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Reposted by Hiten Madhani

David Katz @katzlab.bsky.social · 1d

Very excited to share our very exciting story on how misinherited chromatin affects individual cells to cause a behavior defect in C. elegans (a thread👇) www.pnas.org/doi/10.1073/...

PNAS

Proceedings of the National Academy of Sciences (PNAS), a peer reviewed journal of the National Academy of Sciences (NAS) - an authoritative source of high-impact, original research that broadly spans...

www.pnas.org

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Hiten Madhani @hitenmadhani.bsky.social · 1d

Every university leader should read this.

Jeremy Berg @jeremymberg.bsky.social · 1d

I just emailed my "Silence" essay to the Presidents/Chancellors and Provosts of the 9 Compact universities as well as those from the 4 orgs with which I have been formally affiliated.

The essay can be found here:

jeremymberg.github.io/jeremyberg.g...

and here:

www.linkedin.com/posts/jeremy...

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Reposted by Hiten Madhani

sdwarcher.bsky.social @sdwarcher.bsky.social · 1d

@altnih4science.bsky.social

Trump slashed funding for universities that helped create these vital drugs

Medications that prevent HIV, shrink tumors and treat seizures were invented with government funding. At research universities, that money is now canceled or in jeopardy.

www.washingtonpost.com

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EPIGENETIC HULK @epigenetichulk.bsky.social · 1d

NUCLEOSOME NOMENCLATURE JUST FINE! WHY BE SO CRAZY! {[("H3meLIKEY2"])} www.cell.com/molecular-ce...

A needed nomenclature for nucleosomes

Keogh et al. propose a nomenclature to clearly and concisely describe the post-translational modifications, proteoforms, and nucleoforms that drive chromatin function. This communicates experimental n...

www.cell.com

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NPR @npr.org · 1d

Two groups are calling for new leadership at HHS after Health Secretary Robert F. Kennedy Jr.'s actions on substance abuse treatment and mental health medications, among other issues.

Psychiatrists call for RFK Jr. to be replaced as health secretary

Two groups are calling for new leadership at HHS after Health Secretary Robert F. Kennedy Jr.'s actions on substance abuse treatment and mental health medications, among other issues.

n.pr

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Hiten Madhani @hitenmadhani.bsky.social · 2d

😱

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North Carolina Conference of the AAUP @ncaaup.bsky.social · 3d

www.aaup.org/news/univers...

Universities Must Reject Trump Admin "Loyalty Oath" Compacts

The AAUP and AFT warn that the Trump administration’s offer to give preferential treatment to colleges and universities in exchange for allegiance to a partisan ideological agenda is entirely corrupt.

www.aaup.org

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Hiten Madhani @hitenmadhani.bsky.social · 3d

Nice day for a ride!

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Stand Up for Science! @standupforscience.bsky.social · 5d

The Trump admin has been targeting whistleblowers, from the #FEMA36 to the countless other patriotic public servants and scientists across NIH, CDC, NASA, and more who spoke out about the danger posed by the chaos in our federal agencies. This is an concerted, autocratic effort to silence dissent.

RFK Jr fires top NIH scientist weeks after she files whistleblower complaint

Jeanne Marrazzo’s complaint reportedly involved the Trump administration’s hostility toward vaccines

www.theguardian.com

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Stand Up for Science! @standupforscience.bsky.social · 4d

Today is October 3rd, another day where we are calling to #ImpeachtheQuack!

Page which has the handwritten red text: “This guy is the worst, most useless and unqualified HHS Secretary I have ever met. DO NOT TRUST HIM. He is an incompetent QUACK!”

A picture of RFK Jr. with “Robert F Kennedy Jr.” written underneath it.

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Science and Freedom Alliance - SAFA @safa-science.bsky.social · 5d

@jenna-m-norton.bsky.social ‘s speech at the Capitol on Monday.

“As a federal worker, I am here to tell you that every awful thing that would happen in a shutdown—shuttering programs that Americans rely on, damaging our economy, firing federal workers—all of this is already happening.”

"Nearly impossible for NIH staff to do our jobs": Jenna Norton's speech for the Civil Servants Coalition

At the Capitol, Monday 9/29

scienceandfreedomalliance.substack.com

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Jason Moore @moorejh.bsky.social · 5d

We introduce here the emerging concept of vibe coding, in which AI accelerates coding by converting natural language or abstract intent (a vibe) into functioning software modules, shortening development cycles biodatamining.biomedcentral.com/articles/10.... #vibecoding #bioinformatics #coding

Vibe coding: a new paradigm for biomedical software development - BioData Mining

biodatamining.biomedcentral.com

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Ming Tommy Tang @tommytang.bsky.social · 5d

Your data is lying to you. Here’s how technical artifacts distort biology—and how to see the truth. 👇
1/ Beautiful t-SNE? Shiny heatmap?
Look closer.
Technical artifacts can fake whole cell types.
Here’s where the ghosts hide.

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Reposted by Hiten Madhani

Jeremy Berg @jeremymberg.bsky.social · 5d

A thread with some interesting (at least to me) observations on multi-year funding, past and present...

1/8

a man wearing glasses is looking at the camera and saying let 's take a closer look .

ALT: a man wearing glasses is looking at the camera and saying let 's take a closer look .

media.tenor.com

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ClutchScience (Jen Phillips) @clutchscience.bsky.social · 6d

Very nice reporting on the importance—and the vulnerability— of model organism databases

www.nature.com/articles/d41...

Model organism databases face budget cuts and closures

Beyond the crucial data they contain, these digital archives have provided an important space for academic communities to exchange ideas and resources.

www.nature.com

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Jeremy Berg @jeremymberg.bsky.social · 6d

👇👇👇👇👇

Liz Neeley @lizneeley.bsky.social · 6d

Some problems have simple solutions. This new “Compact for Academic Excellence in Higher Education” is one. The answer is simply saying no.

Simple does not mean easy. But Brown, Dartmouth, MIT, Vanderbilt, Univ of AZ, UPenn, USC, UT Austin & UVA must understand what they’ll lose if they sign on.

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Union of Concerned Scientists @ucs.org · 6d

The data and evidence are clear. Over the past 8 months, the egregious actions of President Trump and his enablers have caused real harm to people and communities across the country.

Science and Democracy Under Siege

This administration's first 6 months have been characterized by destruction, division, and chaos.

www.ucs.org

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Prasad Jallepalli, MD, PhD @prasad.bsky.social · 6d

I am astounded, disgusted, demoralized, & fed up

every single institution of our great nation is under siege by these grifters, scammers, liars, & idiots

they are sabotaging the greatest engine of progress, prosperity, and power that the world has ever known

www.nytimes.com/2025/10/02/u...

The White House on Wednesday sent letters to nine of the nation's top public and private universities, urging campus leaders to pledge support for President Trump's political agenda to help ensure access to federal research funds.

The letters came attached to a 10-page "compact" that serves as a sort of priority statement for the administration's educational goals - the most comprehensive accounting to date of what Mr. Trump aims to achieve from an unparalleled, months long pressure campaign on academia.

The compact would require colleges to freeze tuition for five years, cap the enrollment of international students and commit to strict definitions of gender. Among other steps, universities would also be required to change their governance structures to prohibit anything that would "punish, belittle and even spark violence against conservative ideas."

Colleges that sign the agreement would receive "multiple positive benefits," according to a letter included with the compact signed by Education Secretary Linda McMahon; Vince Haley, the director of the White House Domestic Policy Council; and May Mailman, the White House's senior adviser for special projects.

Colleges that agree would get priority access to federal funds and looser restraints on overhead costs. Signed compacts would also serve as assurance to the government that schools are complying with civil rights laws. Federal civil rights investigations have been used to halt much of the research funding that the administration has blocked so far this year.

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European Research Council (ERC) @erc.europa.eu · 7d

Maria Leptin re-appointed as ERC President! 🇪🇺

ERC Vice Presidents said:

This is excellent news, ensuring continuity at a critical moment. On behalf of the Scientific Council, we thank Maria for her leadership & strong commitment that has taken ERC to new heights.

👇
erc.europa.eu/news-events/...

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Hiten Madhani @hitenmadhani.bsky.social · 7d

I would argue that supporting science (evidence-based thinking) is integral to this battle. #standupforscience

Alexandria Ocasio-Cortez @aoc.bsky.social · 7d

Most of the power authoritarians have is freely given. We should not comply with them in advance.

Trump is far weaker than he looks. So is the GOP. We should draw them out, drain them at every opportunity, and fight for people’s wellbeing at every turn.

We have been sent here to fight for people.

Acyn @acyn.bsky.social · 7d

AOC: I think there's two things that are happening at once: One, there absolutely is an unprecedented abuse of power, destruction of norms, erosion of our government and our democracy in order to prop up an authoritarian style of governance

However, they are weaker than they look…

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Alt NIH Bluesky 🧪 @altnih4science.bsky.social · 7d

This is great. Thank you, @ramirez.house.gov for standing up for science and research — and health care, education, and freedoms too.

Congresswoman Delia C. Ramirez @ramirez.house.gov · 7d

We need to restore funding for health care, for science, for research, for education, and for our communities.

Democrats will continue to fight for a budget bill that centers working families.

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Reposted by Hiten Madhani

Johan Duchêne @johanduchene.bsky.social · 9d

⚠️ Half of commercial antibodies miss their target!
So how do you pick the right one for your experiment?

Here’s the solution 👉
Antibody characterization data (all tested in KO cells) are now available at:
🔗 onlygoodantibodies.co.uk

Tested by @ycharos.bsky.social & @oga-community.bsky.social

OGA - Only Good Antibodies Community

onlygoodantibodies.co.uk

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Hiten Madhani @hitenmadhani.bsky.social · 8d

Thanks for crunching the #!

How much of the discrepancy between project number and dollars spent can be attributed to type 4 awards?

Reposted by Hiten Madhani

Carl Quintanilla @carlquintanilla.bsky.social · 9d

Rest of world already pouncing.

@bloomberg.com @reuters.com #H1B
www.bloomberg.com/news/article...

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Coleen Murphy @ctmurphy1.bsky.social · 9d

Last day to comment - this proposed rule change on foreign students' stay will be disastrous for PhD students and programs. Please add your comments TODAY here: www.regulations.gov/commenton/IC...

Regulations.gov

www.regulations.gov

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