Manuel Mendoza
@longchrom.bsky.social
410 followers 500 following 140 posts
Nuclear pore complexes and RNA export, Chromosomes and cytokinesis @igbmc.bsky.social Strasbourg. Who took the Bomp from the Bompalompalomp? Who took the Ram from the Ramalamading-dong? 🇻🇪 🇪🇸 🇫🇷
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longchrom.bsky.social
Almost 17 years after opening our yeast cell division lab, our first transcription paper in mouse embryonic stem cells! www.science.org/doi/10.1126/...
This schematic illustrates the interplay between transcription coactivator perturbations (e.g., TIP60 or ATAC complex depletion) and RNA homeostasis. Perturbations lead to alterations in mRNA synthesis, which are counterbalanced by changes in mRNA export and cytoplasmic decay of specific transcripts, thereby maintaining RNA homeostasis.
Reposted by Manuel Mendoza
cellarchlab.com
EXCITING NEWS!! We're searching for a new professor colleague at the Biozentrum🇨🇭. Ideal candidates are exploring novel biological questions with structure, biophysics, or high-resolution imaging. 🧪 🧶🧬 🔬

The call closes Nov 3. Please get in touch if you would like more information. Come join us! 👩‍🔬🤓
Reposted by Manuel Mendoza
dijiang319.bsky.social
@science.org ⤵️challenges prevailing notion—repressor and activator act by distinct mechanisms: repressors block via steric hindrance/activators enable Pol II binding to promoter🧬

E. coli transcription factors regulate promoter activity by a universal, homeostatic mechanism | Science bit.ly/adv2064
Reposted by Manuel Mendoza
richardsever.bsky.social
I'm always reminded of Tim Hunt's description of going to the library: "flipping through tables of contents of all the latest issues, hoping there isn't something relevant to your work..." 3/n
longchrom.bsky.social
Glad you enjoyed it! À la prochaine
Reposted by Manuel Mendoza
noelledwyerphd.bsky.social
Our new preprint 😅 ! We show cytokinetic abscission completion is important to maintain polarized epithelial structure, and p53-mediated apoptosis guards the structure when there are failures of abscission. In vivo in brain. #cellbio #abscission #devbio #cilia www.biorxiv.org/content/10.1...
Cytokinetic abscission failures in a polarized epithelium affect apical membrane size and cilia
Cytokinetic abscission is the last step of cell division, during which the intercellular bridge between daughter cells is severed. While abscission genes are linked to cancers and developmental disord...
www.biorxiv.org
longchrom.bsky.social
Some studies suggest that the Earth is flat, but many experts are skeptical
Screen capture of BBC headline:
Trump will reportedly link autism to pain reliever Tylenol - but many experts are sceptical
Some studies have suggested an association between the two, but experts say there is no causal relationship.
Reposted by Manuel Mendoza
jeremymberg.bsky.social
My quote of the day

Masha Gessen
The Soviet system of propaganda and censorship existed not so much for the purpose of spreading a particular message as for the purpose of making learning impossible, replacing facts with mush, and handing the faceless state a monopoly on defining an ever-shifting reality.
Reposted by Manuel Mendoza
wurtz3l.bsky.social
Directed by M. Night Shyamalan.
Pantallazo del titular de una noticia. Dice: “El atropello de un tren a una vaca, que parió en el impacto, deriva en el hallazgo de un cadáver en Gijón”. Justo debajo, la entradilla dice: “Los agentes que acudieron por el accidente se toparon con el cuerpo del fallecido, en avanzado estado de descomposición”.
Reposted by Manuel Mendoza
longchrom.bsky.social
Our chromatin scaling paper is now out in its peer-reviewed form! 🎉
We added some controls, statistics, and a new introduction to better contextualise our findings. Overall a much-improved version we hope! (see my earlier thread for the preprint background)
www.sciencedirect.com/science/arti...
Reposted by Manuel Mendoza
barteltlab.bsky.social
One of the important benefits of @reviewcommons.org is having a peer-reviewed preprint, which to an increasing number of funders counts as a published paper @embo.org

Saves important time for trainees to have their work recognized.
Reposted by Manuel Mendoza
weratedogs.com
This is Finny. He doesn’t go chasing waterfalls. He carefully studies their timing and arrives in advance. 14/10 very impressive (TT: jordancain70)
Reposted by Manuel Mendoza
keithellison.bsky.social
Facts are unfolding but while Trump officials have claimed that the Venezuelan boat was carrying drugs, independent and verifiable proof of the cargo has not been publicly provided. Even if true, then arrest and fair trial are the right response, not the death penalty. 11 were killed.
Reposted by Manuel Mendoza
mirimiam.bsky.social
🚨🚨🚨

Please RT!

We're looking for a postdoc to join an exciting joint project between our lab @upf.edu & @crg.eu (Barcelona) and the Sander lab @mdc-berlin.bsky.social (Berlin) investigating how alternative splicing and microexons influences the maturation of pancreatic islets.

Deadline: 30/09/25👇
www.upf.edu
Reposted by Manuel Mendoza
mhverlhac.bsky.social
Three-Year Funded Postdoctoral Position to study organelle architecture in mammalian oocytes – Terret-Verlhac Lab, CIRB, Collège de France (Starting 2026).
For more information, please contact: [email protected]