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Reposted by Maitreya Dunham

Atlas of Variant Effects Alliance @varianteffect.bsky.social · 20d

Registration is now open for the Mutational Scanning Symposium!! This is one not to miss. Invited speakers include @mehurles.bsky.social @sangerinstitute.bsky.social @maitreya.bsky.social @uwgenome.bsky.social
#VariantEffect26 Register soon for the early bird rate!
ℹ️➡️https://www.mss2026.org

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Maitreya Dunham @maitreya.bsky.social · Aug 19

We've noticed that various yeast auxotrophs smell like sweaty socks when grown in glucose-limited chemostats. Another reason to use prototrophs :)

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Reposted by Maitreya Dunham

Renee Geck @reneegeck.bsky.social · Aug 15

It's been a long time coming but, my postdoc work characterizing thousands of variants in G6PD is now available! Many thanks to @maitreya.bsky.social @dougfowler.bsky.social @afrubin.bsky.social and their labs! www.biorxiv.org/content/10.1...

Functional evidence for G6PD variant classification from mutational scanning

G6PD deficiency is the most common enzyme deficiency worldwide, and increases the likelihood of adverse reactions to certain drugs and foods. Identifying people at risk is challenging, since most are ...

www.biorxiv.org

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Maitreya Dunham @maitreya.bsky.social · Aug 15

So proud of my lab students Tiffany and Amanda for winning the Roman Scholarship from @uwgenome.bsky.social! I always love the story about how yeast genetics got its start at UW because corn wouldn’t grow in Seattle www.gs.washington.edu/about/histor...

50 Years of Genetics at the UW

www.gs.washington.edu

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Maitreya Dunham @maitreya.bsky.social · Jul 22

You can explore our entire dataset here, and even (locally) upload your own data! Obviously we built it out for yeast, but we have instructions on porting to other organisms yevo.org/mutation-bro...

Mutation Browser – yEvo

yevo.org

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Maitreya Dunham @maitreya.bsky.social · Jul 22

Announcing the yEvo Mutation Browser, a Shiny app for visualizing and exploring sequencing data from experimental evolution and genetic screens. This is the latest from our @yevolab.bsky.social high school teaching & research project and led by my grad student Leah. www.biorxiv.org/content/10.1...

The yEvo Mutation Browser: Enhancing student understanding of experimental evolution and genomics through interactive data visualization

Experimental evolution is a powerful method for studying the relationship between genotype and phenotype by observing how populations genetically adapt to controlled selective pressures. In educationa...

www.biorxiv.org

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Maitreya Dunham @maitreya.bsky.social · Jul 11

Genome Sciences is looking for a Director of Departmental Computing. This is a rare opportunity for someone interested in leading our excellent IT team, building and maintaining computational infrastructure, and working closely with our faculty and labs uwhires.admin.washington.edu/ENG/candidat...

UW Human Resources

University of Washington Human Resources

uwhires.admin.washington.edu

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Maitreya Dunham @maitreya.bsky.social · Jul 8

2025 Wednesday Evenings at the Genome poster

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Maitreya Dunham @maitreya.bsky.social · Jul 8

Our annual "Wednesday Evening at the Genome" public lecture series starts this week! Talks by Andrew Stergachis, Ivan Liachko, Gaurav Bhardwaj, & Mary-Claire King geared toward a general audience. 6:00 in Foege auditorium, followed by time to meet the speakers. www.gs.washington.edu/news/publicl...

UW Genome Sciences: Public Lecture

www.gs.washington.edu

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Reposted by Maitreya Dunham

Atlas of Variant Effects Alliance @varianteffect.bsky.social · Jun 23

We have co-organized a MAVE course with Wellcome Connecting Science! Meeting is in November, but the
🗓️📝Application deadline is 18 August 2025 ⏰https://coursesandconferences.wellcomeconnectingscience.org/event/multiplex-assays-of-variant-effects-maves-approaches-analysis-and-interpretation-20251123/

Multiplex assays of variant effects (MAVEs): Approaches, Analysis, and Interpretation — 20251123

.Learn how to analyse, assess, and interpret MAVE data for clinical and research applications

coursesandconferences.wellcomeconnectingscience.org

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Maitreya Dunham @maitreya.bsky.social · Jun 28

You will not regret getting the big foil! So much better than pathetic normal foil.

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Maitreya Dunham @maitreya.bsky.social · Jun 28

Very fun lab party today to celebrate the graduation of several lab undergraduate researchers! Congratulations!

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Maitreya Dunham @maitreya.bsky.social · Jun 26

We did a concept assessment pretest/posttest when I started teaching intro genetics, and, to our great horror, performance on the pop gen-y question decreased on the posttest! We hypothesized that before the class, students reasoned through the question, and after, they tried to pattern match HW :/

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Maitreya Dunham @maitreya.bsky.social · Jun 25

One of them has a camera, but we're keeping that one for training purposes. The 'scope that the Center has for microfluidics-based lifespans is unfortunately down right now. Sorry!

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Maitreya Dunham @maitreya.bsky.social · Jun 23

Unfortunately we don't have packing crates for them, so for now loans are restricted to people willing to drive to Seattle. We will train you on how to use them too!

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Maitreya Dunham @maitreya.bsky.social · Jun 23

We also had 4 tetrad dissection microscopes join the lab this week, as part of the @uw-nsc.bsky.social renewal! These belonged to Matt Kaeberlein as part of their large scale efforts to measure replicative lifespan in yeast. We are now offering them as loaners for labs who want to try lifespans.

tetrad dissection microscopes lined up on a bench

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Maitreya Dunham @maitreya.bsky.social · Jun 23

Welcome to our new lab members, postdoc Sarah (co with @kelleyharris.bsky.social) and grad students Zanny and Megan! Very exciting!

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Reposted by Maitreya Dunham

John Murray @jisaacmurray.bsky.social · Jun 20

Happy to announce our paper comparing embryonic gene expression between C. elegans and C. briggsae, work led by Christopher Large with Rupa Khanal and in collaboration with Junhyong Kim and Bob Waterston. www.science.org/doi/10.1126/...

Lineage-resolved analysis of embryonic gene expression evolution in C. elegans and C. briggsae

The constraints that govern the evolution of gene expression patterns across development remain unclear. Single-cell RNA sequencing can detail these constraints by systematically profiling homologous ...

www.science.org

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Maitreya Dunham @maitreya.bsky.social · Jun 21

Had a great day at UBC with a cohort from my lab for the Pacific Northwest Yeast Club meeting! Great science and community, and my student Leah won best talk!

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Reposted by Maitreya Dunham

Brotman Baty Institute @brotmanbaty.bsky.social · Jun 16

POSTDOC ALERT: Applications now open for SeaBridge postdoc fellowship; opportunity to work on leading-edge biotech w/researchers at the Seattle Hub for Synthetic Biology.
brotmanbaty.org/news/new-pos...
@marionpepper.bsky.social
@jshendure.bsky.social
@coletrapnell.bsky.social

New Postdoc Fellowship Program Builds on Innovative SeattleHub Research | Brotman Baty Institute

BBI

brotmanbaty.org

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Maitreya Dunham @maitreya.bsky.social · Jun 10

Another art piece created by argot chen last week during Sxaffold, this one snippets of text pulled from one of my papers. how do you Hope to be changed

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Reposted by Maitreya Dunham

Vaughn Cooper @vscooper.micropopbio.org · Jun 8

Sharing the most significant work from my group, led by the @evolvingstem.bsky.social team.

Come for the discoveries of how Pseudomonas adapts in biofilms, stay for the story of how they were discovered by thousands of young scientists in grades 9-12. 🧪🧫🧬🧵

www.biorxiv.org/content/10.1...

Student-led experimental evolution reveals novel biofilm regulatory networks underlying adaptations to multiple niches

We established a research-education partnership known as EvolvingSTEM that provides secondary school students the opportunity to conduct authentic research experiments centered on microbial evolution....

www.biorxiv.org

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Reposted by Maitreya Dunham

bioRxiv Microbiology @biorxiv-microbiol.bsky.social · Jun 7

Student-led experimental evolution reveals novel biofilm regulatory networks underlying adaptations to multiple niches https://www.biorxiv.org/content/10.1101/2025.06.06.658356v1

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Maitreya Dunham @maitreya.bsky.social · Jun 6

It's definitely going back into the incubator tonight to see how it evolves.

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Maitreya Dunham @maitreya.bsky.social · Jun 6

Had a great time collaborating with artist argot chen this week as part of the inaugural Sxaffold scientist/artist encounter. We made Mt. Rainier from agar using a 3D printed mold, then painted with colorful yeast strains www.sxaffold.org

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