Zeynep Baharoglu
@zeynepbaharoglu.bsky.social
RNA modifications, antibiotic tolerance, bacterial stress, non coding RNAs, Vibrio cholerae.
Institut Pasteur & EGM (IBPC, CNRS)
Institut Pasteur & EGM (IBPC, CNRS)
Pinned
Beyond RNA modification: a novel role for tRNA modifying enzyme in oxidative stress response and metabolism
Abstract. RNA modifications play a fundamental role in regulating essential cellular processes, including translation fidelity and stress adaptation. While
academic.oup.com
Our new paper on DusB’s role in redox metabolism in V. cholerae is now out in @narjournal.bsky.social linking tRNAmodif enzymes and metabolic adaptation.
Beyond RNA modification: a tRNA-modifying enzyme shaping oxidative stress resilience and metabolism in V. cholerae #rnasky #rnabiology
😊🦠💫
Beyond RNA modification: a tRNA-modifying enzyme shaping oxidative stress resilience and metabolism in V. cholerae #rnasky #rnabiology
😊🦠💫
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Multilayered regulation by RNA thermometers enables precise control of Cas9 expression in E. coli
Abstract. Cas9-based genome editing technologies can rapidly generate mutations to probe a diverse array of mutant genotypes. However, aberrant Cas9 nuclea
academic.oup.com
January 30, 2026 at 4:36 PM
🦠
accumulation of the 50S subunit in delta-tlyA with cold sensitive phenotype and resistance to aminoglycosides 🦠 #RNAmodifications #RNAbiology #rnasky
TlyA is a 23S and 16S 2′-O-methylcytidine methyltransferase important for ribosome assembly in Bacillus subtilis
Abstract. Ribosomal RNA (rRNA) methylation is conserved across biology, yet the effect of rRNA methylation on ribosome function is poorly understood. In th
academic.oup.com
January 30, 2026 at 4:29 PM
accumulation of the 50S subunit in delta-tlyA with cold sensitive phenotype and resistance to aminoglycosides 🦠 #RNAmodifications #RNAbiology #rnasky
Signature codon usage patterns define functional gene families, this is in yeast and could be also very informative for bacteria and link with tRNA modifs #rnasky #codonusage #rnabiology #rnamodifications
Synonymous codon usage defines functional gene families - BMC Biology
Background The degeneracy of the genetic code is increasingly recognized for roles in regulating translation rate, protein folding, and cell response. However, the functional genomics of codon usage p...
link.springer.com
January 30, 2026 at 12:43 PM
Signature codon usage patterns define functional gene families, this is in yeast and could be also very informative for bacteria and link with tRNA modifs #rnasky #codonusage #rnabiology #rnamodifications
trans-Translation inhibitors that kill M. tuberculosis and pathogenic Non-tuberculous Mycobacteria have a dual mechanism of action www.biorxiv.org/content/10.6...
www.biorxiv.org
January 26, 2026 at 1:17 PM
trans-Translation inhibitors that kill M. tuberculosis and pathogenic Non-tuberculous Mycobacteria have a dual mechanism of action www.biorxiv.org/content/10.6...
Structure of the 30S translation initiation complex coupled to paused RNA polymerase and its potential for riboregulation #rnasky 🦠
Structure of the 30S translation initiation complex coupled to paused RNA polymerase and its potential for riboregulation - Nature Communications
Small regulatory RNAs can act on target mRNAs to control their translation and stability. Here, the authors present evidence that this riboregulation can potentially regulate by pairing to a target si...
www.nature.com
January 26, 2026 at 12:59 PM
Structure of the 30S translation initiation complex coupled to paused RNA polymerase and its potential for riboregulation #rnasky 🦠
Probing the epitranscriptome and RNA damage with nanopore direct RNA sequencing #tnasky
Probing the epitranscriptome and RNA damage with nanopore direct RNA sequencing
A monthly journal publishing high-quality, peer-reviewed research on all topics related to RNA and its metabolism in all organisms
bit.ly
January 22, 2026 at 7:31 AM
Probing the epitranscriptome and RNA damage with nanopore direct RNA sequencing #tnasky
Reposted by Zeynep Baharoglu
'This video is the culmination of several yrs attempting to: (1) Figure out best practices for modeling ptn-ptn interactions; (2) Understand the outputs of programs like AlphaFold & adjacent software including quantitative metrics;(3) Communicate my thoughts to unwitting victims through workshops'
AlphaFold protein interaction modeling tutorial and workshop - the Node
This video is the culmination of several years attempting to: (1) Figure out best practices for modeling protein-protein interactions; (2) Understand the This video is the culmination of several years...
thenode.biologists.com
January 18, 2026 at 8:52 AM
'This video is the culmination of several yrs attempting to: (1) Figure out best practices for modeling ptn-ptn interactions; (2) Understand the outputs of programs like AlphaFold & adjacent software including quantitative metrics;(3) Communicate my thoughts to unwitting victims through workshops'
A to I RNA editing at the replication fork #RNAsky #RNAbiology
Redox-driven ADAR1 activation promotes Okazaki fragment maturation and DNA replication integrity - Nature Structural & Molecular Biology
Chen et al. show that redox signals activate ADAR1 to fix faulty RNA pieces during DNA copying, ensuring smooth replication and protecting genome stability.
www.nature.com
January 16, 2026 at 5:50 PM
A to I RNA editing at the replication fork #RNAsky #RNAbiology
DNA modif and phages 🦠
Carboxymethylcytosine is a natural base modification and a handle for bacteriophage DNA hypermodification - Nature Communications
DNA in many bacteriophages contains unusual chemical modifications. Here, the authors discover that carboxymethylcytosine is a natural DNA base and reveal its role as an intermediate enabling further ...
www.nature.com
January 16, 2026 at 5:48 PM
DNA modif and phages 🦠
Reposted by Zeynep Baharoglu
Seeking scientist volunteers for the 2026 spring semester! Want to practice science communication and help author a 🌟comic🌟 about your research? Apply by 1/25. Please share widely. bit.ly/comicscollabspring2026
January 15, 2026 at 8:19 PM
"under low amino acid availability, co-cultures of leucine and phenylalanine auxotrophs display greater tolerance to chloramphenicol than monocultures"=> community level tolerance 🦠
Stress-Induced Cooperation Promotes Tolerance in Resource-Limited Auxotrophic Microbial Consortia
Microbial communities often rely on metabolic cooperation, especially under nutrient limitation, but how antibiotics influence these interactions remains unclear. Here, we show that exposure to chlora...
www.biorxiv.org
January 10, 2026 at 1:06 PM
"under low amino acid availability, co-cultures of leucine and phenylalanine auxotrophs display greater tolerance to chloramphenicol than monocultures"=> community level tolerance 🦠
Role of RimM ribosome maturation factor in recovery after protein synthesis arrest 🦠 #ribosome #rnasky #rnabiology
Mechanistic insights into E. coli recovery from growth arrest
Bacteria survive hostile conditions in clinically relevant conditions by shutting down protein synthesis, but how they restart growth remains poorly understood. Here, we use an E. coli delta-rimM stra...
www.biorxiv.org
January 10, 2026 at 1:03 PM
Role of RimM ribosome maturation factor in recovery after protein synthesis arrest 🦠 #ribosome #rnasky #rnabiology
Reposted by Zeynep Baharoglu
Ribosome profiling reveals distinct translational programs underlying Arabidopsis seed dormancy and germination https://www.biorxiv.org/content/10.64898/2026.01.08.696037v1
January 8, 2026 at 9:03 PM
Ribosome profiling reveals distinct translational programs underlying Arabidopsis seed dormancy and germination https://www.biorxiv.org/content/10.64898/2026.01.08.696037v1
Reposted by Zeynep Baharoglu
#ResultatScientifique🔎| Quand Candida albicans réduit ses ribosomes, ses cellules deviennent plus fluides, ce qui l’aide à changer de forme et à mieux infecter l’organisme 🍄
✍️ Robert Arkowitz
📕 @natmicrobiol.nature.com | buff.ly/zPSLael
✍️ Robert Arkowitz
📕 @natmicrobiol.nature.com | buff.ly/zPSLael
Fluidité intracellulaire et pouvoir infectieux du champignon Candida albicans
Dans un article publié dans la revue Nature Microbiology, des scientifiques mettent en évidence un mécanisme jusque-là inconnu chez Candida albic
www.insb.cnrs.fr
January 9, 2026 at 1:00 PM
#ResultatScientifique🔎| Quand Candida albicans réduit ses ribosomes, ses cellules deviennent plus fluides, ce qui l’aide à changer de forme et à mieux infecter l’organisme 🍄
✍️ Robert Arkowitz
📕 @natmicrobiol.nature.com | buff.ly/zPSLael
✍️ Robert Arkowitz
📕 @natmicrobiol.nature.com | buff.ly/zPSLael
Crispr immunity by cutting RNA and not DNA 🦠
January 9, 2026 at 7:57 AM
Crispr immunity by cutting RNA and not DNA 🦠
Reposted by Zeynep Baharoglu
Canada Research Chairs www.canada.ca/en/impact-pl...: $1M/year for 8 years, plus up to $6M in CFI infrastructure support. Looking for leading researchers abroad interested in AMR research, antibiotic discovery (Pandemicstopai.ca), phages. Email short vision + CV. Tight deadlines: March 10 & June 15
Canada Impact+ Research Chairs - Canada.ca
www.canada.ca
January 8, 2026 at 7:18 PM
Canada Research Chairs www.canada.ca/en/impact-pl...: $1M/year for 8 years, plus up to $6M in CFI infrastructure support. Looking for leading researchers abroad interested in AMR research, antibiotic discovery (Pandemicstopai.ca), phages. Email short vision + CV. Tight deadlines: March 10 & June 15
Proximity-specific ribosome profiling #ribosome #rnabiology in mitochondria
www.cell.com/cell/fulltex...
www.cell.com/cell/fulltex...
Proximity-specific ribosome profiling reveals the logic of localized mitochondrial translation
Development of LOV-domain-controlled ligase for translation localization (LOCL-TL),
an optogenetic approach for monitoring translation with codon resolution at any defined
subcellular location under p...
www.cell.com
January 5, 2026 at 9:57 AM
Proximity-specific ribosome profiling #ribosome #rnabiology in mitochondria
www.cell.com/cell/fulltex...
www.cell.com/cell/fulltex...
#AMR 🦠
Antibiotic contamination and antimicrobial resistance dynamics in the urban sewage microbiome in India - Nature Communications
This study used metagenomic analyses of Indian urban sewage. It revealed antibiotic contamination, resistance genes, and mobile genetic elements from multidrug-resistant pathogens, highlighting sewage...
www.nature.com
January 4, 2026 at 2:18 PM
#AMR 🦠
Stress dependent rRNA modifs 🦠💫 #rnasky #rnabiology
Direct RNA Sequencing Reveals Stress-Dependent and Pathway-Specific rRNA Modification Reprogramming During 50S Biogenesis
Ribosomal RNA (rRNA) modification and processing are essential steps in ribosome assembly. Using Oxford Nanopore direct RNA sequencing, we simultaneously detect and quantify eight classes of 23S rRNA ...
www.biorxiv.org
January 4, 2026 at 2:15 PM
Stress dependent rRNA modifs 🦠💫 #rnasky #rnabiology
🧬❄️ RNA Modifications Newsletter - Jan 2026 is out!
RNA mods, ribosome remodeling, codon effects, nanopore detection, translation under stress - winter edition
❄️🧫From hypoxia-driven rRNA methylation to tRNA-linked virulence and ribosome structure.
#RNAsky #RNAbiology #Ribosome #microsky
RNA mods, ribosome remodeling, codon effects, nanopore detection, translation under stress - winter edition
❄️🧫From hypoxia-driven rRNA methylation to tRNA-linked virulence and ribosome structure.
#RNAsky #RNAbiology #Ribosome #microsky
RNA Modifications Newsletter - January 1st, 2026 - Winter Edition ❄️
Issue #7 - Happy new year!
rnamodifupdates.substack.com
January 2, 2026 at 10:43 AM
🧬❄️ RNA Modifications Newsletter - Jan 2026 is out!
RNA mods, ribosome remodeling, codon effects, nanopore detection, translation under stress - winter edition
❄️🧫From hypoxia-driven rRNA methylation to tRNA-linked virulence and ribosome structure.
#RNAsky #RNAbiology #Ribosome #microsky
RNA mods, ribosome remodeling, codon effects, nanopore detection, translation under stress - winter edition
❄️🧫From hypoxia-driven rRNA methylation to tRNA-linked virulence and ribosome structure.
#RNAsky #RNAbiology #Ribosome #microsky
2025 in a nutshell 🚀
6 papers out 👇, 1 press release 🔖(www.pasteur.fr/en/press-are...) from @pasteur.fr, a move to EGM - IBPC 🚚, and the launch of RNA Modif Newsletter 🦠
Also: new faces 😊, farewells 🥲, great collaborations 💫, and we even saved the world from a meteorite.🤩
More coming in 2026 ✨🤞
6 papers out 👇, 1 press release 🔖(www.pasteur.fr/en/press-are...) from @pasteur.fr, a move to EGM - IBPC 🚚, and the launch of RNA Modif Newsletter 🦠
Also: new faces 😊, farewells 🥲, great collaborations 💫, and we even saved the world from a meteorite.🤩
More coming in 2026 ✨🤞
December 30, 2025 at 3:47 PM
2025 in a nutshell 🚀
6 papers out 👇, 1 press release 🔖(www.pasteur.fr/en/press-are...) from @pasteur.fr, a move to EGM - IBPC 🚚, and the launch of RNA Modif Newsletter 🦠
Also: new faces 😊, farewells 🥲, great collaborations 💫, and we even saved the world from a meteorite.🤩
More coming in 2026 ✨🤞
6 papers out 👇, 1 press release 🔖(www.pasteur.fr/en/press-are...) from @pasteur.fr, a move to EGM - IBPC 🚚, and the launch of RNA Modif Newsletter 🦠
Also: new faces 😊, farewells 🥲, great collaborations 💫, and we even saved the world from a meteorite.🤩
More coming in 2026 ✨🤞
Reposted by Zeynep Baharoglu
Cells maintain protein synthesis quality by allowing more efficient ribosomes to outcompete and trigger the removal of less efficient ones, supporting cellular accuracy and resilience.
Cells reveal 'survival of the fittest' through ribosome competition
Ribosomes—the tiny factories that build proteins in our cells—don't all work with the same efficiency. Researchers from Japan have discovered that ribosomes actually compete with one another, and those that perform poorly are selectively broken down when more efficient ones are present.
phys.org
December 22, 2025 at 6:36 PM