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Jamie Hackett @jamiehackett.bsky.social · 4d

Important to raise this. Agree with Ewan, we essentially mean (a)

But (a) *may* actually also involve aspects of (b) and (c), whilst there is absolutely an influence of (d) as a context.

In this scenario of incomplete understanding I actually think ‘epigenetic’ is a useful terminology.

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Reposted by Jamie Hackett

EMBL @embl.org · 8d

New research from EMBL Rome shows how paternal environment prior to conception can shape early embryo development.

These findings are a step toward understanding the mechanism of epigenetic inheritance, opening up new possibilities for disease prevention.
www.embl.org/news/science...

Fathers shape embryonic development through molecular ‘signatures’. Credits: Daniela Velasco/EMBL

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Reposted by Jamie Hackett

David Suter @davidsuter.bsky.social · 12d

📣 New preprint from the lab - Endogenous fluctuations of transcription factor levels shape their occupancy in unexpected ways
www.biorxiv.org/content/10.1...

Endogenous variability in transcription factor concentrations shapes their genome-wide occupancy

The control of transcription factor (TF) concentrations is crucial for the precise regulation of gene expression and cell fate decisions during development. Yet, TF concentrations can display substant...

www.biorxiv.org

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Jamie Hackett @jamiehackett.bsky.social · 11d

Huge shoutout fantastic co-first leads @mdura.bsky.social @bbbranjan.bsky.social and all authors. Great collaboration with the fabulous Ana Boskovic

Project enabled by @embl.org Human Ecosystems transversal theme! 🙏

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Jamie Hackett @jamiehackett.bsky.social · 11d

❓Can a father’s environmental exposures before conception influence their offspring?

We systematically tackled this - identifying effects of paternal age, environment and genetics on early embryos - as well as confounding influences

www.embopress.org/doi/full/10....

Embryonic signatures of intergenerational epigenetic inheritance across paternal environments and genetic backgrounds | The EMBO Journal

imageimagePaternal environmental exposures have been linked with modulation of phenotype and disease risk in offspring via largely unclear mechanisms. This study employs in vitro fertilization and sin...

www.embopress.org

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Reposted by Jamie Hackett

Jan Żylicz @jzylicz.bsky.social · 20d

Genes are not On/Off switches. In a new preprint we show that HDAC3 is key to establish correct transcriptional dose in development. Gr8 work from N. Stamidis @ucph.bsky.social and collab. @jamiehackett.bsky.social @gregersenlab.bsky.social . Huge thx to all authors! www.biorxiv.org/content/10.1...

HDAC3 prevents enhancer hyperactivation to enable developmental transitions

Dynamic gene regulation requires precise cooperation between transcription factors and chromatin modifiers at regulatory elements to achieve not only activation or repression, but also appropriate tra...

www.biorxiv.org

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Jamie Hackett @jamiehackett.bsky.social · May 21

🤩🤩 it’s been a while

Greg Jenner @gregjenner.bsky.social · May 21

I CANNOT STOP GIGGLING!!!! #COYS

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Jamie Hackett @jamiehackett.bsky.social · May 20

New haircut 😁

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Jamie Hackett @jamiehackett.bsky.social · May 19

Awhh, my lab are absolute legends!

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Jamie Hackett @jamiehackett.bsky.social · May 15

... and it comes with a stipend!

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Jamie Hackett @jamiehackett.bsky.social · May 15

We are looking to take on an intern at EMBL Rome, for anyone interested in CRISPR and Epigenetics training.

The traineeship is 3-12-months, in Rome (Italy), should start by July, and is supervised by the outstanding @steliostsagkris.bsky.social.

#job #internship; see info below...

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Reposted by Jamie Hackett

Wolfgang Huber @wkhuber.bsky.social · Mar 19

Interested in doing a sabbatical at EMBL, at one of its 6 sites in Barcelona, Cambridge, Grenoble, Hamburg, Heidelberg or Rome?

Funding call with deadline 15 June, decisions in July.

www.embl.org/about/info/s...

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Jamie Hackett @jamiehackett.bsky.social · Feb 12

This is great work Jake! the specificity of H3K4 editing in plants is very cool

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Jamie Hackett @jamiehackett.bsky.social · Feb 12

Personally, I am partial to a microbe or two. But yes, focus would be on mammalian physiology

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Jamie Hackett @jamiehackett.bsky.social · Feb 11

Absolutely

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Jamie Hackett @jamiehackett.bsky.social · Feb 11

Want to start an independent research group? ...with core funding, outstanding facilities & a curiosity-driven culture? Join us at @embl.org

We are recruiting across research themes, inc (epi)genomics, human dev bio, predictive modelling & neurobiology👇

embl.wd103.myworkdayjobs.com/en-US/EMBL/d...

Group Leader - Molecular Mechanisms of Environmental Adaptation

We are seeking to recruit a highly motivated scientist to establish and lead an independent research laboratory at the EMBL Epigenetics and Neurobiology Unit in Rome. EMBL provides a unique environmen...

embl.wd103.myworkdayjobs.com

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Jamie Hackett @jamiehackett.bsky.social · Dec 30

Last day to apply for a postdoc in systems epigenomics in sunny Rome!

www.embl.org/jobs/positio...

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Reposted by Jamie Hackett

Bork Group at EMBL Heidelberg @borklab.bsky.social · Dec 19

As an "EIPOD" interdisciplinary postdoc in @jamiehackett.bsky.social and our lab, @denbobalab.bsky.social found that "Paternal microbiome perturbations impact offspring fitness" (2024): antibiotic treatment of male mice led to low birth weight & higher mortality in offspring

www.nature.com/artic...

Paternal microbiome perturbations impact offspring fitness

Nature - Disturbances in the gut microbiota of male mice manifest as fitness defects in their offspring by affecting plancenta function, revealing a paternal gut–germline axis.

www.nature.com

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Reposted by Jamie Hackett

Maxim Greenberg @maxvcg.bsky.social · Dec 9

Strongly recommend DNAme researchers to take a look at this important study. Consistent with work from Schubeler lab: higher-order mut in DNAme reader proteins lead to only minor transcriptional changes. Reinforces the idea that DNAme does not establish heterochromatin through reader proteins

James Lloyd 🧬 @jamespblloyd.bsky.social · Dec 9

After a year of extra work and edits with @joncahn.bsky.social, I am overjoyed to share the final version of our work:

Characterization of DNA methylation reader proteins of Arabidopsis thaliana

Published in Genome Research @genomeresearch.bsky.social

genome.cshlp.org/content/earl...

Characterization of DNA methylation reader proteins of Arabidopsis thaliana

An international, peer-reviewed genome sciences journal featuring outstanding original research that offers novel insights into the biology of all organisms

genome.cshlp.org

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Reposted by Jamie Hackett

Rob Schneider @robertife.bsky.social · Dec 8

Please RS/RT. #GordonConference on "Histone and DNA Modifications" #epigenetics #chromatin 20-25. July 2025. Il Ciocco, Italy. Great speaker lineup.
➡️Register now www.grc.org/histone-and-...

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Reposted by Jamie Hackett

Ewan Birney @ewanbirney.bsky.social · Dec 6

Computational with a PhD in some quantiative science, and want to make the world a better place with AI in healthcare? Want to work with some of the most innovative AI groups in the life sciences? Want to work for Europe, across Cambridge and Heidelberg, living in the UK? Two more days to apply:

Open Targets @opentargets.org · Nov 14

NEW: Postdoctoral Fellow with @ewanbirney

The project is based in the Birney Research group at @emblebi and working closely with Open Targets and @MoritzGerstung's group at DKFZ

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Reposted by Jamie Hackett

Marzia Munafò @munafomarzia.bsky.social · Dec 7

One of my illustrations made an appearance at the MPI #epigenetics conference! thanks to the boss @jamiehackett.bsky.social presenting the cool science we do in the lab 🔥

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Jamie Hackett @jamiehackett.bsky.social · Dec 3

Hi Kitty, just pointing out this independent position. Lots of other opportunities coming up at EMBL in Rome too.

www.embl.org/jobs/positio...

EMBL Jobs

We offer a wide range of challenging scientific and non-scientific positions at all of our European locations and encourage applications from international candidates at all career levels.

www.embl.org

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Reposted by Jamie Hackett

Duncan Sproul @sproullab.bsky.social · Dec 3

Interested in an #interdisciplinary PhD on the #epigenetics of human disease (or know someone who is)? Come work with us through the 2025 MRC HGU PhD program. Excellent and friendly collegiate environment and a great city:
institute-genetics-cancer.ed.ac.uk/igc-graduate...

Please share 🙏 (1/2)

MRC four-year International PhD programme: Human Genetics, Genomics and Disease

Applications now open.

institute-genetics-cancer.ed.ac.uk

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Jamie Hackett @jamiehackett.bsky.social · Dec 3

What a 1-2 last few days! Huge congrats Christa 👏

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