Ammonia can store and transport renewable energy for large-scale and long-term use. This Review discusses its synthesis under mild conditions through metal-mediated electrochemical, direct plasma-catalytic and tandem plasma-electrocatalytic processes, along with economic considerations and utilization in hydrogen production and fuel cells.

Nature Reviews Chemistry, Published online: 08 October 2025; doi:10.1038/s41570-025-00763-xLipid nanoparticle-based delivery vehicles for mRNA are assembled from several different components. This Perspective discusses how these components react with each other and pose a particular analytical challenge that must be addressed to ensure the reproducibility, stability and safety of such drug formulations.

Nature Reviews Chemistry, Published online: 08 October 2025; doi:10.1038/s41570-025-00763-xLipid nanoparticle-based delivery vehicles for mRNA are assembled from several different components. This Perspective discusses how these components react with each other and pose a particular analytical challenge that must be addressed to ensure the reproducibility, stability and safety of such drug formulations.

The 2025 Nobel Prize in Chemistry has been awarded to Susumu Kitagawa, Richard Robson and Omar M. Yaghi “for the development of metal–organic frameworks.”

Nature Reviews Chemistry - Ahead of his 60th birthday, Omar Yaghi discussed his life in science so far and where he believes is the exciting space for future developments.

Nature Reviews Chemistry, Published online: 26 September 2025; doi:10.1038/s41570-025-00761-zMolecular-level insight into hydrogen isotope separation processes with triazole-based metal–organic frameworks [Mn(ta)2] have recently been studied through in situ neutron diffraction and cryogenic thermal desorption spectroscopy. By fine-tuning the ligands of the framework, remarkable separation efficiencies are observed.

Nature Reviews Chemistry, Published online: 26 September 2025; doi:10.1038/s41570-025-00762-yThe Chemical Weapons Convention is underpinned by science. The Organisation for the Prohibition of Chemical Weapons Designated Laboratory network provides confidence to states parties that any misuse of chemicals as weapons can be properly investigated.

Nature Reviews Chemistry, Published online: 26 September 2025; doi:10.1038/s41570-025-00762-yThe Chemical Weapons Convention is underpinned by science. The Organisation for the Prohibition of Chemical Weapons Designated Laboratory network provides confidence to states parties that any misuse of chemicals as weapons can be properly investigated.

Nature Reviews Chemistry, Published online: 26 September 2025; doi:10.1038/s41570-025-00761-zMolecular-level insight into hydrogen isotope separation processes with triazole-based metal–organic frameworks [Mn(ta)2] have recently been studied through in situ neutron diffraction and cryogenic thermal desorption spectroscopy. By fine-tuning the ligands of the framework, remarkable separation efficiencies are observed.

Nature Reviews Chemistry, Published online: 26 September 2025; doi:10.1038/s41570-025-00762-yThe Chemical Weapons Convention is underpinned by science. The Organisation for the Prohibition of Chemical Weapons Designated Laboratory network provides confidence to states parties that any misuse of chemicals as weapons can be properly investigated.

Nature Reviews Chemistry, Published online: 26 September 2025; doi:10.1038/s41570-025-00761-zMolecular-level insight into hydrogen isotope separation processes with triazole-based metal–organic frameworks [Mn(ta)2] have recently been studied through in situ neutron diffraction and cryogenic thermal desorption spectroscopy. By fine-tuning the ligands of the framework, remarkable separation efficiencies are observed.

Nature Reviews Chemistry, Published online: 17 September 2025; doi:10.1038/s41570-025-00759-7The isolation of critical materials from minerals is challenging due to their comparable chemical properties and tendency to co-exist with one another. Instead of driving lanthanide separation by chemical extraction, a study leverages solubility differences between adjacent lanthanides to isolate Nd from used NdFeB magnets.

Nature Reviews Chemistry, Published online: 17 September 2025; doi:10.1038/s41570-025-00751-1Non-covalent interactions between organocatalyst molecules can change catalytic behaviour, leading to changes in reaction rates and selectivities. This Review discusses how to identify such interactions, measure their effect on catalysis and ultimately how to avoid or exploit them in synthesis.

Nature Reviews Chemistry, Published online: 16 September 2025; doi:10.1038/s41570-025-00757-9When generative artificial intelligence (AI) draws molecules, it doesn’t just get the science wrong — it risks reshaping how we see chemistry, spreading incorrect representations of our world that mislead learners, distort peer-reviewed reports, and erode trust in scientific work and rigour.

Nature Reviews Chemistry, Published online: 16 September 2025; doi:10.1038/s41570-025-00760-0Electron counting and oxidation states are fundamental concepts used for understanding a molecule’s electronic structure. A recent study of PuO2 provides insights into how covalency can impact our assessment of the electronic structures of f-element materials.

Nature Reviews Chemistry, Published online: 15 September 2025; doi:10.1038/s41570-025-00756-wDisabled scientists encounter many barriers in laboratory spaces, especially a lack of accessible lab equipment. #labdaptations is an ever-growing database of inclusive equipment created to improve the accessibility of laboratory work.

Nature Reviews Chemistry, Published online: 17 September 2025; doi:10.1038/s41570-025-00759-7The isolation of critical materials from minerals is challenging due to their comparable chemical properties and tendency to co-exist with one another. Instead of driving lanthanide separation by chemical extraction, a study leverages solubility differences between adjacent lanthanides to isolate Nd from used NdFeB magnets.

Nature Reviews Chemistry, Published online: 17 September 2025; doi:10.1038/s41570-025-00751-1Non-covalent interactions between organocatalyst molecules can change catalytic behaviour, leading to changes in reaction rates and selectivities. This Review discusses how to identify such interactions, measure their effect on catalysis and ultimately how to avoid or exploit them in synthesis.

Nature Reviews Chemistry, Published online: 16 September 2025; doi:10.1038/s41570-025-00757-9When generative artificial intelligence (AI) draws molecules, it doesn’t just get the science wrong — it risks reshaping how we see chemistry, spreading incorrect representations of our world that mislead learners, distort peer-reviewed reports, and erode trust in scientific work and rigour.

Nature Reviews Chemistry, Published online: 16 September 2025; doi:10.1038/s41570-025-00760-0Electron counting and oxidation states are fundamental concepts used for understanding a molecule’s electronic structure. A recent study of PuO2 provides insights into how covalency can impact our assessment of the electronic structures of f-element materials.

Nature Reviews Chemistry, Published online: 17 September 2025; doi:10.1038/s41570-025-00759-7The isolation of critical materials from minerals is challenging due to their comparable chemical properties and tendency to co-exist with one another. Instead of driving lanthanide separation by chemical extraction, a study leverages solubility differences between adjacent lanthanides to isolate Nd from used NdFeB magnets.

Nature Reviews Chemistry, Published online: 17 September 2025; doi:10.1038/s41570-025-00751-1Non-covalent interactions between organocatalyst molecules can change catalytic behaviour, leading to changes in reaction rates and selectivities. This Review discusses how to identify such interactions, measure their effect on catalysis and ultimately how to avoid or exploit them in synthesis.

Nature Reviews Chemistry, Published online: 10 September 2025; doi:10.1038/s41570-025-00758-8Ahead of her 75th birthday, Jane Clarke discussed her life in science, including her career change from school science teacher to protein folding researcher.