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Nature Neuroscience @natneuro.nature.com · 18h

Muscle-derived miR-126 regulates TDP-43 axonal local synthesis and NMJ integrity in ALS models

www.nature.com/articles/s41...

Muscle-derived miR-126 regulates TDP-43 axonal local synthesis and NMJ integrity in ALS models - Nature Neuroscience

Ionescu, Ankol et al. show that, in ALS mouse and iPSC models, TDP-43 aggregation at NMJs stems from aberrant axonal translation, normally repressed by muscle EV-derived miR126. Loss of miR126 in ALS increases TDP-43 buildup, impairs local synthesis and triggers degeneration.

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Reposted by Nature Neuroscience

Springer Nature @springernature.com · 2d

Want to close the gender gap in research? Start with the data.

Our Springer Nature report: Closing the Gender Gap highlights where change is needed most — and how you can be part of it. Read the report: spklr.io/63324ByG4y

Against a red backdrop, geometric shapes accent the title, "Closing the Gender Gap," with the subtitle, "Peer Review at Nature Portfolio". The shapes include circles and rectangles of white, blue, green, and brown.

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Nature Neuroscience @natneuro.nature.com · 2d

A single dose of #psilocybin induces a rapid and sustained reversal of both mechanical allodynia (pain) and anxiodepression-like states in adult male and female mice

www.nature.com/articles/s41...

Single-dose psilocybin rapidly and sustainably relieves allodynia and anxiodepressive-like behaviors in mouse models of chronic pain - Nature Neuroscience

Hammo et al. show that a single dose of psilocybin rapidly and sustainably relieves both chronic pain and anxiodepressive-like behaviors in mice by restoring prefrontal activity through partial agonism at 5-HT2A and 5-HT1A receptors.

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Nature Neuroscience @natneuro.nature.com · 3d

And, check out this video of Lan Yun Ju Hua painting it!

www.bilibili.com/video/BV1eKK...

入我画竹影，入我网蜻蜓。_哔哩哔哩_bilibili

-, 视频播放量 1343、弹幕量 0、点赞数 157、投硬币枚数 20、收藏人数 34、转发人数 5, 视频作者懒云居画, 作者简介国画｜收藏/合作邮箱[email protected]，相关视频：莫使金樽空对鹤，采荷遇白鹿，且放白鹿青崖间，须行即骑访名山。，乘叶秋游，夏日荷仙走进国画，国画采莲，梦里不知身是鹤，携鹤伴松风，但愿人长久，千里共婵娟～，大漠孤烟直

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Nature Neuroscience @natneuro.nature.com · 3d

Our October issue is now live!

www.nature.com/neuro/volume...

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Nature Neuroscience @natneuro.nature.com · 6d

Characteristic facial features in mice simultaneously encode not only currently used decision variables but also independent and unexpressed ones, and these features partially originate from neural activity in the secondary motor cortex

@fannycazettes.bsky.social

www.nature.com/articles/s41...

Facial expressions in mice reveal latent cognitive variables and their neural correlates - Nature Neuroscience

The face reveals more than just emotion. Cazettes, Reato and colleagues show that subtle facial movements reveal hidden cognitive states, reflecting the brain’s ongoing computations and offering a noninvasive window into unexpressed thoughts and decisions.

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Nature Neuroscience @natneuro.nature.com · 7d

Hormonal milieu influences whole-brain structural dynamics across the menstrual cycle using dense sampling in multiple individuals

@carinaheller.bsky.social, @uni-jena.de,
@umn-midb.bsky.social, @icsantabarbara.bsky.social

www.nature.com/articles/s41...

Hormonal milieu influences whole-brain structural dynamics across the menstrual cycle using dense sampling in multiple individuals - Nature Neuroscience

Heller et al. showed dense longitudinal imaging in four females, including one with endometriosis and one using oral contraceptives, and the finding that different hormonal milieus influence widespread brain volume changes linked to progesterone or estradiol.

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Nature Neuroscience @natneuro.nature.com · 8d

An inhibitory pathway from the medial septum (MS) to the subfornical organ (SFO) that is involved in the control of anticipatory drinking behavior in mice

www.nature.com/articles/s41...

A bottom-up septal inhibitory circuit mediates anticipatory control of drinking - Nature Neuroscience

Xu et al. reveal that a bottom-up neural circuit from the medial septum to the subfornical organ prevents overhydration in mice by integrating oral and gastrointestinal signals before osmolality changes, demonstrating precise drinking control mechanisms.

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Nature Neuroscience @natneuro.nature.com · 9d

Temporal integration throughout the human auditory cortex is predominantly locked to absolute time and does not vary with the duration of speech structures such as phonemes or words

@samnorman-haignere.bsky.social @urneuroscience.bsky.social @urochester.bsky.social

www.nature.com/articles/s41...

Temporal integration in human auditory cortex is predominantly yoked to absolute time - Nature Neuroscience

Temporal integration throughout the human auditory cortex is predominantly locked to absolute time and does not vary with the duration of speech structures such as phonemes or words.

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Reposted by Nature Neuroscience

Nature Portfolio @natureportfolio.nature.com · 14d

The abstract submission deadline for our three-day conference on brain energy metabolism is Oct. 3! Join experts such as @rioslab.bsky.social and @carmensandi10.bsky.social to share findings and exchange ideas. Learn more: go.nature.com/4p4rqV9 #Neuroskyence #Academicsky #STEMconference

Swipe to meet some of the experts presenting at Brain Energy Metabolism in Health and Disease, Dec. 3-5, KRAUST Campus, Saudi Arabia

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Nature Neuroscience @natneuro.nature.com · 21d

And

High-throughput synaptic connectivity mapping using in vivo two-photon holographic optogenetics and compressive sensing

www.nature.com/articles/s41...

High-throughput synaptic connectivity mapping using in vivo two-photon holographic optogenetics and compressive sensing - Nature Neuroscience

Using two-photon optogenetics, electrical recordings and sparse signal reconstruction, the authors demonstrate in vivo synaptic connectivity mapping in the mouse visual cortex.

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Nature Neuroscience @natneuro.nature.com · 21d

A pair of papers on using holographic optogenetics and compressed sensing for connectomics:

Rapid learning of neural circuitry from holographic ensemble stimulation enabled by model-based compressed sensing

www.nature.com/articles/s41...

Rapid learning of neural circuitry from holographic ensemble stimulation enabled by model-based compressed sensing - Nature Neuroscience

The authors develop a new computational system for high-throughput mapping of synaptic connectivity using two-photon holographic optogenetics and intracellular recordings.

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Nature Neuroscience @natneuro.nature.com · 22d

Neurons in mouse primary visual cortex that respond emergently to illusory contours drive pattern completion

www.nature.com/articles/s41...

Recurrent pattern completion drives the neocortical representation of sensory inference - Nature Neuroscience

Neurons that respond emergently to illusory contours drive pattern completion in V1. Pattern completion in lower cortical areas may therefore mediate perceptual inference by selectively reinforcing ac...

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Nature Neuroscience @natneuro.nature.com · 23d

Our Chief Editor Shari Wiseman @shariwiseman.bsky.social will be at the Chinese Neuroscience Society meeting in Xi'an next week. Send her an email if you'd like to meet to talk about your work!

#CNS2025

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Nature Neuroscience @natneuro.nature.com · 24d

Augmenting AMPA receptor signaling after spinal cord injury increases ependymal-derived neural stem/progenitor cell migration and promotes functional recovery

www.nature.com/articles/s41...

Augmenting AMPA receptor signaling after spinal cord injury increases ependymal-derived neural stem/progenitor cell migration and promotes functional recovery - Nature Neuroscience

Hachem et al. show that AMPAR signaling drives the acute activation of ependymal-derived neural stem/progenitor cells after spinal cord injury and that this mechanism can be targeted therapeutically to harness the endogenous regenerative potential of the spinal cord.

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Nature Neuroscience @natneuro.nature.com · 27d

Review: A neural manifold view of the brain

www.nature.com/articles/s41...

A neural manifold view of the brain - Nature Neuroscience

Recent advances in neuroscience have revealed how neural population activity underlying behavior can be well described by topological objects called neural manifolds. Understanding how nature, nurture...

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Nature Neuroscience @natneuro.nature.com · 29d

Grid cells do not operate as a global positioning system but rather estimate position within multiple local reference frames

www.nature.com/articles/s41...

Grid cells accurately track movement during path integration-based navigation despite switching reference frames - Nature Neuroscience

Grid cells do not maintain a stable pattern during a self-motion-based task, but track animal movement in multiple local reference frames and reanchor to task-relevant objects, thus estimating local r...

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Nature Neuroscience @natneuro.nature.com · Sep 9

The activations of large-scale cortical functional networks are organized in an inherently cyclical manner, ensuring periodic activation of essential cognitive functions

@matsvanes.bsky.social @oxcin.bsky.social @oxfordpsychiatry.bsky.social @ox.ac.uk

www.nature.com/articles/s41...

Large-scale cortical functional networks are organized in structured cycles - Nature Neuroscience

The human brain cycles through a repertoire of brain networks on a 1-second timescale during rest and tasks. This cycling appears to allow periodic engagement of essential cognitive functions, with th...

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Nature Neuroscience @natneuro.nature.com · Sep 8

Allothetic and idiothetic spatial cues control the multiplexed theta phase coding of place cells

www.nature.com/articles/s41...

Allothetic and idiothetic spatial cues control the multiplexed theta phase coding of place cells - Nature Neuroscience

Using a virtual reality apparatus in rats that dissociates external landmarks from self-motion cues, the authors describe how the two modes of theta phase coding in the hippocampus during navigation a...

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Nature Neuroscience @natneuro.nature.com · Sep 6

Check out our September issue!

www.nature.com/neuro/volume...

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Nature Neuroscience @natneuro.nature.com · Sep 5

CRISPR screening by AAV episome-sequencing (CrAAVe-seq): a scalable cell-type-specific in vivo platform uncovers neuronal essential genes

@kampmann.bsky.social @ivlrose.bsky.social

www.nature.com/articles/s41...

CRISPR screening by AAV episome-sequencing (CrAAVe-seq): a scalable cell-type-specific in vivo platform uncovers neuronal essential genes - Nature Neuroscience

The authors developed an adeno-associated virus-based high-throughput in vivo CRISPR screening platform for endogenous mouse brain cell types. Using this platform, they define genes and pathways essen...

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Nature Neuroscience @natneuro.nature.com · Sep 4

Toxoplasma gondii infection and chronic IL-1 elevation drive hippocampal DNA double-strand break signaling, leading to cognitive deficits

www.nature.com/articles/s41...

Toxoplasma gondii infection and chronic IL-1 elevation drive hippocampal DNA double-strand break signaling, leading to cognitive deficits - Nature Neuroscience

Chronic brain infection and IL-1 exposure impair spatial memory by triggering DNA double-strand break signaling in hippocampal neurons. Blocking this pathway prevents memory deficits, suggesting new t...

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Nature Neuroscience @natneuro.nature.com · Sep 3

Longitudinal neuroimaging in three adults, followed before and up to 5 years after arm amputation, reveals that amputation does not trigger large-scale cortical reorganization

@hunterschone.bsky.social @cibaker.bsky.social @plasticity-lab.bsky.social

www.nature.com/articles/s41...

Stable cortical body maps before and after arm amputation - Nature Neuroscience

Longitudinal neuroimaging of participants with planned arm amputations shows that the cortical body map remains stable after amputation, with no evidence of hand or face reorganization, thus challengi...

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Nature Neuroscience @natneuro.nature.com · Sep 2

FOXP genes regulate Purkinje cell diversity and cerebellar morphogenesis

@nagham-farah.bsky.social

www.nature.com/articles/s41...

FOXP genes regulate Purkinje cell diversity and cerebellar morphogenesis - Nature Neuroscience

The Li lab mapped molecularly distinct Purkinje cell (PC) subtypes in 3D and linked them to adult cerebellar architecture. They found that Foxp1/Foxp2 are essential for PC diversity and that Foxp1+ PC...

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Nature Neuroscience @natneuro.nature.com · Aug 29

Impaired capillary–venous drainage contributes to gliosis and demyelination in mouse white matter during aging

www.nature.com/articles/s41...

Impaired capillary–venous drainage contributes to gliosis and demyelination in mouse white matter during aging - Nature Neuroscience

How reduced blood flow plays a role in progressive white matter loss during aging and associated cognitive decline is unclear. Here the authors show that selective constriction and rarefaction of capi...

www.nature.com

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