Vijay G. Sankaran
@bloodgenes.bsky.social
Pediatric Hematologist/Oncologist, Geneticist, Stem Cell Biologist
bloodgenes.org
bloodgenes.org
Reposted by Vijay G. Sankaran
🩸 Dr. Lucrezia della Volpe and a team in Dr. Vijay Sankaran's lab (@bloodgenes.bsky.social) discovered that ferroptosis is a key barrier to HSC survival during ex vivo culture.
Read their @natcellbio.nature.com paper: https://go.nature.com/4ib4Ln6
Listen to the discussion: https://bit.ly/48dmghX
Read their @natcellbio.nature.com paper: https://go.nature.com/4ib4Ln6
Listen to the discussion: https://bit.ly/48dmghX
November 27, 2025 at 4:53 PM
🩸 Dr. Lucrezia della Volpe and a team in Dr. Vijay Sankaran's lab (@bloodgenes.bsky.social) discovered that ferroptosis is a key barrier to HSC survival during ex vivo culture.
Read their @natcellbio.nature.com paper: https://go.nature.com/4ib4Ln6
Listen to the discussion: https://bit.ly/48dmghX
Read their @natcellbio.nature.com paper: https://go.nature.com/4ib4Ln6
Listen to the discussion: https://bit.ly/48dmghX
Reposted by Vijay G. Sankaran
The US government support of cancer research via NCI
has been severely cut.
And of June 2025, "There were 181 individual terminated NCI funded grants, with a total award amount of $640,867, 956."
jamanetwork.com/journals/jam...
has been severely cut.
And of June 2025, "There were 181 individual terminated NCI funded grants, with a total award amount of $640,867, 956."
jamanetwork.com/journals/jam...
Disrupted Federal Funding for Extramural Cancer Research
This cross-sectional study assesses the scale and scope of terminated cancer research grants from the National Cancer Institute.
jamanetwork.com
November 26, 2025 at 4:59 PM
The US government support of cancer research via NCI
has been severely cut.
And of June 2025, "There were 181 individual terminated NCI funded grants, with a total award amount of $640,867, 956."
jamanetwork.com/journals/jam...
has been severely cut.
And of June 2025, "There were 181 individual terminated NCI funded grants, with a total award amount of $640,867, 956."
jamanetwork.com/journals/jam...
Reposted by Vijay G. Sankaran
Excited to share a preprint of my PhD project looking at interactions between SNPs and polygenic scores in the UK Biobank!
A thread... 🧵
www.medrxiv.org/content/10.1...
A thread... 🧵
www.medrxiv.org/content/10.1...
Interactions with polygenic background impact quantitative traits in the UK Biobank
Association studies have linked many genetic variants to a variety of phenotypes but under-standing the biological mechanisms underlying these signals remains a major challenge. Since genes operate wi...
www.medrxiv.org
November 24, 2025 at 5:13 PM
Excited to share a preprint of my PhD project looking at interactions between SNPs and polygenic scores in the UK Biobank!
A thread... 🧵
www.medrxiv.org/content/10.1...
A thread... 🧵
www.medrxiv.org/content/10.1...
If you have not read this moving and courageous essay from Tatiana Schlossberg in the @newyorker.com, please check it out. You may be wondering why inv(3) leukemia is so deadly? Here is a brief 🧵 (1/n)
Tatiana Schlossberg, the daughter of Caroline Kennedy, had just given birth when she was diagnosed with a rare form of leukemia. She writes about her fear of adding another tragedy to her family’s life. https://newyorkermag.visitlink.me/CLpbsb
November 24, 2025 at 2:40 PM
If you have not read this moving and courageous essay from Tatiana Schlossberg in the @newyorker.com, please check it out. You may be wondering why inv(3) leukemia is so deadly? Here is a brief 🧵 (1/n)
Reposted by Vijay G. Sankaran
I wrote a little bit about the "missing heritability" question and several recent studies that have brought it to a close. A short 🧵
The missing heritability question is now (mostly) answered
Not with a bang but with a whimper
theinfinitesimal.substack.com
November 21, 2025 at 10:34 PM
I wrote a little bit about the "missing heritability" question and several recent studies that have brought it to a close. A short 🧵
Reposted by Vijay G. Sankaran
Your bloodstream is a battlefield and a delivery service, all at once! 🩸🧪
Quinten Geldhof, also known as Microhobbyist, takes you into a drop of blood to explain how red blood cells lack a nucleus so they can carry more oxygen throughout your body.
Watch the video here:
Quinten Geldhof, also known as Microhobbyist, takes you into a drop of blood to explain how red blood cells lack a nucleus so they can carry more oxygen throughout your body.
Watch the video here:
Blood Under A Microscope: An Ecosystem That Keeps You Alive
YouTube video by Museum of Science
www.youtube.com
November 20, 2025 at 9:17 PM
Your bloodstream is a battlefield and a delivery service, all at once! 🩸🧪
Quinten Geldhof, also known as Microhobbyist, takes you into a drop of blood to explain how red blood cells lack a nucleus so they can carry more oxygen throughout your body.
Watch the video here:
Quinten Geldhof, also known as Microhobbyist, takes you into a drop of blood to explain how red blood cells lack a nucleus so they can carry more oxygen throughout your body.
Watch the video here:
Reposted by Vijay G. Sankaran
New discovery in ulcerative colitis: a bacterial toxin that kills macrophages and increases inflammation, which could be the foundation for a new treatment
science.org/doi/10.1126/...
science.org/doi/10.1126/...
@science.org
science.org/doi/10.1126/...
science.org/doi/10.1126/...
@science.org
A bacterial toxin disarms gut defenses against inflammation
Macrophage-toxic bacteria from patients with ulcerative colitis worsen gut inflammation in mice
science.org
November 20, 2025 at 7:25 PM
New discovery in ulcerative colitis: a bacterial toxin that kills macrophages and increases inflammation, which could be the foundation for a new treatment
science.org/doi/10.1126/...
science.org/doi/10.1126/...
@science.org
science.org/doi/10.1126/...
science.org/doi/10.1126/...
@science.org
Ferroptosis and 🩸 stem cell biology have a lot to say to each other... Hoping this work inspires #ferroptosis researchers to explore HSCs and #hematopoiesis researchers to lean into ferroptosis 🤝
Excited to share our new study, led by @dellaVolpe_L, now out in @natcellbio.nature.com! Blocking #ferroptosis enhances human 🩸 stem cell expansion, with implications for transplantation and gene therapy. www.nature.com/articles/s41...
November 19, 2025 at 10:07 PM
Ferroptosis and 🩸 stem cell biology have a lot to say to each other... Hoping this work inspires #ferroptosis researchers to explore HSCs and #hematopoiesis researchers to lean into ferroptosis 🤝
Excited to share our new study, led by @dellaVolpe_L, now out in @natcellbio.nature.com! Blocking #ferroptosis enhances human 🩸 stem cell expansion, with implications for transplantation and gene therapy. www.nature.com/articles/s41...
November 18, 2025 at 5:49 PM
Excited to share our new study, led by @dellaVolpe_L, now out in @natcellbio.nature.com! Blocking #ferroptosis enhances human 🩸 stem cell expansion, with implications for transplantation and gene therapy. www.nature.com/articles/s41...
Honored to be recognized by @usnews.com as a 2025 #BestLeader alongside so many incredible colleagues and individuals I admire!
www.usnews.com/news/best-le...
www.usnews.com/news/best-le...
November 17, 2025 at 2:09 PM
Honored to be recognized by @usnews.com as a 2025 #BestLeader alongside so many incredible colleagues and individuals I admire!
www.usnews.com/news/best-le...
www.usnews.com/news/best-le...
Really excited for this session at #ASH25 💻🧠🩸!! Please come and join us on Saturday, December 6th, at 4 pm!
#ASH25 is your front-row seat to the future of #hematology Experience the breakthroughs changing the field with Dr. Vijay G. Sankaran as experts explore how #AI is driving new possibilities in research & the care of patients.
🔗 https://ow.ly/7Ev850XpIzU
#ASHinaFlash
🔗 https://ow.ly/7Ev850XpIzU
#ASHinaFlash
November 11, 2025 at 1:25 AM
Really excited for this session at #ASH25 💻🧠🩸!! Please come and join us on Saturday, December 6th, at 4 pm!
Reposted by Vijay G. Sankaran
Therapeutic benefit of intratumoral inhibition of FSP1 & ferroptosis in pre-clinical lung cancer and versus melanoma growth in lymph nodes @nature.com
www.nature.com/articles/s41...
www.nature.com/articles/s41...
www.nature.com/articles/s41...
www.nature.com/articles/s41...
November 5, 2025 at 10:45 PM
Therapeutic benefit of intratumoral inhibition of FSP1 & ferroptosis in pre-clinical lung cancer and versus melanoma growth in lymph nodes @nature.com
www.nature.com/articles/s41...
www.nature.com/articles/s41...
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Great to see these fantastic studies defining thymic stromal cells that could enable regeneration of T cells from @ScaddenLab (mesenchymal) and from @dudakov-lab.bsky.social, @DrMvandenBrink, and colleagues (epithelial):
www.nature.com/articles/s41...
www.nature.com/articles/s41...
www.nature.com/articles/s41...
www.nature.com/articles/s41...
November 4, 2025 at 1:52 PM
Great to see these fantastic studies defining thymic stromal cells that could enable regeneration of T cells from @ScaddenLab (mesenchymal) and from @dudakov-lab.bsky.social, @DrMvandenBrink, and colleagues (epithelial):
www.nature.com/articles/s41...
www.nature.com/articles/s41...
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Really fortunate to have had the privilege to work with Parmesh Thakoordial! Congratulations, Parmesh!!!
www.albany.edu/news-center/...
www.albany.edu/news-center/...
Junior Earns Obama-Chesky Scholarship for Public Service
UAlbany Junior Parmesh Thakoordial was recently named a recipient of the Obama-Chesky Scholarship for Public Service, a prestigious national program created by former President Barack Obama, Michelle ...
www.albany.edu
October 30, 2025 at 12:50 PM
Really fortunate to have had the privilege to work with Parmesh Thakoordial! Congratulations, Parmesh!!!
www.albany.edu/news-center/...
www.albany.edu/news-center/...
Reposted by Vijay G. Sankaran
What happens to our immune system with aging, reducing vaccine response?
Our memory T cells undergo a dramatic shift resulting in dysregulated B cell antibody production
@alleninstitute.org @nature.com
www.nature.com/articles/s41...
Our memory T cells undergo a dramatic shift resulting in dysregulated B cell antibody production
@alleninstitute.org @nature.com
www.nature.com/articles/s41...
Multi-omic profiling reveals age-related immune dynamics in healthy adults - Nature
This multi-omic longitudinal analysis of the healthy human peripheral immune system constructs the Human Immune Health Atlas and assembles data on immune cell composition and state changes w...
www.nature.com
October 29, 2025 at 4:10 PM
What happens to our immune system with aging, reducing vaccine response?
Our memory T cells undergo a dramatic shift resulting in dysregulated B cell antibody production
@alleninstitute.org @nature.com
www.nature.com/articles/s41...
Our memory T cells undergo a dramatic shift resulting in dysregulated B cell antibody production
@alleninstitute.org @nature.com
www.nature.com/articles/s41...
Reposted by Vijay G. Sankaran
Excited to share our study out in @natcellbio.nature.com! Led by @mikelangelipid.bsky.social, we identify the first #LipidDroplet lipid quality control pathway: LD-localized FSP1 protects stored lipids from oxidative damage and prevents LD-initiated #ferroptosis.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
FSP1-mediated lipid droplet quality control prevents neutral lipid peroxidation and ferroptosis - Nature Cell Biology
Lange et al. identify a lipid droplet quality control pathway in which FSP1 safeguards stored neutral lipids from lipid peroxidation, thereby preventing the induction of ferroptosis.
www.nature.com
October 29, 2025 at 5:21 PM
Excited to share our study out in @natcellbio.nature.com! Led by @mikelangelipid.bsky.social, we identify the first #LipidDroplet lipid quality control pathway: LD-localized FSP1 protects stored lipids from oxidative damage and prevents LD-initiated #ferroptosis.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by Vijay G. Sankaran
New findings from Xiaohui Zhang, Bo Huang et al. not only elucidate the molecular mechanism of JAK2V617F essential #thrombocythemia but also provide a potential strategy for its treatment. rupress.org/jem/article/...
#Hematopoiesis
#Hematopoiesis
October 29, 2025 at 2:45 PM
New findings from Xiaohui Zhang, Bo Huang et al. not only elucidate the molecular mechanism of JAK2V617F essential #thrombocythemia but also provide a potential strategy for its treatment. rupress.org/jem/article/...
#Hematopoiesis
#Hematopoiesis
Terrific work from @kyleferchen.bsky.social, @nathansalomonis.bsky.social, @leegrimeslab.bsky.social, and colleagues that advances our understanding of hematopoiesis by integrating multiple single-cell data types in @natimmunol.nature.com: rdcu.be/eL8oO
October 29, 2025 at 1:25 PM
Terrific work from @kyleferchen.bsky.social, @nathansalomonis.bsky.social, @leegrimeslab.bsky.social, and colleagues that advances our understanding of hematopoiesis by integrating multiple single-cell data types in @natimmunol.nature.com: rdcu.be/eL8oO
If you are stuck in an airport, it is made so much better by having friendly hematologists around!🩸
October 25, 2025 at 12:56 AM
If you are stuck in an airport, it is made so much better by having friendly hematologists around!🩸
Reposted by Vijay G. Sankaran
1/10 Genome maintenance by telomerase is a fundamental process in nearly all eukaryotes. But where does it come from?
Today, we report the discovery of telomerase homologs in a family of antiviral RTs, revealing an unexpected evolutionary origin in bacteria.
www.biorxiv.org/content/10.1...
Today, we report the discovery of telomerase homologs in a family of antiviral RTs, revealing an unexpected evolutionary origin in bacteria.
www.biorxiv.org/content/10.1...
Antiviral reverse transcriptases reveal the evolutionary origin of telomerase
Defense-associated reverse transcriptases (DRTs) employ diverse and distinctive mechanisms of cDNA synthesis to protect bacteria against viral infection. However, much of DRT family diversity remains ...
www.biorxiv.org
October 17, 2025 at 5:22 PM
1/10 Genome maintenance by telomerase is a fundamental process in nearly all eukaryotes. But where does it come from?
Today, we report the discovery of telomerase homologs in a family of antiviral RTs, revealing an unexpected evolutionary origin in bacteria.
www.biorxiv.org/content/10.1...
Today, we report the discovery of telomerase homologs in a family of antiviral RTs, revealing an unexpected evolutionary origin in bacteria.
www.biorxiv.org/content/10.1...
Reposted by Vijay G. Sankaran
We are pleased to announce Dr. Wendy Chung of Harvard Medical School as the 2026 APS & SPR Mary Ellen Avery Neonatal Award Recipient! The award will be presented at the PAS 2026 Meeting. Congratulations, Dr. Chung!
Read More: https://ow.ly/kOb850Xbagg
Read More: https://ow.ly/kOb850Xbagg
October 14, 2025 at 4:02 PM
We are pleased to announce Dr. Wendy Chung of Harvard Medical School as the 2026 APS & SPR Mary Ellen Avery Neonatal Award Recipient! The award will be presented at the PAS 2026 Meeting. Congratulations, Dr. Chung!
Read More: https://ow.ly/kOb850Xbagg
Read More: https://ow.ly/kOb850Xbagg
Fortunate to work and 🎳 with this amazing team!!!
October 9, 2025 at 9:27 PM
Fortunate to work and 🎳 with this amazing team!!!
Reposted by Vijay G. Sankaran
Our latest work is out in Nature today. In this paper, we introduce an improved version of NanoSeq, a duplex sequencing protocol with <5 errors per billion bp in single DNA molecules, and use it to study the somatic mutation landscape of oral epithelium in >1000 people www.nature.com/articles/s41...
Somatic mutation and selection at population scale - Nature
A new version of nanorate DNA sequencing, with an error rate lower than five errors per billion base pairs and compatible with whole-exome and targeted capture, enables epidemiological-scale studies of somatic mutation and selection and the generation of high-resolution selection maps across coding and non-coding sites for many genes.
www.nature.com
October 8, 2025 at 4:31 PM
Our latest work is out in Nature today. In this paper, we introduce an improved version of NanoSeq, a duplex sequencing protocol with <5 errors per billion bp in single DNA molecules, and use it to study the somatic mutation landscape of oral epithelium in >1000 people www.nature.com/articles/s41...
Reposted by Vijay G. Sankaran
We are proud to announce that U.S. News & World Report has recognized Dana-Farber/Boston Children's (@bostonchildrens.bsky.social) Cancer and Blood Disorders Center as the #3 pediatric cancer program in the nation in its 2025-26 Best Children's Hospitals report.
Learn more: bit.ly/4o7ApUc
Learn more: bit.ly/4o7ApUc
October 7, 2025 at 5:10 PM
We are proud to announce that U.S. News & World Report has recognized Dana-Farber/Boston Children's (@bostonchildrens.bsky.social) Cancer and Blood Disorders Center as the #3 pediatric cancer program in the nation in its 2025-26 Best Children's Hospitals report.
Learn more: bit.ly/4o7ApUc
Learn more: bit.ly/4o7ApUc