James Briscoe
@jamesbriscoe.bsky.social
Developmental Biologist working at the Francis Crick Institute. Neural tube, morphogens, and gene regulatory networks. Editor-in-chief, Development.
London · briscoelab.org
London · briscoelab.org
I'd be curious whether a fit of the data to a "binary flip" landscape worked and a comparison to the mechanistic LDE model. Does BMP control the lower saddle (between cardiac & neural) & hence which attractor the unstable manifold connects; with BRM determining the initial "tilt" of the landscape?
December 5, 2025 at 8:55 AM
I'd be curious whether a fit of the data to a "binary flip" landscape worked and a comparison to the mechanistic LDE model. Does BMP control the lower saddle (between cardiac & neural) & hence which attractor the unstable manifold connects; with BRM determining the initial "tilt" of the landscape?
It makes the many hours of Zoom calls and discussion all worth while.
For a further extension of this strategy see:
www.biorxiv.org/content/10.1...
For a further extension of this strategy see:
www.biorxiv.org/content/10.1...
Dynamic Landscape Analysis of Cell Fate Decisions: Predictive Models of Neural Development From Single-Cell Data
Building a mechanistic understanding of cell fate decisions remains a fundamental goal of developmental biology, with implications for stem cell therapies, regenerative medicine and understanding dise...
www.biorxiv.org
December 4, 2025 at 6:29 AM
It makes the many hours of Zoom calls and discussion all worth while.
For a further extension of this strategy see:
www.biorxiv.org/content/10.1...
For a further extension of this strategy see:
www.biorxiv.org/content/10.1...