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opentargets.org
Open Targets
@opentargets.org
600 followers 38 following 170 posts
Public-private partnership using human genetics and genomics data for systematic drug target identification and prioritisation. http://blog.opentargets.org
blog.opentargets.org
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Open Targets @opentargets.org · 5d
CLOSING: Postdoc in @francescoiorio.bsky.social's lab at @humantechnopole.bsky.social

Apply through LinkedIn by 5 October: www.linkedin.com/jobs/view/43...

#scienceJobs #AcademicSky #postdocJobs
Closing job ad for a postdoc in CRISPR meta-analytics and AI, from Open Targets and the Human Technopole. The role is in the Iorio Lab, salary up to 40k euros, apply by 5 October. The description reads: The Perturbation Catalogue project aims to create an online repository of data from post-perturbational experiments. You will focus on a meta-analytics project, developing computational methods for the reproducibility assessment, harmonisation and analysis or inter-study CRISPR datasets, aggregating data and developing and using innovative AI-based methods for therapeutic target prioritisation pipelines.
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opentargets.org
Open Targets @opentargets.org · 6d
USP18 is a negative regulator of interferon response, which suggests that the variant increases SLE risk by affecting USP18’s ability to limit the interferon response

Congratulations to the team on this work!
opentargets.org
Open Targets @opentargets.org · 6d
They found an interesting variant in the USP18 locus: a trans-eQTL that increases the expression of 50 interferon response genes. This variant also colocalises with a GWAS signal for systemic lupus erythematosus (SLE)
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opentargets.org
Open Targets @opentargets.org · 6d
Out now in Nature Comms: the largest trans-eQTL meta-analysis in a single cell type!

An Open Targets team led by Krista Freimann and @kauralasoo.bsky.social analysed 3,734 lymphoblastoid cell line samples across nine cohorts, identifying four robust loci

www.nature.com/articles/s41...
Trans-eQTL mapping prioritises USP18 as a negative regulator of interferon response at a lupus risk locus - Nature Communications | Open Targets
Out now in Nature Comms: the largest trans-eQTL meta-analysis in a single cell type! An Open Targets team led by Krista Freimann and Kaur Alasoo analysed 3,734 lymphoblastoid cell line samples across...
www.linkedin.com
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opentargets.org
Open Targets @opentargets.org · 13d
CLOSING:

➡️ Senior Bioinformatician with Roser Vento Tormo
sanger.wd103.myworkdayjobs.com/en-US/Wellco...

➡️ Technical Specialist (neuro) with Omer Ali Bayraktar
sanger.wd103.myworkdayjobs.com/en-US/Wellco...

Both @sangerinstitute.bsky.social roles close on 2 October
Technical Specialist: Neurodegenerative Disease Spatial Transcriptomics and Data Generation
Do you want to help us improve human health and understand life on Earth? Make your mark by shaping the future to enable or deliver life-changing science to solve some of humanity’s greatest challenge...
sanger.wd103.myworkdayjobs.com
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Reposted by Open Targets
jengreitz.bsky.social
Jesse Engreitz @jengreitz.bsky.social · 20d
Excited for a major milestone in our efforts to map enhancers and interpret variants in the human genome:

The E2G Portal! e2g.stanford.edu

This collates our predictions of enhancer-gene regulatory interactions across >1,600 cell types and tissues.

Uses cases 👇

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opentargets.org
Open Targets @opentargets.org · 20d
This release also features:

➡️ molQTL credible sets for targets
➡️ new options for the variant structural viewer
➡️ data updates from GWAS Catalog, Expression Atlas, gnomAD, DepMap, and Probes&Drugs

What do you think of this update?
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opentargets.org
Open Targets @opentargets.org · 20d
@riyavsinha.bsky.social @jengreitz.bsky.social sky.social @anshulkundaje.bsky.social y.social have made the ENCODE-rE2G data available to browse through the E2G portal, a custom-built extension of the Platform 👇

We plan to further integrate their data 👀

e2g.stanford.edu
E2G
E2G is a tool based on the Open Targets Platform for predicting enhancer-gene interactions.
e2g.stanford.edu
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opentargets.org
Open Targets @opentargets.org · 20d
This new data can provide insights about the function of genetic variants by linking them to likely regulatory elements that affect the transcriptional activity of nearby genes, and is available to browse on our variant pages
An example of an intervals widget for a variant in the Open Targets Platform
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opentargets.org
Open Targets @opentargets.org · 20d
The Open Targets Platform autumn release is out! 🍂

We have ingested the full dataset of over 13 million enhancer-gene regulatory interactions in the human genome across 1,458 DNase-seq experiments covering 369 cell types and tissues from the ENCODE-rE2G model

blog.opentargets.org/open-targets...
Open Targets Platform 25.09 has been released!
The September 25 release includes enhancer-gene data predicted by ENCODE-rE2G, molQTL credible sets for targets, new options for the variant structural viewer, and a number of data updates from GWAS C...
blog.opentargets.org
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opentargets.org
Open Targets @opentargets.org · 22d
This is fantastic — congratulations @gwascatalog.bsky.social!
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Reposted by Open Targets
gwascatalog.bsky.social
GWAS Catalog @gwascatalog.bsky.social · 22d
🚩1 MILLION curated associations!!! 🚩
Launched in 2008, took us 15 years to reach 500K, and thanks to your research and collaboration, we doubled the number in less than 3 years!
See some data insights tinyurl.com/mw53njbb
#OpenAccess
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opentargets.org
Open Targets @opentargets.org · Sep 4
Last call to submit a project for the Open Targets Hackathon!

Submit a project by 12 September: docs.google.com/forms/d/e/1F...

We will prioritise projects where the project leads have signed up to attend the hackathon. Registrations are currently full but you can sign up to the waiting list
Open Targets Hackathon: one week left to submit a project
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opentargets.org
Open Targets @opentargets.org · Aug 26
Out now on bioRxiv! 🧬🖥️

A team from the Cowley, Bassett, and @gosiatrynka.bsky.social labs integrate pooled iPSC phenotyping, transcriptomics, and CRISPR perturbations to identify genetic drivers of molecular and cellular phenotypes in microglia

www.biorxiv.org/content/10.1...
#neuroskyence
Integrated QTL mapping and CRISPR screening in pooled iPSC-derived microglia reveals genetic drivers of neurodegenerative risk
Mounting evidence implicates microglia in neurodegeneration, but linking disease-associated genetic variants to target genes and cellular phenotypes is hindered by the inaccessibility of these cells. ...
www.biorxiv.org
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opentargets.org
Open Targets @opentargets.org · Aug 19
The authors suggest that small molecule inhibition of LRRK2, or reduction in LRRK2 protein levels, may help slow the progression of diseases involving tau or alpha-synuclein, such as Alzheimer’s and Parkinson’s disease.

Congratulations to the whole team for this work! 🎉
opentargets.org
Open Targets @opentargets.org · Aug 19
The study revealed that LRRK2 was required for the uptake of tau and alpha-synuclein, and that the LRRK2 Parkinson’s disease gain-of-function mutation increases the uptake of both forms of tau and alpha-synuclein.
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opentargets.org
Open Targets @opentargets.org · Aug 19
They found that monomeric and fibrillar tau are taken up by neurons in overlapping but distinct pathways.
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opentargets.org
Open Targets @opentargets.org · Aug 19
Using genome-wide CRISPR knockout screens, the team delineate the genes required for extracellular uptake of monomeric and fibrillar tau in human iPSC-derived excitatory neurons, the primary cell type affected in tauopathies.
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opentargets.org
Open Targets @opentargets.org · Aug 19
Several neurodegenerative diseases are characterised by the formation fibrils of misfolded tau protein, and it is thought that disease progresses through the central nervous system from affected neurons releasing pathogenic forms of tau protein, which are then taken up by neighbouring neurons.
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opentargets.org
Open Targets @opentargets.org · Aug 19
Out now! 🧬

Lewis Evans and the team at @sangerinstitute.bsky.social and UCL define the pathways for tau entry into human neurons, a key mechanism for the progression of tauopathies associated with Parkinson’s and Alzheimer’s disease

www.embopress.org/doi/full/10....

#neuroscience #neuroskyence
Tau uptake by human neurons depends on receptor LRP1 and kinase LRRK2 | The EMBO Journal
imageimageNeuronal uptake of extracellular tau protein is thought to propagate intracellular protein aggregation between neurons, contributing to the pathogenesis of Alzheimer’s and other neurodegener...
www.embopress.org
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opentargets.org
Open Targets @opentargets.org · Aug 12
CLOSING: Front end developer for the Open Targets Platform

Join @carcruz.dev's team and help us turn complex data into powerful discovery tools, working closely with our industry and academic partners

Apply by 19 August

embl.wd103.myworkdayjobs.com/EMBL/job/Hin...

#ReactJobs #DevJobs
Front-End Web Developer
We are looking for an exceptional Web Developer to join Open Targets at EMBL-EBI. Join Open Targets at EMBL-EBI as a Web Developer and help transform vast biomedical data into insights that drive safe...
embl.wd103.myworkdayjobs.com
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opentargets.org
Open Targets @opentargets.org · Aug 7
NEW: Front-End Web Dev @ebi.embl.org

Join the Open Targets Platform team!

Design and build this cloud-first, open-source application, used to explore and prioritise potential drug targets

embl.wd103.myworkdayjobs.com/EMBL/job/Hin...
Front-End Web Developer
We are looking for an exceptional Web Developer to join Open Targets at EMBL-EBI. Join Open Targets at EMBL-EBI as a Web Developer and help transform vast biomedical data into insights that drive safe...
embl.wd103.myworkdayjobs.com
opentargets.org
Open Targets @opentargets.org · Aug 5
“It’s been a very collaborative experience.”

@malloryfreeberg.bsky.social talks to us about developing the Perturbation Catalogue

The beta version is available to explore now, and the team are keen to hear your feedback!
www.ebi.ac.uk/perturbation...

blog.opentargets.org/creating-a-p...
Why Mallory Freeberg is creating a perturbation catalogue
The Perturbation Catalogue is an Open Targets project which aims to bring genetic perturbation data into one curated, harmonised, and discoverable platform. Mallory Freeberg, one of the project leads,...
blog.opentargets.org
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opentargets.org
Open Targets @opentargets.org · Jul 31
Google Cloud is sponsoring the compute for the Open Targets hackathon!

There is now a waiting list to attend the event in person, but project submissions and online registrations are still open.

The two-day hackathon will explore data, analyses, and tools for target discovery
Text reads: Open Targets hackathon, 21-22 October 2025, compute sponsored by Google Cloud
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opentargets.org
Open Targets @opentargets.org · Jul 29
Thank you!

Do you have more questions for Carlos?