Jeff Mold
@jeffmold.bsky.social
American/Swedish Biomedical Scientist studying immunology and cancer. My favorite cell atlases say “here be dragons” on the UMAPs. @karolinska institute
https://scholar.google.com/citations?hl=en&user=_owb98cAAAAJ&view_op=list_works&sortby=pubdate
https://scholar.google.com/citations?hl=en&user=_owb98cAAAAJ&view_op=list_works&sortby=pubdate
Feels too aggressive given I’m not attacking anyone I am trying to avoid that sort of speech with people I don’t know and have no bad feelings towards. I got loaded on here but my intent was only to implore for more efforts to make amends. Sorry if my voice is not wanted :)
January 27, 2026 at 9:36 AM
Feels too aggressive given I’m not attacking anyone I am trying to avoid that sort of speech with people I don’t know and have no bad feelings towards. I got loaded on here but my intent was only to implore for more efforts to make amends. Sorry if my voice is not wanted :)
My intent in the initial comment seems pretty lost at this point. I just wanted to make an appeal for more people owning up to mistakes. I didn’t attempt to understand whether he was sincere
January 27, 2026 at 9:13 AM
My intent in the initial comment seems pretty lost at this point. I just wanted to make an appeal for more people owning up to mistakes. I didn’t attempt to understand whether he was sincere
Not trying to be offensive. Sorry
January 27, 2026 at 9:04 AM
Not trying to be offensive. Sorry
No I’m not but I hope we can all try to be a bit less hateful. I understand you are upset. I am only trying to be offensive. I get a bit worried that Bluesky is the shadow of X. Hate from any perspective isn’t helpful. Now I’ll shut the “fuck” up.
January 27, 2026 at 9:03 AM
No I’m not but I hope we can all try to be a bit less hateful. I understand you are upset. I am only trying to be offensive. I get a bit worried that Bluesky is the shadow of X. Hate from any perspective isn’t helpful. Now I’ll shut the “fuck” up.
I don’t like the guy - he seems to be mentally ill and his letter seems to acknowledge brain injury. I just think a world where we attack people who try to make amends will be a worse world than one where we try to incentivize powerful individuals trying to admit fault.
January 27, 2026 at 8:57 AM
I don’t like the guy - he seems to be mentally ill and his letter seems to acknowledge brain injury. I just think a world where we attack people who try to make amends will be a worse world than one where we try to incentivize powerful individuals trying to admit fault.
Fair enough - I’m looking around at a world of conmen and fraudsters and racists and fascists and I just worry that attacking a person who tries to admit wrongdoing will just teach them to be more like Trump and never admit fault. But true I have no personal stake This doesn’t mean I like the guy
January 26, 2026 at 5:26 PM
Fair enough - I’m looking around at a world of conmen and fraudsters and racists and fascists and I just worry that attacking a person who tries to admit wrongdoing will just teach them to be more like Trump and never admit fault. But true I have no personal stake This doesn’t mean I like the guy
We should praise people who admit their mistakes - it’s increasingly rare. So let’s applaud him regardless of the motivations
January 26, 2026 at 2:40 PM
We should praise people who admit their mistakes - it’s increasingly rare. So let’s applaud him regardless of the motivations
Real Stasi shit. They should read history…
January 23, 2026 at 7:07 PM
Real Stasi shit. They should read history…
No idea - maybe it thinks I like Nature 😂
January 23, 2026 at 11:03 AM
No idea - maybe it thinks I like Nature 😂
The problem is that it wants to please me - and it remembers what I like so it tells me (unprompted) that genes are important for things I am interested in, which could fool me into thinking it’s more important than it is
January 23, 2026 at 11:02 AM
The problem is that it wants to please me - and it remembers what I like so it tells me (unprompted) that genes are important for things I am interested in, which could fool me into thinking it’s more important than it is
It’s not BS… but I could probably push it that direction
January 23, 2026 at 10:54 AM
It’s not BS… but I could probably push it that direction
It also was more than happy to reaffirm my beliefs I was on to something big 😂
January 23, 2026 at 8:47 AM
It also was more than happy to reaffirm my beliefs I was on to something big 😂
I asked it to find genes in a long list that have been linked to a pathway and it asked me if I wanted it to make a publication ready figure formatted for Cell, Nature Immunology or Immunity
January 23, 2026 at 8:47 AM
I asked it to find genes in a long list that have been linked to a pathway and it asked me if I wanted it to make a publication ready figure formatted for Cell, Nature Immunology or Immunity
What if I want to say my cells are stem-like but my test says they rank highest for “purine metabolism”. Get what I mean?
January 22, 2026 at 6:23 PM
What if I want to say my cells are stem-like but my test says they rank highest for “purine metabolism”. Get what I mean?
I use EMT as an example. “Stemness” or “senescence “ are similarly vague definitions at a transcriptional level
January 22, 2026 at 6:21 PM
I use EMT as an example. “Stemness” or “senescence “ are similarly vague definitions at a transcriptional level
I guess checking wont help if you desire to find “EMT” and you curate lists till it ends up on top. Even if you know the particular genes associated with that “phenomenon” are there. It becomes a circular argument. I believe I see it but I need a test to tell other people my belief is valid?
January 22, 2026 at 6:21 PM
I guess checking wont help if you desire to find “EMT” and you curate lists till it ends up on top. Even if you know the particular genes associated with that “phenomenon” are there. It becomes a circular argument. I believe I see it but I need a test to tell other people my belief is valid?
I’ve also noticed in some papers that the background of these intracellular markers can shift across cell types which will definitely impact mfi and might be hard to assess if raw data isn’t shown
January 22, 2026 at 6:16 PM
I’ve also noticed in some papers that the background of these intracellular markers can shift across cell types which will definitely impact mfi and might be hard to assess if raw data isn’t shown
Oh getting modules is easy and hotspot is great. I’m more interested in the steps taken to “name” or annotate the modules and pick which genes to highlight. To go for “module 3” to an interpretable name
January 22, 2026 at 10:13 AM
Oh getting modules is easy and hotspot is great. I’m more interested in the steps taken to “name” or annotate the modules and pick which genes to highlight. To go for “module 3” to an interpretable name
In molecular biology we are stuck with antiquated notions that a genes original assigned function is its main and only function and that the gene name means something. So… I feel you
January 22, 2026 at 9:51 AM
In molecular biology we are stuck with antiquated notions that a genes original assigned function is its main and only function and that the gene name means something. So… I feel you
So I will show you the pinnacle of module assignment (IMO) and I will say that I think this is a very good paper - just not so easy to interpret how they made the figures so easy to interpret...
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Progressive plasticity during colorectal cancer metastasis - Nature
Colorectal cancer metastasis involves dramatic plasticity and loss of PROX1-mediated repression of non-intestinal lineages.
www.nature.com
January 22, 2026 at 9:42 AM
So I will show you the pinnacle of module assignment (IMO) and I will say that I think this is a very good paper - just not so easy to interpret how they made the figures so easy to interpret...
www.nature.com/articles/s41...
www.nature.com/articles/s41...