Thierry Galli 🧫🧬🔬🎸🔊
@tgalli.bsky.social
480 followers
760 following
28 posts
Cell Biologist, Neuroscientist, Guitarist. #VAMP7 #Sybl1 #TIVAMP #Longin aficionado. Only personal views.
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Reposted by Thierry Galli 🧫🧬🔬🎸🔊
Thierry Galli 🧫🧬🔬🎸🔊
@tgalli.bsky.social
· Aug 28
Les aliments ultratransformés ont des effets négatifs forts sur la santé en quelques semaines
Dans le cadre d’un essai clinique analogue à ceux qui sont utilisés pour tester les médicaments, des scientifiques ont étudié les impacts sur la santé d’une alimentation riche en aliments ultratransfo...
www.lemonde.fr
Reposted by Thierry Galli 🧫🧬🔬🎸🔊
Reposted by Thierry Galli 🧫🧬🔬🎸🔊
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· Aug 26
CIN85 and CD2AP Are Novel Constituents of Dynamic Tubular Recycling Endosomes That Regulate Recycling Upon Recruitment by MICAL‐L1
In this study, we characterize tubular recycling endosomes and demonstrate that they are dynamic and undergo biogenesis upon CD98 internalization and fission over time. We identify CD2AP and CIN85 as...
onlinelibrary.wiley.com
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· Aug 26
FGF Signaling Promotes Lysosome Biogenesis in Chondrocytes via the Mannose Phosphate Receptor Pathway
FGF signaling regulates lysosomal homeostasis in RCS chondrocytes by inducing TFEB/TFE3 nuclear translocation and activation. This promotes the expression of lysosomal genes and mannose 6-phosphate r....
onlinelibrary.wiley.com
Reposted by Thierry Galli 🧫🧬🔬🎸🔊
Reposted by Thierry Galli 🧫🧬🔬🎸🔊
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· Jul 30
Eukaryote‐Wide Distribution of a Family of Longin Domain‐Containing GAP Complexes for Small GTPases
The three longin domain-containing GAP complexes - CSW, folliculin, and GATOR1 - have a sporadic but pan-eukaryotic distribution and were likely already present in LECA in some form. Their catalytic ...
onlinelibrary.wiley.com
Reposted by Thierry Galli 🧫🧬🔬🎸🔊
Reposted by Thierry Galli 🧫🧬🔬🎸🔊
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· Jun 6
Salmonella Typhimurium Manipulates Syntaxin 7 to Navigate Endo‐Lysosomal Trafficking in Host Cells
Salmonella Typhimurium hijacks the host Qa-SNARE syntaxin 7 (STX7) to manipulate endo-lysosomal trafficking and sustain intracellular survival. STX7 displays cell–type–specific expression and localis...
onlinelibrary.wiley.com
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· Jun 6
TENT5/FAM46: An Enigmatic Family of Secretory Tuners
TENT5s multifaceted roles in key biological processes and human diseases. TENT5 is a family of four proteins (TENT5A–D) with tissue-specific functions influencing tumor proliferation, fertility, bone....
onlinelibrary.wiley.com
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· Jun 6
A Sensitive and Versatile Cell‐Based Assay Combines Luminescence and Trapping Approaches to Monitor Unconventional Protein Secretion
In this study, Denus et al. develop a powerful and highly customizable split luciferase-based assay allowing the analysis of multiple cargo proteins released by unconventional protein secretion. This...
onlinelibrary.wiley.com
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· Jun 6
BicD and MAP7 Collaborate to Activate Homodimeric Drosophila Kinesin‐1 by Complementary Mechanisms
Kinesin-1 is auto-inhibited and binds microtubules weakly. Binding of kinesin-1 to the adaptor protein BicD enhances processive motion, while the microtubule-associated protein MAP7 recruits more kin....
onlinelibrary.wiley.com
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· Jun 6
TNF‐α‐Driven Changes in Polarized EGF Receptor Trafficking Facilitate Phosphatidylinositol 3‐Kinase/Protein Kinase B Signaling From the Apical Surface of MDCK Epithelial Cells
Epithelial-immune cell crosstalk is tightly regulated by secretion of immune cell mediators into luminal and serosal fluid spaces of epithelial tissues. We report two major new findings regarding how...
onlinelibrary.wiley.com
Reposted by Thierry Galli 🧫🧬🔬🎸🔊
Thierry Galli 🧫🧬🔬🎸🔊
@tgalli.bsky.social
· May 16
A new role of RAB21 and VARP in autophagy and autophagic exocytosis of ATP
Autophagy has been implicated in various cellular processes, including non-conventional secretion. Our previous findings suggest that ATP is loaded into amphisomes and secreted upon autophagy stimu...
www.tandfonline.com
Reposted by Thierry Galli 🧫🧬🔬🎸🔊
Reposted by Thierry Galli 🧫🧬🔬🎸🔊
Reposted by Thierry Galli 🧫🧬🔬🎸🔊
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· May 2
Golgi Localized Arl15 Regulates Cargo Transport and Cell Adhesion
The model illustrates the function of Arl15 in vesicular transport and cell surface organization. Arl15 localizes majorly to the Golgi and plasma membrane (PM), which is primarily dependent on Arf1-d...
doi.org