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Kentsis Research Group @kentsisresearch.bsky.social · 15d

Developmental Mutators: A unified theory of why young people develop cancer ☛ alexkentsis.net/lecture-deve...

Lecture: Developmental Mutators: A unified theory of why young people develop cancer - Kentsis Research Group at Memorial Sloan Kettering Cancer Center

Listen to my lecture at the St. Jude Science of Childhood Cancer Series

alexkentsis.net

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Reposted by Kentsis Research Group

IonOpticks @ionopticks.bsky.social · 23d

@kentsisresearch.bsky.social develop a proteogenomics workflow to detect 1000s of unknown cancer proteins. PG3 combines long-read RNA sequencing with multi-protease MS to discover non-canonical proteins in cancer cells. Used a timsTOF HT, nanoElute 2 & Aurora Ultimate 25x75 column:
bit.ly/4mlQSmu

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Reposted by Kentsis Research Group

Carl Zimmer @carlzimmer.com · 24d

A deep dive into the destruction of US cancer research by @jonathanmahler.bsky.social “It’s an absolutely unmitigated disaster,” a former top official at NIH told him. “It will take decades to recover from this, if we ever do.” Gift link: nyti.ms/48iH3Cr

nyti.ms

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Kentsis Research Group @kentsisresearch.bsky.social · 24d

www.stjude.org/education-tr...

Science of Childhood Cancer Lecture Series

A 15-week virtual lecture series focused on key questions in pediatric cancer research. View the expert speakers and recordings of prior seminars.

www.stjude.org

Kentsis Research Group @kentsisresearch.bsky.social · 27d

Listen to my new lecture "Developmental mutagenesis: A unified theory of why young people develop cancer" as part of
@stjude.bsky.social @stjuderesearch.bsky.social
Science of Childhood Lecture Series on September 18, 2025: www.linkedin.com/events/73719...

LinkedIn Login, Sign in | LinkedIn

Login to LinkedIn to keep in touch with people you know, share ideas, and build your career.

www.linkedin.com

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Reposted by Kentsis Research Group

Denis Wirtz @deniswirtz.bsky.social · Aug 11

These are the most challenging times for early-career scientists and engineers.

My team is doing its bit to help by maintaining and even expanding our database of funding opportunities for early-career researchers.

We found 437 of them.

Download it freely here: research.jhu.edu/rdt/funding-...

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Reposted by Kentsis Research Group

Vivek Subbiah, MD @viveksubbiah.bsky.social · Aug 11

Patterns in genomic mutations among patients with early-onset colorectal cancer: an international, multicohort, observational study - The Lancet Oncology www.thelancet.com/journals/lan...

Patterns in genomic mutations among patients with early-onset colorectal cancer: an international, multicohort, observational study

Within hypermutated colorectal cancer, younger patients exhibited a higher mutational burden than older patients. Our study reveals an abnormal accumulation of distinct somatic mutations in hypermutat...

www.thelancet.com

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Reposted by Kentsis Research Group

🧬Jacob L Steenwyk @jlsteenwyk.bsky.social · Jul 10

NEW pub: The role of metabolism in shaping #enzyme structures over 400 million years. Now out in @nature.com

Super grateful to have played a small role in this project - congrats to lead/corr authors Oliver, Benjamin, and Markus!

www.nature.com/articles/s41...

#alphafold #evolution #genomics

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Reposted by Kentsis Research Group

Lars Velten @larsplus.bsky.social · May 8

Out in Cell @cp-cell.bsky.social: Design principles of cell-state-specific enhancers in hematopoiesis
🧬🩸 screen of fully synthetic enhancers in blood progenitors
🤖 AI that creates new cell state specific enhancers
🔍 negative synergies between TFs lead to specificity!
www.cell.com/cell/fulltex...
🧵

Design principles of cell-state-specific enhancers in hematopoiesis

Screen of minimalistic enhancers in blood progenitor cells demonstrates widespread dual activator-repressor function of transcription factors (TFs) and enables the model-guided design of cell-state-sp...

www.cell.com

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Kentsis Research Group @kentsisresearch.bsky.social · May 1

Sorry to hear this (again), Jan

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Kentsis Research Group @kentsisresearch.bsky.social · Apr 26

This would be a great application for single-cell proteomics!

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Kentsis Research Group @kentsisresearch.bsky.social · Apr 25

Supporting medical science in the USA - The Lancet www.thelancet.com/journals/lan...

Supporting medical science in the USA

The pursuit of rigorous medical science is not compatible with capitulation to government demands aimed at weaponising and eroding science. On April 14, Edwin R Martin Jr, the Trump-appointed interim ...

www.thelancet.com

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Kentsis Research Group @kentsisresearch.bsky.social · Apr 20

What would the National Cancer Act look like today? Bravo Kevin Cullen! Act! cancerletter.com/guest-editor...

What would Mary do? Trump’s actions call for Lasker-style advocacy - The Cancer Letter

A diagnosis of cancer brings with it fear and uncertainty. Changes proposed by the Trump administration pose a grave new risk to those who suffer from cancer today or will suffer from cancer in the fu...

cancerletter.com

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Kentsis Research Group @kentsisresearch.bsky.social · Apr 16

Most of my proposals have two Aims. Coincidentally, most of the time I also eat two tacos at a time, but have them more frequently. Deep insights!

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Kentsis Research Group @kentsisresearch.bsky.social · Apr 4

Lars, it was pure joy working with you

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Reposted by Kentsis Research Group

Memorial Sloan Kettering Cancer Center @mskcancercenter.bsky.social · Apr 4

New in @naturecomms.bsky.social: MSK's @kentsisresearch.bsky.social & collaborators identified a rare population of stem cells responsible for disease persistence & therapy resistance in acute myeloid leukemia (#AML), which could help improve treatment strategies: www.nature.com/articles/s41...

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Kentsis Research Group @kentsisresearch.bsky.social · Apr 3

A new KRG study led by Sumiko Takao @naturecomms.bsky.social uncovers how epigenetic mechanisms control human leukemia stem cells (LSCs) that fuel therapy resistance in AML. www.nature.com/articles/s41...

Epigenetic mechanisms controlling human leukemia stem cells and therapy resistance - Nature Communications

Acute myeloid leukemia (AML) arise from mutations of stem and progenitor cells. Here, authors identify a quiescent, label-retaining cell population in AML patient specimens that have tumor-initiation ...

www.nature.com

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Kentsis Research Group @kentsisresearch.bsky.social · Mar 22

A little lab fun

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Reposted by Kentsis Research Group

Tianxiong (Bear) Yu @tianxiong-bear-yu.bsky.social · Mar 9

I am thrilled to share our story online at @cellpress.bsky.social . Big thanks to all authors: Zhiping, Bill, @lubanlab.bsky.social, Keith & bluesky-less!

authors.elsevier.com/c/1kjdaL7PXu...

How to tame a genome invader? It takes wild koalas 🐨🐨 to learn it.
#Retrovirus #koala #piRNA

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