Jeff Mold
@jeffmold.bsky.social
American/Swedish Biomedical Scientist studying immunology and cancer. My favorite cell atlases say “here be dragons” on the UMAPs. @karolinska institute
https://scholar.google.com/citations?hl=en&user=_owb98cAAAAJ&view_op=list_works&sortby=pubdate
https://scholar.google.com/citations?hl=en&user=_owb98cAAAAJ&view_op=list_works&sortby=pubdate
Pinned
Jeff Mold
@jeffmold.bsky.social
· Nov 15
My policy on this app is to follow as many scientists as possible. I want a robust, highly varied network of people to discuss all biological research. Especially students
This fits my biases in how I imagine tissues age www.science.org/doi/10.1126/...
Cellular survivorship bias as a mechanistic driver of muscle stem cell aging
Aging is characterized by a decline in the ability of tissue repair and regeneration after injury. In skeletal muscle, this decline is largely driven by impaired function of muscle stem cells (MuSCs) ...
www.science.org
January 29, 2026 at 8:24 PM
This fits my biases in how I imagine tissues age www.science.org/doi/10.1126/...
I doubt I’ll understand this but I’ll try - www.science.org/doi/10.1126/...
Heritability of intrinsic human life span is about 50% when confounding factors are addressed
How heritable is human life span? If genetic heritability is high, longevity genes can reveal aging mechanisms and inform medicine and public health. However, current estimates of heritability are low...
www.science.org
January 29, 2026 at 8:22 PM
I doubt I’ll understand this but I’ll try - www.science.org/doi/10.1126/...
Reposted by Jeff Mold
Really excited to share our new paper in @nature.com! We uncovered how a physical instability of the cytoplasm coupled with the cell cycle drives cytoplasmic partitioning in early embryos #zebrafish #drosophila. Read more in this🧵 www.nature.com/articles/s41... 🤩
@poldresden.bsky.social @mpi-cbg.de
@poldresden.bsky.social @mpi-cbg.de
January 28, 2026 at 4:10 PM
Really excited to share our new paper in @nature.com! We uncovered how a physical instability of the cytoplasm coupled with the cell cycle drives cytoplasmic partitioning in early embryos #zebrafish #drosophila. Read more in this🧵 www.nature.com/articles/s41... 🤩
@poldresden.bsky.social @mpi-cbg.de
@poldresden.bsky.social @mpi-cbg.de
Reposted by Jeff Mold
Today in @nature.com, we describe how discarded reads in biobank-scale WGS can help resolve the genetic predictors and consequences of Epstein-Barr Virus (EBV) infection.
Wonderful working with @ryandhindsa.bsky.social @sherrynyeo.bsky.social @erinmayc.bsky.social
www.nature.com/articles/s41...
Wonderful working with @ryandhindsa.bsky.social @sherrynyeo.bsky.social @erinmayc.bsky.social
www.nature.com/articles/s41...
Population-scale sequencing resolves determinants of persistent EBV DNA - Nature
Population-scale WGS reveals genetic determinants of persistent EBV DNA, linking immune regulation—especially antigen processing and MHC class II variation—to EBV persistence and heterogeneous di...
www.nature.com
January 28, 2026 at 5:07 PM
Today in @nature.com, we describe how discarded reads in biobank-scale WGS can help resolve the genetic predictors and consequences of Epstein-Barr Virus (EBV) infection.
Wonderful working with @ryandhindsa.bsky.social @sherrynyeo.bsky.social @erinmayc.bsky.social
www.nature.com/articles/s41...
Wonderful working with @ryandhindsa.bsky.social @sherrynyeo.bsky.social @erinmayc.bsky.social
www.nature.com/articles/s41...
Reposted by Jeff Mold
This article is now freely available to everyone in PubMed!
www.ncbi.nlm.nih.gov/pmc/articles...
www.ncbi.nlm.nih.gov/pmc/articles...
January 27, 2026 at 12:12 PM
This article is now freely available to everyone in PubMed!
www.ncbi.nlm.nih.gov/pmc/articles...
www.ncbi.nlm.nih.gov/pmc/articles...
Reposted by Jeff Mold
For everyone not fortunate enough to be at the Midwinter #Immunology conference in Seefeld, you can have a little taste of it through my talk on #tissueTregs and using lung Tregs to fight #respiratory #pathology (unpublished work from @drntombizodwa.bsky.social!)
www.youtube.com/watch?v=o_X4...
www.youtube.com/watch?v=o_X4...
Lung Treg seminar
YouTube video by Adrian Liston
www.youtube.com
January 26, 2026 at 1:49 PM
For everyone not fortunate enough to be at the Midwinter #Immunology conference in Seefeld, you can have a little taste of it through my talk on #tissueTregs and using lung Tregs to fight #respiratory #pathology (unpublished work from @drntombizodwa.bsky.social!)
www.youtube.com/watch?v=o_X4...
www.youtube.com/watch?v=o_X4...
Reposted by Jeff Mold
Last term I tried an experiment: I walked into my Tech and Design Ethics class, admitted that I had *no idea* what to do about ChatGPT - so I would let them figure it out.
As in: their first project was to decide and write the ChatGPT policy for the class.
Here's what happened:
As in: their first project was to decide and write the ChatGPT policy for the class.
Here's what happened:
January 22, 2026 at 11:36 PM
Last term I tried an experiment: I walked into my Tech and Design Ethics class, admitted that I had *no idea* what to do about ChatGPT - so I would let them figure it out.
As in: their first project was to decide and write the ChatGPT policy for the class.
Here's what happened:
As in: their first project was to decide and write the ChatGPT policy for the class.
Here's what happened:
Reposted by Jeff Mold
Towards the end of typological thinking in cell biology?
"To answer these questions, we must link variability in cell phenotypes to underlying genetic variation and determine the evolutionary forces that gave rise to that genetic variation. This is not an easy task."
"To answer these questions, we must link variability in cell phenotypes to underlying genetic variation and determine the evolutionary forces that gave rise to that genetic variation. This is not an easy task."
Evolutionary cell biology comes of age
Summary: This Perspective discusses how the discipline of evolutionary cell biology, by integrating evolutionary theory, comparative physiology and modern molecular approaches, works to understand how...
journals.biologists.com
January 22, 2026 at 3:33 PM
Towards the end of typological thinking in cell biology?
"To answer these questions, we must link variability in cell phenotypes to underlying genetic variation and determine the evolutionary forces that gave rise to that genetic variation. This is not an easy task."
"To answer these questions, we must link variability in cell phenotypes to underlying genetic variation and determine the evolutionary forces that gave rise to that genetic variation. This is not an easy task."
I have a serious question for the bioinformatics community - it is now very trendy to assign genes to modules or groups and then annotate those groups using various strategies. When I read the methods for papers it is unclear to me how one comes up with the strategy they use - see below:
January 22, 2026 at 9:18 AM
I have a serious question for the bioinformatics community - it is now very trendy to assign genes to modules or groups and then annotate those groups using various strategies. When I read the methods for papers it is unclear to me how one comes up with the strategy they use - see below:
Few will get this but watching Trump at Davos gave me flashbacks to Mario Incandenza’s puppet show explanatory chapter of the origins of ONAN in Infinite Jest…
January 21, 2026 at 7:14 PM
Few will get this but watching Trump at Davos gave me flashbacks to Mario Incandenza’s puppet show explanatory chapter of the origins of ONAN in Infinite Jest…
Wow what a paper - www.nature.com/articles/s41...
Critical role for a high-plasticity cell state in lung cancer - Nature
The high-plasticity cell state (HPCS) is a critical hub that enables reciprocal transitions between cancer cell states, and targeting the HPCS may suppress cancer progression and eradicate treatment r...
www.nature.com
January 21, 2026 at 6:26 PM
Wow what a paper - www.nature.com/articles/s41...
As more and more high dimensional datasets are generated it seems like everyone is starting to discover that things form a 'continuum'. I bet once people adopt more barcoding tools we will move back towards a world where things fall in buckets but just a lot more than we thought.
January 21, 2026 at 1:55 PM
As more and more high dimensional datasets are generated it seems like everyone is starting to discover that things form a 'continuum'. I bet once people adopt more barcoding tools we will move back towards a world where things fall in buckets but just a lot more than we thought.
Holy crap - is China going to take the USA position as the global peacemaker?! Remember they own an enormous amount of USA debt… edition.cnn.com/2026/01/21/c...
Analysis: As Trump sows division, China says it’s the calm, dependable leader the world needs | CNN
As US President Donald Trump primed his arrival in Davos by sowing discord with allies – ramping up threats to take control of Greenland, vowing to levy tariffs on opponents of that bid, and leaking p...
edition.cnn.com
January 21, 2026 at 8:19 AM
Holy crap - is China going to take the USA position as the global peacemaker?! Remember they own an enormous amount of USA debt… edition.cnn.com/2026/01/21/c...
Remember that Michael Burry who called the financial crisis in 2008 long before everyone else is currently investing everything in clean water…. edition.cnn.com/2026/01/20/c...
The world has entered a new era of ‘water bankruptcy’ with irreversible consequences | CNN
Over-allocation of water, chronic groundwater depletion, pollution and climate change have pushed the world into a drastic situation, a new United Nations report finds.
edition.cnn.com
January 20, 2026 at 8:44 PM
Remember that Michael Burry who called the financial crisis in 2008 long before everyone else is currently investing everything in clean water…. edition.cnn.com/2026/01/20/c...
Trump keeps complaining to the Norwegian government about his lack of prizes…. “https://edition.cnn.com/2026/01/19/europe/trump-norway-nobel-prize-snub-intl”
January 20, 2026 at 4:45 AM
Trump keeps complaining to the Norwegian government about his lack of prizes…. “https://edition.cnn.com/2026/01/19/europe/trump-norway-nobel-prize-snub-intl”
Every once in a while you stumble upon a story that explains a certain type of person. If you want to know why Trump or Rupert Murdock or other types like this are the way they are listen to this - open.spotify.com/episode/5gLD...
#86 Man of the People
open.spotify.com
January 19, 2026 at 10:04 PM
Every once in a while you stumble upon a story that explains a certain type of person. If you want to know why Trump or Rupert Murdock or other types like this are the way they are listen to this - open.spotify.com/episode/5gLD...
Ok he must be just trolling people now right? edition.cnn.com/2026/01/19/e...
Putin invited to join Trump’s ‘Board of Peace’ for Gaza, Kremlin says | CNN
Russian President Vladimir Putin has been invited to join US President Donald Trump’s “Board of Peace,” the committee that will oversee the reconstruction of Gaza, his spokesman said on Monday.
edition.cnn.com
January 19, 2026 at 12:15 PM
Ok he must be just trolling people now right? edition.cnn.com/2026/01/19/e...
I would think that most people would just be so upset with the unfairness of this sort of thing…. www.latimes.com/california/s...
Trump pardons convicted California fraudster he previously freed for different crime
President Trump this week pardoned Adriana Camberos, whose sentence he commuted during his first term but who shortly wound up back in prison for a different scheme.
www.latimes.com
January 18, 2026 at 3:56 PM
I would think that most people would just be so upset with the unfairness of this sort of thing…. www.latimes.com/california/s...
Anyone know about how cd8 T cell responses are impacted by PTEN mutations or inhibition in humans?
January 18, 2026 at 3:55 PM
Anyone know about how cd8 T cell responses are impacted by PTEN mutations or inhibition in humans?
Good job America. Be prepared to pay 10% more for your cheap ikea furniture, Swedish candies, HM cheap knock off couture clothing, and Volvos 😂
January 18, 2026 at 3:48 PM
Good job America. Be prepared to pay 10% more for your cheap ikea furniture, Swedish candies, HM cheap knock off couture clothing, and Volvos 😂
I always have trouble interpreting plots where authors create bespoke 'scores' or even use some previously defined 'score' to define differences between groups. (1) I think there is no end to how you can define such scores and I wonder how many things were tried and if FDR was considered... (1/2)
January 17, 2026 at 3:46 PM
I always have trouble interpreting plots where authors create bespoke 'scores' or even use some previously defined 'score' to define differences between groups. (1) I think there is no end to how you can define such scores and I wonder how many things were tried and if FDR was considered... (1/2)
One to watch - youtu.be/9150MCMSrgc
Mr Nobody Against Putin - Official Trailer
YouTube video by Madman Films
youtu.be
January 17, 2026 at 3:04 PM
One to watch - youtu.be/9150MCMSrgc
Color me intrigued www.science.org/doi/10.1126/...
A genetically encoded device for transcriptome storage in mammalian cells
Understanding how cells make decisions over time requires the ability to link past molecular states to future phenotypic outcomes. We present TimeVault, a genetically encoded system that records and s...
www.science.org
January 15, 2026 at 9:34 PM
Color me intrigued www.science.org/doi/10.1126/...
The pain isn’t in the first review - it’s the second round where the authors are like here’s another 50 graphs to clarify your confusion about the previous 50 😂
every big data paper with a bold story that is impossible to comprehend, evaluate, and independently verify reminds me of DOPRA. i've come to increasingly appreciate small, unassuming papers with humble conclusions that you can track word for word, data point by data point, assumption by assumption.
January 15, 2026 at 5:51 PM
The pain isn’t in the first review - it’s the second round where the authors are like here’s another 50 graphs to clarify your confusion about the previous 50 😂