Sophie Bonnal
@sobonnal.bsky.social
Senior Research Staff Scientist | PhD - Molecular Biology | INSA France - Biochemistry
https://www.linkedin.com/in/sophie-bonnal-89309058
https://www.linkedin.com/in/sophie-bonnal-89309058
Wonderful read on microexons — their regulation, cross-species functions, disease relevance & therapeutic potential.
🚨🚨🚨 New review article on #microexons from the lab! A comprehensive recap of the current state of the field by @tahneema.bsky.social.
www.annualreviews.org/content/jour...
www.annualreviews.org/content/jour...
September 1, 2025 at 11:31 AM
Wonderful read on microexons — their regulation, cross-species functions, disease relevance & therapeutic potential.
Thanks to all co-authors and to everyone who supported this work - check it out!
Very happy to share the peer-reviewed version of our work on the cis-regulatory determinants of #microexon #splicing regulation by SRRM3/4, published in @natsmb.nature.com!
rdcu.be/ezGqT
Work led by @sobonnal.bsky.social, with Simon Bajew & @rmartinezcorral.bsky.social. @crg.eu @upf.edu
rdcu.be/ezGqT
Work led by @sobonnal.bsky.social, with Simon Bajew & @rmartinezcorral.bsky.social. @crg.eu @upf.edu
Core splicing architecture and early spliceosomal recognition determine microexon sensitivity to SRRM3/4
Nature Structural & Molecular Biology - Using massively parallel splicing assays and mathematical modeling, Bonnal et al. uncover that conserved splice site strength and exon length encode...
rdcu.be
August 11, 2025 at 7:01 AM
Thanks to all co-authors and to everyone who supported this work - check it out!
Reposted by Sophie Bonnal
New online: Core splicing architecture and early spliceosomal recognition determine microexon sensitivity to SRRM3/4
Core splicing architecture and early spliceosomal recognition determine microexon sensitivity to SRRM3/4
Nature Structural & Molecular Biology, Published online: 07 August 2025; doi:10.1038/s41594-025-01634-1Using massively parallel splicing assays and mathematical modeling, Bonnal et al. uncover that conserved splice site strength and exon length encode microexon sensitivity to SRRM3 and SRRM4. This work revises the switch-like splicing regulation model into a dose-responsive continuum.
go.nature.com
August 7, 2025 at 10:59 AM
New online: Core splicing architecture and early spliceosomal recognition determine microexon sensitivity to SRRM3/4
Reposted by Sophie Bonnal
A resource of RNA-binding protein motifs across eukaryotes reveals evolutionary dynamics and gene-regulatory function go.nature.com/4mc1SmQ
A resource of RNA-binding protein motifs across eukaryotes reveals evolutionary dynamics and gene-regulatory function - Nature Biotechnology
RNA-binding motifs in eukaryotic proteins are presented in a comprehensive resource.
go.nature.com
July 25, 2025 at 3:46 PM
A resource of RNA-binding protein motifs across eukaryotes reveals evolutionary dynamics and gene-regulatory function go.nature.com/4mc1SmQ
🐁 A highly conserved neuronal microexon in DAAM1 controls actin dynamics, RHOA/ROCK signaling, and memory formation.
Thrilled to share my 1st PhD paper exploring the role of a DAAM1 microexon in memory formation and learning! 🧠🐭💻🔬(and first post at @bsky.app :)
Finally published in
@natcomms.nature.com
nature.com/articles/s41... .
With @mirimiam.bsky.social, @maradierssen.bsky.social,
@crg.eu
Details below:
Finally published in
@natcomms.nature.com
nature.com/articles/s41... .
With @mirimiam.bsky.social, @maradierssen.bsky.social,
@crg.eu
Details below:
A highly conserved neuronal microexon in DAAM1 controls actin dynamics, RHOA/ROCK signaling, and memory formation - Nature Communications
Actin is crucial for nervous system function yet the role of microexons in its modulation is unclear. Here, the authors show that a microexon in DAAM1 has a role in actin dynamics, neuronal function a...
nature.com
May 9, 2025 at 11:08 AM
🐁 A highly conserved neuronal microexon in DAAM1 controls actin dynamics, RHOA/ROCK signaling, and memory formation.