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mzhlab.bsky.social @mzhlab.bsky.social · Aug 23

Our paper was just published in Nat Comm. First single‑nucleus atlas of human sural nerves in health and disease. Identified lipid‑phagocytosing macrophages and focal perineurial hyperplasia especially in immune-mediated polyneuropathies. rdcu.be/eB2Dg

Multi-omic identification of perineurial hyperplasia and lipid-associated nerve macrophages in human polyneuropathies

Nature Communications - Polyneuropathy causes are difficult to pinpoint. Here, authors used single-nucleus and spatial transcriptomics of 37 human peripheral nerves to identify focal perineurial...

rdcu.be

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mzhlab.bsky.social @mzhlab.bsky.social · Jul 1

Thrilled to announce that our latest work is now online in Genome Medicine!
We identified a mechanism driving ICANS following CAR T cell treatment.
doi.org/10.1186/s130...

The CXCL16/CXCR6 axis is linked to immune effector cell-associated neurotoxicity in chimeric antigen receptor (CAR) T cell therapy - Genome Medicine

Background Immune effector cell-associated neurotoxicity syndrome (ICANS) is a common and potentially life-threatening complication of chimeric antigen receptor (CAR) T cell therapy. The underlying me...

doi.org

Reposted

mheming.bsky.social @mheming.bsky.social · Dec 10

We are excited to present a first large-scale (365,708 nuclei) single cell atlas of human peripheral nerves combined with subcelullar spatial transcriptomics (#Xenium). A

www.biorxiv.org/content/11.1...
Explore: pns-atlas.mzhlab.com
A tweetorial 1/11

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mzhlab.bsky.social @mzhlab.bsky.social · Dec 12

Exciting news! Our new paper is published at Annals of Neurology!

Check it out to see how large-scale CSF and blood flow cytometry can reveal disease clusters to improve diagnosis and understanding

t.co/JzIIUSuKVn

http://doi.org/10.1002/ana.27157

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