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MolinariLab-ER @molinarilab-er.bsky.social · 5d

Grazie Stefan!

MolinariLab-ER @molinarilab-er.bsky.social · 25d

Organellophagy receptors display cytoplasmic intrinsically disordered regions (IDRS). The IDRs of ER-phagy and mitophagy receptors are interchangeable, required and sufficient for ER and mitochondria fragmentation that precedes lysosomal clearance of the organelle’s portions.
rdcu.be/eF5DR

The intrinsically disordered regions of organellophagy receptors are interchangeable and control organelle fragmentation, ER-phagy and mitophagy flux

Nature Cell Biology - Rudinskiy et al. examine organellophagy receptor features, finding modules of functionally conserved intrinsically disordered regions and defining shared features despite...

rdcu.be

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MolinariLab-ER @molinarilab-er.bsky.social · Aug 27

An interesting study from the ETH-Zurich

ethz.ch/en/news-and-...

Why the foam on Belgian beers lasts so long

ETH Zurich researchers have found the holy grail of brewing: the formula for stable beer foam. But it's not just breweries that will benefit from these findings.

ethz.ch

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Reposted by MolinariLab-ER

Stella Hurtley @smhsci.bsky.social · Aug 22

Come join us @science.org. We’re looking for a new editor to look after infectious disease and microbiome submissions.
Check out this Associate or Senior Editor opportunity recruiting.ultipro.com/AME1123ASEM/...

recruiting.ultipro.com

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MolinariLab-ER @molinarilab-er.bsky.social · Aug 21

From Switzerland to Portugal … and back. 🤔

Reposted by MolinariLab-ER

Nature Cell Biology @natcellbio.nature.com · Aug 19

💫NEW: @molinarilab-er.bsky.social & co examine organellophagy receptor features, finding modules of functionally conserved intrinsically disordered regions and defining shared features despite sequence divergence, such as a net negative charge, that promote fragmentation.
bit.ly/4fLWe99

The intrinsically disordered regions of organellophagy receptors are interchangeable and control organelle fragmentation, ER-phagy and mitophagy flux - Nature Cell Biology

Rudinskiy et al. examine organellophagy receptor features, finding modules of functionally conserved intrinsically disordered regions and defining shared features despite sequence divergence, such as ...

bit.ly

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MolinariLab-ER @molinarilab-er.bsky.social · Aug 18

Thank you Yasin, I have shared this in my Country😀. “We all leave in a … splendid isolation” reminds me a Beatles song …

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MolinariLab-ER @molinarilab-er.bsky.social · Aug 9

Grok3, 3 attempts

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Reposted by MolinariLab-ER

MolinariLab-ER @molinarilab-er.bsky.social · Aug 4

Selective autophagy of organelles: the “disorder” is key. Intrinsically disordered regions of organellophagy receptors are interchangeable, required, and sufficient for organelle fragmentation and lysosomal delivery … and all about ORGATACs 😉
rdcu.be/ey8iL

The intrinsically disordered regions of organellophagy receptors are interchangeable and control organelle fragmentation, ER-phagy and mitophagy flux

Nature Cell Biology - Rudinskiy et al. examine organellophagy receptor features, finding modules of functionally conserved intrinsically disordered regions and defining shared features despite...

rdcu.be

1 16 37

MolinariLab-ER @molinarilab-er.bsky.social · Aug 4

Selective autophagy of organelles: the “disorder” is key. Intrinsically disordered regions of organellophagy receptors are interchangeable, required, and sufficient for organelle fragmentation and lysosomal delivery … and all about ORGATACs 😉
rdcu.be/ey8iL

The intrinsically disordered regions of organellophagy receptors are interchangeable and control organelle fragmentation, ER-phagy and mitophagy flux

Nature Cell Biology - Rudinskiy et al. examine organellophagy receptor features, finding modules of functionally conserved intrinsically disordered regions and defining shared features despite...

rdcu.be

1 16 37

Reposted by MolinariLab-ER

Eric Chevet @ericchevet.bsky.social · Jul 24

@olzmannlab.bsky.social @tgalli.bsky.social @demangelab.bsky.social @agostinislab.bsky.social @abdourachidthiam.bsky.social @molinarilab-er.bsky.social @hennelab.bsky.social @jdejuan-sanz.bsky.social

Thierry Galli 🧫🧬🔬🎸🔊 @tgalli.bsky.social · Jul 24

ER_2025 #endoplasmicreticulum #ER #conference Paris October 8-10 2025 Register! itbcrde.inserm.fr/index.php?page…

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Reposted by MolinariLab-ER

Stefan Marciniak @profmarciniak.bsky.social · Jul 25

🚨 Job alert

We’re looking for a communications manager for the LifeArc Rare Respiratory Disease Centre. Deadline for applications 1st August

@lifearc.bsky.social

elxw.fa.em3.oraclecloud.com/hcmUI/Candid...

Research Communications Manager

We’re looking for a Research Communications Manager to help shape and share the ground breaking work of the LifeArc Centre for Rare Respiratory Diseases and our Pandemic Science Hub (PSH) based in the...

elxw.fa.em3.oraclecloud.com

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MolinariLab-ER @molinarilab-er.bsky.social · Jul 12

As an angler, getting old, … on your small boat looking down there, where you know pikes are waiting for you ... and then you stop the boat, and it only remains to knot your fishing hook … and you hardly see your fingers.

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Reposted by MolinariLab-ER

Jim Hurley @jimhurley.bsky.social · Jun 25

The ESCRT complexes are a fascinating membrane cutting machine with roles in countless cell pathways, but they are also ubiquitous in disease and offer new opportunities as drug targets. See our new review with Alyssa Coyne, Marta Miączyńska, and Harald Stenmark at tinyurl.com/yex3trem

The expanding repertoire of ESCRT functions in cell biology and disease - Nature

This Review examines recently gained insights into the roles of ESCRT complexes in viral infection, immunity, cancer and neurological disease.

tinyurl.com

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Reposted by MolinariLab-ER

Hesso Farhan @hessofarhan.bsky.social · Jul 11

Our review on the role of ER proteostasis in bone disease is out today in Trends in Molecular Medicine www.cell.com/trends/molec...

The endoplasmic reticulum proteostasis network and bone disease

Bone homeostasis relies on the coordinated activity of osteoblasts and osteoclasts that balances bone formation and resorption, and of osteocytes for biomechanical sensing and hormone secretion. A key...

www.cell.com

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Reposted by MolinariLab-ER

Hesso Farhan @hessofarhan.bsky.social · Jul 9

Our new paper is out in Leukemia on Targeting proteostasis in multiple myeloma through inhibition of LTK. Thanks to Ludvig and Thea for this great collaborative work
rdcu.be/evyfX

Targeting proteostasis in multiple myeloma through inhibition of LTK

Leukemia - Targeting proteostasis in multiple myeloma through inhibition of LTK

rdcu.be

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MolinariLab-ER @molinarilab-er.bsky.social · Jul 9

ATZ polymers elicit intervention of CNX:FAM134B-LC3II segregation complexes + formation of VAPA-ORP1L-RAB7 membrane contact sites to facilitate Syntaxin18/VAMP8-driven fusion of ER and endolysosomal membrane. One of the ER-to-Lysosome-Associated Degradation flavors.
www.biorxiv.org/content/10.1...

The involvement of the ER-phagy receptor FAM134B in membrane contact sites between ER and endolysosomes promotes ERLAD

Membrane contact sites (MCS) between organelles maintain the proximity required for controlled exchange of small molecules and ions yet preventing fusion events that would compromise organelles identi...

www.biorxiv.org

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Reposted by MolinariLab-ER

Stefan Marciniak @profmarciniak.bsky.social · Jul 4

We've just posted a new preprint:

"A GCN1-independent activator of the kinase GCN2"

bioRxiv Cell Biology @biorxiv-cellbio.bsky.social · Jul 3

A GCN1-independent activator of the kinase GCN2 https://www.biorxiv.org/content/10.1101/2025.06.29.662197v1

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Reposted by MolinariLab-ER

Robert Arkowitz @robertarkowitz.bsky.social · Jul 3

Excellent opportunity for interdisciplinary scientists. Please repost...

www.linkedin.com/posts/instit...

🔬 📢 3 Interdisciplinary Research Chair Positions Open in Nice, France! | institut de Biologie Valrose - iBV

🔬 📢 3 Interdisciplinary Research Chair Positions Open in Nice, France! Join the DYNABIO Cluster of Excellence at Université Côte d’Azur and launch your independent research program at the crossroads ...

www.linkedin.com

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MolinariLab-ER @molinarilab-er.bsky.social · Jul 2

I would like to warmly thank the ALPHA-1 Foundation for the important support allocated to our research project “Understanding the Molecular Mechanisms of Lysosomal Clearance of ATZ Polymers".

A1F recognizes 2025 Grant Award Recipients during ATS

alpha1.org/a1f-recogniz...

A1F recognizes 2025 Grant Award Recipients during ATS - Alpha-1 Foundation

On Monday, May 19th, 2025, the Alpha-1 Foundation (A1F) hosted its annual A1F Grants Award Reception at the San Francisco [...]Read More... from A1F recognizes 2025 Grant Award Recipients during ATS

alpha1.org

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MolinariLab-ER @molinarilab-er.bsky.social · Jun 20

Testing oysters for the college?

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MolinariLab-ER @molinarilab-er.bsky.social · Jun 20

Testing wines for the college?

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Reposted by MolinariLab-ER

Sonya Neal @neal-lab.bsky.social · Jun 12

Huge thanks to @gthibault.bsky.social and Julie Hollien for organizing a warm, welcoming FASEB ER meeting filled with incredible science! Excited that I will carry the torch as a co-organizer for the 2027 meeting….can’t wait! @faseborg.bsky.social

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Reposted by MolinariLab-ER

James Olzmann @olzmannlab.bsky.social · Jun 12

What a terrific FASEB ER meeting! Exceptional science and community! ❤️ Plus we got to see sea turtles nesting on the beach and a spaceX rocket launch! Cool!

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MolinariLab-ER @molinarilab-er.bsky.social · Jun 12

Early morning discussion about see turtles with Jeff Brodsky. FASEB Endoplasmic Reticulum meeting, Melbourne, Florida.
@faseborg.bsky.social

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