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Tommy Vierbuchen

@tvierbuchen.bsky.social

1.2K followers 650 following 30 posts

Assistant Professor, Developmental Biology, Center for Stem Cell Biology at Sloan Kettering. Building next generation stem cell models to study genetics of brain development. https://www.mskcc.org/research/ski/labs/thomas-vierbuchen

www.mskcc.org

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Tommy Vierbuchen @tvierbuchen.bsky.social · Aug 27

A mouse organoid platform for modeling cerebral cortex development and cis-regulatory evolution in vitro: Developmental Cell www.cell.com/developmenta...

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Reposted by Tommy Vierbuchen

James Briscoe @jamesbriscoe.bsky.social · 1d

Very sad news, John Gurdon has died.

A developmental biologist's developmental biologist, Nobel prize winner

His work is the foundation of much of today's dev & stem cell bio.

An inspiration to many, including me. Always asking questions & wanting the answers

www.magd.cam.ac.uk/news/profess...

Professor Sir John Gurdon FRS (1933-2025) | Magdalene College

Magdalene College is deeply saddened to announce the death of Professor Sir John Gurdon FRS, who served as Master of the College from 1995 to 2002.

www.magd.cam.ac.uk

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Andrew Locking @andrews-walks.bsky.social · 4d

A walk up Castle Crag:
www.andrewswalks.co.uk/castle-crag-...

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Nature Biotechnology @natbiotech.nature.com · 8d

Derivation of embryonic stem cells across avian species - @stemcell.keck.usc.edu go.nature.com/4gLAGcZ

Derivation of embryonic stem cells across avian species - Nature Biotechnology

Embryonic stem cells for chicken and seven other avian species are derived.

go.nature.com

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Reposted by Tommy Vierbuchen

Raquel Fueyo @fueyoraquel.bsky.social · 7d

Today in @nature.com, we present our work leveraging functional genomics and human blastoids to uncover a human-specific mechanism in preimplantation development driven by the endogenous retrovirus HERVK.
Special thanks to the reviewers whose comments improved our manuscript a lot! rdcu.be/eI3tD

A human-specific regulatory mechanism revealed in a pre-implantation model

Nature - Genetic manipulation of blastoids reveals the role of recently emerged transposable elements and genes in human development.

rdcu.be

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Reposted by Tommy Vierbuchen

Sally Lowell @cellysally.bsky.social · 8d

Hot off the press!

Cell-type-specific functionality encoded within the intrinsically disordered regions of OCT4

www.nature.com/articles/s41...

Cell-type-specific functionality encoded within the intrinsically disordered regions of OCT4 - Nature Communications

Here they perform a systematic dissection of OCT4 and reveal how intrinsically disordered regions can be used to serve specific functions during reprogramming and embryonic development. This can be exploited to engineer more efficient and specific reprogramming factors.

www.nature.com

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Reposted by Tommy Vierbuchen

bioRxiv Genetics @biorxiv-genetic.bsky.social · 9d

Cell villages and Dirichlet modeling map human cell fitness genetics https://www.biorxiv.org/content/10.1101/2025.09.26.678880v1

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Reposted by Tommy Vierbuchen

Kentsis Research Group @kentsisresearch.bsky.social · 15d

Developmental Mutators: A unified theory of why young people develop cancer ☛ alexkentsis.net/lecture-deve...

Lecture: Developmental Mutators: A unified theory of why young people develop cancer - Kentsis Research Group at Memorial Sloan Kettering Cancer Center

Listen to my lecture at the St. Jude Science of Childhood Cancer Series

alexkentsis.net

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Reposted by Tommy Vierbuchen

Epigenetics Podcast @epigeneticspod.bsky.social · 16d

In the most recent episode of the Epigenetics Podcast, we talked with @em6wong.bsky.social from the University of New South Wales in Sydney about her work on how evolution shapes mammalian genes. #podcast #epigenetics #chromatin

Listen here: www.activemotif.com/podcasts-emi...

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Reposted by Tommy Vierbuchen

Denis Jabaudon @djabaudon.bsky.social · 19d

Ever wondered how robust cellular identity is to external perturbations? Here we disrupt cellular environmnent in vivo and in vitro, and find cell population specific sensitivities. Environment sculpts development yes, but not all cells are made of the same wood. www.science.org/doi/10.1126/...

Cell-extrinsic controls over neocortical neuron fate and diversity

Cell-extrinsic cues are key for neocortical cell identity and diversity.

www.science.org

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Reposted by Tommy Vierbuchen

Yael David @davidlabmsk.bsky.social · 23d

Thrilled to announce the upcoming Center for Epigenetic Research Symposium @mskcancercenter.bsky.social on Nov 17! 🎉 A full day of cutting-edge science featuring stellar external speakers & our outstanding trainees. Registration is now open! Join us in NYC or virtually from anywhere! link⬇️

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bioRxivpreprint @biorxivpreprint.bsky.social · 24d

Molecular rewiring of human induced pluripotent stem cell-derived cardiomyocytes during metabolic maturation https://www.biorxiv.org/content/10.1101/2025.09.14.676131v1

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Kevin Mitchell @wiringthebrain.bsky.social · 27d

Here's a link to the paper: Beyond Mechanism—Extending Our Concepts of Causation in Neuroscience onlinelibrary.wiley.com/doi/10.1111/...

Beyond Mechanism—Extending Our Concepts of Causation in Neuroscience

The search for neural mechanisms of behaviour often relies on a synchronic, driving view of causation, where neural activity drives more neural activity, which eventually drives behaviour. The real c...

onlinelibrary.wiley.com

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Ollie Inge @oliveringe.bsky.social · 29d

1/7 Really happy to see my PhD work published in ✨Developmental Cell✨ today! We find human endoderm is specified by two developmental trajectories 🔀, and the choice between alternate routes is dictated by the combinatorial BMP4/Activin signalling. www.cell.com/developmenta...

Combinatorial BMP4 and activin direct the choice between alternate routes to endoderm in a stem cell model of human gastrulation

Inge et al. show that human endoderm originates from two converging developmental routes with distinct dynamics and efficiencies yet similar developmental potential. Combinatorial activin and BMP4 sig...

www.cell.com

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Steve Portugal @sjportugal.bsky.social · 29d

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Andres Bendesky @bendeskylab.com · Sep 8

New review on how changes in cell type composition in and outside the brain contribute to the evolution of behavior. 🧪

authors.elsevier.com/a/1lihM,LqAZ...

Changes in cell type composition, including cell expansions, cell losses, and novel cell gains, are associated with the evolution of specific behaviors.
Figure credit: Matteo Farinella.

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Laura Santini @laurasantini.bsky.social · Aug 29

Start the weekend by checking out the latest paper from the Vierbuchen lab, spearheaded by amazing @danielmedinacano.bsky.social 🎉 Congrats to all authors!!

Tommy Vierbuchen @tvierbuchen.bsky.social · Aug 27

A mouse organoid platform for modeling cerebral cortex development and cis-regulatory evolution in vitro: Developmental Cell www.cell.com/developmenta...

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Reposted by Tommy Vierbuchen

Paul Robson @paulrobson.bsky.social · Aug 28

Nice piece from our JAX Communication team outlining our efforts within the MorPhiC Consortium towards characterizing the function of all human protein coding genes:
www.jax.org/news-and-ins...

MorPhiC: Cellular modeling at scale

JAX plays key role in national effort to decode the function of every human gene.

www.jax.org

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Reposted by Tommy Vierbuchen

Emily Wong @em6wong.bsky.social · Aug 28

Congrats to Tommy and team, especially to PhD student Veronika Petrova who led the work on our end. Great to see it out! @victorchang.edu.au

Tommy Vierbuchen @tvierbuchen.bsky.social · Aug 27

A mouse organoid platform for modeling cerebral cortex development and cis-regulatory evolution in vitro: Developmental Cell www.cell.com/developmenta...

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Reposted by Tommy Vierbuchen

Cedric Boeckx @cedricboeckx.bsky.social · Aug 28

“A mouse organoid platform for modeling cerebral cortex development and cis-regulatory evolution in vitro”
Nice work by @danielmedinacano.bsky.social
@tvierbuchen.bsky.social @em6wong.bsky.social
@stadtfeldlab.bsky.social
🧪🧫🧠

www.cell.com/developmenta...

A mouse organoid platform for modeling cerebral cortex development and cis-regulatory evolution in vitro

Medina-Cano et al. report a new protocol for the reproducible generation of cerebral cortical organoids from mouse epiblast stem cells, which recapitulate the developmental tempo, cytoarchitecture, an...

www.cell.com

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Daniel Medina-Cano @danielmedinacano.bsky.social · Aug 27

… my work with the Stadtfeld lab @stadtfeldlab.bsky.social‬ on the role of OTX2 during definitive endoderm and anterior gut development is also out (tinyurl.com/3unwh3eb)! Thank you so much to all collaborators, and I’ll be more than happy to discuss these protocols with anyone interested!

ScienceDirect.com | Science, health and medical journals, full text articles and books.

tinyurl.com

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Tommy Vierbuchen @tvierbuchen.bsky.social · Aug 28

Thanks Cedric!

Reposted by Tommy Vierbuchen

Tatjana Sauka-Spengler @saukaspengler.bsky.social · Aug 27

Fully integrated hybrid option available for the XII International Avian Meeting @stowersinstitute.bsky.social! Submit an abstract, present your work and participate in Q&As—remotely or in person. @biologists.bsky.social awards available for early-career researchers on-site. tinyurl.com/avian-models

Avian Models System Meeting Stowers Institute

Research Organisms in Flight: Revealing the Roots of Vertebrate Form and Function. The XII Avian Model Systems Meeting will showcase the integrative power…

tinyurl.com

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Reposted by Tommy Vierbuchen

Daniel Medina-Cano @danielmedinacano.bsky.social · Aug 27

I'm really happy to announce that my two main postdoctoral works have been published in the same issue of Developmental Cell! First, the final form of the mouse cortical organoid protocol (tinyurl.com/bddfmx8n), which I recently presented at Development presents (tinyurl.com/36udcpme) and…

tinyurl.com

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Tommy Vierbuchen @tvierbuchen.bsky.social · Aug 27

A mouse organoid platform for modeling cerebral cortex development and cis-regulatory evolution in vitro: Developmental Cell www.cell.com/developmenta...

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Reposted by Tommy Vierbuchen

Martin Kampmann @kampmann.bsky.social · Aug 22

Excited that the paper presenting our mouse brain in vivo CRISPR screening platform is out today in @natneuro.nature.com!

Great team effort, led by Biswa Ramani and @ivlrose.bsky.social in the Kampmann lab.

www.nature.com/articles/s41...

CRISPR screening by AAV episome-sequencing (CrAAVe-seq): a scalable cell-type-specific in vivo platform uncovers neuronal essential genes - Nature Neuroscience

The authors developed an adeno-associated virus-based high-throughput in vivo CRISPR screening platform for endogenous mouse brain cell types. Using this platform, they define genes and pathways essen...

www.nature.com

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