Dan Landau
@landau.bsky.social
Oncologist-scientist at Weill Cornell and New York genome center. Into somatic evolution, trees and words
Reposted by Dan Landau
Hot off the press! Our latest paper led by @fernpizza.bsky.social, understanding how plasmids evolve inside cells. These small, self-replicating DNA circles live inside bacteria and carry antibiotic resistance genes, but also compete with one another to replicate. 1/
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
Intracellular competition shapes plasmid population dynamics
From populations of multicellular organisms to selfish genetic elements, conflicts between levels of biological organization are central to evolution. Plasmids are extrachromosomal, self-replicating g...
www.science.org
November 20, 2025 at 9:42 PM
Hot off the press! Our latest paper led by @fernpizza.bsky.social, understanding how plasmids evolve inside cells. These small, self-replicating DNA circles live inside bacteria and carry antibiotic resistance genes, but also compete with one another to replicate. 1/
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
Reposted by Dan Landau
Super cool paper from Sheel Chandra + Ziyue Gao. kmer context matters a lot for mutability of both methylated and unmethylated CpGs.
But!! the effect of kmer context on unmethylated CpGs is basically independent of the effect of kmer context on methylated CpGs!
www.biorxiv.org/content/10.1...
But!! the effect of kmer context on unmethylated CpGs is basically independent of the effect of kmer context on methylated CpGs!
www.biorxiv.org/content/10.1...
Sequence context and methylation interact to shape germline mutation rate variation at CpG sites
A prominent example of sequence context-dependent mutation rate variation is the elevated transition rate at CpG sites, which is largely attributed to cytosine methylation. CpGs with different flankin...
www.biorxiv.org
November 18, 2025 at 8:13 PM
Super cool paper from Sheel Chandra + Ziyue Gao. kmer context matters a lot for mutability of both methylated and unmethylated CpGs.
But!! the effect of kmer context on unmethylated CpGs is basically independent of the effect of kmer context on methylated CpGs!
www.biorxiv.org/content/10.1...
But!! the effect of kmer context on unmethylated CpGs is basically independent of the effect of kmer context on methylated CpGs!
www.biorxiv.org/content/10.1...
Reposted by Dan Landau
Honored to be recognized by @usnews.com as a 2025 #BestLeader alongside so many incredible colleagues and individuals I admire!
www.usnews.com/news/best-le...
www.usnews.com/news/best-le...
November 17, 2025 at 2:09 PM
Honored to be recognized by @usnews.com as a 2025 #BestLeader alongside so many incredible colleagues and individuals I admire!
www.usnews.com/news/best-le...
www.usnews.com/news/best-le...
Reposted by Dan Landau
So awesome to have this great paper from Sam Reffsin and Sara Cherry out! In it, we use retrospective clone tracing to show that there are particular single cell states that are more susceptible to viral infection (both SARS-CoV-2 and flu)!
www.cell.com/cell/fulltex...
www.cell.com/cell/fulltex...
Single-cell susceptibility to viral infection is driven by variable cell states
Not all cells that can be infected by a virus become infected with that virus. Single-cell
clone tracing reveals intrinsic cell states with variable expression patterns that
increase susceptibility to...
www.cell.com
November 14, 2025 at 4:47 PM
So awesome to have this great paper from Sam Reffsin and Sara Cherry out! In it, we use retrospective clone tracing to show that there are particular single cell states that are more susceptible to viral infection (both SARS-CoV-2 and flu)!
www.cell.com/cell/fulltex...
www.cell.com/cell/fulltex...
Reposted by Dan Landau
You are infinitely closer to struggling than you ever will be to billionaires
James Van Der Beek Auctioning Off Dawson’s Creek Items Amid Cancer Journey
James Van Der Beek has put several Dawson’s Creek and Varsity Blues items up for auction as he continues to battle stage 3 colon cancer.
www.eonline.com
November 13, 2025 at 12:09 AM
You are infinitely closer to struggling than you ever will be to billionaires
Reposted by Dan Landau
Super excited about first Shendure/Baker Lab collaboration & preprint on a multiplex sequencing-based strategy for screening de novo proteome editors in mammalian cells. Kudos to the brilliant Chase Suiter (not here) & @greenahn.bsky.social on the work! Preprint here:
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
October 14, 2025 at 6:45 PM
Super excited about first Shendure/Baker Lab collaboration & preprint on a multiplex sequencing-based strategy for screening de novo proteome editors in mammalian cells. Kudos to the brilliant Chase Suiter (not here) & @greenahn.bsky.social on the work! Preprint here:
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Reposted by Dan Landau
Trying to work from home with my kids around
October 14, 2025 at 5:05 PM
Trying to work from home with my kids around
Reposted by Dan Landau
🚀 Excited to share SMART-PTA (miniaturized Primary Template Amplification) a high-throughput single-cell whole-genome amplification method that preserves clonal lineage information while enabling deep genomic and transcriptomic profiling.
Shout out to Tamara Prieto, Dennis Yuan, John Zinno and @ivanraimondi.bsky.social . Thank you to our funders at @themarkfdn.bsky.social
October 14, 2025 at 2:42 PM
🚀 Excited to share SMART-PTA (miniaturized Primary Template Amplification) a high-throughput single-cell whole-genome amplification method that preserves clonal lineage information while enabling deep genomic and transcriptomic profiling.
Big, beautiful trees!!
SMART-PTA for whole-genome+transcriptome on thousand of single cells from the normal human esophagus 🤯 Massively scaling up the power of scWGS to build deep phylogenies and chart somatic evolution from birth throughout life.
www.biorxiv.org/content/10.1...
SMART-PTA for whole-genome+transcriptome on thousand of single cells from the normal human esophagus 🤯 Massively scaling up the power of scWGS to build deep phylogenies and chart somatic evolution from birth throughout life.
www.biorxiv.org/content/10.1...
October 14, 2025 at 2:37 PM
Big, beautiful trees!!
SMART-PTA for whole-genome+transcriptome on thousand of single cells from the normal human esophagus 🤯 Massively scaling up the power of scWGS to build deep phylogenies and chart somatic evolution from birth throughout life.
www.biorxiv.org/content/10.1...
SMART-PTA for whole-genome+transcriptome on thousand of single cells from the normal human esophagus 🤯 Massively scaling up the power of scWGS to build deep phylogenies and chart somatic evolution from birth throughout life.
www.biorxiv.org/content/10.1...
Reposted by Dan Landau
I'm very pleased to announce the official publication of our lab's paper "DNA mutagenesis driven by transcription factor competition with mismatch repair" in today's issue of Cell! www.cell.com/cell/abstrac...
DNA mutagenesis driven by transcription factor competition with mismatch repair
Competition between transcription factors and mismatch repair machinery drives localized
hypermutation at regulatory elements, with implications for cancer and genome evolution.
www.cell.com
October 2, 2025 at 11:37 PM
I'm very pleased to announce the official publication of our lab's paper "DNA mutagenesis driven by transcription factor competition with mismatch repair" in today's issue of Cell! www.cell.com/cell/abstrac...
Reposted by Dan Landau
Do you like theoretical biology, mathematical&conceptual modelling and want to apply yourself to cutting-edge research at all levels of biology, from molecules to ecosystems?
Come to EMBL! Scope includes physics-based models, emergence, statistics, ML/AI
embl.wd103.myworkdayjobs.com/en-US/EMBL/j...
Come to EMBL! Scope includes physics-based models, emergence, statistics, ML/AI
embl.wd103.myworkdayjobs.com/en-US/EMBL/j...
September 29, 2025 at 7:03 AM
Do you like theoretical biology, mathematical&conceptual modelling and want to apply yourself to cutting-edge research at all levels of biology, from molecules to ecosystems?
Come to EMBL! Scope includes physics-based models, emergence, statistics, ML/AI
embl.wd103.myworkdayjobs.com/en-US/EMBL/j...
Come to EMBL! Scope includes physics-based models, emergence, statistics, ML/AI
embl.wd103.myworkdayjobs.com/en-US/EMBL/j...
Reposted by Dan Landau
If you want to deep dive in to immunology you could do worse than Gabriel's evolutionary landscaping
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Replaying germinal center evolution on a quantified affinity landscape
Darwinian evolution of immunoglobulin genes within germinal centers (GC) underlies the progressive increase in antibody affinity following antigen exposure. Whereas the mechanics of how competition be...
www.biorxiv.org
September 27, 2025 at 1:41 PM
If you want to deep dive in to immunology you could do worse than Gabriel's evolutionary landscaping
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Reposted by Dan Landau
It's probably the deterioration of social media (I hope) but i'm exposed to a lot less cool science. It used to feel like a new cool study is being preprinted/published every week, and lately it's rare (at least so it seems). Share a recent study that's worth knowing!
September 26, 2025 at 10:26 AM
It's probably the deterioration of social media (I hope) but i'm exposed to a lot less cool science. It used to feel like a new cool study is being preprinted/published every week, and lately it's rare (at least so it seems). Share a recent study that's worth knowing!
Reposted by Dan Landau
Well don't I feel stupid
September 26, 2025 at 11:02 PM
Well don't I feel stupid
Reposted by Dan Landau
Seven years.
Over 400 pages.
About 750 references.
Over 40 figures.
Finally I get to hold the finished book.
It’s a big day.
#EpigeneticsBook
@cshlpress.bsky.social
Over 400 pages.
About 750 references.
Over 40 figures.
Finally I get to hold the finished book.
It’s a big day.
#EpigeneticsBook
@cshlpress.bsky.social
September 25, 2025 at 5:23 PM
Seven years.
Over 400 pages.
About 750 references.
Over 40 figures.
Finally I get to hold the finished book.
It’s a big day.
#EpigeneticsBook
@cshlpress.bsky.social
Over 400 pages.
About 750 references.
Over 40 figures.
Finally I get to hold the finished book.
It’s a big day.
#EpigeneticsBook
@cshlpress.bsky.social
Reposted by Dan Landau
Epigenetic diagnosis of acute leukemia within two hours from sample receipt 🚀
Very happy to share the results of a great collaboration between @hovestadt.bsky.social and Griffin Labs, I co-led with @sbenfatto.bsky.social, published today in @natgenet.nature.com
📄 www.nature.com/articles/s41...
🧵1/n
Very happy to share the results of a great collaboration between @hovestadt.bsky.social and Griffin Labs, I co-led with @sbenfatto.bsky.social, published today in @natgenet.nature.com
📄 www.nature.com/articles/s41...
🧵1/n
Rapid epigenomic classification of acute leukemia - Nature Genetics
The authors present a molecular classification of acute leukemia using 5-methylcytosine signatures, together with a neural network-based classifier for clinical use.
www.nature.com
September 22, 2025 at 8:41 PM
Epigenetic diagnosis of acute leukemia within two hours from sample receipt 🚀
Very happy to share the results of a great collaboration between @hovestadt.bsky.social and Griffin Labs, I co-led with @sbenfatto.bsky.social, published today in @natgenet.nature.com
📄 www.nature.com/articles/s41...
🧵1/n
Very happy to share the results of a great collaboration between @hovestadt.bsky.social and Griffin Labs, I co-led with @sbenfatto.bsky.social, published today in @natgenet.nature.com
📄 www.nature.com/articles/s41...
🧵1/n
Reposted by Dan Landau
Major advance for refractory lupus by engineering the T cells in the patient's body (in vivo) and achieving success in 5 patients @nejm.org (uses mRNA/nanoparticle package)
www.nejm.org/doi/full/10....
www.nejm.org/doi/full/10....
September 17, 2025 at 9:33 PM
Major advance for refractory lupus by engineering the T cells in the patient's body (in vivo) and achieving success in 5 patients @nejm.org (uses mRNA/nanoparticle package)
www.nejm.org/doi/full/10....
www.nejm.org/doi/full/10....
Reposted by Dan Landau
Interested in cellular plasticity? Come to my live virtual talk at the Night Science Seminar Series! Free register here: cassyni.com/events/ApfsK...
September 12, 2025 at 9:17 PM
Interested in cellular plasticity? Come to my live virtual talk at the Night Science Seminar Series! Free register here: cassyni.com/events/ApfsK...
Reposted by Dan Landau
I feel deeply honored to receive the 2025 Dr. Josef Steiner Cancer Research Award for our work on decoding and rewiring the immune-evasive TME. It truly is a recognition of the entire team past and present as well as our collaborators and mentors.🙌 Thank you for your trust!
Congratulations to our @obenaufa.bsky.social on receiving the highly prestigious Dr. Josef Steiner Cancer Research Award 2025! 🎉
Read more in this interview with Anna: www.imp.ac.at/news/article...
Read more in this interview with Anna: www.imp.ac.at/news/article...
September 12, 2025 at 4:22 PM
I feel deeply honored to receive the 2025 Dr. Josef Steiner Cancer Research Award for our work on decoding and rewiring the immune-evasive TME. It truly is a recognition of the entire team past and present as well as our collaborators and mentors.🙌 Thank you for your trust!
Reposted by Dan Landau
Reposted by Dan Landau
Paper from me, Michelle Curtis, @soumya-boston.bsky.social and co out now in @natmethods.nature.com! We now call it starCAT instead of *CAT but the strategy is the same: Build a catalog of ~50 interpretable T cell gene expression programs + use them to interpret new data nature.com/articles/s41...
Reproducible single-cell annotation of programs underlying T cell subsets, activation states and functions - Nature Methods
TCAT is a pipeline that can simultaneously capture gene expression programs related to T cell subsets and activation states for accurate T cell characterization.
nature.com
September 3, 2025 at 4:46 PM
Paper from me, Michelle Curtis, @soumya-boston.bsky.social and co out now in @natmethods.nature.com! We now call it starCAT instead of *CAT but the strategy is the same: Build a catalog of ~50 interpretable T cell gene expression programs + use them to interpret new data nature.com/articles/s41...
Reposted by Dan Landau
Microbiomes are interactive, multispecies communities, but bulk analysis obscures functional diversification from environmental and genetic heterogeneity. In our new review we describe how single-bacterium transcriptomics dissects microbiomes at cellular resolution.
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
September 6, 2025 at 10:13 PM
Microbiomes are interactive, multispecies communities, but bulk analysis obscures functional diversification from environmental and genetic heterogeneity. In our new review we describe how single-bacterium transcriptomics dissects microbiomes at cellular resolution.
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
Reposted by Dan Landau
Postscript by Seamus Heaney who died twelve years ago today
August 30, 2025 at 4:35 PM
Postscript by Seamus Heaney who died twelve years ago today
Reposted by Dan Landau
Looks interesting! www.nature.com/articles/s41...
Maternal stress triggers early-life eczema through fetal mast cell programming - Nature
Prenatal stress triggers molecular dysregulations in fetal neuroimmune circuits, leading to altered mast cell and sensory neuron function, which predisposes offspring to develop eczema in response to ...
www.nature.com
August 27, 2025 at 6:04 PM
Looks interesting! www.nature.com/articles/s41...
Reposted by Dan Landau
