Omaya Dudin 𓂆 ¦🍉¦🦠¦🔬¦
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dudinlab.bsky.social
Omaya Dudin 𓂆 ¦🍉¦🦠¦🔬¦
@dudinlab.bsky.social
Asst. Prof. at UNIGE

Evolutionary cell biology & multicellular developmental diversity of protists.

www.dudinlab.com

#Ichthyosporea, #Multicellularity, #Evolution, #Embryo, #Development, #Protist, #UExM, #Cytoskeleton, #Actin, #Expansion #Microscopy
Pinned
🚨Our collaboration with @centriolelab.bsky.social & @gautamdey.bsky.social is out today in @cp-cell.bsky.social
We show that #Expansion #Microscopy is a broad-spectrum modality for Euks, enabling 3D phenotypic maps rooted to phylogeny.
#ProtistsOnSky #SciComm #SciSky

www.cell.com/cell/fulltex...
Reposted by Omaya Dudin 𓂆 ¦🍉¦🦠¦🔬¦
Just uploaded our new preprint to @ecoevorxiv.bsky.social

Multinucleate life really is everywhere...from deep sea forams to slime molds, intracellular parasites, and beyond. 🚀

We explore how scaling, ecology, & evolution intersect when many nuclei share a single cytoplasm.
doi.org/10.32942/X2M...
November 26, 2025 at 3:06 PM
Reposted by Omaya Dudin 𓂆 ¦🍉¦🦠¦🔬¦
Our attempt to give multinucleate cells the spotlight they deserve (seriously, they’re everywhere), led by the fearless @mrosjac.bsky.social and with @Markus Ganter

doi.org/10.32942/X2M...

We’d love your feedback while this goes through the peer review process!

#MicroEvoSky
#ProtistsonSky 🧪🌏
November 26, 2025 at 2:05 PM
Reposted by Omaya Dudin 𓂆 ¦🍉¦🦠¦🔬¦
Curious about how this story came to be (we never planned to study centromeres!)? Here’s a glimpse behind the scenes of how a naive method to count chromosomes unlocked the rules behind centromere evolution.

P.S. There are cartoons!

👉 tinyurl.com/4rz4ve6u
Counting Chromosomes: The Simple Idea That Unlocked the Rules Behind Centromere Evolution
tinyurl.com
November 26, 2025 at 4:27 PM
You must check this one out ! CONGRATS @helsenjana.bsky.social
How do new centromeres evolve while staying compatible with the division machinery?

Discover it in our new Nature paper! We show centromeres transition gradually via a mix of drift, selection, and sex, reaching new states that still work with the kinetochore.

👉 doi.org/10.1038/s41586-025-09779-1
November 26, 2025 at 6:59 PM
So i'm usually interested about how cells divide in the cold, but couldnt resist helping out a tiny bit for a Euk dividing at 63°C.
Congrats to the whole team @hbrappap.bsky.social & Kudos to @fmikus.bsky.social for yet again the almighty #UExM !
So happy to announce our new preprint, “A geothermal amoeba sets a new upper temperature limit for eukaryotes.” We cultured a novel amoeba from Lassen Volcanic NP (CA, USA) that divides at 63°C (145°F) 🔥 - a new record for euk growth!
#protistsonsky 🧵
November 25, 2025 at 8:43 PM
Reposted by Omaya Dudin 𓂆 ¦🍉¦🦠¦🔬¦
Check out that spindle 🤩🔥

At 63C, most eukaryotic cells would be busy exploding noisily, forget even trying to divide.

The microbial universe never ceases to astound 😍

Thanks for letting us be a tiny part of this! #ExpandThemAll
While 𝘝. 𝘷𝘦𝘳𝘮𝘪𝘧𝘰𝘳𝘮𝘪𝘴 max temp is around 45°C, we found 𝘐. 𝘤𝘢𝘴𝘤𝘢𝘥𝘦𝘯𝘴𝘪𝘴 grows up to 63°C with optimal growth at 55-57°C🥵. We showed cellular replication via Ultrastructure Expansion Microscopy at 63°C. The previous limit for euks is 60°C!
November 25, 2025 at 8:30 PM
Reposted by Omaya Dudin 𓂆 ¦🍉¦🦠¦🔬¦
What a day at the Académie des Sciences! 🎉 Honored to receive the Allianz Prize / Institut de France. Huge shoutout to my dream team — none of this happens without you. 🙏🏽💥

@ugrenoblealpes.bsky.social
@inserm.fr
@cnrs.fr
November 25, 2025 at 6:12 PM
Reposted by Omaya Dudin 𓂆 ¦🍉¦🦠¦🔬¦
We will be at @ccapoban.bsky.social in stunning Oban for the next two weeks fixing samples from their remarkable collection for #ExAME - thank you Ceci Mikey Jo Naomi and everyone at SAMS for the warm Scottish welcome ❤️

#ProtistsonSky #ExpandThemAll

@fmikus.bsky.social
November 24, 2025 at 5:53 PM
Quite a busy day on #Bluesky !
Been a while since we have been #preLight -ed !

Discover HAK-Actin if you haven't already ;)
November 19, 2025 at 12:36 PM
I mean, how does Microtubules & centrin cytoskeleton shapes the suctorian resting and feeding tip ? Just how ?

#UExM #Expansion #Microscopy
Key transcripts encoded centrin-like proteins, a frequent component of sensory/contractile structures in protists. We visualized tentacle ultrastructure by U-ExM with @dudinlab.bsky.social lab, discovering stunning tip and collar structures 🤯that add structural complexity to new tentacle formation.
November 19, 2025 at 8:33 AM
Very happy to see this out there ! Amazing work by @zjmaggiexu.bsky.social @amyweeks.bsky.social & @cellraiser.bsky.social!

All #ProtistsOnSky are amazing, but when I bumbed into @zjmaggiexu.bsky.social & her poster 2y ago at a #GRC conference, I got the urge to attempt #ExpnasionMicroscopy!
n/1
How do cells adapt morphology to function? In a 🔥 preprint by @zjmaggiexu.bsky.social , with @dudinlab.bsky.social and @amyweeks.bsky.social , we identify a self-organizing single-cell morphology circuit that optimizes the feeding trap structure of the suctorian P. collini. 🧵 tinyurl.com/4k8nv926
November 18, 2025 at 5:19 PM
Reposted by Omaya Dudin 𓂆 ¦🍉¦🦠¦🔬¦
Out today, our take on 6-methyladenine #6mA evolution in Eukaryotes @natgenet.nature.com. We asked a simple question, is really DNA 6mA common across the eukaryotes? The answer is "yes" if you're a unicellular eukaryote 🦠, not so if you're multicellular 🐝🌱🍄. www.nature.com/articles/s41... 1/9
Adenine DNA methylation associated with transcriptionally permissive chromatin is widespread across eukaryotes - Nature Genetics
Long-read sequencing in 18 unicellular eukaryotes reveals that 6mA is widespread across eukaryotes and is enriched at transcriptionally permissive regions, which are also marked by H3K4me3.
www.nature.com
November 18, 2025 at 12:00 PM
Big Congrats @jlsteenwyk.bsky.social & Nicole for this amazing and impressive work !
I hope it settles the debate for sometime !
November 13, 2025 at 8:38 PM
Reposted by Omaya Dudin 𓂆 ¦🍉¦🦠¦🔬¦
Let me use this as an opportunity to talk about Jordi et al's very cool paper, now out in PNAS 🧪:

pmc.ncbi.nlm.nih.gov/articles/PMC...

You can read our news and views here: www.pnas.org/doi/10.1073/...
November 13, 2025 at 4:13 PM
Reposted by Omaya Dudin 𓂆 ¦🍉¦🦠¦🔬¦
We are looking for a PhD student to work on an exciting plastid endosymbiosis in microbial eukaryotes. This position involves sampling, exciting microscopy such as CARDFISH, ExM and FIBSEM, single-cell transcriptomics and more. #protistsonsky 1/2
November 12, 2025 at 9:50 AM
Come and Join Us.
Not only will it be fun, but you will be learning a lot of methods & travel some more ;)!
November 12, 2025 at 9:51 AM
Reposted by Omaya Dudin 𓂆 ¦🍉¦🦠¦🔬¦
Weekend #Plankton Factoid 🦠🦐
November 8, 2025 at 2:53 PM
Reposted by Omaya Dudin 𓂆 ¦🍉¦🦠¦🔬¦
This is a glimpse of the cytoskeletal structures we found doing U-ExM in more than 200 species, now in Cell🤩: shorturl.at/6oHvi
Amazing collaboration between @centriolelab.bsky.social , @dudinlab.bsky.social and @gautamdey.bsky.social labs.
I believe last one is a 🕷️
#FluorescenceFriday
#Microscopy
November 7, 2025 at 1:35 PM
Reposted by Omaya Dudin 𓂆 ¦🍉¦🦠¦🔬¦
An Asgard archaeon with internal membrane compartments

Brilliant study led by @fmacleod.bsky.social and Andriko von Kügelgen. Tight collaboration with @buzzbaum.bsky.social and lab. Congrats to all authors!

www.biorxiv.org/content/10.1...
November 7, 2025 at 10:44 AM
Reposted by Omaya Dudin 𓂆 ¦🍉¦🦠¦🔬¦
Our study, just published in #ScienceAdvances and funded by @hfspo.bsky.social, explores the post metamorphic cell composition of the sea urchin juvenile, revealing that its body is head-like. Long considered brainless creatures, they’re all brain instead!
www.science.org/doi/10.1126/...
Single-nucleus profiling highlights the all-brain echinoderm nervous system
A sea urchin is a head with a brain-like organization and a vertebrate-type retinal signature.
www.science.org
November 5, 2025 at 7:03 PM
Reposted by Omaya Dudin 𓂆 ¦🍉¦🦠¦🔬¦
1/ Preprint alert:

🌾 The developing leaf of the wild grass Brachypodium distachyon at single-cell resolution

👉 doi.org/10.1101/2025...
A 70k-cell single-cell RNA-seq atlas of the developing grass leaf—from the shoot meristem to mature leaf tissues. @cerealcell.bsky.social @lbmountain.bsky.social
November 5, 2025 at 12:32 PM
Reposted by Omaya Dudin 𓂆 ¦🍉¦🦠¦🔬¦
(1/2) A new study from EMBL researchers and their collaborators provides unprecedented insights into the cellular architecture of over 200 species of plankton – tiny but ecologically critical marine organisms – using ultrastructure expansion microscopy.

Learn more: www.cell.com/cell/fulltex...
November 4, 2025 at 8:30 AM
Reposted by Omaya Dudin 𓂆 ¦🍉¦🦠¦🔬¦
Reposted by Omaya Dudin 𓂆 ¦🍉¦🦠¦🔬¦
November 3, 2025 at 1:34 PM