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oliveringe.bsky.social
Ollie Inge
@oliveringe.bsky.social
160 followers 300 following 11 posts
Postdoctoral Research Assistant - Quantitative Stem Cell Biology Lab (Santos Lab) at The Francis Crick Institute. Single-cell dynamics, signalling and lineage specification during human development.
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oliveringe.bsky.social
Ollie Inge @oliveringe.bsky.social · 28d
1/7 Really happy to see my PhD work published in ✨Developmental Cell✨ today! We find human endoderm is specified by two developmental trajectories 🔀, and the choice between alternate routes is dictated by the combinatorial BMP4/Activin signalling. www.cell.com/developmenta...
Combinatorial BMP4 and activin direct the choice between alternate routes to endoderm in a stem cell model of human gastrulation
Inge et al. show that human endoderm originates from two converging developmental routes with distinct dynamics and efficiencies yet similar developmental potential. Combinatorial activin and BMP4 sig...
www.cell.com
6 28 78
Reposted by Ollie Inge
katherine-brown.bsky.social
Katherine Brown @katherine-brown.bsky.social · 23h
Very saddened to hear of John Gurdon’s passing. I’ve been lucky enough to interact with him at multiple points through my career - from undergrad lectures, through his position as former Chair of @biologists.bsky.social’s Board of Directors, and as an author at @dev-journal.bsky.social.
Nobel Laureate Professor Sir John Gurdon dies aged 92
It is with great sadness that the University shares the news of the death of Professor Sir John Gurdon, founder of the Gurdon Institute.
www.cam.ac.uk
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Reposted by Ollie Inge
alexisbarr.bsky.social
Alexis Barr @alexisbarr.bsky.social · 1d
Just over one week until this opportunity closes!

If you’re an ambitious computational scientist looking for a Postdoc position, apply now
alexisbarr.bsky.social
Alexis Barr @alexisbarr.bsky.social · 19d
@mariasecrier.bsky.social & I are looking for an enthusiastic & excellent data scientist for a 4-year postdoc to understand cell cycle dysregulation in cancer.

Deadline 15th October. Get in touch if you have any questions.

Please repost!

More details:
www.imperial.ac.uk/jobs/search-...
Description
Please note that job descriptions are not exhaustive, and you may be asked to take on additional duties that align with the key responsibilities ment...
www.imperial.ac.uk
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Reposted by Ollie Inge
fabiantheis.bsky.social
Fabian Theis @fabiantheis.bsky.social · 9d
🚀 Excited to share scPortrait! Led by Sophia Mädler & Niklas Schmacke w/ the Mann lab — a new @scverse tool for standardized single-cell image data. Enables ML-ready extraction, >1B cell processing, cross-omics, & cancer macrophage insights.
🔗 www.biorxiv.org/content/10.1...
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Reposted by Ollie Inge
santoslab.bsky.social
Santos lab @santoslab.bsky.social · 12d
Farewell dinner for @oliveringe.bsky.social with our wonderful Santos lab family. Ollie was our 1st Crick PhD student! Lots to celebrate and many fun memories. We are so grateful to have had Ollie in the lab and cannot wait to see what’s next for him in the Morris lab at Harvard! Best of luck,Ollie!
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Reposted by Ollie Inge
alexisbarr.bsky.social
Alexis Barr @alexisbarr.bsky.social · 19d
@mariasecrier.bsky.social & I are looking for an enthusiastic & excellent data scientist for a 4-year postdoc to understand cell cycle dysregulation in cancer.

Deadline 15th October. Get in touch if you have any questions.

Please repost!

More details:
www.imperial.ac.uk/jobs/search-...
Description
Please note that job descriptions are not exhaustive, and you may be asked to take on additional duties that align with the key responsibilities ment...
www.imperial.ac.uk
35 30
Reposted by Ollie Inge
jzylicz.bsky.social
Jan Żylicz @jzylicz.bsky.social · 20d
Genes are not On/Off switches. In a new preprint we show that HDAC3 is key to establish correct transcriptional dose in development. Gr8 work from N. Stamidis @ucph.bsky.social and collab. @jamiehackett.bsky.social @gregersenlab.bsky.social . Huge thx to all authors! www.biorxiv.org/content/10.1...
HDAC3 prevents enhancer hyperactivation to enable developmental transitions
Dynamic gene regulation requires precise cooperation between transcription factors and chromatin modifiers at regulatory elements to achieve not only activation or repression, but also appropriate tra...
www.biorxiv.org
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Reposted by Ollie Inge
katherine-brown.bsky.social
Katherine Brown @katherine-brown.bsky.social · 21d
It was fun to look back over a decade of 'From Stem Cells to Human Development' meetings at @dev-journal.bsky.social. This is one of the projects I most enjoyed during my time at the journal - and I really hope we helped to catalyse and support a community... journals.biologists.com/dev/article/...
From stem cells to human development: supporting a growing field
In 2014, Development organised the first of The Company of Biologists’ Journal Meetings: ‘From Stem Cells to Human Development’. Conceived to help bring together the developmental biology and stem cel...
journals.biologists.com
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Reposted by Ollie Inge
zenahadjivasiliou.bsky.social
Zena Hadjivasiliou @zenahadjivasiliou.bsky.social · 21d
Fresh from the press💥 We asked what happens when you evolve gene regulatory networks computationally at scale. Do general principles of GRN evolution jump out? Is the process predictable? Read on to find out @prxlife.bsky.social @crick.ac.uk @ucl-ipls.bsky.social 👉 journals.aps.org/prxlife/abst...
Gene Network Organization, Mutation, and Selection Collectively Drive Developmental Pattern Evolvability and Predictability
The historical order in which mutations appear during evolution determine the evolutionary trajectory of gene regulatory networks and influence how developmental patterns change and diversify over tim...
journals.aps.org
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Reposted by Ollie Inge
santoslab.bsky.social
Santos lab @santoslab.bsky.social · 23d
This is Mirjam, Santos Lab’ PhD student presenting her work at the EMBL meeting on Developmental Metabolism 🫶. Conference was incredible and Mirjam had an amazing time!
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oliveringe.bsky.social
Ollie Inge @oliveringe.bsky.social · 25d
3/3 I will be starting as a postdoc fellow this autumn at @massgeneralbrigham.bsky.social and @harvardmed.bsky.social with Samantha A. Morris.
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oliveringe.bsky.social
Ollie Inge @oliveringe.bsky.social · 25d
2/3 Special thank you to my supervisor Silvia, her continued mentorship and support throughout the PhD and onto my next step. 🙏
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oliveringe.bsky.social
Ollie Inge @oliveringe.bsky.social · 25d
1/3 After 6+ years at @crick.ac.uk I split my last cells and hung up my lab coat! Thank you to the brilliant community from fellow PhDs/Postdocs, LOAs, STPs, academic training team and to all past/present @santoslab.bsky.social members. My Crick journey would not have been the same without you all!
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Reposted by Ollie Inge
stemcellpodcast.com
Stem Cell Podcast @stemcellpodcast.com · 27d
Drs. @dbenzinger.bsky.social‬ and @jamesbriscoe.bsky.social at the @crick.ac.uk established an #optogenetic system for the precise spatiotemporal control in vitro of Sonic hedgehog morphogen production. 🦔

📄 - https://bit.ly/3Vxf0rf
🎙️ - https://bit.ly/3JWWpT9
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Reposted by Ollie Inge
crick.ac.uk
The Francis Crick Institute @crick.ac.uk · 28d
Researchers have found that early embryonic cells start to specialise via converging developmental paths, rather than following linear trajectories as was previously believed.
www.crick.ac.uk/news/2025-09...
Converging development: how cell paths unite in the embryo
By tracking the fate of individual embryonic stem cells, researchers have found that endoderm cells – early embryonic cells that give rise to tissues such as the gut and lungs – originate from multipl...
www.crick.ac.uk
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oliveringe.bsky.social
Ollie Inge @oliveringe.bsky.social · 28d
7/7 🙏Thank you so much for my brilliant co-authors and collaborators including @eliascopin.bsky.social @borzogharibi.bsky.social @jcornwallscoones.bsky.social @jamesbriscoe.bsky.social and my PhD supervisor @santoslab.bsky.social for helping at each step of the way.
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oliveringe.bsky.social
Ollie Inge @oliveringe.bsky.social · 28d
6/7 Overall, this work demonstrates that distinct cell identities can arise through different developmental trajectories coordinated by combinatorial signalling.
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oliveringe.bsky.social
Ollie Inge @oliveringe.bsky.social · 28d
5/7 When varying signalling conditions and measuring the proportion of endoderm cells from different paths, we found that the choice between routes to endoderm depends on the specific combination of BMP4 and Activin signals that cells are exposed to ⚖️.
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oliveringe.bsky.social
Ollie Inge @oliveringe.bsky.social · 28d
4/7 Despite divergent origins we found that endoderm cells derived from different routes have the same developmental potential to form downstream cell types 🧫.
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oliveringe.bsky.social
Ollie Inge @oliveringe.bsky.social · 28d
3/7 🔬Using single-cell transcriptomics as well as live-cell imaging of engineered hESCs, we measured individual gene expression histories and found that human endoderm arises from two distinct developmental trajectories: a direct path and an indirect one through a FOXC1+ progenitor state.
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oliveringe.bsky.social
Ollie Inge @oliveringe.bsky.social · 28d
2/7 🔢 Pairing quantitative measurements of cell fate proportions in response to signalling combinations and mathematical modelling we found that hESC differentiation was best captured by cell state transitions including multiple paths to terminal fates.
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oliveringe.bsky.social
Ollie Inge @oliveringe.bsky.social · 28d
1/7 Really happy to see my PhD work published in ✨Developmental Cell✨ today! We find human endoderm is specified by two developmental trajectories 🔀, and the choice between alternate routes is dictated by the combinatorial BMP4/Activin signalling. www.cell.com/developmenta...
Combinatorial BMP4 and activin direct the choice between alternate routes to endoderm in a stem cell model of human gastrulation
Inge et al. show that human endoderm originates from two converging developmental routes with distinct dynamics and efficiencies yet similar developmental potential. Combinatorial activin and BMP4 sig...
www.cell.com
6 28 78
Reposted by Ollie Inge
jamesbriscoe.bsky.social
James Briscoe @jamesbriscoe.bsky.social · Aug 14
Latest on Waddington Landscapes: Computational methods to fit dynamical landscapes directly to single cell data

Applied to neural tube patterning shows morphogen-signalling landscapes can be linearly interpolated

Connects interpretable landscape models with data

www.biorxiv.org/content/10.1...
Reconstructing Waddington's Landscape from Data
The development of a zygote into a functional organism requires that this single progenitor cell gives rise to numerous distinct cell types. Attempts to exhaustively tabulate the interactions within d...
www.biorxiv.org
2 24 67
Reposted by Ollie Inge
tobyandrews.bsky.social
Toby Andrews @tobyandrews.bsky.social · Aug 6
Thrilled to bits to see our latest work online in Dev Cell! 🥳

We wanted to know how cells build functional organs with precision🫀🫁📏 Here we show how coupling of cell shape and organ function fine tunes the form and contractile power of the developing #zebrafish heart 1/n

tinyurl.com/cell-stretch
Mechanochemical coupling of cell shape and organ function optimizes heart size and contractile efficiency in zebrafish
Andrews et al. demonstrate that multiscale feedback between mechanical and chemical cues builds a functional heart to support zebrafish embryonic life. Cell recruitment and organ-scale forces drive tr...
tinyurl.com
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Reposted by Ollie Inge
barttheeuwes.bsky.social
Bart Theeuwes @barttheeuwes.bsky.social · Jun 24
So happy to finally see this work published! We reveal that an in vitro system mimics specification of extra-embryonic mesoderm into the visceral yolk-sac and allantois, and use this model alongside in vivo experiments to study the role of Eomes and T in these tissues. Big thanks to all co-authors 🥳
bertiegottgens.bsky.social
Bertie Gottgens @bertiegottgens.bsky.social · Jun 24
Collaborative science is just so much fun! From our brilliant collaboration with Liz Robertson from @dunnschool.bsky.social; embryology, single cell omics and computational biology deliver new insights into the intricacies of blood and endothelial development. www.sciencedirect.com/science/arti...
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Reposted by Ollie Inge
jamesbriscoe.bsky.social
James Briscoe @jamesbriscoe.bsky.social · Jul 23
New work with Saunders & Charras labs

Physical boundaries guide cell fate decisions during human trunk development

Reaction Diffusion model shows how geometry shapes biology with TBXT expression forming consistent domains regardless of colony size & shape

www.biorxiv.org/content/10.1...
Boundary constraints can determine pattern emergence
The robust patterning of cell fates during embryonic development requires precise coordination of signalling gradients within defined spatial constraints. Using a geometrically confined in vitro syste...
www.biorxiv.org
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