fellowships between @icr.ac.uk & @imperialcollegeldn.bsky.social that support fellows to be competitive for faculty jobs at the end of the 2 year funding. www.imperial.ac.uk/jobs/search-...
New review from @chloecolson.bsky.social on cancer evolution & plasticity from a mathematical modelling lens: www.sciencedirect.com/science/arti...
Chloe provides a framework to think about plasticity & evolution, & explains how maths models can reveal cell dynamics that we can't directly observe.
Chloe provides a framework to think about plasticity & evolution, & explains how maths models can reveal cell dynamics that we can't directly observe.
Mathematical modelling of cancer cell evolution and plasticity
In this review, we argue that mathematical modelling is an essential tool for understanding cancer cell evolution and phenotypic plasticity. We show t…
www.sciencedirect.com
July 10, 2025 at 1:42 PM
New review from @chloecolson.bsky.social on cancer evolution & plasticity from a mathematical modelling lens: www.sciencedirect.com/science/arti...
Chloe provides a framework to think about plasticity & evolution, & explains how maths models can reveal cell dynamics that we can't directly observe.
Chloe provides a framework to think about plasticity & evolution, & explains how maths models can reveal cell dynamics that we can't directly observe.
Enjoyed this @natrevcancer.nature.com article on comparative oncology - how we can learn from other species 🐘🐋🦜🐍 about ways to prevent (& possibly treat) cancer. Both a review and a call to action for the research community. www.nature.com/articles/s41... @atjcagan.bsky.social @cmaley.bsky.social
Advancing cancer research via comparative oncology - Nature Reviews Cancer
Comparative oncology combines evolutionary biology, ecology, veterinary medicine and clinical oncology to better understand cancer, for example, by identifying the molecular and cellular mechanisms un...
www.nature.com
July 8, 2025 at 2:04 PM
Enjoyed this @natrevcancer.nature.com article on comparative oncology - how we can learn from other species 🐘🐋🦜🐍 about ways to prevent (& possibly treat) cancer. Both a review and a call to action for the research community. www.nature.com/articles/s41... @atjcagan.bsky.social @cmaley.bsky.social
Congratulations @vinaya-gunasri.bsky.social. Fantastic achievement, look forward to seeing your lab grow.
🏆 Honoured to receive the 2025 Inaugural BACR Early Career Award!
Grateful to @thebacr.bsky.social and all who’ve supported me — esp. @trevorgraham.bsky.social, @eszterlakatos.bsky.social & @cancerresearchuk.org 💙
Reflections→ www.bacr.org.uk/news/2025-in...
#CancerResearch #EarlyCareer #ScienceWins
Grateful to @thebacr.bsky.social and all who’ve supported me — esp. @trevorgraham.bsky.social, @eszterlakatos.bsky.social & @cancerresearchuk.org 💙
Reflections→ www.bacr.org.uk/news/2025-in...
#CancerResearch #EarlyCareer #ScienceWins
July 4, 2025 at 6:07 PM
Congratulations @vinaya-gunasri.bsky.social. Fantastic achievement, look forward to seeing your lab grow.
Great press write up of @beckilee.bsky.social's DyNAMIC clinical trial, testing adaptive targeted therapy for melanoma with ctDNA guided decision making. The hope is that ctDNA guided treatment cessation and restart (potentially less drug, less often) will improve outcomes for patients.
Mathematical models and ctdna have reached the clinic - the ultimate personalised trial testing adaptive targeted therapy highlighted in the news today!
#EBEcancer25
www.express.co.uk/life-style/h...
#EBEcancer25
www.express.co.uk/life-style/h...
UK cancer breakthrough as simple blood test could help pinpoint treatment
EXCLUSIVE: Skin cancers can be among the most aggressive forms of the disease so using drugs to shrink them must be used with precision.
www.express.co.uk
July 2, 2025 at 7:25 PM
Great press write up of @beckilee.bsky.social's DyNAMIC clinical trial, testing adaptive targeted therapy for melanoma with ctDNA guided decision making. The hope is that ctDNA guided treatment cessation and restart (potentially less drug, less often) will improve outcomes for patients.
Reposted by Trevor Graham
Who were the ancient Egyptians?
It is expressed in the extraordinary historical and archaeological record, but what about ancestry links to other ancient individuals?
Today we report the successful sequencing of the whole genome of an individual who lived in Egypt about ~4700 years ago.
It is expressed in the extraordinary historical and archaeological record, but what about ancestry links to other ancient individuals?
Today we report the successful sequencing of the whole genome of an individual who lived in Egypt about ~4700 years ago.
July 2, 2025 at 3:22 PM
Who were the ancient Egyptians?
It is expressed in the extraordinary historical and archaeological record, but what about ancestry links to other ancient individuals?
Today we report the successful sequencing of the whole genome of an individual who lived in Egypt about ~4700 years ago.
It is expressed in the extraordinary historical and archaeological record, but what about ancestry links to other ancient individuals?
Today we report the successful sequencing of the whole genome of an individual who lived in Egypt about ~4700 years ago.
Our Evolutionary Biology and Ecology of Cancer Summer School #EBECancer2025 in full swing @eventswcs.bsky.social in sunny Hinxton, Cambridge. @florentmouliere.bsky.social giving a deep dive into tracking cancer evolution with cfDNA. @amyboddy.bsky.social @yosoykit.bsky.social @afrankell.bsky.social
July 1, 2025 at 11:30 AM
Our Evolutionary Biology and Ecology of Cancer Summer School #EBECancer2025 in full swing @eventswcs.bsky.social in sunny Hinxton, Cambridge. @florentmouliere.bsky.social giving a deep dive into tracking cancer evolution with cfDNA. @amyboddy.bsky.social @yosoykit.bsky.social @afrankell.bsky.social