Nils Homer
@nilshomer.com
I write software for Biologists. Founder @fulcrumgenomics, Bioinformatician, Computer Scientist, Coder, Father of 2xGirls. Opinions are my own.
Reposted by Nils Homer
10th Anniversary Core Values blog series: Valuing People
Valuing People is one of our deepest commitments: to ourselves, to our team, and to our clients. Life is messy—just like biology. When life gets complicated, we don’t look away. We step in.
Read More: blog.fulcrumgenomics.com/p/core-value...
Valuing People is one of our deepest commitments: to ourselves, to our team, and to our clients. Life is messy—just like biology. When life gets complicated, we don’t look away. We step in.
Read More: blog.fulcrumgenomics.com/p/core-value...
Core Value: Valuing People
Fulcrum Genomics 10th Anniversary Series
blog.fulcrumgenomics.com
October 23, 2025 at 7:35 PM
10th Anniversary Core Values blog series: Valuing People
Valuing People is one of our deepest commitments: to ourselves, to our team, and to our clients. Life is messy—just like biology. When life gets complicated, we don’t look away. We step in.
Read More: blog.fulcrumgenomics.com/p/core-value...
Valuing People is one of our deepest commitments: to ourselves, to our team, and to our clients. Life is messy—just like biology. When life gets complicated, we don’t look away. We step in.
Read More: blog.fulcrumgenomics.com/p/core-value...
@plasmidsaurus.bsky.social next time in Boston for #ASHG25, consider catering with Bagelsaurus!
October 20, 2025 at 10:40 PM
@plasmidsaurus.bsky.social next time in Boston for #ASHG25, consider catering with Bagelsaurus!
Ever want a live code review of your #bioinformatics code?
DM me if you’re at #ASHG25 and I’ll take look to give you suggestions on how to improve reproducibility, maintainability, and overall engineering quality.
DM me if you’re at #ASHG25 and I’ll take look to give you suggestions on how to improve reproducibility, maintainability, and overall engineering quality.
October 14, 2025 at 10:10 PM
Ever want a live code review of your #bioinformatics code?
DM me if you’re at #ASHG25 and I’ll take look to give you suggestions on how to improve reproducibility, maintainability, and overall engineering quality.
DM me if you’re at #ASHG25 and I’ll take look to give you suggestions on how to improve reproducibility, maintainability, and overall engineering quality.
Reposted by Nils Homer
10th Anniversary Core Values blog series: Openness
Openness is an action. It’s a positive, and proactive, choice to lean-in.
It begins with a simple but powerful question: What do I know that others need to know?
Read more: blog.fulcrumgenomics.com/p/core-value...
Openness is an action. It’s a positive, and proactive, choice to lean-in.
It begins with a simple but powerful question: What do I know that others need to know?
Read more: blog.fulcrumgenomics.com/p/core-value...
Core Value: Openness
Fulcrum Genomics 10th Anniversary Series
blog.fulcrumgenomics.com
October 2, 2025 at 5:52 PM
10th Anniversary Core Values blog series: Openness
Openness is an action. It’s a positive, and proactive, choice to lean-in.
It begins with a simple but powerful question: What do I know that others need to know?
Read more: blog.fulcrumgenomics.com/p/core-value...
Openness is an action. It’s a positive, and proactive, choice to lean-in.
It begins with a simple but powerful question: What do I know that others need to know?
Read more: blog.fulcrumgenomics.com/p/core-value...
I'll be there to prove I'm not an AI. Lets meet up!
@nilshomer.com, Yossi Farjoun, and @tfenne.bsky.social will be attending #ASHG25 in Boston this year on behalf of Fulcrum Genomics. Let us know if you'll be there too!
September 30, 2025 at 5:59 PM
I'll be there to prove I'm not an AI. Lets meet up!
Reposted by Nils Homer
@nilshomer.com, Yossi Farjoun, and @tfenne.bsky.social will be attending #ASHG25 in Boston this year on behalf of Fulcrum Genomics. Let us know if you'll be there too!
September 25, 2025 at 9:39 AM
@nilshomer.com, Yossi Farjoun, and @tfenne.bsky.social will be attending #ASHG25 in Boston this year on behalf of Fulcrum Genomics. Let us know if you'll be there too!
Reposted by Nils Homer
@nilshomer.com, Yossi Farjoun and I will be attending ASHG in Boston this year on behalf of Fulcrum Genomics. Let us know if you'll be there too!
September 18, 2025 at 3:19 PM
@nilshomer.com, Yossi Farjoun and I will be attending ASHG in Boston this year on behalf of Fulcrum Genomics. Let us know if you'll be there too!
Here’s to another ten years working with awesome and talented people on challenging and impactful Bioinformatics problems!
blog.fulcrumgenomics.com/p/ten-years-...
blog.fulcrumgenomics.com/p/ten-years-...
Ten Years of Fulcrum Genomics
Fulcrum Genomics Founded July 27, 2015
blog.fulcrumgenomics.com
July 28, 2025 at 2:28 PM
Here’s to another ten years working with awesome and talented people on challenging and impactful Bioinformatics problems!
blog.fulcrumgenomics.com/p/ten-years-...
blog.fulcrumgenomics.com/p/ten-years-...
Reposted by Nils Homer
We love working with people who notice how things fit together, who make unwieldy problems work better. The 'Meet the Team' series spotlights humans behind our bioinformatics work. We hope you'll feel like you've met us — or want to. Meet Erin McAuley: blog.fulcrumgenomics.com/p/meet-erin-...
Meet Erin McAuley
Scaling Science Without Losing the Plot
blog.fulcrumgenomics.com
July 23, 2025 at 2:44 PM
We love working with people who notice how things fit together, who make unwieldy problems work better. The 'Meet the Team' series spotlights humans behind our bioinformatics work. We hope you'll feel like you've met us — or want to. Meet Erin McAuley: blog.fulcrumgenomics.com/p/meet-erin-...
Saying no when someone offers to help deprives them of the opportunity to be generous.
July 23, 2025 at 8:12 AM
Saying no when someone offers to help deprives them of the opportunity to be generous.
My Genetic Data are public: blog.fulcrumgenomics.com/p/my-genetic...
My Genetic Data are public
Genomics, privacy, and the acquisition of 23andMe.
blog.fulcrumgenomics.com
July 2, 2025 at 9:25 PM
My Genetic Data are public: blog.fulcrumgenomics.com/p/my-genetic...
Create conda recipes with Grayskull
Master the Conda Universe
blog.fulcrumgenomics.com
May 27, 2025 at 4:04 PM
Cunningham’s Law, but making feature requests to get the correct answer. There’s got to be a German word for that.
May 22, 2025 at 4:48 AM
Cunningham’s Law, but making feature requests to get the correct answer. There’s got to be a German word for that.
Half the battle is knowing the right reference to use...
May 15, 2025 at 4:31 PM
Half the battle is knowing the right reference to use...
We try to be good #bioinformatics community members; check out our recent Open Source work @fulcrumgenomics.com
blog.fulcrumgenomics.com/p/recent-ope...
blog.fulcrumgenomics.com/p/recent-ope...
Recent Open Source Work by Fulcrum Genomics
Highlights from the last 3-4 months of our work in open source software
blog.fulcrumgenomics.com
May 13, 2025 at 4:04 PM
We try to be good #bioinformatics community members; check out our recent Open Source work @fulcrumgenomics.com
blog.fulcrumgenomics.com/p/recent-ope...
blog.fulcrumgenomics.com/p/recent-ope...
"As of May 1st 2025, GATK forums will be community-driven and self-moderated. They will not be moderated or monitored by a GATK team member."
See more: gatk.broadinstitute.org/hc/en-us
See more: gatk.broadinstitute.org/hc/en-us
a man is covering his mouth with his hand and says `` and like that ... he 's gone . ''
ALT: a man is covering his mouth with his hand and says `` and like that ... he 's gone . ''
media.tenor.com
April 30, 2025 at 4:34 PM
"As of May 1st 2025, GATK forums will be community-driven and self-moderated. They will not be moderated or monitored by a GATK team member."
See more: gatk.broadinstitute.org/hc/en-us
See more: gatk.broadinstitute.org/hc/en-us
fgbio in use again!
Who says we can't have OSS #bioinformatics from an commercial organization?
www.nature.com/articles/s41...
Who says we can't have OSS #bioinformatics from an commercial organization?
www.nature.com/articles/s41...
Single duplex DNA sequencing with CODEC detects mutations with high sensitivity - Nature Genetics
Concatenating Original Duplex for Error Correction (CODEC) is a method that concatenates both strands of each DNA duplex to enable highly sensitive mutation detection in a range of analytes with fewer...
www.nature.com
April 28, 2025 at 5:12 PM
fgbio in use again!
Who says we can't have OSS #bioinformatics from an commercial organization?
www.nature.com/articles/s41...
Who says we can't have OSS #bioinformatics from an commercial organization?
www.nature.com/articles/s41...
Reposted by Nils Homer
Python is a simple language, but using it isn't always easy.
Today I reflected on the following code. To really understand it, one must learn: generators, type hinting, pytest fixtures, advanced usage of fixtures, monkey patching the OS environment, mocking impure environments, generators...
Today I reflected on the following code. To really understand it, one must learn: generators, type hinting, pytest fixtures, advanced usage of fixtures, monkey patching the OS environment, mocking impure environments, generators...
April 16, 2025 at 1:52 AM
Python is a simple language, but using it isn't always easy.
Today I reflected on the following code. To really understand it, one must learn: generators, type hinting, pytest fixtures, advanced usage of fixtures, monkey patching the OS environment, mocking impure environments, generators...
Today I reflected on the following code. To really understand it, one must learn: generators, type hinting, pytest fixtures, advanced usage of fixtures, monkey patching the OS environment, mocking impure environments, generators...
April 15, 2025 at 1:30 AM
Reposted by Nils Homer
How to use Conda without running afoul of Anaconda licensing. Read more on our blog:
#bioinformatics #conda #software
open.substack.com/pub/fulcrumg...
#bioinformatics #conda #software
open.substack.com/pub/fulcrumg...
Anaconda Licensing Changes
How to use Conda without running afoul of Anaconda licensing.
open.substack.com
April 14, 2025 at 9:58 PM
How to use Conda without running afoul of Anaconda licensing. Read more on our blog:
#bioinformatics #conda #software
open.substack.com/pub/fulcrumg...
#bioinformatics #conda #software
open.substack.com/pub/fulcrumg...
Reposted by Nils Homer
New release of fastquorum!
This nf-core #nextflow fgbio Best Practices FASTQ to Consensus Pipeline to produce consensus reads using unique molecular indexes/barcodes (UMIs).
This nf-core #nextflow fgbio Best Practices FASTQ to Consensus Pipeline to produce consensus reads using unique molecular indexes/barcodes (UMIs).
Pipeline release! nf-core/fastquorum v1.2.0 - 1.2.0!
Please see the changelog: https://github.com/nf-core/fastquorum/releases/tag/1.2.0
Please see the changelog: https://github.com/nf-core/fastquorum/releases/tag/1.2.0
April 11, 2025 at 3:47 PM
New release of fastquorum!
This nf-core #nextflow fgbio Best Practices FASTQ to Consensus Pipeline to produce consensus reads using unique molecular indexes/barcodes (UMIs).
This nf-core #nextflow fgbio Best Practices FASTQ to Consensus Pipeline to produce consensus reads using unique molecular indexes/barcodes (UMIs).
Breaking: from the Series-A MVP slide deck!
April 7, 2025 at 10:54 PM
Breaking: from the Series-A MVP slide deck!
Reposted by Nils Homer
Public service announcement. They are not Dire Wolves. They have 20 single letter changes in their entire genomes. I’ve done shits with more mutations.
Every time journalists write up a Colossus press release, They are making people stupider. Client journalism by a ridiculous company.
Every time journalists write up a Colossus press release, They are making people stupider. Client journalism by a ridiculous company.
April 7, 2025 at 8:02 PM
Public service announcement. They are not Dire Wolves. They have 20 single letter changes in their entire genomes. I’ve done shits with more mutations.
Every time journalists write up a Colossus press release, They are making people stupider. Client journalism by a ridiculous company.
Every time journalists write up a Colossus press release, They are making people stupider. Client journalism by a ridiculous company.