Actin filaments created by the Arp2/3 complex form branched networks, that grow and push against cellular membranes. We employ theory and simulation to describe how membrane surfaces accelerate filame...

Co-infection with Staphylococcus aureus and Candida albicans leads to worsened disease severity compared to mono-microbial infection. Because our understanding of the mechanisms driving enhanced disea...

Critics say linking funds to adherence to the White House’s principles undermines academic freedom

Engineered aminoacyl-tRNA synthetase (aaRS) mutants have been developed that facilitate ultrafast bioorthogonal noncanonical amino acid tagging (BONCAT) of newly synthesized proteins in diverse bacteria, including ESKAPE pathogens. The substrate polyspecificity of the aaRS mutants enables pulse-chase BONCAT and differential tagging of temporally distinct nascent proteomes in cells.

Cells tightly control the homeostatic levels and subcellular localizations of membrane phospholipids through the regulation of the activities of numerous lipid-metabolizing enzymes and lipid transfer ...

The former director of a CDC center reveals how political ideology is undermining science, threatening vaccine policy and endangering public health across the U.S.

This administration's first 6 months have been characterized by destruction, division, and chaos.

Despite being a virulence factor, candidalysin toxin is essential for Candida albicans to penetrate the oral epithelium to establish and maintain non-infectious colonization

Hepatocellular carcinoma (HCC) is a malignant tumor that has been associated with dysbiosis of the gut microbiota. However, how the gut microbiota plays an oncogenic role in HCC remains largely unknow...

Biological systems can display diverse patterns of self-organization, even when built on conserved networks of interaction between molecular species. In these cases, reaction-diffusion equations provi...

The regulation of the actin cytoskeleton is key for controlling cell shape and structure. While the Rho GTPase RhoA is well known to regulate the actomyosin cytoskeleton, its function in controlling t...

Tip growth is closely tied to fungal pathogenicity. Spa2, a multi-domain protein and member of the polarisome, orchestrates tip growth in yeast and other fungi. We identified a conserved short linear ...

DPH Member Elizabeth Jacobs shares some thoughts about misdirection and misinformation regarding acetaminophen by Robert F. Kennedy Jr. and friends.

Studying how actin filaments are assembled into different subcellular structures can provide insights into both physiological processes and the mechanisms of disease. However, quantifying the size, ab...

When Senator Wyden stated he’d heard from thousands of doctors and scientists concerned by RFK Jr’s policies, Kennedy responded "I'll put my mailbag against your mailbag any day.” Let's prove Kennedy ...

imageimageAn ensemble of phenotypes measured in the genome-sequenced 1,011 S. cerevisiae collection were coupled with genomics and molecular-level data to benchmark machine learning models for quantit...