laurasantini.bsky.social
Laura Santini
@laurasantini.bsky.social
55 followers 100 following 3 posts
Stem cell Researcher in love with Developmental and Chromatin Biology PostDoc at @mskcc in @tommyvierbuchen lab Formerly PhD student at @viennabiocenter in @theleeboratory
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laurasantini.bsky.social
Laura Santini @laurasantini.bsky.social · 5d
It was great to be there and see your lab blossoming! All the best for next 10 years and more to come 🎊🎊
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laurasantini.bsky.social
Laura Santini @laurasantini.bsky.social · Aug 29
Start the weekend by checking out the latest paper from the Vierbuchen lab, spearheaded by amazing @danielmedinacano.bsky.social 🎉 Congrats to all authors!!
tvierbuchen.bsky.social
Tommy Vierbuchen @tvierbuchen.bsky.social · Aug 27
A mouse organoid platform for modeling cerebral cortex development and cis-regulatory evolution in vitro: Developmental Cell www.cell.com/developmenta...
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Reposted by Laura Santini
tvierbuchen.bsky.social
Tommy Vierbuchen @tvierbuchen.bsky.social · May 13
Excited to share our latest manuscript, a collaboration with @justinperryphd.bsky.social led by Weill Cornell Neuroscience PhD student @annbaako.bsky.social. Ann developed a new, improved mouse PSC model for studying tissue-resident macrophage differentiation.

www.biorxiv.org/content/10.1...
Modeling tissue-resident macrophage development from mouse pluripotent stem cells
Tissue-resident macrophages (TRMs) are innate immune cells that participate in tissue development, homeostasis, and immune surveillance. Extensive efforts have been made to recapitulate TRM developmen...
www.biorxiv.org
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laurasantini.bsky.social
Laura Santini @laurasantini.bsky.social · Dec 3
So glad this great story is finally out! Congrats to all authors!
chribue.bsky.social
Christa Buecker @chribue.bsky.social · Dec 2
By definition, enhancers can activate from a distance. But with increased distance between enhancer and promoter, the activation drops. To study this systematically, we build a synthetic locus: www.cell.com/molecular-ce... 1/12
Redirecting
doi.org
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Reposted by Laura Santini
danielmedinacano.bsky.social
Daniel Medina-Cano @danielmedinacano.bsky.social · Nov 22
Happy to share our mouse cortical organoid system, which recapitulates in vivo tempos and cell types. We used it to identify gene expression changes across subspecies during development, which might underlie neuroanatomical differences and affect disease penetrance. www.biorxiv.org/content/10.1...
A MOUSE ORGANOID PLATFORM FOR MODELING CEREBRAL CORTEX DEVELOPMENT AND CIS-REGULATORY EVOLUTION IN VITRO
Natural selection has shaped the gene regulatory networks that orchestrate the development of the neocortex, leading to diverse neocortical structure and function across mammals, but the molecular and...
www.biorxiv.org
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