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sobonnal.bsky.social
Sophie Bonnal
@sobonnal.bsky.social
27 followers 28 following 4 posts
Senior Research Staff Scientist | PhD - Molecular Biology | INSA France - Biochemistry https://www.linkedin.com/in/sophie-bonnal-89309058
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Sophie Bonnal @sobonnal.bsky.social · 14d
sobonnal.bsky.social
Sophie Bonnal @sobonnal.bsky.social · 14d
sobonnal.bsky.social
Sophie Bonnal @sobonnal.bsky.social · Sep 1
Wonderful read on microexons — their regulation, cross-species functions, disease relevance & therapeutic potential.
mirimiam.bsky.social
Manuel Irimia @mirimiam.bsky.social · Sep 1
🚨🚨🚨 New review article on #microexons from the lab! A comprehensive recap of the current state of the field by @tahneema.bsky.social.

www.annualreviews.org/content/jour...
Network plot with microexon-associated phenotypes (nodes shown in dark gray). Microexon nodes are colored by exon length, and node size represents the level of conservation to the LCA as given in VastDB (109): human specific, Euarchontoglires (conserved from human to mouse and/or rat), Eutheria (to cow), Amniota (to chicken), Euteleostomi (to zebrafish), and Bilateria (to fruit fly).
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sobonnal.bsky.social
Sophie Bonnal @sobonnal.bsky.social · Aug 11
Thanks to all co-authors and to everyone who supported this work - check it out!
mirimiam.bsky.social
Manuel Irimia @mirimiam.bsky.social · Aug 7
Very happy to share the peer-reviewed version of our work on the cis-regulatory determinants of #microexon #splicing regulation by SRRM3/4, published in @natsmb.nature.com!

rdcu.be/ezGqT

Work led by @sobonnal.bsky.social, with Simon Bajew & @rmartinezcorral.bsky.social. @crg.eu @upf.edu
Core splicing architecture and early spliceosomal recognition determine microexon sensitivity to SRRM3/4
Nature Structural & Molecular Biology - Using massively parallel splicing assays and mathematical modeling, Bonnal et al. uncover that conserved splice site strength and exon length encode...
rdcu.be
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Reposted by Sophie Bonnal
natsmb.nature.com
Nature Structural & Molecular Biology @natsmb.nature.com · Aug 7
New online: Core splicing architecture and early spliceosomal recognition determine microexon sensitivity to SRRM3/4
Core splicing architecture and early spliceosomal recognition determine microexon sensitivity to SRRM3/4
Nature Structural & Molecular Biology, Published online: 07 August 2025; doi:10.1038/s41594-025-01634-1Using massively parallel splicing assays and mathematical modeling, Bonnal et al. uncover that conserved splice site strength and exon length encode microexon sensitivity to SRRM3 and SRRM4. This work revises the switch-like splicing regulation model into a dose-responsive continuum.
go.nature.com
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Reposted by Sophie Bonnal
natbiotech.nature.com
Nature Biotechnology @natbiotech.nature.com · Jul 25
A resource of RNA-binding protein motifs across eukaryotes reveals evolutionary dynamics and gene-regulatory function go.nature.com/4mc1SmQ
A resource of RNA-binding protein motifs across eukaryotes reveals evolutionary dynamics and gene-regulatory function - Nature Biotechnology
RNA-binding motifs in eukaryotic proteins are presented in a comprehensive resource.
go.nature.com
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sobonnal.bsky.social
Sophie Bonnal @sobonnal.bsky.social · May 9
🐁 A highly conserved neuronal microexon in DAAM1 controls actin dynamics, RHOA/ROCK signaling, and memory formation.
ppolinski.bsky.social
Patryk Poliński @ppolinski.bsky.social · May 9
Thrilled to share my 1st PhD paper exploring the role of a DAAM1 microexon in memory formation and learning! 🧠🐭💻🔬(and first post at @bsky.app :)

Finally published in
@natcomms.nature.com
nature.com/articles/s41... .
With @mirimiam.bsky.social, @maradierssen.bsky.social,
@crg.eu

Details below:
A highly conserved neuronal microexon in DAAM1 controls actin dynamics, RHOA/ROCK signaling, and memory formation - Nature Communications
Actin is crucial for nervous system function yet the role of microexons in its modulation is unclear. Here, the authors show that a microexon in DAAM1 has a role in actin dynamics, neuronal function a...
nature.com
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