NC3Rs
@nc3rs.bsky.social
A UK-based scientific organisation dedicated to helping the research community worldwide to identify, develop and use 3Rs technologies and approaches. https://nc3rs.org.uk/
We are delighted to publish a report with @abpi.bsky.social that examines the UK landscape in human relevant in vitro models. It will help inform wider policy, funding and infrastructure requirements to accelerate translation and deliver benefits for pharmaceutical R&D. nc3rs.org.uk/news/landsca...
A landscape review of human relevant pre-clinical model development in the UK
New report by the Association of the British Pharmaceutical Industry (ABPI) and the NC3Rs examines the UK's capabilities in developing human relevant pre-clinical models for medicine development.
nc3rs.org.uk
February 12, 2026 at 12:33 PM
We are delighted to publish a report with @abpi.bsky.social that examines the UK landscape in human relevant in vitro models. It will help inform wider policy, funding and infrastructure requirements to accelerate translation and deliver benefits for pharmaceutical R&D. nc3rs.org.uk/news/landsca...
We are working with @oga-community.bsky.social to recruit a cohort of early career researchers who will drive the validation and use of better antibodies. Are you our next Antibody Champion?
More details, eligibility and application process: nc3rs.org.uk/news/antibod...
More details, eligibility and application process: nc3rs.org.uk/news/antibod...
February 5, 2026 at 2:04 PM
We are working with @oga-community.bsky.social to recruit a cohort of early career researchers who will drive the validation and use of better antibodies. Are you our next Antibody Champion?
More details, eligibility and application process: nc3rs.org.uk/news/antibod...
More details, eligibility and application process: nc3rs.org.uk/news/antibod...
Registration deadline: If you would like to join us on Thursday (5 February) for our interactive webinar on commercialising NAMs technologies, please register by 13.00 on Wednesday.
Join the conversation about commercialising new approach methodologies (NAMs) for safety assessment in an interactive webinar featuring a live Q&A with expert method developers at our next NAMs Network event.
📅 5 February, 13.00 (GMT)
⏰ Registration closes: 4 February
👉 nc3rs.org.uk/events/nc3rs...
📅 5 February, 13.00 (GMT)
⏰ Registration closes: 4 February
👉 nc3rs.org.uk/events/nc3rs...
February 2, 2026 at 3:12 PM
Registration deadline: If you would like to join us on Thursday (5 February) for our interactive webinar on commercialising NAMs technologies, please register by 13.00 on Wednesday.
📢 Delivering the alternatives strategy – Pharmacokinetics and cardiac safety: nc3rs.org.uk/events/nc3rs...
Join us and @innovateuk.bsky.social to explore how research collaboration and innovation can deliver government targets to replace animal use in drug development.
📅 10 March, Central London
Join us and @innovateuk.bsky.social to explore how research collaboration and innovation can deliver government targets to replace animal use in drug development.
📅 10 March, Central London
January 30, 2026 at 10:46 AM
📢 Delivering the alternatives strategy – Pharmacokinetics and cardiac safety: nc3rs.org.uk/events/nc3rs...
Join us and @innovateuk.bsky.social to explore how research collaboration and innovation can deliver government targets to replace animal use in drug development.
📅 10 March, Central London
Join us and @innovateuk.bsky.social to explore how research collaboration and innovation can deliver government targets to replace animal use in drug development.
📅 10 March, Central London
Webinar recording – Replacing fish studies in chemical safety screening and regulatory environmental risk assessment: nc3rs.org.uk/3rs-resource...
Learn more about fish cell line-based reproductive toxicity assays developed by aQuaTox Solutions GmbH and Eawag through our SAFE CRACK IT Challenge.
Learn more about fish cell line-based reproductive toxicity assays developed by aQuaTox Solutions GmbH and Eawag through our SAFE CRACK IT Challenge.
Data-driven design of fish cell line-based reproductive toxicity assays
Outcomes from the SAFE CRACK IT Challenge to replace fish studies in chemical safety screening and environmental risk assessment.
nc3rs.org.uk
January 27, 2026 at 4:02 PM
Webinar recording – Replacing fish studies in chemical safety screening and regulatory environmental risk assessment: nc3rs.org.uk/3rs-resource...
Learn more about fish cell line-based reproductive toxicity assays developed by aQuaTox Solutions GmbH and Eawag through our SAFE CRACK IT Challenge.
Learn more about fish cell line-based reproductive toxicity assays developed by aQuaTox Solutions GmbH and Eawag through our SAFE CRACK IT Challenge.
Do you use artificial intelligence to improve toxicity prediction, support regulatory science or reduce the reliance on animal use in safety assessment?
Share your work and insights with the 3Rs Collaborative AI Initiative: forms.cloud.microsoft/pages/respon...
⏰ Survey closes: 21 February.
Share your work and insights with the 3Rs Collaborative AI Initiative: forms.cloud.microsoft/pages/respon...
⏰ Survey closes: 21 February.
January 26, 2026 at 10:18 AM
Do you use artificial intelligence to improve toxicity prediction, support regulatory science or reduce the reliance on animal use in safety assessment?
Share your work and insights with the 3Rs Collaborative AI Initiative: forms.cloud.microsoft/pages/respon...
⏰ Survey closes: 21 February.
Share your work and insights with the 3Rs Collaborative AI Initiative: forms.cloud.microsoft/pages/respon...
⏰ Survey closes: 21 February.
Join the conversation about commercialising new approach methodologies (NAMs) for safety assessment in an interactive webinar featuring a live Q&A with expert method developers at our next NAMs Network event.
📅 5 February, 13.00 (GMT)
⏰ Registration closes: 4 February
👉 nc3rs.org.uk/events/nc3rs...
📅 5 February, 13.00 (GMT)
⏰ Registration closes: 4 February
👉 nc3rs.org.uk/events/nc3rs...
January 21, 2026 at 12:10 PM
Join the conversation about commercialising new approach methodologies (NAMs) for safety assessment in an interactive webinar featuring a live Q&A with expert method developers at our next NAMs Network event.
📅 5 February, 13.00 (GMT)
⏰ Registration closes: 4 February
👉 nc3rs.org.uk/events/nc3rs...
📅 5 February, 13.00 (GMT)
⏰ Registration closes: 4 February
👉 nc3rs.org.uk/events/nc3rs...
@gmrc.bsky.social has published its rearing manual online: nc3rs.org.uk/3rs-resource...
Reviewed by the NC3Rs and other external experts, this resource supports consistent, reliable and reproducible insect husbandry and empowers institutions to adopt wax moth larvae as a partial replacement model.
Reviewed by the NC3Rs and other external experts, this resource supports consistent, reliable and reproducible insect husbandry and empowers institutions to adopt wax moth larvae as a partial replacement model.
Galleria mellonella rearing manual
Developed by the Galleria Mellonella Research Centre at the University of Exeter, to support consistent, reliable and reproducible insect husbandry.
nc3rs.org.uk
January 16, 2026 at 11:40 AM
@gmrc.bsky.social has published its rearing manual online: nc3rs.org.uk/3rs-resource...
Reviewed by the NC3Rs and other external experts, this resource supports consistent, reliable and reproducible insect husbandry and empowers institutions to adopt wax moth larvae as a partial replacement model.
Reviewed by the NC3Rs and other external experts, this resource supports consistent, reliable and reproducible insect husbandry and empowers institutions to adopt wax moth larvae as a partial replacement model.
Are you involved in toxicology studies with dogs, minipigs or non-human primates? Register for our next welfare webinar to learn habituation techniques to refine their use in safety assessment: nc3rs.org.uk/events/welfa...
📅 29 January, 12.30 – 13.30 (GMT)
⏰ Registration closes: 28 January
📅 29 January, 12.30 – 13.30 (GMT)
⏰ Registration closes: 28 January
Welfare webinar: Habituation of minipigs, non-human primates and dogs for procedures in toxicology studies
Practical guidance to reduce stress during inhalation studies, blood sampling and ophthalmological exams.
nc3rs.org.uk
January 13, 2026 at 11:09 AM
Are you involved in toxicology studies with dogs, minipigs or non-human primates? Register for our next welfare webinar to learn habituation techniques to refine their use in safety assessment: nc3rs.org.uk/events/welfa...
📅 29 January, 12.30 – 13.30 (GMT)
⏰ Registration closes: 28 January
📅 29 January, 12.30 – 13.30 (GMT)
⏰ Registration closes: 28 January
Register for our online workshop ‘Rigorous experiments and clear communication with the Experimental Design Assistant’ as part of Love Methods Week this January: nc3rs.org.uk/events/love-...
📅 20 January, 9.00 – 11.00 (GMT)
⏰ Registration closes 19 January
📜 Certificates of attendance available
📅 20 January, 9.00 – 11.00 (GMT)
⏰ Registration closes 19 January
📜 Certificates of attendance available
January 9, 2026 at 1:11 PM
Register for our online workshop ‘Rigorous experiments and clear communication with the Experimental Design Assistant’ as part of Love Methods Week this January: nc3rs.org.uk/events/love-...
📅 20 January, 9.00 – 11.00 (GMT)
⏰ Registration closes 19 January
📜 Certificates of attendance available
📅 20 January, 9.00 – 11.00 (GMT)
⏰ Registration closes 19 January
📜 Certificates of attendance available
2026 is continuing where 2025 left off with a focus on alternatives to animal use in research and testing. Today the Parliamentary Office of Science and Technology published a POSTnote on this topic highlighting the opportunities and challenges: post.parliament.uk/research-bri...
Technology alternatives to animals in life sciences research
How is the UK replacing animal testing with technology alternatives? What are the opportunities, risks and barriers?
post.parliament.uk
January 5, 2026 at 12:25 PM
2026 is continuing where 2025 left off with a focus on alternatives to animal use in research and testing. Today the Parliamentary Office of Science and Technology published a POSTnote on this topic highlighting the opportunities and challenges: post.parliament.uk/research-bri...
Developed in direct response to NC3Rs recommendations, new guidance from the World Health Organisation (@who.int) encourages manufacturers and regulators to replace or remove animal-based quality control methods for vaccines and biologics: nc3rs.org.uk/news/new-who...
New WHO guidelines on non-animal tests for quality control of biologics
Developed in direct response to NC3Rs recommendations, new guidance supports manufacturers and regulators to transition to non-animal testing strategies.
nc3rs.org.uk
December 18, 2025 at 10:00 AM
Developed in direct response to NC3Rs recommendations, new guidance from the World Health Organisation (@who.int) encourages manufacturers and regulators to replace or remove animal-based quality control methods for vaccines and biologics: nc3rs.org.uk/news/new-who...
Eight teams kick-started the commercialisation of their 3Rs tools and technologies this year through the BBSRC-NC3Rs ICURe Explore programme.
Learn more about their success and next steps to translate new approaches into real-world applications that minimise animal use: nc3rs.org.uk/news/driving...
Learn more about their success and next steps to translate new approaches into real-world applications that minimise animal use: nc3rs.org.uk/news/driving...
December 17, 2025 at 2:05 PM
Eight teams kick-started the commercialisation of their 3Rs tools and technologies this year through the BBSRC-NC3Rs ICURe Explore programme.
Learn more about their success and next steps to translate new approaches into real-world applications that minimise animal use: nc3rs.org.uk/news/driving...
Learn more about their success and next steps to translate new approaches into real-world applications that minimise animal use: nc3rs.org.uk/news/driving...
Our next welfare webinar will focus on practical guidance to habituate dogs, minipigs and non-human primates to procedures in toxicology studies, minimising stress and refining their use in safety assessment.
📅 Thursday 29 January, 12.30 – 13.30 (GMT)
👉 Register: nc3rs.org.uk/events/welfa...
📅 Thursday 29 January, 12.30 – 13.30 (GMT)
👉 Register: nc3rs.org.uk/events/welfa...
Welfare webinar: Habituation of minipigs, non-human primates and dogs for procedures in toxicology studies
Practical guidance to reduce stress during inhalation studies, blood sampling and ophthalmological exams.
nc3rs.org.uk
December 10, 2025 at 3:47 PM
Our next welfare webinar will focus on practical guidance to habituate dogs, minipigs and non-human primates to procedures in toxicology studies, minimising stress and refining their use in safety assessment.
📅 Thursday 29 January, 12.30 – 13.30 (GMT)
👉 Register: nc3rs.org.uk/events/welfa...
📅 Thursday 29 January, 12.30 – 13.30 (GMT)
👉 Register: nc3rs.org.uk/events/welfa...
The OECD has agreed to develop new guidance that will reduce the number of fish used in some environmental toxicology studies. This is a result of work led by the NC3Rs and collaborators to understand and solve challenges in vitellogenin assessment.
Find out more: nc3rs.org.uk/news/new-int...
Find out more: nc3rs.org.uk/news/new-int...
December 5, 2025 at 11:14 AM
The OECD has agreed to develop new guidance that will reduce the number of fish used in some environmental toxicology studies. This is a result of work led by the NC3Rs and collaborators to understand and solve challenges in vitellogenin assessment.
Find out more: nc3rs.org.uk/news/new-int...
Find out more: nc3rs.org.uk/news/new-int...
Join @drejpearl.bsky.social at @unistrathclyde.bsky.social 3Rs day next week for an interactive workshop on using the Experimental Design Assistant to design rigorous in vivo experiments, with live support and guidance on hand.
📅 Friday 5 December
👉 Find out more: nc3rs.org.uk/events/unive...
📅 Friday 5 December
👉 Find out more: nc3rs.org.uk/events/unive...
November 27, 2025 at 3:57 PM
Join @drejpearl.bsky.social at @unistrathclyde.bsky.social 3Rs day next week for an interactive workshop on using the Experimental Design Assistant to design rigorous in vivo experiments, with live support and guidance on hand.
📅 Friday 5 December
👉 Find out more: nc3rs.org.uk/events/unive...
📅 Friday 5 December
👉 Find out more: nc3rs.org.uk/events/unive...
Our Chief Executive Vicky Robinson appears in @resprofnews.bsky.social today, in an opinion piece focusing on the UK government's ambitious strategy to replace the use of animals in research and testing: www.researchprofessionalnews.com/rr-news-uk-v....
UK’s plan to reduce animal experiments is strong - Research Professional News
Government strategy reflects recent progress and sets a path to the future, says Vicky Robinson
www.researchprofessionalnews.com
November 26, 2025 at 12:07 PM
Our Chief Executive Vicky Robinson appears in @resprofnews.bsky.social today, in an opinion piece focusing on the UK government's ambitious strategy to replace the use of animals in research and testing: www.researchprofessionalnews.com/rr-news-uk-v....
📢 Webinar: Data-driven design of fish cell line-based reproductive toxicity assays
📅 Tuesday 9 December, 14.00 – 15.00 (GMT)
👉 nc3rs.org.uk/events/data-...
Learn about in vitro assays to replace some in vivo fish tests in environmental risk assessment, developed through our SAFE CRACK IT Challenge.
📅 Tuesday 9 December, 14.00 – 15.00 (GMT)
👉 nc3rs.org.uk/events/data-...
Learn about in vitro assays to replace some in vivo fish tests in environmental risk assessment, developed through our SAFE CRACK IT Challenge.
November 24, 2025 at 4:29 PM
📢 Webinar: Data-driven design of fish cell line-based reproductive toxicity assays
📅 Tuesday 9 December, 14.00 – 15.00 (GMT)
👉 nc3rs.org.uk/events/data-...
Learn about in vitro assays to replace some in vivo fish tests in environmental risk assessment, developed through our SAFE CRACK IT Challenge.
📅 Tuesday 9 December, 14.00 – 15.00 (GMT)
👉 nc3rs.org.uk/events/data-...
Learn about in vitro assays to replace some in vivo fish tests in environmental risk assessment, developed through our SAFE CRACK IT Challenge.
At the @lasa-uk.bsky.social conference this week Jess Eddy shared NC3Rs resources on evaluating environmental enrichment: nc3rs.org.uk/3rs-resource...
Other talks in a great 3Rs session covered best practice in oncology, positive welfare science, zebrafish enrichment and rodent housing refinements.
Other talks in a great 3Rs session covered best practice in oncology, positive welfare science, zebrafish enrichment and rodent housing refinements.
November 20, 2025 at 3:30 PM
At the @lasa-uk.bsky.social conference this week Jess Eddy shared NC3Rs resources on evaluating environmental enrichment: nc3rs.org.uk/3rs-resource...
Other talks in a great 3Rs session covered best practice in oncology, positive welfare science, zebrafish enrichment and rodent housing refinements.
Other talks in a great 3Rs session covered best practice in oncology, positive welfare science, zebrafish enrichment and rodent housing refinements.
Congratulations to @alessiovagnoni.bsky.social who has been announced as a recipient of this year’s AAALAC International Global 3Rs Award recognising his ongoing work in advancing the 3Rs: www.aaalac.org/awards/globa...
Global 3Rs Winners
LEARN MORE / APPLY 2025 Award Winners ASIA-PACIFIC Bing Zhou, Ph.D., M.D. “Amelioration of nonalcoholic fatty liver disease by inhibiting the deubiquitylating enzyme RPN11” Cell Metabolism Sha
www.aaalac.org
November 14, 2025 at 12:40 PM
Congratulations to @alessiovagnoni.bsky.social who has been announced as a recipient of this year’s AAALAC International Global 3Rs Award recognising his ongoing work in advancing the 3Rs: www.aaalac.org/awards/globa...
The latest issue of Tech3Rs, our newsletter for animal technicians, has been published: nc3rs.org.uk/3rs-resource...
November 12, 2025 at 3:21 PM
The latest issue of Tech3Rs, our newsletter for animal technicians, has been published: nc3rs.org.uk/3rs-resource...
The NC3Rs has a strong track record in investing in in vitro models of human disease that replace the use of animals. We have recently partnered with the MRC, Wellcome and Innovate UK on a £15.9M funding call to develop human in vitro models of complex disease.
nc3rs.org.uk/news/nc3rs-g...
nc3rs.org.uk/news/nc3rs-g...
NC3Rs grant holders receive funding in MRC call
£15.9M awarded to develop human in vitro models of complex disease.
nc3rs.org.uk
November 12, 2025 at 10:37 AM
The NC3Rs has a strong track record in investing in in vitro models of human disease that replace the use of animals. We have recently partnered with the MRC, Wellcome and Innovate UK on a £15.9M funding call to develop human in vitro models of complex disease.
nc3rs.org.uk/news/nc3rs-g...
nc3rs.org.uk/news/nc3rs-g...
Today the UK government has released a strategy to support the development, validation and uptake of alternative methods.
Read more: www.gov.uk/government/n...
Read more: www.gov.uk/government/n...
Animal testing to be phased out faster as UK unveils roadmap for alternative methods
New plan backs researchers to seize on new and developing opportunities to phase out animal tests with specific commitments for the coming years.
www.gov.uk
November 11, 2025 at 9:26 AM
Today the UK government has released a strategy to support the development, validation and uptake of alternative methods.
Read more: www.gov.uk/government/n...
Read more: www.gov.uk/government/n...
❗Survey deadline extended: Friday 12 December❗
If you have experience of the monocyte activation test as a replacement for the rabbit pyrogen test, please take 30 minutes to share your insights: nc3rs.org.uk/our-portfoli...
If you have experience of the monocyte activation test as a replacement for the rabbit pyrogen test, please take 30 minutes to share your insights: nc3rs.org.uk/our-portfoli...
NEW SURVEY. Do you manufacture, regulate or produce biological therapeutics? Help the NC3Rs shape the future of non-animal pyrogenicity testing of biologics: nc3rs.org.uk/our-portfoli...
Supporting 3Rs approaches in biologicals testing
nc3rs.org.uk
November 10, 2025 at 12:54 PM
❗Survey deadline extended: Friday 12 December❗
If you have experience of the monocyte activation test as a replacement for the rabbit pyrogen test, please take 30 minutes to share your insights: nc3rs.org.uk/our-portfoli...
If you have experience of the monocyte activation test as a replacement for the rabbit pyrogen test, please take 30 minutes to share your insights: nc3rs.org.uk/our-portfoli...
Our next welfare webinar will focus on using positive reinforcement techniques to improve the welfare of pigs and dogs in research by encouraging voluntary cooperation with procedures and reducing stress.
📅 Thursday 27 November, 12.30 – 13.30 (GMT)
👉 Register: nc3rs.org.uk/events/welfa...
📅 Thursday 27 November, 12.30 – 13.30 (GMT)
👉 Register: nc3rs.org.uk/events/welfa...
November 6, 2025 at 3:02 PM
Our next welfare webinar will focus on using positive reinforcement techniques to improve the welfare of pigs and dogs in research by encouraging voluntary cooperation with procedures and reducing stress.
📅 Thursday 27 November, 12.30 – 13.30 (GMT)
👉 Register: nc3rs.org.uk/events/welfa...
📅 Thursday 27 November, 12.30 – 13.30 (GMT)
👉 Register: nc3rs.org.uk/events/welfa...