Neil Floch MD FACS FASMBS DABOM
@neilflochmd.bsky.social
1.9K followers 2.8K following 150 posts
Bariatric and Foregut Surgeon passionate about educating and advocating about obesity causes and treatments including medications and bariatric surgery - Associate Professor of Surgery Yale School of Medicine and a self-taught artist - Tufts Graduate
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The Yale Obesity Symposium
A one-day 7 CME event
November 21 2025
NEW developments in
Obesity Treatment

Speakers including:

Lee Kaplan MD PhD
Ania Jastreboff MD PhD
John Morton MD

Register NOW! cme.edu
@Yale @YaleMed @YaleSurgery
Obesity GLP-1ra Semaglutide Tirzepatide Retatrutide GLP1
Reposted by Neil Floch MD FACS FASMBS DABOM
From our September issue: Bile acids in the crosshairs for hypoglycaemia after gastric bypass, a News & Views from Marzieh Salehi (£) bit.ly/3H6tHhG #EndoSky #MedSky
The Impact of Bariatric Surgery on Cardiovascular Risk Factors and Outcomes: A Systematic Review | Cureus
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Reposted by Neil Floch MD FACS FASMBS DABOM
Oral semaglutide cost-effective vs. liraglutide—even at 50% ⤵️ price

🔹 🇬🇧 modelled data: ⤴️ QALYs (+0.18) & ⤵️ comp.

🔸 💊 = ⤵️ Rx burden vs. daily 💉

🔹 Results robust across sensitivity analyses

⚠️ funded by NovoNordisk

👉 Challenges low-cost liraglutide, supports 🎯 oral GLP-1 use

🔗 ggdocs.co/9h0bz1
Reposted by Neil Floch MD FACS FASMBS DABOM
📢 #GLP1 ⤵️ kidney decline, CV events & mortality in CKD❗️

🔹 Meta-analysis of 18K pts w/ eGFR <60:
⤵️ eGFR decline ≥50% (OR 0.72)
⤵️ 💔 (OR 0.86)
⤵️ ☠️ (OR 0.77)

🔸 ⤵️⤵️ with human GLP-1 backbone

🥇Evidence across CKD stages—not just macroalbuminuria

👉 GLP-1 now a key 🎯 in CKD + #T2D

🔗 ggdocs.co/tnqomz
Reposted by Neil Floch MD FACS FASMBS DABOM
📢 Danuglipron dropped—can orforglipron still be the “oral GLP-1 that delivers”?

🔹 Pfizer halts danuglipron after liver signal

🔸 Orforglipron P2=HbA1c ⤵️2.1%, Wt ⤵️14.7%, no liver signal

🔹 P3 2025—will it safely deliver?

👉 Small molecule GLP-1: blockbuster or cautionary tale?

🔗 ggdocs.co/5qu8y3
ggdocs.co
A message from @OMAsocial past PRESIDENT and #OAC board member @DrAngelaFitch:

IT IS TIME for #GLP1 #obesity medication pharmaceutical producers to:

#betheHERO #betheHERO!

Cut the cost to $299 a month and Increase access to care!
Reposted by Neil Floch MD FACS FASMBS DABOM
As bariatric surgery evolves to make the most of GLP-1 drugs, issues of when and how to use them for best results are a key focus: http://ms.spr.ly/63320qwot8
Reposted by Neil Floch MD FACS FASMBS DABOM
There are a lot of errors in this misleading article. For instance… reducing the size of the stomach is only one way in which bariatric surgery works - it also increases GLP-1, PYY, and other gut hormones, reduces Ghrelin, increases blood bile acids, alters the microbiome among other benefits
The new weight loss drugs like Ozempic, Wegovy and Mounjaro are wildly popular for weight loss and are changing not just how people approach it, but what they then don't do instead, such as bariatric surgery. This doctor offers lots of important food for thought for anyone considering either.
Surgery or Meds: What’s the Best Approach to Weight Loss?
One may have better outcomes but the other can play a big role, and the decision depends on each person’s specific needs
medium.com