Stella Hurtley
@smhsci.bsky.social
2K followers
120 following
71 posts
Deputy Editor Science magazine
Areas of responsibility include: Cell biology, cellular microbiology, membrane traffic, protein targeting, protein folding, organelle biogenesis, cytoskeleton, cell polarity, prion biology, developmental biology, stem cells
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Stella Hurtley
@smhsci.bsky.social
· Aug 22
Stella Hurtley
@smhsci.bsky.social
· Aug 22
LYVAC/PDZD8 is a lysosomal vacuolator
Lysosomal vacuolation is commonly found in many pathophysiological conditions, but its molecular mechanisms and functions remain largely unknown. Here, we show that the endoplasmic reticulum (ER)–anch...
www.science.org
Stella Hurtley
@smhsci.bsky.social
· Aug 15
Mitochondria protect against an intracellular pathogen by restricting access to folate
As major consumers of cellular metabolites, mitochondria are poised to compete with invading microbes for the nutrients that they need to grow. Whether cells exploit mitochondrial metabolism to protec...
www.science.org
Stella Hurtley
@smhsci.bsky.social
· Aug 1
Cryo-EM structure of endogenous Plasmodium falciparum Pfs230 and Pfs48/45 fertilization complex
Malaria parasite fertilization occurs in the midgut of a female Anopheles mosquito. Blocking fertilization within the mosquito can prevent malaria transmission. Plasmodium falciparum Pfs230 and Pfs48/...
www.science.org
Stella Hurtley
@smhsci.bsky.social
· Aug 1
Silencing mitochondrial gene expression in living cells
Mitochondria fulfill central functions in metabolism and energy supply. They express their own genome, which encodes key subunits of the oxidative phosphorylation system. However, the central mechanis...
www.science.org
Stella Hurtley
@smhsci.bsky.social
· Jul 21
A hypoxia-responsive tRNA-derived small RNA confers renal protection through RNA autophagy
Transfer RNA-derived small RNAs (tsRNAs, or tDRs) perform a range of cellular functions. Here, we showed that a hypoxia-induced tDR, derived from the 3′ end of tRNA-Asp-GTC (tRNA-Asp-GTC-3′tDR), activ...
www.science.org
Stella Hurtley
@smhsci.bsky.social
· Jul 10
ROS transfer at peroxisome-mitochondria contact regulates mitochondrial redox
Maintenance of mitochondrial redox homeostasis is of fundamental importance to cellular health. Mitochondria harbor a host of intrinsic antioxidant defenses, but the contribution of extrinsic, nonmito...
www.science.org
Stella Hurtley
@smhsci.bsky.social
· Jul 4
Stella Hurtley
@smhsci.bsky.social
· Jun 26
Reactivation of mammalian regeneration by turning on an evolutionarily disabled genetic switch
Mammals display prominent diversity in the ability to regenerate damaged ear pinna, but the genetic changes underlying the failure of regeneration remain elusive. We performed comparative single-cell ...
www.science.org
