Maitreya Dunham
@maitreya.bsky.social
My lab works on genome evolution, using yeast genetics and genomics. Chair, Department of Genome Sciences at University of Washington.
Lab website: https://depts.washington.edu/dunhamlab/
Lab website: https://depts.washington.edu/dunhamlab/
Fun new preprint from the lab, headed up by two incredible undergraduate researchers: Using Experimental Evolution to Correct Mother-Daughter Separation Defects in Brewing Yeast. www.biorxiv.org/content/10.1...
Using Experimental Evolution to Correct Mother-Daughter Separation Defects in Brewing Yeast
The budding yeast, Saccharomyces cerevisiae, is the workhorse of the brewing industry. Brewers have domesticated a vast array of different strains with traits that complement the beers they wish to br...
www.biorxiv.org
November 26, 2025 at 8:18 PM
Fun new preprint from the lab, headed up by two incredible undergraduate researchers: Using Experimental Evolution to Correct Mother-Daughter Separation Defects in Brewing Yeast. www.biorxiv.org/content/10.1...
New preprint with @pyjiang.bsky.social and @kelleyharris.bsky.social! The discovery and patterns of the underlying long-standing mild-effect mutator alleles in S. cerevisiae populations www.biorxiv.org/content/10.1...
The discovery and patterns of the underlying long-standing mild-effect mutator alleles in S. cerevisiae populations
Most mutations are neutral or deleterious, and mutator alleles that increase the mutation rate of an organism are considered rare and short-lived. Here, we report a genomic signature consistent with t...
www.biorxiv.org
November 25, 2025 at 3:12 PM
New preprint with @pyjiang.bsky.social and @kelleyharris.bsky.social! The discovery and patterns of the underlying long-standing mild-effect mutator alleles in S. cerevisiae populations www.biorxiv.org/content/10.1...
Open faculty position (Assistant or Associate) in UW Medical Genetics. As you might expect, faculty often end up also interacting with Genome Sciences, so we're hoping for some great prospects! Note the clinical requirements for the position. apply.interfolio.com/176466
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apply.interfolio.com
November 24, 2025 at 7:23 PM
Open faculty position (Assistant or Associate) in UW Medical Genetics. As you might expect, faculty often end up also interacting with Genome Sciences, so we're hoping for some great prospects! Note the clinical requirements for the position. apply.interfolio.com/176466
New aging pilot grant opportunity to collaborate with us! The idea is to do CRISPR screens in mammalian cells with the Oklahoma team, then do mechanistic follow up of some of the results using appropriate model organisms (worms, mice, and, of course, yeast, with my lab!) Applications due in February
The UW Nathan Shock Center is enthusiastic to announce a request for applications for a multi-center collaboration with the NSCs of the Jackson Laboratory and the University of Oklahoma. Please see the call below!
November 22, 2025 at 10:45 PM
New aging pilot grant opportunity to collaborate with us! The idea is to do CRISPR screens in mammalian cells with the Oklahoma team, then do mechanistic follow up of some of the results using appropriate model organisms (worms, mice, and, of course, yeast, with my lab!) Applications due in February
Reposted by Maitreya Dunham
2026 #Yeast #Genetics Meeting is 13–17 June 2026 in Pacific Grove CA. Conference website has invited speakers, abstract submission topics, preliminary schedule, etc. Bookmark the site as additional updates will be published as they become available. #YEAST26
genetics-gsa.org/yeast-2026/
genetics-gsa.org/yeast-2026/
November 7, 2025 at 3:41 PM
2026 #Yeast #Genetics Meeting is 13–17 June 2026 in Pacific Grove CA. Conference website has invited speakers, abstract submission topics, preliminary schedule, etc. Bookmark the site as additional updates will be published as they become available. #YEAST26
genetics-gsa.org/yeast-2026/
genetics-gsa.org/yeast-2026/
Incredible new paper from @schacherer.bsky.social et al rdcu.be/eLcTH
From genotype to phenotype with 1,086 near telomere-to-telomere yeast genomes
Nature - A newly compiled atlas of species-wide structural variants and gene-based and graph pangenomes derived from highly complete assemblies of genomes from 1,086 natural isolates enable...
rdcu.be
October 15, 2025 at 9:06 PM
Incredible new paper from @schacherer.bsky.social et al rdcu.be/eLcTH
Reposted by Maitreya Dunham
The #Yeast26 website is live—start planning your conference attendance now! 🧬
Browse abstract submission topics, key dates, speaker & venue info, details on travel funding, and more: buff.ly/HFIt31b
Bookmark the page to stay updated as new information becomes available!
Browse abstract submission topics, key dates, speaker & venue info, details on travel funding, and more: buff.ly/HFIt31b
Bookmark the page to stay updated as new information becomes available!
October 13, 2025 at 6:03 PM
The #Yeast26 website is live—start planning your conference attendance now! 🧬
Browse abstract submission topics, key dates, speaker & venue info, details on travel funding, and more: buff.ly/HFIt31b
Bookmark the page to stay updated as new information becomes available!
Browse abstract submission topics, key dates, speaker & venue info, details on travel funding, and more: buff.ly/HFIt31b
Bookmark the page to stay updated as new information becomes available!
Reposted by Maitreya Dunham
Registration is now open for the Mutational Scanning Symposium!! This is one not to miss. Invited speakers include @mehurles.bsky.social @sangerinstitute.bsky.social @maitreya.bsky.social @uwgenome.bsky.social
#VariantEffect26 Register soon for the early bird rate!
ℹ️➡️https://www.mss2026.org
#VariantEffect26 Register soon for the early bird rate!
ℹ️➡️https://www.mss2026.org
September 18, 2025 at 1:44 PM
Registration is now open for the Mutational Scanning Symposium!! This is one not to miss. Invited speakers include @mehurles.bsky.social @sangerinstitute.bsky.social @maitreya.bsky.social @uwgenome.bsky.social
#VariantEffect26 Register soon for the early bird rate!
ℹ️➡️https://www.mss2026.org
#VariantEffect26 Register soon for the early bird rate!
ℹ️➡️https://www.mss2026.org
Reposted by Maitreya Dunham
It's been a long time coming but, my postdoc work characterizing thousands of variants in G6PD is now available! Many thanks to @maitreya.bsky.social @dougfowler.bsky.social @afrubin.bsky.social and their labs! www.biorxiv.org/content/10.1...
Functional evidence for G6PD variant classification from mutational scanning
G6PD deficiency is the most common enzyme deficiency worldwide, and increases the likelihood of adverse reactions to certain drugs and foods. Identifying people at risk is challenging, since most are ...
www.biorxiv.org
August 15, 2025 at 2:39 PM
It's been a long time coming but, my postdoc work characterizing thousands of variants in G6PD is now available! Many thanks to @maitreya.bsky.social @dougfowler.bsky.social @afrubin.bsky.social and their labs! www.biorxiv.org/content/10.1...
So proud of my lab students Tiffany and Amanda for winning the Roman Scholarship from @uwgenome.bsky.social! I always love the story about how yeast genetics got its start at UW because corn wouldn’t grow in Seattle www.gs.washington.edu/about/histor...
50 Years of Genetics at the UW
www.gs.washington.edu
August 15, 2025 at 2:34 AM
So proud of my lab students Tiffany and Amanda for winning the Roman Scholarship from @uwgenome.bsky.social! I always love the story about how yeast genetics got its start at UW because corn wouldn’t grow in Seattle www.gs.washington.edu/about/histor...
Announcing the yEvo Mutation Browser, a Shiny app for visualizing and exploring sequencing data from experimental evolution and genetic screens. This is the latest from our @yevolab.bsky.social high school teaching & research project and led by my grad student Leah. www.biorxiv.org/content/10.1...
The yEvo Mutation Browser: Enhancing student understanding of experimental evolution and genomics through interactive data visualization
Experimental evolution is a powerful method for studying the relationship between genotype and phenotype by observing how populations genetically adapt to controlled selective pressures. In educationa...
www.biorxiv.org
July 22, 2025 at 12:53 PM
Announcing the yEvo Mutation Browser, a Shiny app for visualizing and exploring sequencing data from experimental evolution and genetic screens. This is the latest from our @yevolab.bsky.social high school teaching & research project and led by my grad student Leah. www.biorxiv.org/content/10.1...
Genome Sciences is looking for a Director of Departmental Computing. This is a rare opportunity for someone interested in leading our excellent IT team, building and maintaining computational infrastructure, and working closely with our faculty and labs uwhires.admin.washington.edu/ENG/candidat...
UW Human Resources
University of Washington Human Resources
uwhires.admin.washington.edu
July 11, 2025 at 9:54 PM
Genome Sciences is looking for a Director of Departmental Computing. This is a rare opportunity for someone interested in leading our excellent IT team, building and maintaining computational infrastructure, and working closely with our faculty and labs uwhires.admin.washington.edu/ENG/candidat...
Our annual "Wednesday Evening at the Genome" public lecture series starts this week! Talks by Andrew Stergachis, Ivan Liachko, Gaurav Bhardwaj, & Mary-Claire King geared toward a general audience. 6:00 in Foege auditorium, followed by time to meet the speakers. www.gs.washington.edu/news/publicl...
UW Genome Sciences: Public Lecture
www.gs.washington.edu
July 8, 2025 at 4:59 AM
Our annual "Wednesday Evening at the Genome" public lecture series starts this week! Talks by Andrew Stergachis, Ivan Liachko, Gaurav Bhardwaj, & Mary-Claire King geared toward a general audience. 6:00 in Foege auditorium, followed by time to meet the speakers. www.gs.washington.edu/news/publicl...
Reposted by Maitreya Dunham
We have co-organized a MAVE course with Wellcome Connecting Science! Meeting is in November, but the
🗓️📝Application deadline is 18 August 2025 ⏰https://coursesandconferences.wellcomeconnectingscience.org/event/multiplex-assays-of-variant-effects-maves-approaches-analysis-and-interpretation-20251123/
🗓️📝Application deadline is 18 August 2025 ⏰https://coursesandconferences.wellcomeconnectingscience.org/event/multiplex-assays-of-variant-effects-maves-approaches-analysis-and-interpretation-20251123/
Multiplex assays of variant effects (MAVEs): Approaches, Analysis, and Interpretation — 20251123
.Learn how to analyse, assess, and interpret MAVE data for clinical and research applications
coursesandconferences.wellcomeconnectingscience.org
June 23, 2025 at 6:14 PM
We have co-organized a MAVE course with Wellcome Connecting Science! Meeting is in November, but the
🗓️📝Application deadline is 18 August 2025 ⏰https://coursesandconferences.wellcomeconnectingscience.org/event/multiplex-assays-of-variant-effects-maves-approaches-analysis-and-interpretation-20251123/
🗓️📝Application deadline is 18 August 2025 ⏰https://coursesandconferences.wellcomeconnectingscience.org/event/multiplex-assays-of-variant-effects-maves-approaches-analysis-and-interpretation-20251123/
Very fun lab party today to celebrate the graduation of several lab undergraduate researchers! Congratulations!
June 28, 2025 at 1:03 AM
Very fun lab party today to celebrate the graduation of several lab undergraduate researchers! Congratulations!
We also had 4 tetrad dissection microscopes join the lab this week, as part of the @uw-nsc.bsky.social renewal! These belonged to Matt Kaeberlein as part of their large scale efforts to measure replicative lifespan in yeast. We are now offering them as loaners for labs who want to try lifespans.
June 23, 2025 at 11:25 PM
We also had 4 tetrad dissection microscopes join the lab this week, as part of the @uw-nsc.bsky.social renewal! These belonged to Matt Kaeberlein as part of their large scale efforts to measure replicative lifespan in yeast. We are now offering them as loaners for labs who want to try lifespans.
Welcome to our new lab members, postdoc Sarah (co with @kelleyharris.bsky.social) and grad students Zanny and Megan! Very exciting!
June 23, 2025 at 8:01 PM
Welcome to our new lab members, postdoc Sarah (co with @kelleyharris.bsky.social) and grad students Zanny and Megan! Very exciting!
Reposted by Maitreya Dunham
Happy to announce our paper comparing embryonic gene expression between C. elegans and C. briggsae, work led by Christopher Large with Rupa Khanal and in collaboration with Junhyong Kim and Bob Waterston. www.science.org/doi/10.1126/...
Lineage-resolved analysis of embryonic gene expression evolution in C. elegans and C. briggsae
The constraints that govern the evolution of gene expression patterns across development remain unclear. Single-cell RNA sequencing can detail these constraints by systematically profiling homologous ...
www.science.org
June 20, 2025 at 8:25 PM
Happy to announce our paper comparing embryonic gene expression between C. elegans and C. briggsae, work led by Christopher Large with Rupa Khanal and in collaboration with Junhyong Kim and Bob Waterston. www.science.org/doi/10.1126/...
Had a great day at UBC with a cohort from my lab for the Pacific Northwest Yeast Club meeting! Great science and community, and my student Leah won best talk!
June 21, 2025 at 6:10 AM
Had a great day at UBC with a cohort from my lab for the Pacific Northwest Yeast Club meeting! Great science and community, and my student Leah won best talk!
Reposted by Maitreya Dunham
POSTDOC ALERT: Applications now open for SeaBridge postdoc fellowship; opportunity to work on leading-edge biotech w/researchers at the Seattle Hub for Synthetic Biology.
brotmanbaty.org/news/new-pos...
@marionpepper.bsky.social
@jshendure.bsky.social
@coletrapnell.bsky.social
brotmanbaty.org/news/new-pos...
@marionpepper.bsky.social
@jshendure.bsky.social
@coletrapnell.bsky.social
New Postdoc Fellowship Program Builds on Innovative SeattleHub Research | Brotman Baty Institute
BBI
brotmanbaty.org
June 16, 2025 at 4:36 PM
POSTDOC ALERT: Applications now open for SeaBridge postdoc fellowship; opportunity to work on leading-edge biotech w/researchers at the Seattle Hub for Synthetic Biology.
brotmanbaty.org/news/new-pos...
@marionpepper.bsky.social
@jshendure.bsky.social
@coletrapnell.bsky.social
brotmanbaty.org/news/new-pos...
@marionpepper.bsky.social
@jshendure.bsky.social
@coletrapnell.bsky.social
Another art piece created by argot chen last week during Sxaffold, this one snippets of text pulled from one of my papers. how do you Hope to be changed
June 10, 2025 at 4:06 AM
Another art piece created by argot chen last week during Sxaffold, this one snippets of text pulled from one of my papers. how do you Hope to be changed
Reposted by Maitreya Dunham
Sharing the most significant work from my group, led by the @evolvingstem.bsky.social team.
Come for the discoveries of how Pseudomonas adapts in biofilms, stay for the story of how they were discovered by thousands of young scientists in grades 9-12. 🧪🧫🧬🧵
www.biorxiv.org/content/10.1...
Come for the discoveries of how Pseudomonas adapts in biofilms, stay for the story of how they were discovered by thousands of young scientists in grades 9-12. 🧪🧫🧬🧵
www.biorxiv.org/content/10.1...
Student-led experimental evolution reveals novel biofilm regulatory networks underlying adaptations to multiple niches
We established a research-education partnership known as EvolvingSTEM that provides secondary school students the opportunity to conduct authentic research experiments centered on microbial evolution....
www.biorxiv.org
June 8, 2025 at 8:09 PM
Sharing the most significant work from my group, led by the @evolvingstem.bsky.social team.
Come for the discoveries of how Pseudomonas adapts in biofilms, stay for the story of how they were discovered by thousands of young scientists in grades 9-12. 🧪🧫🧬🧵
www.biorxiv.org/content/10.1...
Come for the discoveries of how Pseudomonas adapts in biofilms, stay for the story of how they were discovered by thousands of young scientists in grades 9-12. 🧪🧫🧬🧵
www.biorxiv.org/content/10.1...
Reposted by Maitreya Dunham
Student-led experimental evolution reveals novel biofilm regulatory networks underlying adaptations to multiple niches https://www.biorxiv.org/content/10.1101/2025.06.06.658356v1
June 7, 2025 at 5:17 AM
Student-led experimental evolution reveals novel biofilm regulatory networks underlying adaptations to multiple niches https://www.biorxiv.org/content/10.1101/2025.06.06.658356v1
Had a great time collaborating with artist argot chen this week as part of the inaugural Sxaffold scientist/artist encounter. We made Mt. Rainier from agar using a 3D printed mold, then painted with colorful yeast strains www.sxaffold.org
June 6, 2025 at 8:28 PM
Had a great time collaborating with artist argot chen this week as part of the inaugural Sxaffold scientist/artist encounter. We made Mt. Rainier from agar using a 3D printed mold, then painted with colorful yeast strains www.sxaffold.org
Second of Taylor’s hybrid genetics preprints: A cross-species rescue by mating method to interrogate gene essentiality across the Saccharomyces genus. www.biorxiv.org/content/10.1...
www.biorxiv.org
June 5, 2025 at 7:53 AM
Second of Taylor’s hybrid genetics preprints: A cross-species rescue by mating method to interrogate gene essentiality across the Saccharomyces genus. www.biorxiv.org/content/10.1...