STCmicrobeblog
@stcmicrobeblog.bsky.social
4.1K followers 920 following 3.6K posts
A blog that aims to share appreciation for the width & depth of microbial activities. Posts by Christoph, not necessarily the opinion of all team members of Small Things Considered (STC) https://schaechter.asmblog.org/schaechter/
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stcmicrobeblog.bsky.social
christoph: since long I consider the shape of 𝘚𝘵𝘦𝘭𝘭𝘢 𝘩𝘶𝘮𝘰𝘴𝘢 especially schick, but there are so few images around that I'm not really sure about their morphology.
the other day I found 𝘙𝘶𝘨𝘰𝘴𝘪𝘵𝘢𝘭𝘦𝘢 𝘰𝘳𝘺𝘻𝘢𝘦 YC6860^T, and we can dispute whether they're fusilli or rotini 😋 (🙋‍♂️ pasta addict)
𝘙𝘶𝘨𝘰𝘴𝘪𝘵𝘢𝘭𝘦𝘢 𝘰𝘳𝘺𝘻𝘢𝘦 YC6860^T
https://www.biorxiv.org/content/10.1101/2022.08.29.505124v1 pasta shapes (from fb)
stcmicrobeblog.bsky.social
congrats, julie! 👏👏👏
stcmicrobeblog.bsky.social
congrats to julie 👏👏👏
stcmicrobeblog.bsky.social
#PhageSky
emmanuelkuffo15.bsky.social
The original plan was to isolate >50 phage-host combos (I naively thought this would be the straightforward bit of the project—it wasn’t). Eventually we got 2 phages tripling the number of genome-sequenced, in vitro characterised Strep. suis phages! Read about Bonnie & Clyde👇🏿
stcmicrobeblog.bsky.social
#PhageSky
friendlymicrobe.bsky.social
Very nice talk from @emmanuelkuffo15.bsky.social speaking about his hunt for Strep. suis phage at the @microbiologysociety.org young microbiologist of the year finals - and there's a pre-print up! #MicroSky
emmanuelkuffo15.bsky.social
The original plan was to isolate >50 phage-host combos (I naively thought this would be the straightforward bit of the project—it wasn’t). Eventually we got 2 phages tripling the number of genome-sequenced, in vitro characterised Strep. suis phages! Read about Bonnie & Clyde👇🏿
stcmicrobeblog.bsky.social
#MicroSky
surtlab.bsky.social
Here’s published version of our manuscript using GWAS to investigate tailocin sensitivity in Pseudomonas syringae. TL:DR pretty clear LPS is tailocin receptor but also that P.syringae often completely swaps out its entire O antigen biosynth pathway w/ recombination

academic.oup.com/g3journal/ad...
Genomic correlates of tailocin sensitivity in Pseudomonas syringae
Abstract. Phage-derived bacteriocins, also referred to as tailocins, are structures encoded by bacterial genomes and deployed into the extracellular enviro
academic.oup.com
stcmicrobeblog.bsky.social
christoph: they're certainly more yummi, but they look like rutherford's atom model 😄
rutherford's atom model
stcmicrobeblog.bsky.social
#PhageSky
daumlab.bsky.social
Out in Science Advances: Our #cryoEM structure of HFTV1, a virus infecting the halophile #archaea. *First full atomic structure (containing all structural proteins) of any tailed virus!* Congrats and thanks to all co-authors and our fantastic collaborators! www.science.org/doi/10.1126/...
Cryo-EM resolves the structure of the archaeal dsDNA virus HFTV1 from head to tail
This structure of an archaeal tailed virus (arTV) provides detailed insights into arTV assembly and infection mechanisms.
www.science.org
stcmicrobeblog.bsky.social
who buys from amazon anyways? 😊
amazon - ist kein guter nachbar
stcmicrobeblog.bsky.social
until then, I'll be glad to help you 👍
stcmicrobeblog.bsky.social
great work, congrats to all involved 👏👏👏
stcmicrobeblog.bsky.social
#ProtistsOnSky
thibautbrunet.bsky.social
Latest from ours: www.cell.com/cell-reports...

This is two stories in one: a case study/cautionary tale on developing genetic tools in new organisms, and the first hint at a gene regulatory network for choanoflagellate multicellular development (which turn out to involve a Hippo/YAP/ECM loop!) A 🧵
stcmicrobeblog.bsky.social
btw this year, I didn't see any traces of the old METEOR graffiti on the pier wall in horta, faial that I hadn't screened last year (partly visible in the photo).
marina in horta, faial. viw of pico volcano (own photo, sep 2025)
stcmicrobeblog.bsky.social
... and it could be fun to see if this is mirrored in the Endozoicomonadaceae or not. just fun, probably not really important as these dual-origins are just a few kb (~25 kb) apart and simultaneous firing is unlikely to mess-up the cell cycle in bugs with genome sizes in the 4 Mbp range
stcmicrobeblog.bsky.social
christoph: do you think anyone would be interested in me seeing if I can identify 𝘰𝘳𝘪𝘊 in these guys' genomes (by prediction)? I would of course also look at 𝘌𝘯𝘥𝘰𝘯𝘶𝘤𝘭𝘦𝘰𝘣𝘢𝘤𝘵𝘦𝘳 😎

I recently found 𝘁𝘄𝗼 𝘰𝘳𝘪𝘊 in many of the (not-too-distantly) related Halomonadaceae (www.biorxiv.org/content/10.1...) ...
stcmicrobeblog.bsky.social
christoph: this is an animation of RNase II at work from the perspective of its catalytic site. on the left, I can see clearly its CSD domain.