Check out our new preprint on an integrated pipeline combining in situ #cryo-ET with MALDI #MSImaging for single-cell identification and classification from previously analysed EM-grids.
Link: www.biorxiv.org/content/10.1...

In mESCs autophagy prevents POMP accumulation and nucleolar localization (F). This mechanism is developmentally regulated and lost with differentiation (G). Additionally, POMP nuclear relocalization is observed in a mouse model of Huntington’s disease (H). 🧵4/4

Upon relocalization POMP acquires a new set of interaction partners (D), preserves ribogenesis (E) and drives a protective transcriptional program (F) 🧵3/4

Normally POMP is rapidly degraded during protesome biogenesis (A), but in response to stress it accumulates without a concomitant increase in partner proteasome subunits (B) This stoichiometric uncoupling together with increased ROS leads to its relocalization to the nucleolus (C) 🧵2/4

New Preprint out !

The proteasome maturation factor POMP moonlights as a stress-induced transcriptional regulator
www.biorxiv.org/content/10.1...

Lead by: @sgiando.bsky.social
with: @muellermara.bsky.social , @erin-schuman.bsky.social , @marcvoo.bsky.social and many more

Short thread below 🧵1/4

Normally POMP is rapidly degraded during protesome biogenesis (A), but in response to stress it accumulates without a concomitant increase in partner proteasome subunits (B) This stoichiometric uncoupling together with increased ROS leads to its relocalisation to the nucleolus (C) 🧵2/4

Congratulations to @mpibrain.bsky.social director Gilles Laurent for being awarded the 2025 Louis-Jeantet prize for Medicine! The @louisjeantetfdn.bsky.social recognizes Laurent's pioneering work on the operations of #neurons and dynamics of neuronal networks. More infos 👉 bit.ly/4hqk6ie

"Understanding the molecular diversity of synapses" new review by my boss @erin-schuman.bsky.social and former postdoc @marcvoo.bsky.social out now in Nature Reviews Neuroscience:

www.nature.com/articles/s41...

Seconding @dpastoors.bsky.social recommendation: I use eLabFTW every day and love it. Open-source, freeware, completely customizable and lets you host everything on your own servers
www.elabftw.net