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Reposted by Manuel Irimia

Cristina Pujades @cristinapujades.bsky.social · 3d

We are hiring ! Interested in understanding how neuronal cell diversity arises? Come and join us @upf.edu for a #PhD #FPI fellowship

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Reposted by Manuel Irimia

BIOMICS_GIMM @biomics-twinning.bsky.social · 3d

✨ Getting to know BIOMICS members ✨
Meet the people behind our #Twinning project one story at a time.
🎙️ Who’s our first guest?
Hint: a Group Leader at ETH Zurich exploring how molecular mechanisms shape human biology and disease.

Here ➡️ youtu.be/iqlB74ldyos
#HorizonEurope #BIOMICS #MeetTheTeam

Getting to know BIOMICS members: Pedro Beltrão

YouTube video by BIOMICS Twinning

youtu.be

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Reposted by Manuel Irimia

Denis Duboule @denisduboule.bsky.social · 6d

Vertebrate Genome Evolution. Annual Symposium of the @louisjeantetfdn.bsky.social Foundation in Geneva. Free access on site and on line. Great speakers for a super interesting topic. #SvantePaabo #HenrikKaessmann organisers 🙏 See you there! @biology-unige.bsky.social @genevunige.bsky.social

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Reposted by Manuel Irimia

Moreno-Mateos Lab @crisprscan.bsky.social · 9d

Glad to share that the website for the MZT EMBO workshop that I organize together with Ana Boskovic (EMBL, Rome), Antonio Giraldez (Yale U) and Melissa Harrison (U Wisconsin) is out: meetings.embo.org/event/26-awa...
Please spread the word and join us in beautiful Seville next 4-7 May!

Awakening the Genome During Developmental Reprogramming: From Embryos to Organoids

This EMBO Workshop explores the gene-regulatory mechanisms that drive developmental reprogramming upon fertilization. It focuses on the interplay of transcriptional, post-transcriptional, and develop…

meetings.embo.org

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Al Jord Lab @aljordlab.bsky.social · 9d

🔴✨ Exciting opportunity : we're hiring a PhD student! ✨🔴

👉 Don't hesitate to apply or spread the word!

⏰ Deadline 30th November 2025

ℹ️ More information and application : www.crg.eu/en/content/t...

@crg.eu @prbb.org

Centre for Genomic Regulation Website

www.crg.eu

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EVOMG-Doctoral Network @evomg-dn.bsky.social · 9d

At EvoMG-DN we believe that evolutionary history shapes both the human genome and its pathogens and ultimately disease susceptibility.
We will tackle health challenges from an evolutionary perspective in the topic of: ageing, cancer and infectious diseases.
#PhD #EvolutionaryBiology #MSCA

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EVOMG-Doctoral Network @evomg-dn.bsky.social · 9d

Interested? Check the details of each position here: www.findaphd.com/phds/program...

EVOMG-Doctoral Network @evomg-dn.bsky.social · 9d

At EvoMG-DN we believe that evolutionary history shapes both the human genome and its pathogens and ultimately disease susceptibility.
We will tackle health challenges from an evolutionary perspective in the topic of: ageing, cancer and infectious diseases.
#PhD #EvolutionaryBiology #MSCA

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Reposted by Manuel Irimia

Manuel Irimia @mirimiam.bsky.social · 17d

Last days to apply! Cool project, cool cities! :-)

(Please repost! 🙏)

Manuel Irimia @mirimiam.bsky.social · Jul 23

🚨🚨🚨

Please RT!

We're looking for a postdoc to join an exciting joint project between our lab @upf.edu & @crg.eu (Barcelona) and the Sander lab @mdc-berlin.bsky.social (Berlin) investigating how alternative splicing and microexons influences the maturation of pancreatic islets.

Deadline: 30/09/25👇

www.upf.edu

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Reposted by Manuel Irimia

EVOMG-Doctoral Network @evomg-dn.bsky.social · 14d

🚀 Exciting news: the Evolutionary Medical Genomics Doctoral Network (EVOMG-DN) launches soon!
🔍 15 fully funded PhD positions: ready to shape the future of genomic medicine? Stay tuned for details!
#PhD #EvolutionaryBiology #MSCA #PhDPositions

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Reposted by Manuel Irimia

Arnau Sebé-Pedrós @arnausebe.bsky.social · 15d

Happy to share the Biodiversity Cell Atlas white paper, out today in @nature.com. We look at the possibilities, challenges, and potential impacts of molecularly mapping cells across the tree of life.
www.nature.com/articles/s41...

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Manuel Irimia @mirimiam.bsky.social · 17d

Last days to apply! Cool project, cool cities! :-)

(Please repost! 🙏)

Manuel Irimia @mirimiam.bsky.social · Jul 23

🚨🚨🚨

Please RT!

We're looking for a postdoc to join an exciting joint project between our lab @upf.edu & @crg.eu (Barcelona) and the Sander lab @mdc-berlin.bsky.social (Berlin) investigating how alternative splicing and microexons influences the maturation of pancreatic islets.

Deadline: 30/09/25👇

www.upf.edu

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Reposted by Manuel Irimia

Tobias Warnecke @tobiaswarnecke.bsky.social · Sep 8

Please re-post:

Interested in chromatin and its evolution? Good news! There's still time to join us in beautiful Catalonia (9-12 Dec) to discuss eukaryotic, bacterial, archaeal, and viral chromatin and how it all hangs together meetings.embo.org/event/24-evo...

Abstract deadline: 30 September

EvoChromo: Evolutionary approaches to research in chromatin

Chromatin is the complex of DNA, RNA and protein that is found making up the chromosomes in eukaryotic cells. Chromatin is essential for proper genome function and is involved in chromosome segregati…

meetings.embo.org

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Reposted by Manuel Irimia

Sophie Bonnal @sobonnal.bsky.social · Sep 1

Wonderful read on microexons — their regulation, cross-species functions, disease relevance & therapeutic potential.

Manuel Irimia @mirimiam.bsky.social · Sep 1

🚨🚨🚨 New review article on #microexons from the lab! A comprehensive recap of the current state of the field by @tahneema.bsky.social.

www.annualreviews.org/content/jour...

Network plot with microexon-associated phenotypes (nodes shown in dark gray). Microexon nodes are colored by exon length, and node size represents the level of conservation to the LCA as given in VastDB (109): human specific, Euarchontoglires (conserved from human to mouse and/or rat), Eutheria (to cow), Amniota (to chicken), Euteleostomi (to zebrafish), and Bilateria (to fruit fly).

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Manuel Irimia @mirimiam.bsky.social · Sep 1

🚨🚨🚨 New review article on #microexons from the lab! A comprehensive recap of the current state of the field by @tahneema.bsky.social.

www.annualreviews.org/content/jour...

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Reposted by Manuel Irimia

Manuel Irimia @mirimiam.bsky.social · Jul 23

🚨🚨🚨

Please RT!

We're looking for a postdoc to join an exciting joint project between our lab @upf.edu & @crg.eu (Barcelona) and the Sander lab @mdc-berlin.bsky.social (Berlin) investigating how alternative splicing and microexons influences the maturation of pancreatic islets.

Deadline: 30/09/25👇

www.upf.edu

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Reposted by Manuel Irimia

Manuel Irimia @mirimiam.bsky.social · Aug 7

Very happy to share the peer-reviewed version of our work on the cis-regulatory determinants of #microexon #splicing regulation by SRRM3/4, published in @natsmb.nature.com!

rdcu.be/ezGqT

Work led by @sobonnal.bsky.social, with Simon Bajew & @rmartinezcorral.bsky.social. @crg.eu @upf.edu

Core splicing architecture and early spliceosomal recognition determine microexon sensitivity to SRRM3/4

Nature Structural & Molecular Biology - Using massively parallel splicing assays and mathematical modeling, Bonnal et al. uncover that conserved splice site strength and exon length encode...

rdcu.be

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Manuel Irimia @mirimiam.bsky.social · Aug 7

And a small thread with a tweetorial from our initial bioRxiv pre-print, still during X's times:

x.com/mirimiam/sta...

Manuel Irimia @mirimiam.bsky.social · Aug 7

Very happy to share the peer-reviewed version of our work on the cis-regulatory determinants of #microexon #splicing regulation by SRRM3/4, published in @natsmb.nature.com!

rdcu.be/ezGqT

Work led by @sobonnal.bsky.social, with Simon Bajew & @rmartinezcorral.bsky.social. @crg.eu @upf.edu

Core splicing architecture and early spliceosomal recognition determine microexon sensitivity to SRRM3/4

Nature Structural & Molecular Biology - Using massively parallel splicing assays and mathematical modeling, Bonnal et al. uncover that conserved splice site strength and exon length encode...

rdcu.be

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Manuel Irimia @mirimiam.bsky.social · Aug 6

We discuss 3 major trends in the field of comparative transcriptomics:

(i) Towards increased biological resolution: from bulk to single cells

(ii) Towards expanded evolutionary scales: broader phylogenetic coverage and deeper sampling

(iii) Towards integrated modelling frameworks: advances in ML

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Manuel Irimia @mirimiam.bsky.social · Aug 6

🧬🧬🧬 New review from the lab:

Evolution of comparative transcriptomics: biological scales, phylogenetic spans, and modeling frameworks

authors.elsevier.com/sd/article/S...

By @mattezambon.bsky.social & @fedemantica.bsky.social, together with @jonnyfrazer.bsky.social & Mafalda Dias.

Three major trends in comparative transcriptomics

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katja heuer @k4tj4.bsky.social · Jul 27

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To predict the behaviour of a primate, would you rather base your guess on a closely related species or one with a similar brain shape? We looked at brains & behaviours of 70 species, you’ll be surprised!

🧵Thread on our new preprint with @r3rt0.bsky.social , doi.org/10.1101/2025...

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Manuel Irimia @mirimiam.bsky.social · Jul 23

Further information and instructions for applications in:

www.upf.edu/documents/28...

or

euraxess.ec.europa.eu/jobs/362352

Postdoctoral position on pancreatic beta cell maturation

We are seeking a highly motivated postdoctoral researcher to join an exciting international project investigating how alternative splicing, especially of microexons, influences the maturation of pancr...

euraxess.ec.europa.eu

Manuel Irimia @mirimiam.bsky.social · Jul 23

Ideal experience: 👩‍🔬👨‍🔬
- Pancreatic islet experimental biology and physiology: islet isolation and transplantation in mouse, GTTs, ITTs, in vitro GSIS assays, etc.
- Tissue engineering and in vitro differentiation protocols, especially for human islets.
- Transcriptomic (single-cell) analyses.

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Manuel Irimia @mirimiam.bsky.social · Jul 23

This job involve spending 1-2 years in Berlin and 1-2 years in Barcelona, a truly unique opportunity! 🌍

As the lead scientist, you will apply single-cell long-read sequencing, CRISPR interference, and small molecule modulation to dissect the molecular pathways underlying islet development.

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Manuel Irimia @mirimiam.bsky.social · Jul 23

Despite major advances in stem cell-derived islet differentiation, achieving functionally mature β cells in vitro remains a challenge. Funded by a new CaixaResearch grant, we aim to uncover novel regulatory mechanisms that drive beta cell maturation, with the potential to improve diabetes therapies.

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