Manuel Mendoza
@longchrom.bsky.social
Nuclear pore complexes and RNA export, Chromosomes and cytokinesis @igbmc.bsky.social Strasbourg. Who took the Bomp from the Bompalompalomp? Who took the Ram from the Ramalamading-dong? 🇻🇪 🇪🇸 🇫🇷
Pinned
Manuel Mendoza
@longchrom.bsky.social
· Nov 1
Dam, Moreno, Brownlow, @longchrom.bsky.social et al. @igbmc.bsky.social identify Srs2 as a key mediator of abscission inhibition in yeast and show that its human paralog PARI regulates abscission-associated events. rupress.org/jcb/article/...
#Cytokinesis
#Cytokinesis
Our story on Srs2/PARI family DNA helicases linking chromatin bridges to the Aurora-B dependent NoCut checkpoint is now out in its peer-reviewed version. Thanks to @reviewcommons.org and @jcb.org for a smooth review process! Original preprint thread here: bsky.app/profile/long...
Reposted by Manuel Mendoza
I'm exhausted from reading 'not X but Y' sentence structures.
It's a hallmark of AI, and that's fine, but the issue is that sometimes I find it every other paragraph!
It's a hallmark of AI, and that's fine, but the issue is that sometimes I find it every other paragraph!
February 11, 2026 at 9:01 PM
I'm exhausted from reading 'not X but Y' sentence structures.
It's a hallmark of AI, and that's fine, but the issue is that sometimes I find it every other paragraph!
It's a hallmark of AI, and that's fine, but the issue is that sometimes I find it every other paragraph!
Reposted by Manuel Mendoza
1/3 New bioRxiv preprint from the lab: “Minute-scale coupling of chromatin marks and transcriptional bursts”. Led by Xiohui Gao & Chaebeen Ko. bioRxiv : www.biorxiv.org/cgi/content/...
February 11, 2026 at 4:06 AM
1/3 New bioRxiv preprint from the lab: “Minute-scale coupling of chromatin marks and transcriptional bursts”. Led by Xiohui Gao & Chaebeen Ko. bioRxiv : www.biorxiv.org/cgi/content/...
Reposted by Manuel Mendoza
We are in EMBO J. See DNA and non-octameric nucleosome-like particles in situ
link.springer.com/article/10.1...
link.springer.com/article/10.1...
Direct visualization and tracing of chromatin folding in the Drosophila embryo - The EMBO Journal
Chromatin organization, through the assembly of DNA with histones and the folding of nucleosome chains, regulates DNA accessibility for transcription, DNA replication and repair. Although models deriv...
link.springer.com
February 10, 2026 at 3:44 PM
We are in EMBO J. See DNA and non-octameric nucleosome-like particles in situ
link.springer.com/article/10.1...
link.springer.com/article/10.1...
Reposted by Manuel Mendoza
This graph basically shows that the MSCA are, as of now, useless unless the EU governance does something about it 🧪
February 11, 2026 at 9:42 AM
This graph basically shows that the MSCA are, as of now, useless unless the EU governance does something about it 🧪
Reposted by Manuel Mendoza
📣 Please spread: we’re hiring a Lab Manager! It is a critical position in our new lab. As our lab moves to Barcelona and joins the @crg.eu, we’re looking for a Lab Manager to help build the lab and set the lab atmosphere.
🔗 Apply here 👉 recruitment.crg.eu/content/jobs...
🔗 Apply here 👉 recruitment.crg.eu/content/jobs...
January 23, 2026 at 6:41 AM
📣 Please spread: we’re hiring a Lab Manager! It is a critical position in our new lab. As our lab moves to Barcelona and joins the @crg.eu, we’re looking for a Lab Manager to help build the lab and set the lab atmosphere.
🔗 Apply here 👉 recruitment.crg.eu/content/jobs...
🔗 Apply here 👉 recruitment.crg.eu/content/jobs...
Reposted by Manuel Mendoza
Postdoc job alert at Institut Jacques Monod in Paris! Interested in fundamental membrane trafficking? We seek a postdoc to study collagen secretion as a model for core principles of how cells and their environment build each other. emploi.cnrs.fr/Offres/CDD/U...
Portail Emploi CNRS - Offre d'emploi - Poste de chercheur postdoctoral en trafic membranaire fondamental et sécrétion du collagène (H/F)
Assurez-vous que votre profil candidat soit correctement renseigné avant de postuler
emploi.cnrs.fr
February 6, 2026 at 10:12 AM
Postdoc job alert at Institut Jacques Monod in Paris! Interested in fundamental membrane trafficking? We seek a postdoc to study collagen secretion as a model for core principles of how cells and their environment build each other. emploi.cnrs.fr/Offres/CDD/U...
Reposted by Manuel Mendoza
🧬 #Yeast condensin does more than organize chromosomes.
New study shows it acts as a transient crosslinker in entangled DNA, stabilizing entanglements rather than resolving them. This challenges current models of chromosome organizing proteins.
#YeastResearch #SGD
www.yeastgenome.org/reference/S1...
New study shows it acts as a transient crosslinker in entangled DNA, stabilizing entanglements rather than resolving them. This challenges current models of chromosome organizing proteins.
#YeastResearch #SGD
www.yeastgenome.org/reference/S1...
February 4, 2026 at 11:53 PM
🧬 #Yeast condensin does more than organize chromosomes.
New study shows it acts as a transient crosslinker in entangled DNA, stabilizing entanglements rather than resolving them. This challenges current models of chromosome organizing proteins.
#YeastResearch #SGD
www.yeastgenome.org/reference/S1...
New study shows it acts as a transient crosslinker in entangled DNA, stabilizing entanglements rather than resolving them. This challenges current models of chromosome organizing proteins.
#YeastResearch #SGD
www.yeastgenome.org/reference/S1...
Reposted by Manuel Mendoza
The Muppet Show on Disney+ is glorious.
They haven't tried to update it, or twist it in any way. It's just The Muppet Show you watched when you were a kid.
They haven't tried to update it, or twist it in any way. It's just The Muppet Show you watched when you were a kid.
February 4, 2026 at 10:13 AM
The Muppet Show on Disney+ is glorious.
They haven't tried to update it, or twist it in any way. It's just The Muppet Show you watched when you were a kid.
They haven't tried to update it, or twist it in any way. It's just The Muppet Show you watched when you were a kid.
Reposted by Manuel Mendoza
Hi all- we are searching for a new manager/operator to run and develop KCL's Cryo-EM Structural Discovery Facility: a JEOL cryoARM200 + k3 and sample preparation equipment. This 200kV set up recently achieved a 1.2 Å apoferritin! www.biorxiv.org/content/10.6...
www.kcl.ac.uk/jobs/137165-...
www.kcl.ac.uk/jobs/137165-...
Cryo-EM Facility Manager | King's College London
www.kcl.ac.uk
February 3, 2026 at 12:37 PM
Hi all- we are searching for a new manager/operator to run and develop KCL's Cryo-EM Structural Discovery Facility: a JEOL cryoARM200 + k3 and sample preparation equipment. This 200kV set up recently achieved a 1.2 Å apoferritin! www.biorxiv.org/content/10.6...
www.kcl.ac.uk/jobs/137165-...
www.kcl.ac.uk/jobs/137165-...
Reposted by Manuel Mendoza
So much here that I just cannot wrap my head around...
"Asked about the shooting of Ms. Good, more than half of Republicans said it was a necessary use of force. Asked about Mr. Pretti, just 33 percent said it was a necessary use of force. A large share, 43 percent, said they were not sure."
"Asked about the shooting of Ms. Good, more than half of Republicans said it was a necessary use of force. Asked about Mr. Pretti, just 33 percent said it was a necessary use of force. A large share, 43 percent, said they were not sure."
Polls Show Strong G.O.P. Support for Trump on Immigration
www.nytimes.com
February 3, 2026 at 5:12 PM
So much here that I just cannot wrap my head around...
"Asked about the shooting of Ms. Good, more than half of Republicans said it was a necessary use of force. Asked about Mr. Pretti, just 33 percent said it was a necessary use of force. A large share, 43 percent, said they were not sure."
"Asked about the shooting of Ms. Good, more than half of Republicans said it was a necessary use of force. Asked about Mr. Pretti, just 33 percent said it was a necessary use of force. A large share, 43 percent, said they were not sure."
Reposted by Manuel Mendoza
Please repost and consider applying: we work in such a fantastic context, we ask so interesting questions, and we have such a collegial and best-willing atmosphere… CRBM = Happy & Good Science
January 30, 2026 at 11:49 PM
Please repost and consider applying: we work in such a fantastic context, we ask so interesting questions, and we have such a collegial and best-willing atmosphere… CRBM = Happy & Good Science
Reposted by Manuel Mendoza
Melike Lakadamyali @melikel.bsky.social, Jérôme Solon and Manuel Mendoza @longchrom.bsky.social share the behind the paper story of their research interrogating how chromosome compaction scales with cell size using a combination of live confocal microscopy and 3D STORM.
Seeing Chromatin Scaling with Cell Size, from Interphase to Mitosis - FocalPlane
Seeing Chromatin Scaling with Cell Size, from Interphase to Mitosis -
focalplane.biologists.com
January 29, 2026 at 3:07 PM
Melike Lakadamyali @melikel.bsky.social, Jérôme Solon and Manuel Mendoza @longchrom.bsky.social share the behind the paper story of their research interrogating how chromosome compaction scales with cell size using a combination of live confocal microscopy and 3D STORM.
Reposted by Manuel Mendoza
Mitosis has a timing system. If chromosomes attach properly, cells divide on schedule and keep proliferating. If attachment is slow or incomplete, the delay is recorded — and daughter cells stop dividing.
We explore this link in our new preprint.
🔗 www.biorxiv.org/content/10.6...
We explore this link in our new preprint.
🔗 www.biorxiv.org/content/10.6...
January 29, 2026 at 11:32 AM
Mitosis has a timing system. If chromosomes attach properly, cells divide on schedule and keep proliferating. If attachment is slow or incomplete, the delay is recorded — and daughter cells stop dividing.
We explore this link in our new preprint.
🔗 www.biorxiv.org/content/10.6...
We explore this link in our new preprint.
🔗 www.biorxiv.org/content/10.6...
Reposted by Manuel Mendoza
I wrote this song on Saturday, recorded it yesterday and released it to you today in response to the state terror being visited on the city of Minneapolis. It’s dedicated to the people of Minneapolis, our innocent immigrant neighbors and in memory of Alex Pretti and Renee Good.
Stay free
Stay free
Bruce Springsteen - Streets Of Minneapolis (Official Audio)
YouTube video by Bruce Springsteen
youtu.be
January 28, 2026 at 5:02 PM
I wrote this song on Saturday, recorded it yesterday and released it to you today in response to the state terror being visited on the city of Minneapolis. It’s dedicated to the people of Minneapolis, our innocent immigrant neighbors and in memory of Alex Pretti and Renee Good.
Stay free
Stay free
Thanks to @focalplane.bsky.social for the invitation to highlight our recent @biophysj.bsky.social paper! With @melikel.bsky.social and Jérôme Solon, we combined super-resolution and live imaging to connect interphase chromatin organisation to mitotic chromosome compaction across cell sizes.
Seeing Chromatin Scaling with Cell Size, from Interphase to Mitosis - FocalPlane
Seeing Chromatin Scaling with Cell Size, from Interphase to Mitosis -
focalplane.biologists.com
January 26, 2026 at 2:51 PM
Thanks to @focalplane.bsky.social for the invitation to highlight our recent @biophysj.bsky.social paper! With @melikel.bsky.social and Jérôme Solon, we combined super-resolution and live imaging to connect interphase chromatin organisation to mitotic chromosome compaction across cell sizes.
Reposted by Manuel Mendoza
I’ll soon share a call for a postdoc at Institut Jacques Monod (Paris) on fundamental mechanisms of membrane traffic and protein/collagen secretion in health and disease. Please get in touch if interested.
January 23, 2026 at 10:59 AM
I’ll soon share a call for a postdoc at Institut Jacques Monod (Paris) on fundamental mechanisms of membrane traffic and protein/collagen secretion in health and disease. Please get in touch if interested.
“A student joining a lab is often presented with a hypothesis to work on and may see science as a hypothesis-testing endeavor. Many young postdocs have been told that as a PhD student their job was to answer questions—now they have to discover their own unknown unknowns.”
January 24, 2026 at 9:58 AM
“A student joining a lab is often presented with a hypothesis to work on and may see science as a hypothesis-testing endeavor. Many young postdocs have been told that as a PhD student their job was to answer questions—now they have to discover their own unknown unknowns.”
Reposted by Manuel Mendoza
Comme promis, un texte où je persiste et signe : le film "Le mage du Kremlin" est dangereux, car il se met au service du pouvoir russe en diffusant une vision du pays exactement conforme à ce que le Kremlin veut nous faire penser.
colinlebedev.fr/2026/01/22/h...
colinlebedev.fr/2026/01/22/h...
(Hom)mage du Kremlin.
« ‘Le Mage du Kremlin’ (le film) est à peu près le meilleur cadeau que nous puissions faire au Kremlin (le vrai). » J’ai posté ce commentaire hier sur les réseaux sociaux, en sortant de l…
colinlebedev.fr
January 22, 2026 at 12:38 PM
Comme promis, un texte où je persiste et signe : le film "Le mage du Kremlin" est dangereux, car il se met au service du pouvoir russe en diffusant une vision du pays exactement conforme à ce que le Kremlin veut nous faire penser.
colinlebedev.fr/2026/01/22/h...
colinlebedev.fr/2026/01/22/h...
Reposted by Manuel Mendoza
Reposted by Manuel Mendoza
We are looking for a postdoc to work on mechanisms of #RNA decay in cancer using #cryoEM with #nanobodies and #minibinders! Please RT
January 18, 2026 at 2:30 PM
We are looking for a postdoc to work on mechanisms of #RNA decay in cancer using #cryoEM with #nanobodies and #minibinders! Please RT
Reposted by Manuel Mendoza
This photo was taken in 1911 using glass plate technology by Herbert Ponting who was part of Scott's Antarctic expedition,
The composition and detail are exquisite with the band of white snow/ice creating a perfect frame around the two people and the ship in the distance
Iconic imo
The composition and detail are exquisite with the band of white snow/ice creating a perfect frame around the two people and the ship in the distance
Iconic imo
January 17, 2026 at 7:12 AM
This photo was taken in 1911 using glass plate technology by Herbert Ponting who was part of Scott's Antarctic expedition,
The composition and detail are exquisite with the band of white snow/ice creating a perfect frame around the two people and the ship in the distance
Iconic imo
The composition and detail are exquisite with the band of white snow/ice creating a perfect frame around the two people and the ship in the distance
Iconic imo
Who’s behind this? The answer will not surprise you www.cidrap.umn.edu/childhood-va...
Controversial CDC hep B vaccine study in Guinea-Bissau may be canceled
www.cidrap.umn.edu
January 17, 2026 at 1:36 PM
Who’s behind this? The answer will not surprise you www.cidrap.umn.edu/childhood-va...
This is nuts
Histoire assez dingue : un essai clinique sur un vaccin contre l’hépatite B en Guinée-Bissau, financé par les États-Unis, prévoit de priver la moitié du groupe (soit 7 000 bébés !) du vaccin à la naissance.
C'est "inacceptable"... et l'essai est suspendu. www.cidrap.umn.edu/c...
C'est "inacceptable"... et l'essai est suspendu. www.cidrap.umn.edu/c...
January 17, 2026 at 1:18 PM
This is nuts
Reposted by Manuel Mendoza
Reposted by Manuel Mendoza
0/10
🥳 our #exocyst paper out in @cp-cell.bsky.social, led by Marta, Sebas & @sasmeek.bsky.social in collab with @jonasries.bsky.social, @cmanzo.bsky.social & Castaño-Díez labs #Quantitative_Cell_Biology
Continuum architecture dynamics of vesicle tethering in exocytosis
www.cell.com/cell/fulltex...
🥳 our #exocyst paper out in @cp-cell.bsky.social, led by Marta, Sebas & @sasmeek.bsky.social in collab with @jonasries.bsky.social, @cmanzo.bsky.social & Castaño-Díez labs #Quantitative_Cell_Biology
Continuum architecture dynamics of vesicle tethering in exocytosis
www.cell.com/cell/fulltex...
Continuum architecture dynamics of vesicle tethering in exocytosis
Data from complementary imaging techniques were integrated into a model that resolves
the dynamic exocyst ensemble and membrane architecture during exocytosis, an essential
cellular pathway. Sec18 med...
www.cell.com
January 16, 2026 at 5:28 PM
0/10
🥳 our #exocyst paper out in @cp-cell.bsky.social, led by Marta, Sebas & @sasmeek.bsky.social in collab with @jonasries.bsky.social, @cmanzo.bsky.social & Castaño-Díez labs #Quantitative_Cell_Biology
Continuum architecture dynamics of vesicle tethering in exocytosis
www.cell.com/cell/fulltex...
🥳 our #exocyst paper out in @cp-cell.bsky.social, led by Marta, Sebas & @sasmeek.bsky.social in collab with @jonasries.bsky.social, @cmanzo.bsky.social & Castaño-Díez labs #Quantitative_Cell_Biology
Continuum architecture dynamics of vesicle tethering in exocytosis
www.cell.com/cell/fulltex...